In this study, 13 strong-gluten wheat varieties screened by the Key Project of Modern Agricultural Industry Technology System "Study on Industrial Technology for Strong-gluten Wheat from Lime Concretion Black Soil Ar...In this study, 13 strong-gluten wheat varieties screened by the Key Project of Modern Agricultural Industry Technology System "Study on Industrial Technology for Strong-gluten Wheat from Lime Concretion Black Soil Area in the Huanghuai Wheat Region" were used as experimental materials to investigate their bread-making quality, noodle-making quality and other related characteristics. The results showed that more than half of the wheat varieties had better bread-making quality; the bread made from wheat with longer dough mixing time than 3.0 min had better texture, lighter color, and better taste. All these 13 strong-gluten wheat varieties showed good noodle-making quality in color, appearance, smoothness and taste; the differences between varieties were mainly found in palatability and viscoelasticity. Jimai 20, Xinong 979, Zhengmai 7698, Ji'nan 17 and Zhengmai 9023 exhibited excellent bread-making quality; Zhengmai 366, Jimai 20 and Xinong 979 displayed excellent noodle-making quality. Fresh dough sheets made from Zhengmai 366, Jimai 20 and Xinong 979 exhibited slight color variation within 24 h and high peak starch paste viscosity; dry and cooked noodles made from Zhengmai 366, Jimai 20 and Xinong 979 had good quality.展开更多
To suppress the strong noise in seismic data with wide range of amplitudes, commonly used methods often yield unsatisfactory denoising results owing to inappropriate thresholds and require parametric testing as well a...To suppress the strong noise in seismic data with wide range of amplitudes, commonly used methods often yield unsatisfactory denoising results owing to inappropriate thresholds and require parametric testing as well as iterations to achieve the anticipated results. To overcome these problems, a data-driven strong amplitude suppression method based on the decibel criterion in the wavelet domain (ISANA) is proposed. The method determines the denoising threshold based on the decibel criterion and statistically analyzes the amplitude index rather than the abnormally high amplitudes. The method distinguishes the frequency band distributions of the valid signals in the time-frequency domain based on the wavelet transformation and then calculates thresholds in selected time windows, eventually achieving frequency-divided noise attenuation for better denoising. Simulations based on theoretical and real-world data verify the adaptability and low dependence of the method on the size of the time window. The method suppresses noise without energy loss in the signals.展开更多
A numerical simulation based on a regularized phase field model is developed to describe faceted dendrite growth morphology. The effects of mesh grid, anisotropy, supersaturation and fold symmetry on dendrite growth m...A numerical simulation based on a regularized phase field model is developed to describe faceted dendrite growth morphology. The effects of mesh grid, anisotropy, supersaturation and fold symmetry on dendrite growth morphology were investigated, respectively. These results indicate that the nucleus grows into a hexagonal symmetry faceted dendrite. When the mesh grid is above 640×640, the size has no much effect on the shape. With the increase in the anisotropy value, the tip velocities of faceted dendrite increase and reach a balance value, and then decrease gradually. With the increase in the supersaturation value, crystal evolves from circle to the developed faceted dendrite morphology. Based on the Wulff theory and faceted symmetry morphology diagram, the proposed model was proved to be effective, and it can be generalized to arbitrary crystal symmetries.展开更多
An extraction method of the component parameter values of an enhancement-mode InGaP/AIGaAs/In-GaAs PHEMT small signal equivalent circuit is presented,and these component parameter values are extracted by using the EEH...An extraction method of the component parameter values of an enhancement-mode InGaP/AIGaAs/In-GaAs PHEMT small signal equivalent circuit is presented,and these component parameter values are extracted by using the EEHEMT1 model of IC-CAP software. The extraction results are verified by ADS software,and the DC I-V curves and S parameters simulated by ADS are basically accordant with those of the test results. These results indicate that the EEHEMT1 model can be used for extracting the component parameters of an enhancement-mode PHEMT.展开更多
