吉莲·拉西指出了面向儿童写作和译介中成年人对童年范围拥有的决定权,而儿童文学又被视作面向儿童的具有说教作用的重要工具。根据改写理论,“意识形态”占据制约改写四个层面的最高地位,而在儿童文学的改写动因中“儿童观”占据...吉莲·拉西指出了面向儿童写作和译介中成年人对童年范围拥有的决定权,而儿童文学又被视作面向儿童的具有说教作用的重要工具。根据改写理论,“意识形态”占据制约改写四个层面的最高地位,而在儿童文学的改写动因中“儿童观”占据重要地位。本文将借助改写理论对1940年版The Adventures of Tom Sawyer中译本的改写展开分析,研究该时期复杂多变的儿童观对儿童文学造成了怎样的改写,以及其中各种儿童观的相互作用。展开更多
Children with autism spectrum disorder(ASD)often encounter difficulties in language learning and utilization,a concern that has gained significant academic attention,particularly given the widespread occurrence of ASD...Children with autism spectrum disorder(ASD)often encounter difficulties in language learning and utilization,a concern that has gained significant academic attention,particularly given the widespread occurrence of ASD globally.Previous reviews,however,have relied on empirical observations rather than a more rigorous selection criterion.This preliminary study seeks to systematize the scientific knowledge base regarding language development in autistic children by utilizing the analysis tool Citespace 6.2.R5.We visualized and analyzed research patterns and trends regarding autism by drawing data from the Web of Science.Through document citation and emerging trend analyses,seven key research clusters and their chronological associations are identified,along with research hotspots such as language disorder diagnosis and intervention,social communication,language acquisition,and multilingual and multicultural influences.Research findings show that there exist some issues with the current research,including small sample sizes,the need for further investigation into receptive language development,and a lack of cross-cultural comparative studies.Meanwhile,the scope and depth of interdisciplinary research on language development in autistic children also need to be further enhanced.The research contributes to the extant literature by providing valuable references for autism researchers and practitioners.展开更多
AIM： To investigate the expression and clinical significance of Wnt member 5a （Wnt5a） and receptor tyrosine kinase-like orphan receptor 2 （Ror2） in hepatocellular carcinoma （HCC）.METHODS： In HCC tissues obtain...AIM： To investigate the expression and clinical significance of Wnt member 5a （Wnt5a） and receptor tyrosine kinase-like orphan receptor 2 （Ror2） in hepatocellular carcinoma （HCC）.METHODS： In HCC tissues obtained from 85 patients, the protein expressions of Wnt5a, Rot2, 13-catenin, and Ki-67 via immunohistochemical staining using the Envision Plus System. The antibody binding was visualized with 3, 3＇-diaminobenzidine tetrahydrochloride （DAB） before brief counterstaining with Mayer＇s hematoxylin. The degree of immunohistochemical staining was recorded using a semiquantitative and subjective grading system. The mRNA expression of Rot2 was examined by real time reverse transcription polymerase chain reaction, including nineteen of the 85 HCC and three normal liver tissues. The ratios of Ror2 to the housekeeping gene GAPDH represented the normalized relative levels of Ror2 expression. To determine the prognostic factor, the outcome of the 82 patients was determined by reviewing their medical charts. The overall and diseasefree survival rates were estimated using the Kaplan-Meier method and compared with the logrank test. The prognostic analysis was carried out with univariate and multivariate Cox regressions models.RESULTS： Compared to nontumorous （hepatitis or cirrhotic） tissues, Rot2 mRNA expression was clearly decreased in HCC. Rot2 and Wnt5a protein expressions in the majority of HCC patients （63% and 77%, respectively） was significantly less in tumor tissues, as compared to adjacent nontumorous tissues, and this reduction was correlated with increasing serum α-fetoprotein and tumor stage. In 68% （58/85） of the HCC cases, the expression of IB-catenin in tumor tissues was either downregulated in the cellular membrane, upregulated in the cytoplasm, or both. Survival analysis indicated that Wnt5a and Ror2 protein expressions could be regarded as independent prognostic factors for HCC; HCC patients with decreased Wnt5a or Ror2 protein expression had a poorer prognosis than those with elevated Wnt5a and Ror2 expression （P = 0.016, P = 0.007, respectively）.CONCLUSION： Wnt5a and Ror2 may serve as tumor suppressor genes in the development of HCC, and may serve as clinicopathologic biomarkers for prognosis in HCC patients.展开更多
The FTZ-F1 genes encode orphan receptors of the nuclear receptor superfamily and in mammals have been found to play important roles in the proper development of the adrenal-gonadal axis and sex-determination.We isolat...The FTZ-F1 genes encode orphan receptors of the nuclear receptor superfamily and in mammals have been found to play important roles in the proper development of the adrenal-gonadal axis and sex-determination.We isolated the homologue of FTZ-F1 in genetically improved farmed tilapia(gfFTZ-F1).The full-length cDNA was isolated from the ovary,which included an open reading frame encoding a predicted protein of 486 amino acids.Sequence,tissue distribution and phylogenic analysis of the FTZ-F1 showed that the gfFTZ-F1 belonged to SF-1/Ad4BP group and that gfFTZ-F1 transcripts were only expressed in the gonads and kidney but not in other tissues.Likewise our data suggests that the gfFTZ-F1 gene may share similar functions with other fish and mammalian counterparts,though further study is needed to make any definitive conclusions.展开更多
