孤独迷惘的新生代——吉田修一小说《恶人》解析

芥川奖得主吉田修一的长篇力作《恶人》,围绕着一起保险公司女职员被杀事件,描写了在"格差"社会中挣扎求存的众生相。作者通过对四个不同背景下成长起来的年轻人不同遭遇的刻画,反映了当代年轻人所面临的各种心理问题和社会问题,揭示了浮华社会背后人际关系的疏离与冷漠。

恶人为邻

韩非有与悍者邻,欲卖宅而避之,人曰: “是其贯将满矣,子姑待之!”答曰: “吾恐其以我满贯也。”遂去之。故曰: “物之几者,非所靡也。”——先秦《韩非子》

战地：恶人连Ⅱ——冰火两重天的混战体验

“战地”与“使命召唤”系列除了题材一致以外，几乎没有任何的相同之处，二者也不能算是真正意义上的竞争对手。但如果你觉得《使命召唤：现代战争Ⅱ》（Call of Duty：Modern Warfare2）的网战系统缺乏新意，过于程式化，那么可以考虑一下“战地“系列的最新作品——《恶人连Ⅱ》（Battlefield．Bad Company2，以下简称BC2），这部曾经在Xbox360平台上大红大紫，以全程黑色幽默和全部场景可破坏为特色的多人混战FPS游戏，即将于2010年初在PC平台上推出它的最新作品。

Selective Effect of Qinghaosu on Different Stages of Plasmodium falciparum in Vitro

Using highly synchronous cultures of Plasmodium falciparum in vitro,the susceptibi- lity of the different stages of the intraerythrocytic parasites to Qinghaosu (QHS) was assessed.The anti- parasitic effect of QHS was measured by comparing the changes of irradiation of^3 H-hypoxanthine in- corporated into the nucleic acids of parasites exposed to various concentrations of QHS at different stages of growth.It was found that the trophozoite stage of the parasite was the most sensitive to QHS, whereas the early ring stage was the least sensitive,and the sensitivities of the late ring and schizont stages fell between those of the early ring and trophozoite stages.The results revealed the correlation of stage-dependent effects of QHS with the blockade of the protein metabolism of the parasite.

Incidence of port-site metastasis after undergoing robotic surgery for biliary malignancies

AIM： To investigate the incidence of clinically detected port-site metastasis （PSM） in patients who underwent robotic surgery for biliary malignancies. METHODS： Using a prospective database, the patients undergoing fully robotic surgery for biliary malignan- cies between January 2009 and January 2011 were in- cluded. Records of patients with confirmed malignancy were reviewed for clinicopathological data and informa- tion about PSM. RESULTS： Sixty-four patients with biliary tract cancers underwent robotic surgery, and sixty patients met the inclusion criteria. The median age was 67 year （range： 40-85 year）. During a median 15-mo follow-up period, two female patients were detected solitary PSM after robotic surgery. The incidence of PSM was 3.3%. Pa- tient 1 underwent robotic anatomatic left hemihepa- tectomy and extraction of biliary tumor thrombi for an Klatskin tumor. She had a subcutaneous mass located at the right lateral abdominal wall near a trocar scar. Patient 2 underwent robotic pancreaticoduodenectomy for distal biliary cancer. She had two metachronous subcutaneous mass situated at the right lateral abdomi- nal wall under a same trocar scar at 7 and 26 mo. The pathology of the excised PSM masses confirmed meta- static biliary adenocarcinoma. CONCLUSION： The incidence of PSIVls after robotic surgery for biliary malignancies is relatively low, and biliary cancer can be an indication of robotic surgery.

