《单身男子》(A Single Man)是英国作家克里斯托弗·伊舍伍德(Christopher Isherwood)的小说作品之一,至今没有中文译本,知名度与流传度都相对较低,但被评论界普遍认作是伊舍伍德最好的作品之一。小说的关键信息包括失去的痛苦,居...《单身男子》(A Single Man)是英国作家克里斯托弗·伊舍伍德(Christopher Isherwood)的小说作品之一,至今没有中文译本,知名度与流传度都相对较低,但被评论界普遍认作是伊舍伍德最好的作品之一。小说的关键信息包括失去的痛苦,居住在美国的外国人士,友情与爱情的界限与意义,历史背景(古巴导弹危机与性解放),以及少数派人士与社会主流的冲突与和解。在理解的基础上,译者应抓住作者的写作特点和风格再现原文的风采。但同时翻译中的翻译与再创作应该是有着明确的界限的,在翻译时应牢记译者作为两种语言两种文化之间的桥梁作用。展开更多
To address the scalability and identity federation problems of the traditional single sign-on system, the proposed scheme divides the security systems into different security domains. Each security domain has its own ...To address the scalability and identity federation problems of the traditional single sign-on system, the proposed scheme divides the security systems into different security domains. Each security domain has its own security servers and service providers, and there are trust relationships between different security domains for identity federation. The security server is responsible for authentication and authorization inside the domain, and offers identity federation capability for different domains. The security assertion markup language （SAML） assertion is used as security token in the system for authentication, authorization, and identity federation. The design of the proposed single sign-on process is based on web service security framework and multiple security domains, and the authorization is always deployed in the local area inside the service provider＇ s security domain, which enables web service clients, both inside and outside their security domains, to access the services in a simple, scalable, standard and secure way.展开更多
The aeromechanical st ability for the coupled rotor/fuselage system of helicopters in forward flight i s investigated. The periodic time-varying equations of motion are developed thr ough building a new 24DOF coupled ...The aeromechanical st ability for the coupled rotor/fuselage system of helicopters in forward flight i s investigated. The periodic time-varying equations of motion are developed thr ough building a new 24DOF coupled rigid/elastic blended element based on the fle xible multibody system theory in this paper. It accounts for the effects of prec one, sweep, and the moderately large elastic deflections on the blade and elasti city of shaft and fuselage of the helicopter. The dynamic coupling between the r igid motion of blades about the flap, lag and pitch hinges of articulated rotor and moderately large elastic deflections are included. There is no restriction o n the rotation amplitudes of flap, lag and pitch in the formulation. The stabili ty of periodic solution is studied using the Floquet theory. The transition matr ix is calculated by the Newmark integration method. The aeromechanical stability of a new helicopter is studied. The results show that it is stable in the given forward flight. But the instability arises with the decrease of the bending and torsion stiffness of the shaft.展开更多
The main purpose of this article is to perform a technical-economic analysis of different microgeneration systems （photovoltaic and wind turbine systems） that can be installed in a single-family house. One of the st...The main purpose of this article is to perform a technical-economic analysis of different microgeneration systems （photovoltaic and wind turbine systems） that can be installed in a single-family house. One of the strategies for improving energy performance of buildings is the installation of microgeneration systems. This will enable Portugal to meet the goal regarding the share of renewable sources on gross final energy consumption imposed by the European Commission climate change and energy package for 2020. The analysis of four different micro-generation systems will take into account the local availability of renewable resources and market technologies and the new Portuguese law concerning microgeneration to promote renewable energy sources in households. The Portuguese microgeneration legal framework is also highlighted.展开更多
In this paper we propose two quantum secure direct communication (QSDC) protocols with authentication.The authentication key expansion method is introduced to improve the life of the keys with security.In the first sc...In this paper we propose two quantum secure direct communication (QSDC) protocols with authentication.The authentication key expansion method is introduced to improve the life of the keys with security.In the first scheme,the third party, called Trent is introduced to authenticate the users that participate in the communication.He sends thepolarized photons in blocks to authenticate communication parties Alice and Bob using the authentication keys.In thecommunication process, polarized single photons are used to serve as the carriers, which transmit the secret messagesdirectly.The second QSDC process with authentication between two parties is also discussed.展开更多
