反哺

事情发生在去年冬天的一个星期日。 妈妈住进医院的第二天，病房里住进来一个老奶奶。

在档案史料中把握中华人民共和国史——读《反哺与责任:解放以来上海支援全国研究》

上海支援全国是贯穿中华人民共和国历史的一条重要发展线索。《反哺与责任:解放以来上海支援全国研究》一书,依据大量珍稀档案史料,在细致考证和梳理解放以来上海支援全国历史的同时,从上海与全国经济联动关系的视角深化和推动了学界对中华人民共和国史研究的整体进展。

The Development of Agroecology at Barani （Burkina Faso）

Many researches deal with practices which could adduce reliable answers to insure an ecological development which meets the nowadays global issue ＂feed the world＂ in a sustainable way. But scientific research is much less prolific about social adhesion to those practices. How could we be certain that peasants will integrate them and transform their agriculture？ It is at that particular point that we settled our contribution. Our goal is to determine what are the levers which could be activated to promote agroecological practices, and, on the contrary, what are the obstacles which could prevent social adhesion to agroecology. The meticulous fieldwork carried in Barani, a landlocked small village in the North-West of the Burkina Faso, shows that all the ingredients for the development and the dissemination of agroecology already exist. Indeed, traditional agriculture is not so far from agroecology. But we noticed among peasants ofBarani a rejection of the local farming system synonymous, according to them, with backwardness, and an attraction for industrial agriculture, sign of modernity. Dissemination of agroecology will have to go through a major confidence-building work of the peasants with their own practices, as opposed to multiple trainings where they are always being taught what they already know.

The Role of the Charged Residues of the GP2 Helical Regions in Ebola Entry

The glycoprotein （GP） of Ebola is the sole structural protein that forms the spikes on the viral envelope. The GP contains two subunits, GPI and GP2, linked by a disulfide bond, which are responsible for receptor binding and membrane fusion, respectively. In this study, the full length of GP gene of Ebola Zaire species, 2028 base pairs in length, was synthesized using 38 overlapping oligonucleotides by multiple rounds of polymerase chain reaction （PCR）. The synthesized GP gene was shown to be efficiently expressed in mammalian cells. Furthermore, an efficient HIV-based pseudotyping system was developed using the synthetic GP gene, providing a safe approach to dissecting the entry mechanism of Ebola viruses. Using this pseudotyping system and mutational analysis, the role of the charged residues in the GP2 helical regions was examined. It was found that substitutions of the most charged residues in the regions did not adversely affect GP expression, processing, or viral incorporation, however, most of the mutations greatly impaired the ability of GP to mediate efficient viral infection. These results demonstrate that these charged residues of GP2 play an important role in GP-mediated Ebola entry into its host cells. We propose that these charged residues are involved in forming the intermediate conformation（s） of GP in membrane fusion and Ebola entry.

Alpha-picolinic acid,a fungal toxin and mammal apoptosis-inducing agent,elicits hypersensitive-like response and enhances disease resistance in rice

Alpha-picolinic acid (PA),a metabolite of tryptophan and an inducer of apoptosis in the animal cell,has been reported to be a toxin produced by some of plant fungal pathogens and used in screening for disease resistant mutants. Here,we report that PA is an efficient apoptosis agent triggering cell death of hypersensitive-like response in planta. Confirmed by Fluorescence Activated Cell Sorter (FACS),rice suspension cells and leaves exhibited programmed cell death induced by PA. The PA-induced cell death was associated with the accumulation of reactive oxygen species that could be blocked by diphenylene iodonium chloride,indicating that the generation of reactive oxygen species was NADPHoxidase dependent. We also demonstrated the induction of rice defense-related genes and subsequent resistant enhancement by PA against the rice blast fungus Magnaporthe grisea. Hence,it was concluded that the PA-stimulated defense response likely involves the onset of the hypersensitive response in rice,which also provides a simple eliciting tool for studying apoptosis in the plant cell.

Kinetics of Oxidation of Lactose with Photochemically Generated Radicals

Lactose milk sugar is found only in the milk of mammals. In order to understand the mechanism of oxidation of lactose, a systematic kinetic study of oxidation of lactose with photochemicaUy generated radicals was carried out. The reaction has a first order dependence on chloramine-T as well as on substrate. The reaction is catalysed by H＋ ions as well. On the basis of kinetic results and product analysis a probable mechanism were suggested.

