李繁生年及其《相国邺侯家传》考辨

李繁生年当为唐代宗大历九年(774年)。其《相国邺侯家传》约亡佚于南宋末年。现存《家传》残文总计八十三条,约七千四百言。《类说》之节录与《通鉴考异》之征引保存了较多的《家传》残文,也最接近原貌。

优秀传统家风的活化与传播——以扬州广电《家传》系列纪录片为例

城市广电媒体如何在弘扬和传承优秀家风中,主动发挥自己的责任与担当,将内涵丰富却飘渺无踪的家风内容,转化为鲜活的正能量故事,并用电视手法展现出来,是摆在大家面前的一道难题。扬州广电电视文创中心近两年陆续推出系列《家传》纪录片,通过挖掘家族故事,聚焦家风细节,与新媒体融合,以鲜活的人与故事诠释家风内涵,让节目多渠道抵达用户,在全国产生了较大影响。

清广州十三行行商卢观恒研究——以《家传》和《墓志》为中心

《卢观恒<家传>和<墓志>拓片册页》现藏于广州海事博物馆。《家传》和《墓志》皆作于道光三年卢观恒归葬家乡新会之时,内中记载了卢氏先祖以及观恒早年经历、年少读书、夫人子女、入祀乡贤祠、归葬新会等诸事,为研究卢氏家族人物提供了诸多线索。《家传》和《墓志》揭示了卢观恒经营广利行获得成功的多重原因,包括"敬信远人"的经营理念及结交官府、商界联姻的商业手段等;同时也透露了在清代"商居末等"体制下,十三行商人必须进行多种公私捐输,其中卢观恒在军需、河工等全国性事务,及修河堤道桥、建义学义仓相祠、筑桑园围基等广东地方事务方面表现尤其突出,由此带来的沉重经济负担为日后衰败埋下了隐忧。

Home control system based on ZigBee wireless sensor networks

A new scheme of the home control system based on ZigBee wireless sensor networks is presented. The design and development of the software and hardware of the proposed system are given. In addition to the basic data acquisition and processing functions, the gateway supports the Bluetooth-based local interface and the general packet radio service （GPRS）-based remote interface. Users on the client service side can use a pocket PC or notebook PC to achieve real-time data acquisition and control instruction implementation, or remotely control the home control system through a mobile phone by sending a short message. The Labview graphical development environment is adopted to create PDA applications running on pocket PCs and monitoring platform established on notebook PCs. Except for the gateway, other nodes in the system work in sleep mode most of the time on the system, and thus it improves the lifetime of the whole system efficiently.

Migraine as a sex-conditioned inherited disorder: evidences from China and the world

Migraine is a complex and heterogeneous disorder. Although several genetic models has been proposed including autosomal-dominant/autosomal recessive, sex-linked, sex-limited, mitochondrial, and multi-gene, none of these models can well-explain the transmission of the disease. We hypothesied that migraine is a sex-conditioned inherited disorder （autosomal dominant in females and autosomal recessive in males）. This hypothesis is supported by the evidence such as the locations of genes associated with familial hemiplegic migraine, possibly ＂typical＂ migraine as well （dominantly on chromosome 19p, lq, and 2q）, male：female ratio of prevalence （1：2-1：4）, the mostly youth-onset, the provocation by the contraceptives, the induction by menstruation, and the self-limitation after menopause. Female sex-hormones appear to be the key contributor to a higher prevalence of migraine in female. Socio-environmental factors may also play an important role.

