AIM:To investigate the efficacy and side effects of the combined therapy of oxaliplatin and capecitabine in patients with metastatic esophageal squamous cell cancer(ESCC) and the survival of the patients.METHODS:Sixty...AIM:To investigate the efficacy and side effects of the combined therapy of oxaliplatin and capecitabine in patients with metastatic esophageal squamous cell cancer(ESCC) and the survival of the patients.METHODS:Sixty-four patients(median age of 63 years) with histological or cytological confirmation of ESCC received oxaliplatin 120 mg/m2 intravenously on day 1 and capecitabine 1000 mg/m2 orally twice daily on days 1 to 14 in a 21-d treatment cycle as palliative chemotherapy.Each patient received at least two cycles of treatment.The efficacy,side effects and patient survival were evaluated.RESULTS:The partial response(PR) rate was 43.8%(28/64).Stable disease(SD) rate was 47.9%(26/64),and disease progression rate was 15.6%(10/64).The clinical benefit rate(PR + SD) was 84.4%.The main toxicities were leukopenia(50.0%),nausea and vomiting(51.6%),diarrhea(50.0%),stomatitis(39.1%),polyneuropathy(37.5%) and hand-foot syndrome(37.5%).No grade 4 event in the entire cohort was found.The median progression-free survival was 4 mo,median overall survival was 10 mo(95% CI:8.3-11.7 mo),and the 1-and 2-year survival rates were 38.1% and 8.2%,respectively.High Karnofsky index,single metastatic lesion and response to the regimen indicated respectively good prognosis.CONCLUSION:Oxaliplatin plus capecitabine regimen is effective and tolerable in metastatic ESCC patients.The regimen has improved the survival moderately and merits further studies.展开更多
The aim of this essay is firstly to indicate a little-known film Le Dēpart made by the famous Polish director Jerzy Skolimowski in 1967 year as an example of the Polish New Wave. Although it was made in Belgium and i...The aim of this essay is firstly to indicate a little-known film Le Dēpart made by the famous Polish director Jerzy Skolimowski in 1967 year as an example of the Polish New Wave. Although it was made in Belgium and it stars Jean-Pierre Lēaud as a car-obsessed young man trying to get possession of a Porsche for a race. The film won the Golden Bear at the 17th Berlin International Film Festival and was also selected as the Belgian entry for the Best Foreign Language Film at the 40th Academy Awards, but was not accepted as a nominee. Secondly, I analyze the reasons of misunderstanding the idea of the director in the film when it was shown in the the public. Thirdly, ＂entering＂ this movie in context of art： poetry, painting etc. Then to answer the question （hypothesis）： ＂Is the Polish Film New Wave a phenomenon that did not exist？＂ The methodology used for the paper is analysis and interpretation of the film itself; analysis of its reception in the 60s and now： poetics of receipt, cognitivism, comparative research.展开更多
文摘AIM:To investigate the efficacy and side effects of the combined therapy of oxaliplatin and capecitabine in patients with metastatic esophageal squamous cell cancer(ESCC) and the survival of the patients.METHODS:Sixty-four patients(median age of 63 years) with histological or cytological confirmation of ESCC received oxaliplatin 120 mg/m2 intravenously on day 1 and capecitabine 1000 mg/m2 orally twice daily on days 1 to 14 in a 21-d treatment cycle as palliative chemotherapy.Each patient received at least two cycles of treatment.The efficacy,side effects and patient survival were evaluated.RESULTS:The partial response(PR) rate was 43.8%(28/64).Stable disease(SD) rate was 47.9%(26/64),and disease progression rate was 15.6%(10/64).The clinical benefit rate(PR + SD) was 84.4%.The main toxicities were leukopenia(50.0%),nausea and vomiting(51.6%),diarrhea(50.0%),stomatitis(39.1%),polyneuropathy(37.5%) and hand-foot syndrome(37.5%).No grade 4 event in the entire cohort was found.The median progression-free survival was 4 mo,median overall survival was 10 mo(95% CI:8.3-11.7 mo),and the 1-and 2-year survival rates were 38.1% and 8.2%,respectively.High Karnofsky index,single metastatic lesion and response to the regimen indicated respectively good prognosis.CONCLUSION:Oxaliplatin plus capecitabine regimen is effective and tolerable in metastatic ESCC patients.The regimen has improved the survival moderately and merits further studies.
文摘The aim of this essay is firstly to indicate a little-known film Le Dēpart made by the famous Polish director Jerzy Skolimowski in 1967 year as an example of the Polish New Wave. Although it was made in Belgium and it stars Jean-Pierre Lēaud as a car-obsessed young man trying to get possession of a Porsche for a race. The film won the Golden Bear at the 17th Berlin International Film Festival and was also selected as the Belgian entry for the Best Foreign Language Film at the 40th Academy Awards, but was not accepted as a nominee. Secondly, I analyze the reasons of misunderstanding the idea of the director in the film when it was shown in the the public. Thirdly, ＂entering＂ this movie in context of art： poetry, painting etc. Then to answer the question （hypothesis）： ＂Is the Polish Film New Wave a phenomenon that did not exist？＂ The methodology used for the paper is analysis and interpretation of the film itself; analysis of its reception in the 60s and now： poetics of receipt, cognitivism, comparative research.