Diabetes mellitus as a risk factor for gastrointestinal cancer among American veterans

AIM:To assess the risk of biliary and pancreatic cancers in a large cohort of patients with type 2 diabetes mellitus(DM) .METHODS:Eligibility for this study included patients with type 2 DM(ICD-9 code 250.0) who were discharged from Department of Veteran Affairs hospitals between 1990 and 2000.Non-matched control patients without DM were selected from the same patient treatment files during the same period.Demographic information included age,sex and race.Secondary diagnoses included known risk factors based on their ICD-9 codes.By multivariate logistic regression,the occurrence of biliary and pancreatic cancer was compared between case subjects with DM and controls without DM.RESULTS:A total of 1172496 case and control subjects were analyzed.The mean age for study and control subjects was 65.8 ± 11.3 and 64.8 ± 12.6 years,respectively.The frequency of pancreatic cancer in subjects with DM was increased(0.9%) in comparison to control subjects(0.3%) with an OR of 3.22(95% CI:3.03-3.42) .The incidence of gallbladder andextrahepatic biliary cancers was increased by twofold in diabetic patients when compared to controls.The OR and 95% CI were 2.20(1.56-3.00) and 2.10(1.61-2.53) ,respectively.CONCLUSION:Our study demonstrated that patients with DM have a threefold increased risk for developing pancreatic cancer and a twofold risk for developing biliary cancer.

Evaluation of Human Papillomavirus Infection among Women Using Pap Smear and PCR in Shiraz, Iran

Human papillomaviruses （HPVs） infect mucosal and cutaneous epithelia and cause malignancy and neoplastic lesions. These viruses cause 25,000 deaths per year from cervical cancer most often in developing countries. This major public health problem makes them important targets in the researches of papillomavirus detection methods. Since the early diagnosis of this virus infection would prevent neoplasia and cervical cancer, therefore in this study the combination of molecular and cytological methods were used to show the occurrence of the infection in women referred to Baghiatollah clinic of Shiraz. The results showed out of 110 cases, two samples were positive by PCR using GP5/6 primers but Pap smears showed only one sample of abnormal cytology. The rest 108 samples were negative by PCR and had normal cytology. The samples （1.82%） in evaluated women. present study showed a low occurrence of HPV infection in cervical

Nay or Nyay 3： Epistemic Utility of Shadow of Ignorance that Obscures Mental Images and Associated States

Survival of organisms requires response to sense inputs and feedback. An intuitive picture or mental image of reality from sense experience is apparently structured from orthogonal and independent sense inputs in association with past memories. Such images are not necessarily visual but may have such qualities. Play of mind with information in mental images processed by molecular actors is guided with rules of reality to assure non-contradictory outcome of actions for successful behaviors （Rogers and Jain 1993）. Such functions have evolved to find food before becoming food, and fight or flight when in doubt. Shadows of ignorance that obscure mental images and associated states also have epistemic utility. Their success depends on learning from trials and errors to compensate for incomplete information and uncertainties with consideration of what could go wrong. Outcomes are also influenced by games played on mind by illusions, mistakes, surprises, ignorance. Loss of time, energy, and opportunity associated with ignored or misinterpreted information threaten survival. Equivocation, cynicism, wild goose chase, and vicious circle of sterile ideas encourage contradictory or inconsistent interpretations that compromise outcomes. Throughout the human history, ignorance of horsemen of apocalypse has unleashed havocs, perpetuated wars, epidemics, wrongful medical treatments, and economic disasters. What used to be crisis of ignorance has now become crisis of unintended consequences of inventions and other forms of knowledge. Ignorance of experts and head of states as horsemen of darkness brings misery to countless innocents. In Nay formalism, knowledge （gyan） is what knows with certainty （either as true or false）. Identifying uncertainties introduces doubt （syad） in what one knows. For finding ones way around lack of relevant evidence （agyan）, wisdom lies in recognition of ignorance and identifies problem to seek solution. Note that these states for propositions are not necessarily related by binary negations.

