美国剧作家查尔斯·米(Charles L. Mee)以其风格独特的系列作品,两次获得奥比奖,并荣获笔会/劳拉·佩尔斯国际基金戏剧奖及美国艺术和文学学会的戏剧终身成就奖。在他的个人网站(www.charlesmee.org)上,他的全部剧本都可以免费...美国剧作家查尔斯·米(Charles L. Mee)以其风格独特的系列作品,两次获得奥比奖,并荣获笔会/劳拉·佩尔斯国际基金戏剧奖及美国艺术和文学学会的戏剧终身成就奖。在他的个人网站(www.charlesmee.org)上,他的全部剧本都可以免费下载。这在版权观念深入人心的今天,实属例外行为。展开更多
Aim Intracellular calcium ([Ca^(2+) ]_i) is mainly regulated by mitochondriaand endo-plasmic reticula. This study was carried out to ascertain whether the elementary mechanismof the effects of etimicin (EM) and gentam...Aim Intracellular calcium ([Ca^(2+) ]_i) is mainly regulated by mitochondriaand endo-plasmic reticula. This study was carried out to ascertain whether the elementary mechanismof the effects of etimicin (EM) and gentamicin (GM) on [Ca^(2+) ]_i is related to their effects onmitochondrion Ca^(2+) -uptake and endoplasmic reticulum Ca^(2+) -uptake. Methods The effects of GMand EM on [Ca^(2+) ]_i in LLC-PK1 were determined with a fluorescent probe of Fura-2/AM. The effectsof EM and GM on mitochondrion Ca^(2+) -uptake and endoplasmic reticulum Ca^(2+) -uptake weredetermined by isotope indicator (^(45)Ca^(2+) ) . Results EM and GM at the concentration of 1mmol·L^(-1) had no significant effect on [Ca^(2+) ]_i(P. > 0.05) and at 10 mmol·L^(-1)significantly caused [Ca^(2+) ]_i to increase (P < 0.01). EM and GM at 1 mmol·L^(-1) causedmitochondrion Ca^(2+)-uptake to ascend dramatically (P < 0.05) and at 10 mmol·L^(-1) causedmitochondrion Ca^(2+) -uptake to descend significantly. EM and GM at more than 0.34 mrnol·L^(-1)significantly inhibited endoplasmic reticulum Ca^(2+) -uptake (P < 0.05 or 0.01). Conclusion Novariation of [Ca^(2+) ]_i caused by EM and GM at lower concentrations might relate to theequilibrium of their promotion of mitochondrion Ca^(2+) -uptake with their inhibition of endoplasmicreticulum Ca^(2+) -uptake. The elevation of [Ca^(2+) ]_i caused by EM and GM at higherconcentrations might correlate with their inhibition of mitochondrion Ca^(2+) -uptake andendoplasmic reticulum Ca^(2+) -uptake.展开更多
Objective: To study the effects of etimicin (EM) and gentamicin (GM) on renal endoplasmic reticulum 45 Ca 2+ uptake and Ca 2+ Mg 2+ ATPase activity. Methods: Using 45 Ca 2+ inc...Objective: To study the effects of etimicin (EM) and gentamicin (GM) on renal endoplasmic reticulum 45 Ca 2+ uptake and Ca 2+ Mg 2+ ATPase activity. Methods: Using 45 Ca 2+ incorporation technique and peacock blue spectrophotometry respectively. Results: EM and GM (≥3.4×10 4 mol·L 1 ) inhibited endoplasmic reticulum 45 Ca 2+ uptake (the rate of inhibition: ≥17.4% and ≥25.5%, respectively); EM and GM (3.4×10 2 mol·L 1 ) inhibited Ca 2+ Mg 2+ ATPase activity (the rate of inhibition: 24.2% and 29.2%, respectively). Conclusion: At high concentration, EM and GM elevated intracellular calcium which may be related to their nephrotoxicity.展开更多
Objectives:As Watson's Human Caring Theory continues to evolve and guide the discipline of nursing,the challenge is to find ways to integrate it into practice.The purpose of this study is to describe interprofessi...Objectives:As Watson's Human Caring Theory continues to evolve and guide the discipline of nursing,the challenge is to find ways to integrate it into practice.The purpose of this study is to describe interprofessional team members'perspectives on human caring based on the Ten Caritas Processes(R)/Caritas-Veritas Literacy of Watson's Human Caring Theory within the Unitary Caring Science.Methods:This is a qualitative directed content analysis study,taking place in a Children's Hospital in the United States between November 2017 and April 2018.Information redundancy was utilized to guide the recruitment.Data were collected via a one-time face-to-face individual interview.A qualitative directed content analysis was conducted using Watson's Ten Caritas