Objective] The aim was to explore the potential of Nitzschia capitel ata as excel ent baits and bioenergy, and the optimal light intensity and nitrogen-to-phos-phorus (N/P) ratio suitable for its growth were researc...Objective] The aim was to explore the potential of Nitzschia capitel ata as excel ent baits and bioenergy, and the optimal light intensity and nitrogen-to-phos-phorus (N/P) ratio suitable for its growth were researched as wel . [Method] With light intensity gradient set, Nitzschia capitel ata was cultured with the same nutrients at (25 ±1) ℃ and light cycle at 12 h/d to select optimal light intensity. Then, Nitzschia capitel ata was cultured with the same condition, and nitrogen-to-phospho-rus ratios at 5∶1, 6∶1, 7∶1 and 8∶1. [Result] With light intensity at 3 000 lx, specific growth rate and standing stock achieved the highest at 0.51 d-1 and 7.97×104 cel s/ml. The growth condition with nitrogen-to-phosphorus ratio at 6∶1 was the most suitable for Nitzschia capitel ata growth. [Conclusion] The optimal light intensity and nitrogen-to-phosphorus ratio were 3 000 lx and 6∶1, respectively, for Nitzschia capitel ata.展开更多
This paper considers the differentiability of C 0 semigroups with respect to (w.r.t.) parameters contained in their infinitesimal generators.It is proved that the generalized continuity and strong differentiability ...This paper considers the differentiability of C 0 semigroups with respect to (w.r.t.) parameters contained in their infinitesimal generators.It is proved that the generalized continuity and strong differentiability of their infinitesimal generators w.r.t.parameters imply the differentiability of the C 0 semigroups.The results are applied to the differentiability of the solution of a linear delay differential equation w.r.t.its delays.展开更多
Objective It is known that free radicals are involved in neurodegeneration and cognitive dysfunction, as seen in Alzheimer's disease (AD) and aging. The present study examines the protective effects of aniracetam a...Objective It is known that free radicals are involved in neurodegeneration and cognitive dysfunction, as seen in Alzheimer's disease (AD) and aging. The present study examines the protective effects of aniracetam against H2O2- induced toxicity to neuron viability, mitochondria potential and hippocampal long-term potentiation (LTP). Methods Tetrazolium salt 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) was used to detect neuronal viability. MitoTracker Red (CMX Ros), a fluorescent stain for mitochondria, was used to measure mitochondria potential. Electrophysiological technique was carried out to record hippocampual LTE Results H2O2 exposure impaired the viability of neurons, reduced mitochondria potential, and decreased LTP in the CA region of hippocampus. These deficient effects were significantly rescued by pre-treatment with aniracetam (10 ~100μmol/L). Conclusion These results indicate that aniracetam has a strong neuroprotective effect against H2O2-induced toxicity, which could partly explain the mechanism of its clinical application in neurodegenerative diseases.展开更多
[Objective] The toxicity of Qiangli Bupi Paste was investigated, to provide a test basis for its further development and safe use. [Method] Forty Kunming mice, half male and half female, were selected and divided into...[Objective] The toxicity of Qiangli Bupi Paste was investigated, to provide a test basis for its further development and safe use. [Method] Forty Kunming mice, half male and half female, were selected and divided into the CK group and the Qiangli Bupi Paste group, each of which included 20 mice. The acute toxicity of Qiangli Bupi Paste was observed by the maximum administration dosage method. No mice and abnormal response were observed within 14 d in various groups. The tested animals were also subjected to anatomical observation. [Result] All the tested animals survived in the test, and behaved normally, with glossy hair. Their body weights accorded with the growth regularity. During the anatomy, no important vis- ceral organs showed pathological changes, and there were no significant differences in body weight between the two groups before administration, on the 7~ after ad- ministration and the 14 d after administration (P〉0.05). [Conclusion] In the acute toxicity test of Qiangli Bupi Paste, the maximum administration dosage was 48 g/kg (equivalent to 96 times of the daily dose of adult in clinic), and no obvious toxic response was observed.展开更多
AIM:To investigate the relationship between low-dose aspirin-induced small bowel mucosal damage and blood flow,and the effect of rebamipide. METHODS:Ten healthy volunteers were enrolled in this study.The subjects were...AIM:To investigate the relationship between low-dose aspirin-induced small bowel mucosal damage and blood flow,and the effect of rebamipide. METHODS:Ten healthy volunteers were enrolled in this study.The subjects were divided into two groups:a placebo group given low-dose aspirin plus placebo and a rebamipide group given low-dose aspirin plus rebamipide for a period of 14 d.Capsule endoscopy and contrast-enhanced ultrasonography were performed before and after administration of drugs.Areas under the curves and peak value of time-intensity curve were calculated. RESULTS:Absolute differences in areas under the curves were-1102.5(95%CI:-1980.3 to-224.7,P=0.0194) in the placebo group and-152.7(95%CI:-1604.2 to 641.6,P=0.8172) in the rebamipide group. Peak values of time intensity curves were-148.0(95% CI:-269.4 to-26.2,P=0.0225) in the placebo group and 28.3(95%CI:-269.0 to 325.6,P=0.8343) in the rebamipide group.Capsule endoscopy showed mucosal breaks only in the placebo group. CONCLUSION:Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow.展开更多