Lord of the flies： A survey of evil humanity

The novel, Lord of the flies, written by William Golding （1911-1993） who was among the most popular and influential British authors to have emerged after World War II, is permeated with symbolism. His reputation rested primarily upon his acclaimed first novel. The present paper attempts to examine the theme of Lord of the flies in respects of its counter-tradition treatment of boys, evil actions of innocent boys and its use of symbols and arrives at a tentative conclusion that the combination of the three above-mentioned elements helps the novel to express the theme that evil is human nature.

T. S. Eliot＇s Spiritual Journey in Designing The Cocktail Party as a Drama of Conversion

In his quest for spiritual fulfillment, Thomas Stearns Eliot conducts a meticulous religious study which teaches him distinctive interpretations of human existence and their various functions that they are supposed to assume in the world. Eliot＇s personal attachment to religious knowledge and his reflections of religious studies inevitably manifest themselves in his literary works; be it his dramas or poems, mostly in the forms of philosophical and psychoanalytical analysis of his characters and the detected problems observed in their relationships. The Cocktail Party, a play starting off as a drawing-room comedy soon converts to a serious analysis of human psychology and the nature of human interactions. While engaging with these particular points, the play offers possibilities to discuss several religious allusions, though dealt with subtly. Integrated with religion, characters＇ attitudes towards a given situation and their final decision position them in their quest either in ＂hypothetical＂ enlightenment or in a ＂supposed＂ repetition of a vicious circle. The enforcing power behind the play is interestingly a psychiatrist, who adds dynamism and mystery to the plot and has a special task in making the play a drama of conversion. The inner conflicts of the characters which ultimately lead to a series of problems in their relationships are the main concern which causes the characters search for different solutions. Accordingly, they make their own choices to cease their inner struggles. This paper aims to explore the concept of conversion in Eliot＇s The Cocktail Party with references to the playwright＇s religious journey in his literary career.

mad-overexpression down regulates the malignant growth and p53 mediated apoptosis in human hepatocellular carcinoma BEL-7404 cells

Mad protein has been shown as an antagonist of cMyc protein in some cell lines. The effect of Mad protein to the malignant phenotype of human hepatoma BEL7404 cell line was investigated experimentally. An eukarryotic vector pCDNA Ⅲ containing full ORF fragmentof mad cDNA was transfected into targeted cells. Under G418 selection, stable Mad-overexpressed cells were cloned.Studies on the effect of Mad over-expression in cell proliferation and cell cycle revealed that cell morphology of the Mad-overexpressed BEL-7404-M1 cells was significantly different from the parent and control vector transfected cells. DNA synthesis, cell proliferation and anchorage-independent growth in soft-agar of the madtransfected cel1s were partially inhibited in comparison to control cells.Flow Cytometry analysis indicated that mad over-expression might block more transfectant cells at G0/G1 phase, resulting in the retardation of cell proliferation. RT-PCR detected a marked inhibition of the expression of cdc25A, an important regulator gene of G0/G1to S phase in cell cycle. It was also found that Mad protein overexpression could greatly suppress p53-mediated apoptosis in BEL-7404-M1 cells in the absence of serume.Thus, Mad proteins may function as a negative regulator antagonizing c-Myc activity in the control of cell growth and apoptosis in human hepatocellular carcinoma BEL7404 cells.madoverexpression and regulation of cell growth and apoptosis