《醒世姻缘传》方言词补释

本文补充解释了“除的家”、“打立水”、“黑面”三则向来解释欠确或未曾解释过的词语。

Three novel missense germline mutations in different exons of MSH6 gene in Chinese hereditary non-polyposis colorectal cancer families

AIM: To investigate the germline mutations of MSH6 gene in probands of Chinese hereditary non-polyposis colorectal cancer (HNPCC) families fulfilling different clinical criteria. METHODS: Germline mutations of MSH6 gene were detected by PCR-based DNA sequencing in 39 unrelated HNPCC probands fulfilling different clinical criteria in which MSH2 and MLH1 mutations were excluded. To further investigate the pathological effects of detected missense mutations, we analyzed the above related MSH6 exons using PCR-based sequencing in 137 healthy persons with no family history. The clinicopathological features were collected from the Archive Library of Cancer Hospital, Fudan University and analyzed. RESULTS: Four germline missense mutations distributed in the 4th, 6th and 9th exons were observed. Of them, three were not found in international HNPCC databases and did not occur in 137 healthy controls, indicating that they were novel missense mutations. The remaining mutation which is consistent with the case H14 at c.3488A>T of exon 6 of MSH6 gene was also found in the controls, the rate was approximately 3.65% (5/137) and the type of mutation was not found in the international HNPCC mutational and SNP databases, suggesting that this missense mutation was a new SNP unreported up to date. CONCLUSION: Three novel missense mutations and a new SNP observed in the probands of Chinese HNPCC families, may play an important role in the development of HNPCC.

Nitric Oxide:from a mysterious labile factor to the molecule of the Nobel Prize Recent progress in nitric oxide research

NO is now known to be an important messenger molecule in biology.It regulates a variety of functions within cells and tissues including vasodilation, neurotransmission and immunological process. This review will focus on the nitric oxide synthase gene family and recent progress on molecular genetic analysis of NOS1, NOS2 and N0S3 genes.

Detection of hMSH2 and hMLH1 mutations in Chinese hereditary non-polyposis colorectal cancer kindreds

AIM： To establish and validate the mutation testing for identification and characterization of hereditary non-polyposis colorectal cancer （HNPCC） in suspected Chinese patients. METHODS： Five independent Chinese kindreds with HNPCC fulfilling the classical Amsterdam criteria were collected. Genomic DNA was extracted after informed consent was obtained. The coding region of hMSH2 and hMLH1 genes was detected by polymerase chain reaction （PCR） and denaturing high-performance liquid chromatography （DHPLC）. Mutations identified in the proband by DHPLC were directly sequenced using a 377 DNA sequencer, analyzed with a basic local alignment tool （BLAST）, and tested in the corresponding family members by direct DNA sequencing. RESULTS： Mutations were identified in two Chinese HNPCC kindreds. One was the missense mutation of hMSH2 c.1808A→G resulting in Asp 603 Gly identified in the proband of the fifth HNPCC （HNPCCS） kindred. In the HNP5 kindred, three family members were found to have this mutation and two of them had colorectal cancer. The other mutation of hMLH1 c.1882A→G was identified in the HNP2 kindred＇s proband, which might be the nonsense mutation analyzed by BLAST. CONCLUSION： Pedigree investigation and mutation testing of hMSH2 and hMLH1 are the practical methods to identify high-risk HNPCC patients in China.

Gastroenterology in developing countries:Issues and advances

Developing countries shoulder a considerable burden of gastroenterological disease. Infectious diseases in particular cause enormous morbidity and mortality. Diseases which afflict both western and developing countries are often seen in more florid forms in poorer countries. Innovative techniques continuously improve and update gastroenterological practice. However, advances in diagnosis and treatment which are commonplace in the West, have yet to reach many developing countries. Clinical guidelines, based on these advances and collated in resource-rich environments, lose their relevance outside these settings. In this two-part review, we first highlight the global burden of gastroenterological disease in three major areas： diarrhoeal diseases, hepatitis B, and Helicobacter pylori. Recent progress in their management is explored, with consideration of future solutions. The second part of the review focuses on the delivery of clinical services in developing countries. Inadequate numbers of healthcare workers hamper efforts to combat gastroenterological disease. Reasons for this shortage are examined, along with possibilities for increased specialist training. Endoscopy services, the mainstay of gastroenterology in the West, are in their infancy in many developing countries. The challenges faced by those se^ing up a service are illustrated by the example of a Nigerian endoscopy unit. Finally, we highlight the limited scope of many clinical guidelines produced in western countries. Guidelines which take account of resource limitations in the form of ＂cascades＂ are advocated in order to make these guidelines truly global. Recognition of the different working conditions facing practitioners worldwide is an important step towards narrowing the gap between gastroenterology in rich and poor countries.