Enhanced speech based on the traditional wavelet threshold function had auditory oscillation distortion and the low signal-to-noise ratio (SNR). In order to solve these problems, a new continuous differentiable thresh...Enhanced speech based on the traditional wavelet threshold function had auditory oscillation distortion and the low signal-to-noise ratio (SNR). In order to solve these problems, a new continuous differentiable threshold function for speech enhancement was presented. Firstly, the function adopted narrow threshold areas, preserved the smaller signal speech, and improved the speech quality; secondly, based on the properties of the continuous differentiable and non-fixed deviation, each area function was attained gradually by using the method of mathematical derivation. It ensured that enhanced speech was continuous and smooth; it removed the auditory oscillation distortion; finally, combined with the Bark wavelet packets, it further improved human auditory perception. Experimental results show that the segmental SNR and PESQ (perceptual evaluation of speech quality) of the enhanced speech using this method increase effectively, compared with the existing speech enhancement algorithms based on wavelet threshold.展开更多
In order to investigate the relationship between bar diameter and loading rate of the split Hopkinson pressure bar(SHPB) setup under the failure of rock specimen and realize the medium strain rate loading of specimen,...In order to investigate the relationship between bar diameter and loading rate of the split Hopkinson pressure bar(SHPB) setup under the failure of rock specimen and realize the medium strain rate loading of specimen,new SHPB setups with different elastic bar's diameters of 22,36,50 and 75 mm were constructed.The tests were carried out on these setups at different loading rates,and the specimens had the same diameter of elastic bars and same ratio of length to diameter.The test results show that the larger the elastic bar's diameter is,the less the loading rate is needed to cause specimen failure,they show good power relationship,and that under the same strain rate loading,specimens are broken more seriously with larger diameter SHPB setup than with smaller one.展开更多
In this paper,first we define the concept of strong open set for topological space. Then we prove: 1 ) a distributive lattice L possesses the smallest set of generating elements if and only if the Stone space (L) of L...In this paper,first we define the concept of strong open set for topological space. Then we prove: 1 ) a distributive lattice L possesses the smallest set of generating elements if and only if the Stone space (L) of L possesses a smallest base constructed by strong open sets; 2) a Bollean lattice B possesses the smallest set of generating elements if and only if B is a finite Boolean lattice.展开更多
The relationships between Earth's rotation and the 1975 Haicheng, Liaoning Ms7.3 earthquake, 2008 Wenchuan, Sichuan Ms8.0 earthquake and the 2004 Sumatra Msg. 0 earthquake, as well as moderate-small earthquakes occur...The relationships between Earth's rotation and the 1975 Haicheng, Liaoning Ms7.3 earthquake, 2008 Wenchuan, Sichuan Ms8.0 earthquake and the 2004 Sumatra Msg. 0 earthquake, as well as moderate-small earthquakes occurring around the epicenter regions prior to them are investigated in this study. The obtained results could benefit the further understanding of the relationship between the Earth's rotation and earthquakes.展开更多
Background Ticagrelor provides enhanced antiplatelet efficacy but increased risk of bleeding and dyspnea. This study aimed to display the relationship between ADP-induced platelet-fibrin clot strength (MAADP) and cl...Background Ticagrelor provides enhanced antiplatelet efficacy but increased risk of bleeding and dyspnea. This study aimed to display the relationship between ADP-induced platelet-fibrin clot strength (MAADP) and clinical outcomes in acute coronary syndrome (ACS) patients treated by ticagrelor. Methods Consecutive Chinese-Han patients with ACS who received maintenance dose ofticagrelor on top of aspirin were recruited. After 5-day ticagrelor maintenance treatment, MAADP measured by thrombelastography (TEG) were recorded for the evaluation of ticagrelor anti-platelet reactivity. Pre-specified cutoffs of MAADP 〉 47 mm for high on-treatment platelet reactivity (HTPR) and MAADP 〈 31 mm for low on-treatment platelet reactivity (LTPR) were applied for evaluation. The occurrences of primary ischemic cardiovascular events (including a composite of cardiac death, non-fatal myocardial infarction and stroke), the Thrombolysis in Myocardial Infarction (TIMI) defined bleeding events, and ticagrelor related dyspnea were recorded after a follow-up of three months. Results Overall, 176 ACS patients (Male: 79.55%, Age: 59.91 ±10.54 years) under ticagrelor maintenance treatment were