Processes(R)/Caritas-Veritas Literacy as a coding framework.Results:Twenty-seven healthcare professionals participated in the study.Interprofessional human caring,based on the Ten Caritas Processes(R)/Caritas-Veritas Literacy,was referred to as performing lovingkindness to patients,each other,and self;maintaining faith-hope in teamwork;valuing intersubjective interactions and building trust among team members;cultivating heart-centered-caring relations;acknowledging and processing positive and negative feelings non-judgmentally;applying all ways of knowing in caring;encouraging reciprocal teaching-learning;developing caring-healing environments collaboratively;respecting human dignity of patients and each other;and being open-minded to the unknowns and believing in miracles.Conclusions:Watson's Human Caring Theory can be an underlying guide to enrich human-to-human relations and create a caring-healing environment.When human caring is applied in interprofessional teams,healthcare professionals find a caring consciousness to care for oneself and each other and promote patient care.展开更多
As a huge,intense,and elevated atmospheric heat source(AHS) approaching the mid-troposphere in spring and summer,the Tibetan Plateau(TP) thermal forcing is perceived as an important factor contributing to the formatio...As a huge,intense,and elevated atmospheric heat source(AHS) approaching the mid-troposphere in spring and summer,the Tibetan Plateau(TP) thermal forcing is perceived as an important factor contributing to the formation and variation of the Asian summer monsoon.Despite numerous studies devoted to determine the strength and change of the thermal forcing of the TP on the basis of various data sources and methods,uncertainties remain in quantitative estimation of the AHS and will persist for the following reasons:(1) Routine meteorological stations cover only limited regions and show remarkable spatial inhomogeneity with most distributed in the central and eastern plateau.Moreover,all of these stations are situated at an altitude below 5000 m.Thus,the large area above that elevation is not included in the data.(2) Direct observations on heat fluxes do not exist at most stations,and the sensible heat flux(SHF) is calculated by the bulk formula,in which the drag coefficient for heat is often treated as an empirical constant without considering atmospheric stability and thermal roughness length.(3) Radiation flux derived by satellite remote sensing shows a large discrepancy in the algorithm in data inversion and complex terrain.(4) In reanalysis data,besides the rare observational records employed for data assimilation,model bias in physical processes induces visible errors in producing the diabatic heating fields.展开更多
November 2012, the CPC eighteen report makes clear the ＂three advocacy＂ that is ＂promote a prosperous, democratic, civilized, harmonious, advocating freedom, equality, justice, rule of law, promote patriotism, dedi...November 2012, the CPC eighteen report makes clear the ＂three advocacy＂ that is ＂promote a prosperous, democratic, civilized, harmonious, advocating freedom, equality, justice, rule of law, promote patriotism, dedication, integrity, kindness, and actively cultivate community ism core values＂. Shanghai University of Engineering Science actively exchange, in consultation with Chen Yun Memorial. Chen Yun Memorial becomes education base of Party spirit of Shanghai University of Engineering Science in January 2012. The two sides mutual assistance, resource sharing, innovation, and collaborate on a series of patriotic education, spirit of education, the socialist core value education as the core of ideological education. Make full use of Shanghai University of Engineering Science Chen Yun Memorial rich red cultural resources, cultural heritage and innovation red while actively practice the socialist core values, help young party members to establish a correct outlook on life and values, enhance the spirit of patriotism of young party members to enhance awareness of young party members in the party spirit.展开更多