Concept Paper： Developing Pavement Structural Deterioration Curves

A SN （structural number） can be calculated for a road pavement from the properties and thicknesses of the surface, basecourse, sub-base and subgrade. Historically, the cost of collecting structural data has been very high. Data was initially collected using Benkelman Beams and now by FWD （falling weight deflectometer）. The structural strength of pavements weakens over time due to environmental and traffic loading factors but due to a lack of data, no structural deterioration curve for pavements has been implemented in a PMS （pavement management system）. IRI （international roughness index） is a measure of the road longitudinal profile and has been used as a proxy for a pavement’s structural integrity. This paper offers two conceptual methods to develop PSDC （pavement structural deterioration curves）. Firstly, structural data are grouped in sets by design ESA （equivalent standard axles）. An ISN （“initial” SN）, SNI （intermediate SN） and a TSN （terminal SN）, are used to develop the curves. Using FWD data, the ISN is the SN after the pavement is rehabilitated （Financial Accounting “Modern Equivalent”）. Intermediate SNIs, are SNs other than the ISN and TSN. The TSN was defined as the SN of the pavement when it was approved for pavement rehabilitation. The second method is to use TSD （traffic speed deflectometer） data. The road network already divided into road blocks, is grouped by traffic loading. For each traffic loading group, road blocks that have had a recent pavement rehabilitation, are used to calculate the ISN and those planned for pavement rehabilitation to calculate the TSN. The remaining SNs are used to complete the age-based or if available, historical traffic loading-based SNIs.

Toxicity of Chemotherapy in a Patient with Bloom Syndrome＇s Diagnosis

Bloom＇s syndrome is a rare disease that is related to an increased risk of developing malignant neoplasm. The patient reported was followed up with several hospital staff when she was diagnosed with gastric cancer, but unfortunately, she had already peritoneal implants in moment of the surgery approach. It has been reported in the literature that patients with this syndrome present greater toxicity to the chemotherapeutic treatment, however due to the rarity of the disease, it is not known exactly how the adjustment of these drugs should be performed and which is the better protocol to use. Palliative chemotherapy was proposed, but after receiving one dose of the initially treatment, she developed severe and limiting toxicity.

Congenital bronchoesophageal fistula in an adult: A case report

Bronchoesophageal fistulas are usually diagnosed in the neonatal period. As such, the condition is rare in adults. We present a case of a congenital bronchoesophageal fistula in a 62-year-old man with the complaint of severe bouts of cough and choking after swallowing liquid. His workup included a barium esophagogram that revealed a fistula between the esophagus and a right lower lobe bronchus. The diagnosis should be considered in certain individuals with suggestive symptomatology and unexplained respiratory pathology. The fistula was divided and resected, The patient had an uneventful recovery.

Smartphone Malware Detection Model Based on Artificial Immune System

In order to solve the problem that me traditional signature-based detection technology cannot effectively detect unknown malware, we propose in this study a smartphone malware detection model （SP-MDM） based on artificial immune system, in which static malware analysis and dynamic malware analysis techniques are combined, and antigens are generated by encoding the characteristics extracted from the malware. Based on negative selection algorithm, the mature detectors are generated. By introducing clonal selection algorithm, the detectors with higher affinity are selected to undergo a proliferation and somatic hyper-mutation process, so that more excellent detector offspring can be generated. Experimental result shows that the detection model has a higher detection rate for unknown smartphone malware, and better detection performance can be achieved by increasing the clone generation.

Predictive value of symptoms and demographics in diagnosing malignancy or peptic stricture