recruited. The value of MAADP ranged from 4.80% to 72.90% (21.27% ± 12.07% on average), with the distribution higher skewed towards the lower values. Using the pre-specific cutoffs for HTPR and LTPR, seven patients (3.98%) were identified as HTPR and 144 patients (81.82%) as LTPR. After a follow-up of three months in 172 patients, major cardiovascular events occurred in no patient, but TIMI bleeding events in 81 (47.09%) with major bleedings in three patients. All patients with major bleedings were classified as LTPR. Ticagrelor related dyspnea occurred in 31 (18.02%) patients, with 30 (21.28%) classified as LTPR and no one as HTPR (P = 0.02). Conclusions In ticagrelor treated ACS patients, MAADP measured by TEG might be valuable for the prediction of major bleeding and ticagrelor related dyspnea. Due to the small number of patients with HTPR after ticagrelor maintenance treatment, larger scale study should be warranted to verify the relationship between MAADP defined HTPR and ticagrelor related ischemic events.展开更多
Image enhancement technology plays a very important role to improve image quality in image processing. By enhancing some information and restraining other information selectively, it can improve image visual effect. T...Image enhancement technology plays a very important role to improve image quality in image processing. By enhancing some information and restraining other information selectively, it can improve image visual effect. The objective of this work is to implement the image enhancement to gray scale images using different techniques. After the fundamental methods of image enhancement processing are demonstrated, image enhancement algorithms based on space and frequency domains are systematically investigated and compared. The advantage and defect of the above-mentioned algorithms are analyzed. The algorithms of wavelet based image enhancement are also deduced and generalized. Wavelet transform modulus maxima(WTMM) is a method for detecting the fractal dimension of a signal, it is well used for image enhancement. The image techniques are compared by using the mean(μ),standard deviation(?), mean square error(MSE) and PSNR(peak signal to noise ratio). A group of experimental results demonstrate that the image enhancement algorithm based on wavelet transform is effective for image de-noising and enhancement. Wavelet transform modulus maxima method is one of the best methods for image enhancement.展开更多
AIM: To investigate the clinical outcome of double balloon enteroscopy (DBE)-assisted endoscopic retrograde cholangiopancreatography (DB-ERCP) in patients with altered gastrointestinal anatomy. METHODS: Between Septem...AIM: To investigate the clinical outcome of double balloon enteroscopy (DBE)-assisted endoscopic retrograde cholangiopancreatography (DB-ERCP) in patients with altered gastrointestinal anatomy. METHODS: Between September 2006 and April 2011, 47 procedures of DB-ERCP were performed in 28 patients with a Roux-en-Y total gastrectomy (n = 11), Billroth Ⅱ gastrectomy (n = 15), or Roux-en-Y anastomosis with hepaticojejunostomy (n = 2). DB-ERCP was performed using a short-type DBE combined with several technical innovations such as using an endoscope attachment, marking by submucosal tattooing,selectively applying contrast medium, and CO2 insufflations. RESULTS: The papilla of Vater or hepaticojejunostomy site was reached in its entirety with a 96% success rate (45/47 procedures). There were no significant differences in the success rate of reaching the blind end with a DBE among Roux-en-Y total gastrectomy (96%), Billroth Ⅱ reconstruction (94%), or pancreatoduodenectomy (100%), respectively (P = 0.91). The total successful rate of cannulation and contrast enhancement of the target bile duct in patients whom the blind end was reached with a DBE was 40/45 procedures (89%). Again, there were no significant differences in the success rate of cannulation and contrast enhancement of the target bile duct with a DBE among Roux-en-Y total gastrectomy (88 %), Billroth Ⅱ reconstruction (89%), or pancreatoduodenectomy (100%), respectively (P = 0.67). Treatment was achieved in all 40 procedures (100%) in patients whom the contrast enhancement of the bile duct was successful. Common endoscopic treatments were endoscopic biliary drainage (24 procedures) and extraction of stones (14 procedures). Biliary drainage was done by placement of plastic stents. Stones extraction was done by lithotomy with the mechanical lithotripter followed by extraction with a basket or by the balloon pull-through method. Endoscopic sphincterotomy was performed in 14 procedures with a needle precutting knife using a guidewire. The mean total duration of the procedure was 93.6 ± 6.8 min and the mean time required to reach the papilla was 30.5 ± 3.7 min. The mean time required to reach the papilla tended to be shorter in Billroth Ⅱ reconstruction (20.9 ± 5.8 min) than that in Roux-en-Y total gastrectomy (37.1 ± 4.9 min) but there was no significant difference (P = 0.09). A major complication occurred in one patient (3.5%); perforation of the long limb in a patient with Billroth Ⅱ anastomosis.CONCLUSION: Short-type DBE combined with several technical innovations enabled us to perform ERCP in most patients with altered gastrointestinal anatomy.展开更多