Primary biliary cirrhosis (PBC) is a progressive autoim- mune liver disease of unknown etiology that affects almost exclusively women.Ursodeoxycholic acid (UDCA) is currently the only approved drug by Food and Drug Ad...Primary biliary cirrhosis (PBC) is a progressive autoim- mune liver disease of unknown etiology that affects almost exclusively women.Ursodeoxycholic acid (UDCA) is currently the only approved drug by Food and Drug Administration for patients with PBC.Although the precise pathogenesis of PBC remains unclear,it has been postulated that many cell populations,including B cells,are involved in the ongoing inflammatory process,which implicates,not surprisingly,a potential thera- peutic target of depleting B cell to treat this disorder.Rituximab is a chimeric anti-CD20 monoclonal antibody that has been approved for the treatment of lymphoma and some autoimmune diseases such as rheumatoid arthritis.Whether it is effective in the treatment of PBC has not been evaluated.Recently,Tsuda et al [1] demon- strated that B cell depletion with rituximab significantly reduced the number of anti-mitochondrial antibodies (AMA)-producing B cells,AMA titers,the plasma levels of immunoglobulins (IgA,IgM and IgG) as well as se- rum alkaline phosphatase,and it was well tolerated by all the treated patients with no serious adverse events.This observation provides a novel treatment option for the patients with PBC who have incomplete response to UDCA.展开更多
Objective： Low-density granulocytes （LDGs） can form neutrophil extracellular traps （NETs） spontaneously and excessively. When peripheral blood mononuclear calls （PBMCs） are used for studying T lymphocytes, LDGs...Objective： Low-density granulocytes （LDGs） can form neutrophil extracellular traps （NETs） spontaneously and excessively. When peripheral blood mononuclear calls （PBMCs） are used for studying T lymphocytes, LDGs contained in the PBMCs may decrease the threshold of activating T lymphocytes by forming NETs. This study focused on the profiles of LDGs in common autoimmune diseases and methods for removing LDGs from PBMCs. Methods： The percentages of LDGs in PBMCs from 55 patients with dermatomyositis （DM）, 15 with polymyositis （PM）, 42 with rheumatoid arthritis （RA）, 25 with systemic lupus erythematosus （SLE）, and 19 healthy controls were determined by flow cytometry. Three methods of removing LDGs were explored and compared. After removal, PBMCs from six patients with positive T-SPOT.TB were tested again to find out if LDGs contained in the PBMCs could influence T lymphocyte reactions. Results： Significantly higher LDG percentages were found in PBMCs from patients with DM （（8.41±10.87）%, P〈0.0001 ）, PM （（8.41±10.39）%, P〈0.0001 ）, RA （（4.05±6.97）%, P=0.0249）, and SLE （（7.53±11.52）%, P=0.0006）, compared with the controls （（1.28±0.73）%）. The T-SPOT.TB values significantly decreased after LDGs were removed. Increasing relative centrifugal force （RCF） within a limited range can decrease the LDG percentage from an initial high level, but not markedly increase the LDG clearance rate. Compared with the whole blood sediment method, the PBMC adherence method can significantly remove LDGs yet scarcely influence the T lymphocyte percentage in PBMCs. Conclusions： The LDG percentage in PBMCs is significantly increased in patients with S/E, DM, PM, and RA. The influence of LDGs on T lymphocytes cannot be ignored in PBMC cultures. The adherence method is a simple and easy-to-use method for removing LDGs and purifying T lymphocytes from PBMCs.展开更多
文摘《单身男子》(A Single Man)是英国作家克里斯托弗·伊舍伍德(Christopher Isherwood)的小说作品之一,至今没有中文译本,知名度与流传度都相对较低,但被评论界普遍认作是伊舍伍德最好的作品之一。小说的关键信息包括失去的痛苦,居住在美国的外国人士,友情与爱情的界限与意义,历史背景(古巴导弹危机与性解放),以及少数派人士与社会主流的冲突与和解。在理解的基础上,译者应抓住作者的写作特点和风格再现原文的风采。但同时翻译中的翻译与再创作应该是有着明确的界限的,在翻译时应牢记译者作为两种语言两种文化之间的桥梁作用。
基金The National Natural Science Foundation of China(No60673054)
文摘To address the scalability and identity federation problems of the traditional single sign-on system, the proposed scheme divides the security systems into different security domains. Each security domain has its own security servers and service providers, and there are trust relationships between different security domains for identity federation. The security server is responsible for authentication and authorization inside the domain, and offers identity federation capability for different domains. The security assertion markup language （SAML） assertion is used as security token in the system for authentication, authorization, and identity federation. The design of the proposed single sign-on process is based on web service security framework and multiple security domains, and the authorization is always deployed in the local area inside the service provider＇ s security domain, which enables web service clients, both inside and outside their security domains, to access the services in a simple, scalable, standard and secure way.
文摘The aeromechanical st ability for the coupled rotor/fuselage system of helicopters in forward flight i s investigated. The periodic time-varying equations of motion are developed thr ough building a new 24DOF coupled rigid/elastic blended element based on the fle xible multibody system theory in this paper. It accounts for the effects of prec one, sweep, and the moderately large elastic deflections on the blade and elasti city of shaft and fuselage of the helicopter. The dynamic coupling between the r igid motion of blades about the flap, lag and pitch hinges of articulated rotor and moderately large elastic deflections are included. There is no restriction o n the rotation amplitudes of flap, lag and pitch in the formulation. The stabili ty of periodic solution is studied using the Floquet theory. The transition matr ix is calculated by the Newmark integration method. The aeromechanical stability of a new helicopter is studied. The results show that it is stable in the given forward flight. But the instability arises with the decrease of the bending and torsion stiffness of the shaft.