Familial aggregation in inflammatory bowel disease:Is it genes or environment?

Inflammatory bowel disease (IBD) develops in genetically susceptible individuals due to the influence of environmental factors, leading to an abnormal recognition of microbiota antigens by the innate immune system which triggers an exaggerated immune response and subsequent bowel tissue damage. IBD has been more frequently found in families, an observation that could be due to either genetic, environmental or both types of factors present in these families. In addition to expanding our knowledge on IBD pathogenesis, defining the specific contribution to familial IBD of each one of these factors might have also clinical usefulness. We review the available evidence on familial IBD pathogenesis.

Germline MLH1 and MSH2 mutational spectrum including frequent large genomic aberrations in Hungarian hereditary non-polyposis colorectal cancer families:Implications for genetic testing

AIM: To analyze the prevalence of germline MLH1 and MSH2 gene mutations and evaluate the clinical characteristics of Hungarian hereditary non-polyposis colorectal cancer (HNPCC) families. METHODS: Thirty-six kindreds were tested for mutations using conformation sensitive gel electrophoreses, direct sequencing and also screening for genomic rearrangements applying multiplex ligation-dependent probe amplifi cation (MLPA). RESULTS: Eighteen germline mutations (50%) were identifi ed, 9 in MLH1 and 9 in MSH2. Sixteen of these sequence alterations were considered pathogenic, the remaining two were non-conservative missense alterations occurring at highly conserved functional motifs. The majority of the defi nite pathogenic mutations (81%, 13/16) were found in families fulfilling the stringent Amsterdam Ⅰ/Ⅱ criteria, including three rearrangements revealed by MLPA (two in MSH2 and one in MLH1). However, in three out of sixteen HNPCC-suspected families (19%), a disease-causing alteration could be revealed. Furthermore, nine mutations described here are novel, and none of the sequence changes were found in more than one family.CONCLUSION: Our study describes for the f irst time the prevalence and spectrum of germline mismatch repair gene mutations in Hungarian HNPCC and suspected-HNPCC families. The results presented here suggest that clinical selection criteria should be relaxed and detection of genomic rearrangements should be included in genetic screening in this population.

Blood is not always thicker than water:The limited effect of kin selection on human kinship in the traditional Chinese family

To examine the importance of kin selection in shaping human societies, this study analyzed the kinship system practiced in traditional China for two millennia and teased apart its underlying genetic and other, presumably cultural, components. The results demonstrate that, in the traditional patrilineal Chinese family, both genetic relatedness and the cultural factor of generation were important in determining kinship status for male agnates （genetically related relatives）. For female agnates, however, only genetic relatedness was important. Another surprising finding was that the influence of gender was not as important as genetic relatedness. The most interesting finding in this study, however, was that kin selection and culture （i.e., seniority in generation and age） played vastly different roles in different lineages in the Chinese family： for collateral （indirect） agnates, genetic relatedness was the most important factor in determining their kinship status, but for lineal （direct） agnates, its importance was overridden by seniority in generation and age, a cultural factor. Several other bio-cultural factors also explained a considerable amount of variance in kinship status. Since kinship profoundly affected, and was often the foundation of, the legal and social systems in dynastic China, kin selection, while its strength may differ remarkably between lineal and collateral relatives, could act as a selective force in Chinese families

Microsatellite-Centromere Mapping in Japanese Scallop(Patinopecten yessoensis) Through Half-Tetrad Analysis in Gynogenetic Diploid Families