基金Supported by Earmarked Fund for Modern Agro-industry Technology Research System(CARS-03)Special Fund for Seed Industry Construction from Taishan Scholar FoundationNational Science and Technology Major Project for Genetic Improvement of Crop Quality~~
文摘In this study, 13 strong-gluten wheat varieties screened by the Key Project of Modern Agricultural Industry Technology System "Study on Industrial Technology for Strong-gluten Wheat from Lime Concretion Black Soil Area in the Huanghuai Wheat Region" were used as experimental materials to investigate their bread-making quality, noodle-making quality and other related characteristics. The results showed that more than half of the wheat varieties had better bread-making quality; the bread made from wheat with longer dough mixing time than 3.0 min had better texture, lighter color, and better taste. All these 13 strong-gluten wheat varieties showed good noodle-making quality in color, appearance, smoothness and taste; the differences between varieties were mainly found in palatability and viscoelasticity. Jimai 20, Xinong 979, Zhengmai 7698, Ji'nan 17 and Zhengmai 9023 exhibited excellent bread-making quality; Zhengmai 366, Jimai 20 and Xinong 979 displayed excellent noodle-making quality. Fresh dough sheets made from Zhengmai 366, Jimai 20 and Xinong 979 exhibited slight color variation within 24 h and high peak starch paste viscosity; dry and cooked noodles made from Zhengmai 366, Jimai 20 and Xinong 979 had good quality.
基金supported by the National Science and Technology Major Project(No.2011ZX05002-004-002)the National Natural Science Foundation of China(No.41304111)+3 种基金Key Project of Science and Technology Department of Sichuan Province(No.2016JY0200)Natural Science project of Education Department of Sichuan Province(Nos.16ZB0101 and 14ZA0061)the Sichuan Provincial Youth Science&Technology Innovative Research Group Fund(No.2016TD0023)the Cultivating Program of Excellent Innovation Team of Chengdu University of Technology(No.KYTD201410)
文摘To suppress the strong noise in seismic data with wide range of amplitudes, commonly used methods often yield unsatisfactory denoising results owing to inappropriate thresholds and require parametric testing as well as iterations to achieve the anticipated results. To overcome these problems, a data-driven strong amplitude suppression method based on the decibel criterion in the wavelet domain (ISANA) is proposed. The method determines the denoising threshold based on the decibel criterion and statistically analyzes the amplitude index rather than the abnormally high amplitudes. The method distinguishes the frequency band distributions of the valid signals in the time-frequency domain based on the wavelet transformation and then calculates thresholds in selected time windows, eventually achieving frequency-divided noise attenuation for better denoising. Simulations based on theoretical and real-world data verify the adaptability and low dependence of the method on the size of the time window. The method suppresses noise without energy loss in the signals.
基金Projects(11102164,11304243)supported by the National Natural Science Foundation of ChinaProject(2014JQ1039)supported by the Natural Science Foundation of Shannxi Province,China+1 种基金Project(3102016ZY027)supported by the Fundamental Research Funds for the Central Universities of ChinaProject(13GH014602)supported by the Program of New Staff and Research Area Project of NWPU,China
文摘A numerical simulation based on a regularized phase field model is developed to describe faceted dendrite growth morphology. The effects of mesh grid, anisotropy, supersaturation and fold symmetry on dendrite growth morphology were investigated, respectively. These results indicate that the nucleus grows into a hexagonal symmetry faceted dendrite. When the mesh grid is above 640×640, the size has no much effect on the shape. With the increase in the anisotropy value, the tip velocities of faceted dendrite increase and reach a balance value, and then decrease gradually. With the increase in the supersaturation value, crystal evolves from circle to the developed faceted dendrite morphology. Based on the Wulff theory and faceted symmetry morphology diagram, the proposed model was proved to be effective, and it can be generalized to arbitrary crystal symmetries.
文摘An extraction method of the component parameter values of an enhancement-mode InGaP/AIGaAs/In-GaAs PHEMT small signal equivalent circuit is presented,and these component parameter values are extracted by using the EEHEMT1 model of IC-CAP software. The extraction results are verified by ADS software,and the DC I-V curves and S parameters simulated by ADS are basically accordant with those of the test results. These results indicate that the EEHEMT1 model can be used for extracting the component parameters of an enhancement-mode PHEMT.