According to Felice Vinci＇s revolutionary theory of the Nordic origins of the Homeric poems, the Achaeans who migrated to the Aegean Sea to found the Mycenaean civilization--whose language actually was an Ionian dial...According to Felice Vinci＇s revolutionary theory of the Nordic origins of the Homeric poems, the Achaeans who migrated to the Aegean Sea to found the Mycenaean civilization--whose language actually was an Ionian dialect, similar to that of Homer--were the laones, deriving their origin from Sweden. The Italian scholar offers significant analogies to prove his hypothesis, drawing them from several scientific disciplines, such as history （the movement appears similar to that of Varangians, who in the Middle Ages moved from Sweden to found the kingdom of Rus＇）, geography （the promontory of Cape Sounion, located 43 miles south-southeast of Athens, seems to be a souvenir of the same name）, archaeology （the spiral shape, one of the most popular ones in the volutes of the Ionic capitals, was a common decoration also during the Nordic Bronze Age）, and literature （especially a remarkable quotation taken from Plato, Critias 111e）. In the author＇s contribution, he tries to check Felice Vinci＇s interpretation through a careful survey in ancient literature and linguistics, in order to verify the etymological connections between the ancient people of laones and the Tacitean Suiones.展开更多
文摘Aim Intracellular calcium ([Ca^(2+) ]_i) is mainly regulated by mitochondriaand endo-plasmic reticula. This study was carried out to ascertain whether the elementary mechanismof the effects of etimicin (EM) and gentamicin (GM) on [Ca^(2+) ]_i is related to their effects onmitochondrion Ca^(2+) -uptake and endoplasmic reticulum Ca^(2+) -uptake. Methods The effects of GMand EM on [Ca^(2+) ]_i in LLC-PK1 were determined with a fluorescent probe of Fura-2/AM. The effectsof EM and GM on mitochondrion Ca^(2+) -uptake and endoplasmic reticulum Ca^(2+) -uptake weredetermined by isotope indicator (^(45)Ca^(2+) ) . Results EM and GM at the concentration of 1mmol·L^(-1) had no significant effect on [Ca^(2+) ]_i(P. > 0.05) and at 10 mmol·L^(-1)significantly caused [Ca^(2+) ]_i to increase (P < 0.01). EM and GM at 1 mmol·L^(-1) causedmitochondrion Ca^(2+)-uptake to ascend dramatically (P < 0.05) and at 10 mmol·L^(-1) causedmitochondrion Ca^(2+) -uptake to descend significantly. EM and GM at more than 0.34 mrnol·L^(-1)significantly inhibited endoplasmic reticulum Ca^(2+) -uptake (P < 0.05 or 0.01). Conclusion Novariation of [Ca^(2+) ]_i caused by EM and GM at lower concentrations might relate to theequilibrium of their promotion of mitochondrion Ca^(2+) -uptake with their inhibition of endoplasmicreticulum Ca^(2+) -uptake. The elevation of [Ca^(2+) ]_i caused by EM and GM at higherconcentrations might correlate with their inhibition of mitochondrion Ca^(2+) -uptake andendoplasmic reticulum Ca^(2+) -uptake.
文摘Objective: To study the effects of etimicin (EM) and gentamicin (GM) on renal endoplasmic reticulum 45 Ca 2+ uptake and Ca 2+ Mg 2+ ATPase activity. Methods: Using 45 Ca 2+ incorporation technique and peacock blue spectrophotometry respectively. Results: EM and GM (≥3.4×10 4 mol·L 1 ) inhibited endoplasmic reticulum 45 Ca 2+ uptake (the rate of inhibition: ≥17.4% and ≥25.5%, respectively); EM and GM (3.4×10 2 mol·L 1 ) inhibited Ca 2+ Mg 2+ ATPase activity (the rate of inhibition: 24.2% and 29.2%, respectively). Conclusion: At high concentration, EM and GM elevated intracellular calcium which may be related to their nephrotoxicity.