文摘吉莲·拉西指出了面向儿童写作和译介中成年人对童年范围拥有的决定权,而儿童文学又被视作面向儿童的具有说教作用的重要工具。根据改写理论,“意识形态”占据制约改写四个层面的最高地位,而在儿童文学的改写动因中“儿童观”占据重要地位。本文将借助改写理论对1940年版The Adventures of Tom Sawyer中译本的改写展开分析,研究该时期复杂多变的儿童观对儿童文学造成了怎样的改写,以及其中各种儿童观的相互作用。
文摘Children with autism spectrum disorder(ASD)often encounter difficulties in language learning and utilization,a concern that has gained significant academic attention,particularly given the widespread occurrence of ASD globally.Previous reviews,however,have relied on empirical observations rather than a more rigorous selection criterion.This preliminary study seeks to systematize the scientific knowledge base regarding language development in autistic children by utilizing the analysis tool Citespace 6.2.R5.We visualized and analyzed research patterns and trends regarding autism by drawing data from the Web of Science.Through document citation and emerging trend analyses,seven key research clusters and their chronological associations are identified,along with research hotspots such as language disorder diagnosis and intervention,social communication,language acquisition,and multilingual and multicultural influences.Research findings show that there exist some issues with the current research,including small sample sizes,the need for further investigation into receptive language development,and a lack of cross-cultural comparative studies.Meanwhile,the scope and depth of interdisciplinary research on language development in autistic children also need to be further enhanced.The research contributes to the extant literature by providing valuable references for autism researchers and practitioners.
基金Supported by The fund of Nature Science Foundation of Shandong Province,No.ZR2009CM041
文摘AIM： To investigate the expression and clinical significance of Wnt member 5a （Wnt5a） and receptor tyrosine kinase-like orphan receptor 2 （Ror2） in hepatocellular carcinoma （HCC）.METHODS： In HCC tissues obtained from 85 patients, the protein expressions of Wnt5a, Rot2, 13-catenin, and Ki-67 via immunohistochemical staining using the Envision Plus System. The antibody binding was visualized with 3, 3＇-diaminobenzidine tetrahydrochloride （DAB） before brief counterstaining with Mayer＇s hematoxylin. The degree of immunohistochemical staining was recorded using a semiquantitative and subjective grading system. The mRNA expression of Rot2 was examined by real time reverse transcription polymerase chain reaction, including nineteen of the 85 HCC and three normal liver tissues. The ratios of Ror2 to the housekeeping gene GAPDH represented the normalized relative levels of Ror2 expression. To determine the prognostic factor, the outcome of the 82 patients was determined by reviewing their medical charts. The overall and diseasefree survival rates were estimated using the Kaplan-Meier method and compared with the logrank test. The prognostic analysis was carried out with univariate and multivariate Cox regressions models.RESULTS： Compared to nontumorous （hepatitis or cirrhotic） tissues, Rot2 mRNA expression was clearly decreased in HCC. Rot2 and Wnt5a protein expressions in the majority of HCC patients （63% and 77%, respectively） was significantly less in tumor tissues, as compared to adjacent nontumorous tissues, and this reduction was correlated with increasing serum α-fetoprotein and tumor stage. In 68% （58/85） of the HCC cases, the expression of IB-catenin in tumor tissues was either downregulated in the cellular membrane, upregulated in the cytoplasm, or both. Survival analysis indicated that Wnt5a and Ror2 protein expressions could be regarded as independent prognostic factors for HCC; HCC patients with decreased Wnt5a or Ror2 protein expression had a poorer prognosis than those with elevated Wnt5a and Ror2 expression （P = 0.016, P = 0.007, respectively）.CONCLUSION： Wnt5a and Ror2 may serve as tumor suppressor genes in the development of HCC, and may serve as clinicopathologic biomarkers for prognosis in HCC patients.
基金the Natural Science Foundation of Shanxi Province,China (2009021038)the Doctor Initial Foundation of Shanxi Agricultural University (XB2009003)+2 种基金the Science and Technology Innovational Foundation of Shanxi Agricultural University (2009005)the Nonprofit Research Institutes,Special Foundation for Operating Expenses of Basic Research Projects of Guangxi Zhuang Autonomous Region(2060302 GXIF-2008-01)the Scientific Research and Technological Development Projects of Nanning City(200801016B)
文摘The FTZ-F1 genes encode orphan receptors of the nuclear receptor superfamily and in mammals have been found to play important roles in the proper development of the adrenal-gonadal axis and sex-determination.We isolated the homologue of FTZ-F1 in genetically improved farmed tilapia(gfFTZ-F1).The full-length cDNA was isolated from the ovary,which included an open reading frame encoding a predicted protein of 486 amino acids.Sequence,tissue distribution and phylogenic analysis of the FTZ-F1 showed that the gfFTZ-F1 belonged to SF-1/Ad4BP group and that gfFTZ-F1 transcripts were only expressed in the gonads and kidney but not in other tissues.Likewise our data suggests that the gfFTZ-F1 gene may share similar functions with other fish and mammalian counterparts,though further study is needed to make any definitive conclusions.