基金Supported by Guizhou Provincial Science&Technology Fund((2010)2067)~~
文摘Objective] The aim was to explore the potential of Nitzschia capitel ata as excel ent baits and bioenergy, and the optimal light intensity and nitrogen-to-phos-phorus (N/P) ratio suitable for its growth were researched as wel . [Method] With light intensity gradient set, Nitzschia capitel ata was cultured with the same nutrients at (25 ±1) ℃ and light cycle at 12 h/d to select optimal light intensity. Then, Nitzschia capitel ata was cultured with the same condition, and nitrogen-to-phospho-rus ratios at 5∶1, 6∶1, 7∶1 and 8∶1. [Result] With light intensity at 3 000 lx, specific growth rate and standing stock achieved the highest at 0.51 d-1 and 7.97×104 cel s/ml. The growth condition with nitrogen-to-phosphorus ratio at 6∶1 was the most suitable for Nitzschia capitel ata growth. [Conclusion] The optimal light intensity and nitrogen-to-phosphorus ratio were 3 000 lx and 6∶1, respectively, for Nitzschia capitel ata.
文摘This paper considers the differentiability of C 0 semigroups with respect to (w.r.t.) parameters contained in their infinitesimal generators.It is proved that the generalized continuity and strong differentiability of their infinitesimal generators w.r.t.parameters imply the differentiability of the C 0 semigroups.The results are applied to the differentiability of the solution of a linear delay differential equation w.r.t.its delays.
文摘Objective It is known that free radicals are involved in neurodegeneration and cognitive dysfunction, as seen in Alzheimer's disease (AD) and aging. The present study examines the protective effects of aniracetam against H2O2- induced toxicity to neuron viability, mitochondria potential and hippocampal long-term potentiation (LTP). Methods Tetrazolium salt 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) was used to detect neuronal viability. MitoTracker Red (CMX Ros), a fluorescent stain for mitochondria, was used to measure mitochondria potential. Electrophysiological technique was carried out to record hippocampual LTE Results H2O2 exposure impaired the viability of neurons, reduced mitochondria potential, and decreased LTP in the CA region of hippocampus. These deficient effects were significantly rescued by pre-treatment with aniracetam (10 ~100μmol/L). Conclusion These results indicate that aniracetam has a strong neuroprotective effect against H2O2-induced toxicity, which could partly explain the mechanism of its clinical application in neurodegenerative diseases.
文摘[Objective] The toxicity of Qiangli Bupi Paste was investigated, to provide a test basis for its further development and safe use. [Method] Forty Kunming mice, half male and half female, were selected and divided into the CK group and the Qiangli Bupi Paste group, each of which included 20 mice. The acute toxicity of Qiangli Bupi Paste was observed by the maximum administration dosage method. No mice and abnormal response were observed within 14 d in various groups. The tested animals were also subjected to anatomical observation. [Result] All the tested animals survived in the test, and behaved normally, with glossy hair. Their body weights accorded with the growth regularity. During the anatomy, no important vis- ceral organs showed pathological changes, and there were no significant differences in body weight between the two groups before administration, on the 7~ after ad- ministration and the 14 d after administration (P〉0.05). [Conclusion] In the acute toxicity test of Qiangli Bupi Paste, the maximum administration dosage was 48 g/kg (equivalent to 96 times of the daily dose of adult in clinic), and no obvious toxic response was observed.
文摘AIM:To investigate the relationship between low-dose aspirin-induced small bowel mucosal damage and blood flow,and the effect of rebamipide. METHODS:Ten healthy volunteers were enrolled in this study.The subjects were divided into two groups:a placebo group given low-dose aspirin plus placebo and a rebamipide group given low-dose aspirin plus rebamipide for a period of 14 d.Capsule endoscopy and contrast-enhanced ultrasonography were performed before and after administration of drugs.Areas under the curves and peak value of time-intensity curve were calculated. RESULTS:Absolute differences in areas under the curves were-1102.5(95%CI:-1980.3 to-224.7,P=0.0194) in the placebo group and-152.7(95%CI:-1604.2 to 641.6,P=0.8172) in the rebamipide group. Peak values of time intensity curves were-148.0(95% CI:-269.4 to-26.2,P=0.0225) in the placebo group and 28.3(95%CI:-269.0 to 325.6,P=0.8343) in the rebamipide group.Capsule endoscopy showed mucosal breaks only in the placebo group. CONCLUSION:Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow.