Gene-centromere mapping is an essential prerequisite for understanding the composition and structure of genomes. Half-tetrad analysis is a powerful tool for mapping genes and understanding chromosomal behavior during meiosis. The Japanese scallop(Patinopecten yessoensis), a cold-tolerant species inhabiting the northwestern Pacific coast, is a commercially important marine bivalve in Asian countries. In this study, inheritance of 32 informative microsatellite loci was examined in 70-h D-shaped larvae of three induced meiogynogenetic diploid families of P. yessoensis for centromere mapping using half-tetrad analysis. The ratio of gynogenetic diploids was proven to be 100%, 100% and 96% in the three families, respectively. Inheritance analysis in the control crosses showed that 51 of the 53 genotypic ratios observed were in accordance with Mendelian expectations at the 5% level after Bonferroni correction. Seven of the 32 microsatellite loci showed the existence of null alleles in control crosses. The second division segregation frequency(y) of the microsatellite loci ranged from 0.07 to 0.85 with a mean of 0.38, suggesting the existence of positive interference after a single chiasma formation in some chromosomes in the scallop. Microsatellite-centromere distances ranged from 4 c M to 42 c M under the assumption of complete interference. Information on the positions of centromeres in relation to the microsatellite loci will represent a contribution towards the assembly of genetic maps in the commercially important scallop species.

Image Reconstruction for Invasive ERT in Vertical Oil Well Logging

An invasive electrical resistance tomographic sensor was proposed for production logging in vertical oil well.The sensor consists of 24 electrodes that are fixed to the logging tool,which can move in the pipeline to acquire data on the conductivity distribution of oil/water mixture flow at different depths.A sensitivity-based algorithm was introduced to reconstruct the cross-sectional images.Analysis on the sensitivity of the sensor to the distribution of oil/water mixture flow was carried out to optimize the position of the imaging cross-section.The imaging results obtained using various boundary conditions at the pipe wall and the logging tool were compared.Eight typical models with various conductivity distributions were created and the measurement data were obtained by solving the forward problem of the sensor system.Image reconstruction was then implemented by using the simulation data for each model.Comparisons between the models and the reconstructed images show that the number and spatial distribution of the oil bubbles can be clearly identified.

Epidemiology and genetics of ventricular fibrillation during acute myocardial infarction

Sudden cardiac death （SCD） from ventricular fibrillation （VF） during coronary artery disease （CAD） is a leading cause of total and cardiovascular mortality, and in more than half of SCD cases VF occurs as the first symptom of CAD. Several epidemiological studies have shown that sudden death of a family member is a risk factor for SCD and VF during acute myocardial infarction （MI）, independent of traditional risk factors including family history of MI, suggesting a genetic component in the susceptibility to VF. To prevent SCD and VF due to MI, we need a better understanding of the genetic and molecular mechanisms causing VF in this apparently healthy population. Even though new insights and technologies have become available, the genetic predisposition to VF during MI remains poorly understood. Findings from a variety of different genetic studies have failed to reach reproducibility, although several genetic variants, both common and rare variants, have been associated to either VF or SCD. For this review, we searched PubMed for potentially relevant articles, using the following MeSH-terms： ＂sudden cardiac death＂, ＂ventricular fibrillation＂, ＂out-of-hospital cardiac arrest＂, ＂myocardial infarction, myocardial ische- mia＂, ＂coronary artery disease＂, and ＂genetics＂. This review describes the epidemiology and evidence for genetic susceptibility to VF due to MI.

The Governance of the Chaotic International Security

After the Cold War ended, former traditional security threats withered while non-traditional ones sprouted. More recently as both traditional and non-traditional security threats bloom, concern spreads over whether international security governance can be effective. Worse still, major Western countries' zeal for global governance has cooled,while they turn from being advocates of global governance to obstacles,making the future dimmer.

