Objective: The aim of our study was to compare the efficacy and toxicities of vinorelbine plus cisplatin(NP) regimen with that of vinorelbine plus capecitabine(NX) regimen in the treatment of anthracycline- and taxane...Objective: The aim of our study was to compare the efficacy and toxicities of vinorelbine plus cisplatin(NP) regimen with that of vinorelbine plus capecitabine(NX) regimen in the treatment of anthracycline- and taxane-refractory advanced breast cancer. Methods: Forty-six patients with anthracycline- and taxane-refractory advanced breast cancer were equally randomized into a NP group(n = 23) and a NX group(n = 23). Response rates and toxicities were evaluated after 2 cycles of chemotherapy. Results: The overall response rate were 48.0% in both groups. There were no significant differences in disease control rates(78.0% vs. 83%) or 1-year survival rates(54.6% vs. 55.9%). The main adverse events were bone marrow depression and gastrointestinal reaction, and no significant difference was found in toxicities between the groups. Conclusion: For anthracycline- and taxane-refractory advanced breast cancer, NP and NX regimens exerted similar curative effects with acceptable toxicity.展开更多
基于文学诗歌视阈下,本文运用历史文献分析法来进一步探析古代蹴鞠和现代足球间的主体差异性。以《晚春感事》和'An Ode to Football'为例,着眼于中国古代足球运动'蹴鞠'的发展演变和所处的社会历史背景,以及现代足球...基于文学诗歌视阈下,本文运用历史文献分析法来进一步探析古代蹴鞠和现代足球间的主体差异性。以《晚春感事》和'An Ode to Football'为例,着眼于中国古代足球运动'蹴鞠'的发展演变和所处的社会历史背景,以及现代足球的发展趋势,抓住两者之间的发展演变关联性。与此同时,从诗歌层面更深层次地剖析出古代'蹴鞠'和现代足球的文化差异和二者不同命运的原因。展开更多
During an excavation survey to the Daijiayuan vestige of the Western Zhou Dynasty-Late Spring and Autumn Period at Huoshan in Western Anhui,a ground crack related to tectonic movement and filled with silty fine sand w...During an excavation survey to the Daijiayuan vestige of the Western Zhou Dynasty-Late Spring and Autumn Period at Huoshan in Western Anhui,a ground crack related to tectonic movement and filled with silty fine sand was found. This phenomenon was initially confirmed to be due to seismic liquefaction. Many microscopic seismic relics,such as load structure,flow structure,cutoff plane and flotation of organic matter were found in the directional microscopic analysis of deformation. These discoveries and cognitions prove that there were two earthquake events taking place in the Western Zhou Dynasty-Late Spring and Autumn Period in this area. Above-mentioned works enrich and develop the research methods to identify prehistoric earthquake event in eastern China area to a certain extent.展开更多
To define the criteria of posterior selective thoracic fusion in patients with adolescent idiopathic scoliosis. Methods By reviewing the medical records and roentgenograms of 17 patients with adolescent idiopathic sco...To define the criteria of posterior selective thoracic fusion in patients with adolescent idiopathic scoliosis. Methods By reviewing the medical records and roentgenograms of 17 patients with adolescent idiopathic scoliosis who un-derwent posterior selective thoracic fusion, the curve type, Cobb angle, apical vertebral rotation and translation, trunk shift, and thoracolumbar kyphosis were measured and analyzed. Results There were 17 King type Ⅱ patients (PUMC type: Ⅱb1 13, Ⅱc3 4). The coronal Cobb angle of thoracic curve be-fore and after operation were 56.9°and 21.6° respectively, the mean correction rate was 60.1%. The coronal Cobb angle of lumbar curve before and after operation were 34.8° and 12.1° respectively, and the mean spontaneous correction rate was 64.8%. At final follow-up, the coronal Cobb angle of thoracic and lumbar curve were 23.5° and 15.2° respectively, there were no significant changes in the coronal Cobb angle, apical vertebral translation and rotation compared with that after operation. One patient had 12° of thoracolumbar kyphosis after operation, no progression was noted at final follow-up. There was no trunk decompensation or deterioration of the lumbar curve. In this group, 3.9 levels were saved compared with fusing both the th-oracic and lumbar curves. Conclusion Posterior selective thoracic fusion can be safely and effectively performed in King type Ⅱ patients with a mo-derate and flexible lumbar curve, which can save more mobile segments and at the same time can maintain a good coronal and sagittal balance.展开更多