基金Project(61072087) supported by the National Natural Science Foundation of ChinaProject(2011-035) supported by Shanxi Province Scholarship Foundation, China+2 种基金Project(20120010) supported by Universities High-tech Foundation Projects, ChinaProject (2013021016-1) supported by the Youth Science and Technology Foundation of Shanxi Province, ChinaProjects(2013011016-1, 2012011014-1) supported by the Natural Science Foundation of Shanxi Province, China
文摘Enhanced speech based on the traditional wavelet threshold function had auditory oscillation distortion and the low signal-to-noise ratio (SNR). In order to solve these problems, a new continuous differentiable threshold function for speech enhancement was presented. Firstly, the function adopted narrow threshold areas, preserved the smaller signal speech, and improved the speech quality; secondly, based on the properties of the continuous differentiable and non-fixed deviation, each area function was attained gradually by using the method of mathematical derivation. It ensured that enhanced speech was continuous and smooth; it removed the auditory oscillation distortion; finally, combined with the Bark wavelet packets, it further improved human auditory perception. Experimental results show that the segmental SNR and PESQ (perceptual evaluation of speech quality) of the enhanced speech using this method increase effectively, compared with the existing speech enhancement algorithms based on wavelet threshold.
基金Project(10472134) supported by the National Natural Science Foundation of China
文摘In order to investigate the relationship between bar diameter and loading rate of the split Hopkinson pressure bar(SHPB) setup under the failure of rock specimen and realize the medium strain rate loading of specimen,new SHPB setups with different elastic bar's diameters of 22,36,50 and 75 mm were constructed.The tests were carried out on these setups at different loading rates,and the specimens had the same diameter of elastic bars and same ratio of length to diameter.The test results show that the larger the elastic bar's diameter is,the less the loading rate is needed to cause specimen failure,they show good power relationship,and that under the same strain rate loading,specimens are broken more seriously with larger diameter SHPB setup than with smaller one.
文摘In this paper,first we define the concept of strong open set for topological space. Then we prove: 1 ) a distributive lattice L possesses the smallest set of generating elements if and only if the Stone space (L) of L possesses a smallest base constructed by strong open sets; 2) a Bollean lattice B possesses the smallest set of generating elements if and only if B is a finite Boolean lattice.
基金sponsored by the Teacher's Scientific Research Fund of the China Earthquake Administration(20090103)
文摘The relationships between Earth's rotation and the 1975 Haicheng, Liaoning Ms7.3 earthquake, 2008 Wenchuan, Sichuan Ms8.0 earthquake and the 2004 Sumatra Msg. 0 earthquake, as well as moderate-small earthquakes occurring around the epicenter regions prior to them are investigated in this study. The obtained results could benefit the further understanding of the relationship between the Earth's rotation and earthquakes.
基金This work was supported by grants from the Beijing Natural Science Foundation of China (No. 7152129) and National Natural Science Foundation of China (No. 30971259), the Clinical Research Supportive Fund General Hospital of Chinese People's Liberation Army (No. 2012FC-TSYS-3042). There are no potential conflicts of interest to declare.
文摘Background Ticagrelor provides enhanced antiplatelet efficacy but increased risk of bleeding and dyspnea. This study aimed to display the relationship between ADP-induced platelet-fibrin clot strength (MAADP) and clinical outcomes in acute coronary syndrome (ACS) patients treated by ticagrelor. Methods Consecutive Chinese-Han patients with ACS who received maintenance dose ofticagrelor on top of aspirin were recruited. After 5-day ticagrelor maintenance treatment, MAADP measured by thrombelastography (TEG) were recorded for the evaluation of ticagrelor anti-platelet reactivity. Pre-specified cutoffs of MAADP 〉 47 mm for high on-treatment platelet reactivity (HTPR) and MAADP 〈 31 mm for low on-treatment platelet reactivity (LTPR) were applied for evaluation. The occurrences of primary ischemic cardiovascular events (including a composite of cardiac death, non-fatal myocardial infarction and stroke), the Thrombolysis in Myocardial Infarction (TIMI) defined bleeding events, and ticagrelor related dyspnea were recorded after a follow-up of three months. Results Overall, 176 ACS patients (Male: 79.55%, Age: 59.91 ±10.54 years) under ticagrelor maintenance treatment were recruited. The value of MAADP ranged from 4.80% to 72.90% (21.27% ± 12.07% on average), with the distribution higher skewed towards the lower values. Using the pre-specific cutoffs for HTPR and LTPR, seven patients (3.98%) were identified as HTPR and 144 patients (81.82%) as LTPR. After a follow-up of three months in 172 patients, major cardiovascular events occurred in no patient, but TIMI bleeding events in 81 (47.09%) with major bleedings in three patients. All patients with major bleedings were classified as LTPR. Ticagrelor related dyspnea occurred in 31 (18.02%) patients, with 30 (21.28%) classified as LTPR and no one as HTPR (P = 0.02). Conclusions In ticagrelor treated ACS patients, MAADP measured by TEG might be valuable for the prediction of major bleeding and ticagrelor related dyspnea. Due to the small number of patients with HTPR after ticagrelor maintenance treatment, larger scale study should be warranted to verify the relationship between MAADP defined HTPR and ticagrelor related ischemic events.