Natural Science and the Evolution of Categorial Discourse

In the second half of the last century the problem of categories became less and less prominent in philosophical debates. This twilight of categorial discourse did not go unnoticed, and some authors offered different solutions for the revival of categorial theorizing in contemporary philosophy＇s repertoire. One of these authors is the American philosopher Stephen Pepper. The purpose of the present discussion is to offer yet another explanation for the decline of categorial theory, and to explore Pepper＇s view and its role in the transformation of categorial discourse. The main thesis which I will argue for is that traditional categories did not disappear altogether, but they have been replaced, gradually, by key empirical concepts from natural science. Even if such concepts do not satisfy the traditional requirements categories in shaping our for a categorial scheme, they are, nonetheless, fulfilling the same role as traditional worldviews.

Virtual Political Communication in Bulgaria

Social networks are the result of a couple of circumstances such as the current development of communication technology and the improvement of the opportunities for communication, access to new ideas, web-based information, electronic resources and database serving millions of people all over the world. Social networks have increased their public influence, which contain videotaped speeches and presentations. Multimodality has become a characteristic feature of contemporary political virtual communication. Bulgarian politicians appreciate the Internet as a tool for building popularity in its wealth of features, forms, and modes. Communicative tools and techniques have changed. The forms of the Bulgarian political communication found in the virtual environment such as sites, blogs, social networks, video clips, virtual forums, etc. are heterogeneous. Bulgarian citizens accept the Internet as a tool for increased political and social activities. Civil oratory, which is seen as a mechanism for efficient organizing of public events during election campaigns, protests, and demonstrations, is also present in the social networks. The citizens use a combination of verbal and visual elements; they are bloggers and participants in virtual political forums and actively participate in the spread of all kinds of forms of the social networks. They take part in the street demonstrations and organize performances; they ridicule politicians through posters and cartoons published online. Verbal and visual messages of the citizens come to real life during the protests and to virtual life in the social networks. The polyphony of social networks is a manifestation of virtual civil communication where the citizens in their virtual projection as netizens build up a new complex model of communication.

Genetic Determination and Selection of Sugarcane Families

Sugarcane family evaluation on 108 hybridized combinations generated during 2013-2014 was conducted by measuring the main traits of plant and ratoon crops. Stalk height, stalk diameter, stalk number per stool and brix were investigated in both plant cane and ratoon cane, while stalk weight per stool and brix weight per stool were measured only in plant cane. Genetic variation and genetic parameters of all traits were analyzed, and the families were evaluated based on comprehensive index method. The results showed that the stalk height of both plant and ratoon, stalk diameter of both plant and ratoon, stalk number per stool of plant, brix of both plant and ratoon, stalk weight per stool and brix weight per stool were sig- nificantly different among the families. Stalk height, stalk diameter, stalk number per stool of plant crop showed higher level of broad-sense heritability, genetic variation coefficient and relative genetic advance than those in ratoon crop. But there were no significant differences in broad-sense heritability, genetic variation coefficient and relative genetic advance of brix between plant and ratoon crops. Analysis of phenotypic and genotypic correlation showed that stalk weight per stool was significantly correlated with brix weight per stool, Fifteen elite families including Zhanzhe 74-141× CP72-1210, Guitang 05-3081×Yuetang 91-976, Yunzhe 02-588×ROC22, Funong 39× Guitang 03-1229, Guitang 02-901×Guitang 03-2357, Guitang 05-2743×Guitang 03- 1229, Guitang 92-66×ROC22, Dezhe 93-88×ROC22, Guitang 05-3445×Guitang 03- 2309, Yuetang 00-319×CP72-1210, Guitang 03-3089×ROC22, Yuetang 91-976×CP84- 1198, Yuefu 90-95 ×CP72-1210, Yunzhe 99-601×Guitang 00-122, Yuetang 00-236× ROC22 were selected based on comprehensive index method, and stalk weight per stool and brix weight per stool showed greater genetic gain. The families selected based on comprehensive index were not completely the same as the families selected by brix weight per stool, the rank correlation coefficient of the families selected based on comprehensive index and brix weight per stool was 0.748 （P〈0.01）.