基金Supported by a grant from the Key Project of National 12th Five-year Research Program of China(No.2012ZX0903016-002)
文摘Objective: The aim of our study was to compare the efficacy and toxicities of vinorelbine plus cisplatin(NP) regimen with that of vinorelbine plus capecitabine(NX) regimen in the treatment of anthracycline- and taxane-refractory advanced breast cancer. Methods: Forty-six patients with anthracycline- and taxane-refractory advanced breast cancer were equally randomized into a NP group(n = 23) and a NX group(n = 23). Response rates and toxicities were evaluated after 2 cycles of chemotherapy. Results: The overall response rate were 48.0% in both groups. There were no significant differences in disease control rates(78.0% vs. 83%) or 1-year survival rates(54.6% vs. 55.9%). The main adverse events were bone marrow depression and gastrointestinal reaction, and no significant difference was found in toxicities between the groups. Conclusion: For anthracycline- and taxane-refractory advanced breast cancer, NP and NX regimens exerted similar curative effects with acceptable toxicity.
文摘基于文学诗歌视阈下,本文运用历史文献分析法来进一步探析古代蹴鞠和现代足球间的主体差异性。以《晚春感事》和'An Ode to Football'为例,着眼于中国古代足球运动'蹴鞠'的发展演变和所处的社会历史背景,以及现代足球的发展趋势,抓住两者之间的发展演变关联性。与此同时,从诗歌层面更深层次地剖析出古代'蹴鞠'和现代足球的文化差异和二者不同命运的原因。
基金This paper is a contribution to Scientific Research Special Project of the Earthquake Calling (200808064)Science and Technology Tackle Key Problem Plan Project of Anhui Province(08010302204)Natural Science Fund of Anhui Province(070415222),China
文摘During an excavation survey to the Daijiayuan vestige of the Western Zhou Dynasty-Late Spring and Autumn Period at Huoshan in Western Anhui,a ground crack related to tectonic movement and filled with silty fine sand was found. This phenomenon was initially confirmed to be due to seismic liquefaction. Many microscopic seismic relics,such as load structure,flow structure,cutoff plane and flotation of organic matter were found in the directional microscopic analysis of deformation. These discoveries and cognitions prove that there were two earthquake events taking place in the Western Zhou Dynasty-Late Spring and Autumn Period in this area. Above-mentioned works enrich and develop the research methods to identify prehistoric earthquake event in eastern China area to a certain extent.
文摘To define the criteria of posterior selective thoracic fusion in patients with adolescent idiopathic scoliosis. Methods By reviewing the medical records and roentgenograms of 17 patients with adolescent idiopathic scoliosis who un-derwent posterior selective thoracic fusion, the curve type, Cobb angle, apical vertebral rotation and translation, trunk shift, and thoracolumbar kyphosis were measured and analyzed. Results There were 17 King type Ⅱ patients (PUMC type: Ⅱb1 13, Ⅱc3 4). The coronal Cobb angle of thoracic curve be-fore and after operation were 56.9°and 21.6° respectively, the mean correction rate was 60.1%. The coronal Cobb angle of lumbar curve before and after operation were 34.8° and 12.1° respectively, and the mean spontaneous correction rate was 64.8%. At final follow-up, the coronal Cobb angle of thoracic and lumbar curve were 23.5° and 15.2° respectively, there were no significant changes in the coronal Cobb angle, apical vertebral translation and rotation compared with that after operation. One patient had 12° of thoracolumbar kyphosis after operation, no progression was noted at final follow-up. There was no trunk decompensation or deterioration of the lumbar curve. In this group, 3.9 levels were saved compared with fusing both the th-oracic and lumbar curves. Conclusion Posterior selective thoracic fusion can be safely and effectively performed in King type Ⅱ patients with a mo-derate and flexible lumbar curve, which can save more mobile segments and at the same time can maintain a good coronal and sagittal balance.