AIM:To determine which features of history and demographics predict a diagnosis of malignancy or peptic stricture in patients presenting with dysphagia.METHODS:A prospective case-control study of 2000 consecutive referrals(1031 female,age range:17-103 years) to a rapid access service for dysphagia,based in a teaching hospital within the United Kingdom,over 7 years.The service consists of a nurse-led telephone triage followed by investigation(barium swallow or gastroscopy),if appropriate,within 2 wk.Logistic regression analysis of demographic and clinical variables was performed.This includes age,sex,duration of dysphagia,whether to liquids or solids,and whether there are associated features(reflux,odynophagia,weight loss,regurgitation).We determined odds ratio(OR) for these variables for the diagnoses of malignancy and peptic stricture.We determined the value of the Edinburgh Dysphagia Score(EDS) in predicting cancer in our cohort.Multivariate logistic regression was performed and P < 0.05 considered significant.The local ethics committee confirmed ethics approval was not required(audit).RESULTS:The commonest diagnosis is gastro-esophageal reflux disease(41.3%).Malignancy(11.0%) and peptic stricture(10.0%) were also relatively common.Malignancies were diagnosed by histology(97%) or on radiological criteria,either sequential barium swallows showing progression of disease or unequivocal evidence of malignancy on computed tomography.The majority of malignancies were esophago-gastric in origin but ear,nose and throat tumors,pancreatic cancer and extrinsic compression from lung or mediastinal metastatic cancer were also found.Malignancy was statistically more frequent in older patients(aged >73 years,OR 1.1-3.3,age < 60 years 6.5%,60-73 years 11.2%,> 73 years 11.8%,P < 0.05),males(OR 2.2-4.8,males 14.5%,females 5.6%,P < 0.0005),short duration of dysphagia(≤ 8 wk,OR 4.5-20.7,16.6%,8-26 wk 14.5%,> 26 wk 2.5%,P < 0.0005),progressive symptoms(OR 1.3-2.6:progressive 14.8%,intermittent 9.3%,P < 0.001),with weight loss of ≥ 2 kg(OR 2.5-5.1,weight loss 22.1%,without weight loss 6.4%,P < 0.0005) and without reflux(OR 1.2-2.5,reflux 7.2%,no reflux 15.5%,P < 0.0005).The likelihood of malignancy was greater in those who described true dysphagia(food or drink sticking within 5 s of swallowing than those who did not(15.1%vs 5.2% respectively,P < 0.001).The sensitivity,specificity,positive predictive value and negative predictive value of the EDS were 98.4%,9.3%,11.8% and 98.0% respectively.Three patients with an EDS of 3(high risk EDS ≥ 3.5) had malignancy.Unlike the original validation cohort,there was no difference in likelihood of malignancy based on level of dysphagia(pharyngeal level dysphagia 11.9% vs mid sternal or lower sternal dysphagia 12.4%).Peptic stricture was statistically more frequent in those with longer duration of symptoms(> 6 mo,OR 1.2-2.9,≤ 8 wk 9.8%,8-26 wk 10.6%,> 26 wk 15.7%,P < 0.05) and over 60 s(OR 1.2-3.0,age < 60 years 6.2%,60-73 years 10.2%,> 73 years 10.6%,P < 0.05).CONCLUSION:Malignancy and peptic stricture are frequent findings in those referred with dysphagia.The predictive value for associated features could help determine need for fast track investigation whilst reducing service pressures.

Cairo＇s Slums： A Ticking Time Bomb

Despite being one of the symbols of civilization throughout human history, Greater Cairo has many slum areas, hosting a population of three million people living in deteriorating conditions and lacking the basic human necessities. These slums represent a fertile environment for diseases caused by pollution in all its forms and are subject to crimes, rape and theft. There is a huge difference in the state of conditions when comparing the formally planned areas to the informally planned ones. People living in the formally planned settlements, like Nasr City, and in informal ones, like Ezbet El-Haggana, are similar to the kings and queens and slaves of legends. This paper tries to find solutions to the problem of slums and random areas.

Discovering optimal features using static analysis and a genetic search based method for Android malware detection

Mobile device manufacturers are rapidly producing miscellaneous Android versions worldwide. Simultaneously, cyber criminals are executing malicious actions, such as tracking user activities, stealing personal data, and committing bank fraud. These criminals gain numerous benefits as too many people use Android for their daily routines, including important communications. With this in mind, security practitioners have conducted static and dynamic analyses to identify malware. This study used static analysis because of its overall code coverage, low resource consumption, and rapid processing. However, static analysis requires a minimum number of features to efficiently classify malware. Therefore, we used genetic search（GS）, which is a search based on a genetic algorithm（GA）, to select the features among 106 strings. To evaluate the best features determined by GS, we used five machine learning classifiers, namely, Na？ve Bayes（NB）, functional trees（FT）, J48, random forest（RF）, and multilayer perceptron（MLP）. Among these classifiers, FT gave the highest accuracy（95%） and true positive rate（TPR）（96.7%） with the use of only six features.