The nanoparticles of the hydrophobic drug of danazol with narrow size distribution are facilely prepared by controlled high-gravity anti-solvent precipitation （HGAP） process. Intensified micromixing and uniform nucl...The nanoparticles of the hydrophobic drug of danazol with narrow size distribution are facilely prepared by controlled high-gravity anti-solvent precipitation （HGAP） process. Intensified micromixing and uniform nucleation environment are created by the high-gravity equipment （rotating packed bed） in carrying out the anti-solvent precipitation process to produce nanoparticles. The average particle size decreases from 55 μm of the raw danazol to 190 nm of the nanoparticles. The Brunauer-Emmett-Teller （BET） surface area sharply increases from 0.66 m^2·g^-1 to 15.08 m^2·g^-l. Accordingly, the dissolution rate is greatly improved. The molecular state, chemical composition, and crystal form of the danazol nanoparticles remains unchanged after processing according to Fourier transform infrared （FTIR） and X-ray diffraction （XRD）, The high recovery ratio and continuous production capacity are highly appreciated in industry. Therefore, the HGAP method might offer a general and facile platform for mass production of hydrophobic pharmaceutical danazol particles in nanometer range.展开更多
Hydrophobic ZSM-5 zeolite filled polydimethylsiloxane （PDMS） composite membranes with Nylon micro-filtration membrane as the support layer were prepared to separate acetaldehyde from its aqueous solution. The compos...Hydrophobic ZSM-5 zeolite filled polydimethylsiloxane （PDMS） composite membranes with Nylon micro-filtration membrane as the support layer were prepared to separate acetaldehyde from its aqueous solution. The composite membranes were characterized by Fourier transform infrared spectroscopy and X-ray diffraction. Their structural morphology and thermal stability were also examined. The swelling study showed that the composite membranes presented higher degree of swelling in aqueous solution of acetaldehyde than in pure water at 25℃,展开更多
The cases of cholera in Mariupol and adjacent areas which were observed within the period of May-August, 2011 are investigated. Thirty-two diseased and 22 vibriocarriers were found on the territory of the city in the ...The cases of cholera in Mariupol and adjacent areas which were observed within the period of May-August, 2011 are investigated. Thirty-two diseased and 22 vibriocarriers were found on the territory of the city in the course of epidemic. The potential sources of infection are specified. The ways to avoid similar situations in the future are suggested. The analysis of the locations of the cholera contamination sources results in the obvious conclusion that most of them are connected with the place where the river Kalmius meets the Azov Sea. Waste flow from the residential solid waste landfill brings a considerable harm to the river Kalmius and the Azov Sea.展开更多
基金Supported by the National High Technology Research and Development Program of China (2006AA030202)the Talent Training Program of Beijing (2007B022)
文摘The nanoparticles of the hydrophobic drug of danazol with narrow size distribution are facilely prepared by controlled high-gravity anti-solvent precipitation （HGAP） process. Intensified micromixing and uniform nucleation environment are created by the high-gravity equipment （rotating packed bed） in carrying out the anti-solvent precipitation process to produce nanoparticles. The average particle size decreases from 55 μm of the raw danazol to 190 nm of the nanoparticles. The Brunauer-Emmett-Teller （BET） surface area sharply increases from 0.66 m^2·g^-1 to 15.08 m^2·g^-l. Accordingly, the dissolution rate is greatly improved. The molecular state, chemical composition, and crystal form of the danazol nanoparticles remains unchanged after processing according to Fourier transform infrared （FTIR） and X-ray diffraction （XRD）, The high recovery ratio and continuous production capacity are highly appreciated in industry. Therefore, the HGAP method might offer a general and facile platform for mass production of hydrophobic pharmaceutical danazol particles in nanometer range.
基金Supported by Shanghai Natural Science Foundation (10ZR1432000)Kwang-Hua Fund for College of Civil Engineering,Tongji University
文摘Hydrophobic ZSM-5 zeolite filled polydimethylsiloxane （PDMS） composite membranes with Nylon micro-filtration membrane as the support layer were prepared to separate acetaldehyde from its aqueous solution. The composite membranes were characterized by Fourier transform infrared spectroscopy and X-ray diffraction. Their structural morphology and thermal stability were also examined. The swelling study showed that the composite membranes presented higher degree of swelling in aqueous solution of acetaldehyde than in pure water at 25℃,
文摘The cases of cholera in Mariupol and adjacent areas which were observed within the period of May-August, 2011 are investigated. Thirty-two diseased and 22 vibriocarriers were found on the territory of the city in the course of epidemic. The potential sources of infection are specified. The ways to avoid similar situations in the future are suggested. The analysis of the locations of the cholera contamination sources results in the obvious conclusion that most of them are connected with the place where the river Kalmius meets the Azov Sea. Waste flow from the residential solid waste landfill brings a considerable harm to the river Kalmius and the Azov Sea.