基金Projects(61376076,61274026,61377024)supported by the National Natural Science Foundation of ChinaProjects(12C0108,13C321)supported by the Scientific Research Fund of Hunan Provincial Education Department,ChinaProjects(2013FJ2011,2014FJ2017,2013FJ4232)supported by the Science and Technology Plan Foundation of Hunan Province,China
文摘Image enhancement technology plays a very important role to improve image quality in image processing. By enhancing some information and restraining other information selectively, it can improve image visual effect. The objective of this work is to implement the image enhancement to gray scale images using different techniques. After the fundamental methods of image enhancement processing are demonstrated, image enhancement algorithms based on space and frequency domains are systematically investigated and compared. The advantage and defect of the above-mentioned algorithms are analyzed. The algorithms of wavelet based image enhancement are also deduced and generalized. Wavelet transform modulus maxima(WTMM) is a method for detecting the fractal dimension of a signal, it is well used for image enhancement. The image techniques are compared by using the mean(μ),standard deviation(?), mean square error(MSE) and PSNR(peak signal to noise ratio). A group of experimental results demonstrate that the image enhancement algorithm based on wavelet transform is effective for image de-noising and enhancement. Wavelet transform modulus maxima method is one of the best methods for image enhancement.
文摘AIM: To investigate the clinical outcome of double balloon enteroscopy (DBE)-assisted endoscopic retrograde cholangiopancreatography (DB-ERCP) in patients with altered gastrointestinal anatomy. METHODS: Between September 2006 and April 2011, 47 procedures of DB-ERCP were performed in 28 patients with a Roux-en-Y total gastrectomy (n = 11), Billroth Ⅱ gastrectomy (n = 15), or Roux-en-Y anastomosis with hepaticojejunostomy (n = 2). DB-ERCP was performed using a short-type DBE combined with several technical innovations such as using an endoscope attachment, marking by submucosal tattooing,selectively applying contrast medium, and CO2 insufflations. RESULTS: The papilla of Vater or hepaticojejunostomy site was reached in its entirety with a 96% success rate (45/47 procedures). There were no significant differences in the success rate of reaching the blind end with a DBE among Roux-en-Y total gastrectomy (96%), Billroth Ⅱ reconstruction (94%), or pancreatoduodenectomy (100%), respectively (P = 0.91). The total successful rate of cannulation and contrast enhancement of the target bile duct in patients whom the blind end was reached with a DBE was 40/45 procedures (89%). Again, there were no significant differences in the success rate of cannulation and contrast enhancement of the target bile duct with a DBE among Roux-en-Y total gastrectomy (88 %), Billroth Ⅱ reconstruction (89%), or pancreatoduodenectomy (100%), respectively (P = 0.67). Treatment was achieved in all 40 procedures (100%) in patients whom the contrast enhancement of the bile duct was successful. Common endoscopic treatments were endoscopic biliary drainage (24 procedures) and extraction of stones (14 procedures). Biliary drainage was done by placement of plastic stents. Stones extraction was done by lithotomy with the mechanical lithotripter followed by extraction with a basket or by the balloon pull-through method. Endoscopic sphincterotomy was performed in 14 procedures with a needle precutting knife using a guidewire. The mean total duration of the procedure was 93.6 ± 6.8 min and the mean time required to reach the papilla was 30.5 ± 3.7 min. The mean time required to reach the papilla tended to be shorter in Billroth Ⅱ reconstruction (20.9 ± 5.8 min) than that in Roux-en-Y total gastrectomy (37.1 ± 4.9 min) but there was no significant difference (P = 0.09). A major complication occurred in one patient (3.5%); perforation of the long limb in a patient with Billroth Ⅱ anastomosis.CONCLUSION: Short-type DBE combined with several technical innovations enabled us to perform ERCP in most patients with altered gastrointestinal anatomy.