文摘The main purpose of this article is to perform a technical-economic analysis of different microgeneration systems （photovoltaic and wind turbine systems） that can be installed in a single-family house. One of the strategies for improving energy performance of buildings is the installation of microgeneration systems. This will enable Portugal to meet the goal regarding the share of renewable sources on gross final energy consumption imposed by the European Commission climate change and energy package for 2020. The analysis of four different micro-generation systems will take into account the local availability of renewable resources and market technologies and the new Portuguese law concerning microgeneration to promote renewable energy sources in households. The Portuguese microgeneration legal framework is also highlighted.
基金Supported by the National Fundamental Research Program under Grant No.2010CB923202Specialized Research Fund for the Doctoral Program of Education Ministry of China under Grant No.20090005120008+1 种基金 the Fundamental Research Funds for the Central Universities under Grant No.BUPT2009RC0710 China National Natural Science Foundation under Grant Nos.60871082,60937003 and 10947151
文摘In this paper we propose two quantum secure direct communication (QSDC) protocols with authentication.The authentication key expansion method is introduced to improve the life of the keys with security.In the first scheme,the third party, called Trent is introduced to authenticate the users that participate in the communication.He sends thepolarized photons in blocks to authenticate communication parties Alice and Bob using the authentication keys.In thecommunication process, polarized single photons are used to serve as the carriers, which transmit the secret messagesdirectly.The second QSDC process with authentication between two parties is also discussed.
文摘Primary biliary cirrhosis (PBC) is a progressive autoim- mune liver disease of unknown etiology that affects almost exclusively women.Ursodeoxycholic acid (UDCA) is currently the only approved drug by Food and Drug Administration for patients with PBC.Although the precise pathogenesis of PBC remains unclear,it has been postulated that many cell populations,including B cells,are involved in the ongoing inflammatory process,which implicates,not surprisingly,a potential thera- peutic target of depleting B cell to treat this disorder.Rituximab is a chimeric anti-CD20 monoclonal antibody that has been approved for the treatment of lymphoma and some autoimmune diseases such as rheumatoid arthritis.Whether it is effective in the treatment of PBC has not been evaluated.Recently,Tsuda et al [1] demon- strated that B cell depletion with rituximab significantly reduced the number of anti-mitochondrial antibodies (AMA)-producing B cells,AMA titers,the plasma levels of immunoglobulins (IgA,IgM and IgG) as well as se- rum alkaline phosphatase,and it was well tolerated by all the treated patients with no serious adverse events.This observation provides a novel treatment option for the patients with PBC who have incomplete response to UDCA.
基金Project supported by the National Natural Science Foundation of China(Nos.81560267 and 81401363)the Natural Science Foundation of Gansu Province(No.1606RJZA213)the Asia Pacific League of Associations for Rheumatology(APLAR) Research Grant 2015
文摘Objective： Low-density granulocytes （LDGs） can form neutrophil extracellular traps （NETs） spontaneously and excessively. When peripheral blood mononuclear calls （PBMCs） are used for studying T lymphocytes, LDGs contained in the PBMCs may decrease the threshold of activating T lymphocytes by forming NETs. This study focused on the profiles of LDGs in common autoimmune diseases and methods for removing LDGs from PBMCs. Methods： The percentages of LDGs in PBMCs from 55 patients with dermatomyositis （DM）, 15 with polymyositis （PM）, 42 with rheumatoid arthritis （RA）, 25 with systemic lupus erythematosus （SLE）, and 19 healthy controls were determined by flow cytometry. Three methods of removing LDGs were explored and compared. After removal, PBMCs from six patients with positive T-SPOT.TB were tested again to find out if LDGs contained in the PBMCs could influence T lymphocyte reactions. Results： Significantly higher LDG percentages were found in PBMCs from patients with DM （（8.41±10.87）%, P〈0.0001 ）, PM （（8.41±10.39）%, P〈0.0001 ）, RA （（4.05±6.97）%, P=0.0249）, and SLE （（7.53±11.52）%, P=0.0006）, compared with the controls （（1.28±0.73）%）. The T-SPOT.TB values significantly decreased after LDGs were removed. Increasing relative centrifugal force （RCF） within a limited range can decrease the LDG percentage from an initial high level, but not markedly increase the LDG clearance rate. Compared with the whole blood sediment method, the PBMC adherence method can significantly remove LDGs yet scarcely influence the T lymphocyte percentage in PBMCs. Conclusions： The LDG percentage in PBMCs is significantly increased in patients with S/E, DM, PM, and RA. The influence of LDGs on T lymphocytes cannot be ignored in PBMC cultures. The adherence method is a simple and easy-to-use method for removing LDGs and purifying T lymphocytes from PBMCs.
