Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes an outbreak of corona virus disease 2019(COVID-19)globally.It is to date one of the biggest public health threat in the world.Although studies on this ...Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes an outbreak of corona virus disease 2019(COVID-19)globally.It is to date one of the biggest public health threat in the world.Although studies on this emerging coronavirus have developed rapidly since the COVID-19 case was confirmed,there is much remains unknown about SARS-CoV-2.To better understand the mechanism of cross-species transmission and search for efficient vaccines and therapeutics for COVID-19,animal models are highly required to evaluate countermeasures against emerging COVID-19.An ideal animal model should respond as similar as human be-ings to SARS-CoV-2 infection and show analogical symptoms,reflecting the human beings clinical sign,viral replication,and pathology that can be applied to identify in human beings.Fortunately,several animal models have been developed to study SARS-CoV-2 and aim to find new vaccines,antiviral agents,and Chinese materia medica very shortly.We aim to review the climical presentations of COVID-19 concerning pathologic features in humans and summarize the current animal models'strengths and limitations of use for SARS-CoV-2.展开更多
Insects are a group of arthropods and the largest group of animals on Earth,with over one million species described to date.Like other life forms,insects suffer from viruses that cause disease and death.Viruses that a...Insects are a group of arthropods and the largest group of animals on Earth,with over one million species described to date.Like other life forms,insects suffer from viruses that cause disease and death.Viruses that are pathogenic to beneficial insects cause dramatic economic losses on agriculture.In contrast,viruses that are pathogenic to insect pests can be exploited as attractive biological control agents.All of these factors have led to an explosion in the amount of research into insect viruses in recent years,generating impressive quantities of information on the molecular and cellular biology of these viruses.Due to the wide variety of insect viruses,a better understanding of these viruses will expand our overall knowledge of their virology.Here,we review studies of several newly discovered RNA insect viruses in China.展开更多
基金We thank for the funding support from the Key Scientifie Research Projects of Henan Province Colleges and Universities(21 A360021)Natural Science Foundation of Henan Province(202300410259)+1 种基金Postdoctoral Research Startup Project in Henan Province(202001043)Special Program of the Postdoctoral Science Foundation of China(2021 T140184).
文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes an outbreak of corona virus disease 2019(COVID-19)globally.It is to date one of the biggest public health threat in the world.Although studies on this emerging coronavirus have developed rapidly since the COVID-19 case was confirmed,there is much remains unknown about SARS-CoV-2.To better understand the mechanism of cross-species transmission and search for efficient vaccines and therapeutics for COVID-19,animal models are highly required to evaluate countermeasures against emerging COVID-19.An ideal animal model should respond as similar as human be-ings to SARS-CoV-2 infection and show analogical symptoms,reflecting the human beings clinical sign,viral replication,and pathology that can be applied to identify in human beings.Fortunately,several animal models have been developed to study SARS-CoV-2 and aim to find new vaccines,antiviral agents,and Chinese materia medica very shortly.We aim to review the climical presentations of COVID-19 concerning pathologic features in humans and summarize the current animal models'strengths and limitations of use for SARS-CoV-2.
基金supported by the National Natural Science Foundation of China (31270190 and 81201292 to Zhou Xi,31270189 to Hu YuanYang)the Chinese 111 Project (B06018)
文摘Insects are a group of arthropods and the largest group of animals on Earth,with over one million species described to date.Like other life forms,insects suffer from viruses that cause disease and death.Viruses that are pathogenic to beneficial insects cause dramatic economic losses on agriculture.In contrast,viruses that are pathogenic to insect pests can be exploited as attractive biological control agents.All of these factors have led to an explosion in the amount of research into insect viruses in recent years,generating impressive quantities of information on the molecular and cellular biology of these viruses.Due to the wide variety of insect viruses,a better understanding of these viruses will expand our overall knowledge of their virology.Here,we review studies of several newly discovered RNA insect viruses in China.
