目的观察当归止痒方治疗成人血虚风燥型特应性皮炎的临床疗效及安全性。方法2021年7月—2022年1月该院皮肤科就诊的成人特应性皮炎患者中纳入符合血虚风燥证型患者,共76例。随机分入试验组和对照组,每组38例。对照组口服润燥止痒胶囊,...目的观察当归止痒方治疗成人血虚风燥型特应性皮炎的临床疗效及安全性。方法2021年7月—2022年1月该院皮肤科就诊的成人特应性皮炎患者中纳入符合血虚风燥证型患者,共76例。随机分入试验组和对照组,每组38例。对照组口服润燥止痒胶囊,试验组口服当归止痒方,两组皆外用纽强倍润型润肤露。治疗8周,对两组瘙痒面积及严重度指数(Eczema Area and Severity Index,EASI)评分、患者主观湿疹评分(Patient-Oriented Eczema Measure,POEM)评分、皮肤病患者生活质量量表(Dermatology Life Quality Index,DLQI)评分、研究者整体评估(Investigator′s Global Assessment,IGA)评分、瘙痒数值评分(Itch-Numerical Rating Scores,Itch-NRS)评分、血清总IgE、血清嗜酸性粒细胞计数(EOS)、中医症状积分及安全性指标等方面进行评价。结果(1)试验组总有效率91.89%(34/37),高于对照组61.76%(21/34)(P<0.05);试验组中医症状积分改善有效率86.49%(32/37),高于对照组47.05%(16/34)(P<0.05)。(2)试验组EASI评分(17.81±6.06)分、POEM评分(11.19±3.76)分、DLQI评分(14.16±3.03)分、IGA评分(2.24±0.68)分、Itch-NRS评分(4.73±1.37)分的下降均较对照组明显(P均<0.05)。(3)两组血清EOS水平在治疗后均有所下降(P<0.05);血清IgE水平两组均无明显干预效果。结论当归止痒方治疗成人血虚风燥型特应性皮炎的临床疗效显著优于润燥止痒胶囊,没有使用首乌的情况下也能够有效改善患者瘙痒症状,提高患者生活质量,同时能够改善患者血虚、便秘、皮肤干燥、瘙痒等中医伴随症状,且没有不良反应发生。展开更多
In the process of shield tunneling through soft soil layers,the presence of confined water ahead poses a significant threat to the stability of the tunnel face.Therefore,it is crucial to consider the impact of confine...In the process of shield tunneling through soft soil layers,the presence of confined water ahead poses a significant threat to the stability of the tunnel face.Therefore,it is crucial to consider the impact of confined water on the limit support pressure of the tunnel face.This study employed the finite element method(FEM)to analyze the limit support pressure of shield tunnel face instability within a pressurized water-containing layer.Subsequently,a multiple linear regression approach was applied to derive a concise solution formula for the limit support pressure,incorporating various influencing factors.The analysis yields the following conclusions:1)The influence of confined water on the instability mode of the tunnel face in soft soil layers makes the displacement response of the strata not significant when the face is unstable;2)The limit support pressure increases approximately linearly with the pressure head,shield tunnel diameter,and tunnel burial depth.And inversely proportional to the thickness of the impermeable layer,soil cohesion and internal friction angle;3)Through an engineering case study analysis,the results align well with those obtained from traditional theoretical methods,thereby validating the rationality of the equations proposed in this paper.Furthermore,the proposed equations overcome the limitation of traditional theoretical approaches considering the influence of changes in impermeable layer thickness.It can accurately depict the dynamic variation in the required limit support pressure to maintain the stability of the tunnel face during shield tunneling,thus better reflecting engineering reality.展开更多
文摘目的观察当归止痒方治疗成人血虚风燥型特应性皮炎的临床疗效及安全性。方法2021年7月—2022年1月该院皮肤科就诊的成人特应性皮炎患者中纳入符合血虚风燥证型患者,共76例。随机分入试验组和对照组,每组38例。对照组口服润燥止痒胶囊,试验组口服当归止痒方,两组皆外用纽强倍润型润肤露。治疗8周,对两组瘙痒面积及严重度指数(Eczema Area and Severity Index,EASI)评分、患者主观湿疹评分(Patient-Oriented Eczema Measure,POEM)评分、皮肤病患者生活质量量表(Dermatology Life Quality Index,DLQI)评分、研究者整体评估(Investigator′s Global Assessment,IGA)评分、瘙痒数值评分(Itch-Numerical Rating Scores,Itch-NRS)评分、血清总IgE、血清嗜酸性粒细胞计数(EOS)、中医症状积分及安全性指标等方面进行评价。结果(1)试验组总有效率91.89%(34/37),高于对照组61.76%(21/34)(P<0.05);试验组中医症状积分改善有效率86.49%(32/37),高于对照组47.05%(16/34)(P<0.05)。(2)试验组EASI评分(17.81±6.06)分、POEM评分(11.19±3.76)分、DLQI评分(14.16±3.03)分、IGA评分(2.24±0.68)分、Itch-NRS评分(4.73±1.37)分的下降均较对照组明显(P均<0.05)。(3)两组血清EOS水平在治疗后均有所下降(P<0.05);血清IgE水平两组均无明显干预效果。结论当归止痒方治疗成人血虚风燥型特应性皮炎的临床疗效显著优于润燥止痒胶囊,没有使用首乌的情况下也能够有效改善患者瘙痒症状,提高患者生活质量,同时能够改善患者血虚、便秘、皮肤干燥、瘙痒等中医伴随症状,且没有不良反应发生。
基金Project(ZDRW-ZS-2021-3)supported by the Key Deployment Projects of Chinese Academy of SciencesProjects(52179116,51991392)supported by the National Natural Science Foundation of China。
文摘In the process of shield tunneling through soft soil layers,the presence of confined water ahead poses a significant threat to the stability of the tunnel face.Therefore,it is crucial to consider the impact of confined water on the limit support pressure of the tunnel face.This study employed the finite element method(FEM)to analyze the limit support pressure of shield tunnel face instability within a pressurized water-containing layer.Subsequently,a multiple linear regression approach was applied to derive a concise solution formula for the limit support pressure,incorporating various influencing factors.The analysis yields the following conclusions:1)The influence of confined water on the instability mode of the tunnel face in soft soil layers makes the displacement response of the strata not significant when the face is unstable;2)The limit support pressure increases approximately linearly with the pressure head,shield tunnel diameter,and tunnel burial depth.And inversely proportional to the thickness of the impermeable layer,soil cohesion and internal friction angle;3)Through an engineering case study analysis,the results align well with those obtained from traditional theoretical methods,thereby validating the rationality of the equations proposed in this paper.Furthermore,the proposed equations overcome the limitation of traditional theoretical approaches considering the influence of changes in impermeable layer thickness.It can accurately depict the dynamic variation in the required limit support pressure to maintain the stability of the tunnel face during shield tunneling,thus better reflecting engineering reality.