Agricultural Heritage Systems:A Bridge between Urban and Rural Development

In the early 1990 s,China stepped into the stage of rapid urbanization with a flourishing economy and new technological development.Surplus labor from rural areas flooded into cities and became the main force of urban development.However some severe threats to human survival emerged from urbanization,such as overextensive urban development,excessive resource consumption,ecological degradation,food security and safety risks and social crises.It has become an imperative to balance urban and rural development to achieve greater harmony between nature and society.This paper firstly tried to focus on public dietary change,agricultural industry development,institutional guarantee,ecological restoration,as well as cultural tourism in urban and peri-urban agricultural heritage sites.Then,it established a development model,balanced the urbanization and urban-supported agriculture.This paper proposed ＂Agricultural heritage systems＂ as an entry point for balancing the development of urban areas and rural areas.Agricultural heritage systems can inherit local traditional culture,keep the green and organic agriculture cultivation systems,exploit the distinct landscape tourism,and the like for diversified development;In addition,agricultural heritage systems can take full advantage of abundant funds,firm the institutional guarantee and advanced technologies from the nearby urban complex for regurgitation-feeding of rural enterprises.With the help of these strategies,we can achieve the harmony of ＂Ecological Urban＂ and ＂Garden Countryside＂.

Cultural Feedback and Intergenerational Transmission in Artifact Civilization

＂Cultural feedback＂ （wenhua fanbu, literally ＂cultural reverse feeding＂）, an indigenous concept coined to facilitate the understanding of intergenerational relations in China＇s drastically changing society, focuses on the subversion or reversal of conventional intergenerational relations in the light of changes triggered jointly by globalization and social transformation and views the extensive absorption of emerging cultural elements by the older generation from the young generation as a new mode of transmission. The process of the dissemination and selection of three kinds of modem artifacts-new foods, cell phones and computers--highlights the intergenerational tilt, the phenomenon of decentralization and the trend towards a digital divide. The subversion of conventional intergenerational relations in the process of the transmission of artifact civilization, as a significant part of Chinese psychological reactions to over three decades of reform and opening up, is indispensable to the psychological integrity of Chinese experience.

Inactivation of Cipc alters the expression of Per1 but not circadian rhythms in mice

Circadian clocks are comprised of self-sustained transcriptional/translational feedback loops, which regulate the rhythms of physiology and behavior in mammals. CLOCK-interacting protein, Circadian(CIPC), has been indicated as an additional negative-feedback regulator of the circadian clock in vitro, although its physiological roles in circadian clock are unknown. Here, we generated Cipc homozygous knockout(Cipc-/-) mice and assessed the resultant circadian phenotypes. Surprisingly, the m RNA expression profiles of core clock genes in the liver of Cipc-/- mice showed no significant differences from that in wild-type mice except for Per1. Cipc-/- mice displayed normal locomotor rhythm and entrained activity pattern in both 12:12 light-dark cycle and constant dark cycle. Furthermore, deletion of Cipc in lungs and adipose tissues did not influence their peripheral clock. The results from this work provided more conclusive data suggesting that CIPC is not critically required for basic clock function.

Why not to avoid the smell of danger？ Unexpected behavior of the Cypriot mouse surviving on the island invaded by black rats

Mus cypriaeus is a recently discovered endemic species that evolved about half a million years ago on the Cyprus Is- land in an absence of most mammalian predators and competitors. As on other Mediterranean islands, the faunal composition was dramatically changed by the invasion of commensal and domestic species following Holocene colonization by humans. We exa- mined the behavioral responses of the Cypriot mouse to the odors of these new competitors （black and Norway rat, house mouse and spiny-mouse） and predator （domestic cat） as well as controls （Herb-field mouse, guinea pig）. We compared them with those of mainland population of house mouse from Syria with different coexistence history. Surprisingly, the Cypriot mouse failed to avoid the odor of its current main competitor, the black rat. Moreover, the response patterns of both the Cypriot and Syrian house mice to the examined odor sources appeared fairly comparable. There was a clear tendency to prefer odors of other murids over unscented sawdust as well as to avoid the odor of a domestic cat. In conclusion, neither the long-term isolation from predators nor the recent strong competition with black rats affected mice eompetitory and antipredatory responses fundamentally [Current Zoology 61 （4）： 781-791, 2015].