基金This study was supported in part by a Seed Grant from the College of Nursing at East Carolina University received by the first author
文摘Objectives:As Watson's Human Caring Theory continues to evolve and guide the discipline of nursing,the challenge is to find ways to integrate it into practice.The purpose of this study is to describe interprofessional team members'perspectives on human caring based on the Ten Caritas Processes(R)/Caritas-Veritas Literacy of Watson's Human Caring Theory within the Unitary Caring Science.Methods:This is a qualitative directed content analysis study,taking place in a Children's Hospital in the United States between November 2017 and April 2018.Information redundancy was utilized to guide the recruitment.Data were collected via a one-time face-to-face individual interview.A qualitative directed content analysis was conducted using Watson's Ten Caritas Processes(R)/Caritas-Veritas Literacy as a coding framework.Results:Twenty-seven healthcare professionals participated in the study.Interprofessional human caring,based on the Ten Caritas Processes(R)/Caritas-Veritas Literacy,was referred to as performing lovingkindness to patients,each other,and self;maintaining faith-hope in teamwork;valuing intersubjective interactions and building trust among team members;cultivating heart-centered-caring relations;acknowledging and processing positive and negative feelings non-judgmentally;applying all ways of knowing in caring;encouraging reciprocal teaching-learning;developing caring-healing environments collaboratively;respecting human dignity of patients and each other;and being open-minded to the unknowns and believing in miracles.Conclusions:Watson's Human Caring Theory can be an underlying guide to enrich human-to-human relations and create a caring-healing environment.When human caring is applied in interprofessional teams,healthcare professionals find a caring consciousness to care for oneself and each other and promote patient care.
基金supported by the the National Natural Science Foundation of China (Grants 91337216 and 41175070)and the Open Project of the Key Laboratory of Meteorological Disaster of Ministry of Education (Grant KLME1309)
文摘As a huge,intense,and elevated atmospheric heat source(AHS) approaching the mid-troposphere in spring and summer,the Tibetan Plateau(TP) thermal forcing is perceived as an important factor contributing to the formation and variation of the Asian summer monsoon.Despite numerous studies devoted to determine the strength and change of the thermal forcing of the TP on the basis of various data sources and methods,uncertainties remain in quantitative estimation of the AHS and will persist for the following reasons:(1) Routine meteorological stations cover only limited regions and show remarkable spatial inhomogeneity with most distributed in the central and eastern plateau.Moreover,all of these stations are situated at an altitude below 5000 m.Thus,the large area above that elevation is not included in the data.(2) Direct observations on heat fluxes do not exist at most stations,and the sensible heat flux(SHF) is calculated by the bulk formula,in which the drag coefficient for heat is often treated as an empirical constant without considering atmospheric stability and thermal roughness length.(3) Radiation flux derived by satellite remote sensing shows a large discrepancy in the algorithm in data inversion and complex terrain.(4) In reanalysis data,besides the rare observational records employed for data assimilation,model bias in physical processes induces visible errors in producing the diabatic heating fields.
文摘November 2012, the CPC eighteen report makes clear the ＂three advocacy＂ that is ＂promote a prosperous, democratic, civilized, harmonious, advocating freedom, equality, justice, rule of law, promote patriotism, dedication, integrity, kindness, and actively cultivate community ism core values＂. Shanghai University of Engineering Science actively exchange, in consultation with Chen Yun Memorial. Chen Yun Memorial becomes education base of Party spirit of Shanghai University of Engineering Science in January 2012. The two sides mutual assistance, resource sharing, innovation, and collaborate on a series of patriotic education, spirit of education, the socialist core value education as the core of ideological education. Make full use of Shanghai University of Engineering Science Chen Yun Memorial rich red cultural resources, cultural heritage and innovation red while actively practice the socialist core values, help young party members to establish a correct outlook on life and values, enhance the spirit of patriotism of young party members to enhance awareness of young party members in the party spirit.
文摘According to Felice Vinci＇s revolutionary theory of the Nordic origins of the Homeric poems, the Achaeans who migrated to the Aegean Sea to found the Mycenaean civilization--whose language actually was an Ionian dialect, similar to that of Homer--were the laones, deriving their origin from Sweden. The Italian scholar offers significant analogies to prove his hypothesis, drawing them from several scientific disciplines, such as history （the movement appears similar to that of Varangians, who in the Middle Ages moved from Sweden to found the kingdom of Rus＇）, geography （the promontory of Cape Sounion, located 43 miles south-southeast of Athens, seems to be a souvenir of the same name）, archaeology （the spiral shape, one of the most popular ones in the volutes of the Ionic capitals, was a common decoration also during the Nordic Bronze Age）, and literature （especially a remarkable quotation taken from Plato, Critias 111e）. In the author＇s contribution, he tries to check Felice Vinci＇s interpretation through a careful survey in ancient literature and linguistics, in order to verify the etymological connections between the ancient people of laones and the Tacitean Suiones.
