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《本草纲目》对江户时代食物本草书的影响——以《本朝食鉴》为中心 被引量:1
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作者 周敏 刘士永 《中医药文化》 2021年第4期353-361,共9页
《本草纲目》自江户时代伊始东传日本后,引起日本学者的高度重视,随后围绕《本草纲目》展开了一系列学术研究工作,食物本草书籍的编撰当列其中。食物本草类专书出现于江户时代早期,其中最具典范性的当推人见必大所著《本朝食鉴》。通过... 《本草纲目》自江户时代伊始东传日本后,引起日本学者的高度重视,随后围绕《本草纲目》展开了一系列学术研究工作,食物本草书籍的编撰当列其中。食物本草类专书出现于江户时代早期,其中最具典范性的当推人见必大所著《本朝食鉴》。通过对是书的考察发现,人见必大对《本草纲目》知识的吸纳存在选择性,并非全盘接受,亦记载了大量日本独有的食物品种,较全面地反映了当时日本食物的种类和数量。总体而言,《本朝食鉴》的编撰过程是日本学者群体对以《本草纲目》为核心的本草学知识体系进行本土化改造的缩影。作为个案研究,有助于从细节层面了解中国本草学知识在异文化传播过程中所历经的改造过程,在方法和内容上可丰富《本草纲目》的传日研究。 展开更多
关键词 食物本草 江户时代 《本朝食鉴》 《本草纲目》
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《天工开物》与《本草纲目》中几种染色药材的对比研究
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作者 鄢梁裕 惠宏 《中医药文化》 2019年第5期92-100,共9页
《天工开物》与同时期的《本草纲目》有着密切的联系,两书中记载有数量可观的染色药材。在同时期两本书中,对同一种染色药材出现不同的记述,将两书进行对比研究,可以纠正和补充相关染色药材在产地、开采方法、加工炮制记载中的错误与不... 《天工开物》与同时期的《本草纲目》有着密切的联系,两书中记载有数量可观的染色药材。在同时期两本书中,对同一种染色药材出现不同的记述,将两书进行对比研究,可以纠正和补充相关染色药材在产地、开采方法、加工炮制记载中的错误与不足,同时,通过对这些问题的分析可以窥探明代对于染色药材认识与利用的发展,也间接地体现了我国古代科学技术和手工业在明代的发展状况。 展开更多
关键词 《天工开物》 《本草纲目》 染色药材 中药
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探讨固本通络方基于细菌脂多糖介导的肠B细胞激活对Gd-IgA1的影响
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作者 汪容 沈沛成 +1 位作者 何立群 吴卿 《辽宁中医药大学学报》 CAS 2024年第2期47-53,F0003,共8页
目的探讨固本通络方对IgA肾病小鼠肠道细菌脂多糖(LPS)和糖基化缺陷IgA1(Gd-IgA1)的干预及肾保护作用。方法将36只雄性小鼠分为正常对照组、模型组、固本通络方低剂量组、固本通络方中剂量组、固本通络方高剂量组、依立托仑组。实验采用... 目的探讨固本通络方对IgA肾病小鼠肠道细菌脂多糖(LPS)和糖基化缺陷IgA1(Gd-IgA1)的干预及肾保护作用。方法将36只雄性小鼠分为正常对照组、模型组、固本通络方低剂量组、固本通络方中剂量组、固本通络方高剂量组、依立托仑组。实验采用ddY小鼠构建IgA肾病动物模型,将模型组和各药物组进行造模,中药干预各组分别予以固本通络方免煎颗粒低(13.2 g/kg)、中(26.4 g/kg)、高(52.8 g/kg)3种不同剂量药液灌胃给药,正常对照组和模型组小鼠给予0.9%氯化钠溶液灌胃(10 mL/kg),依立托仑组予以腹腔注射依立托仑药液,各药物组每天给予药物1次,连续8周。干预4周、8周后,测定各组24 h尿蛋白定量;8周测定血清及肠道黏膜LPS、IgA、GdIgA1水平,观察肾脏病理染色及右肾IgA沉积情况,实时荧光定量PCR检测Cosmc基因表达,Western blot法测定Cosmc蛋白表达及IgA肠道菌群特异性,流式细胞术检测肠道B淋巴细胞活化率及分泌IgA前体B淋巴细胞比率,对肠道黏膜组织LPS水平与B细胞活化率及IgA前体B细胞比率行相关性分析。结果固本通络方可降低24 h尿蛋白定量水平及血清肌酐水平(P<0.05)。HE染色发现,与模型组相比,固本通络方用药组肾小球系膜细胞、内皮细胞及基质增生显著减少,肾小球系膜区IgA沉积显著改善;血清及肠道黏膜LPS水平检测发现,与模型组比较,各中药干预组均能降低小鼠血清和肠道黏膜组织LPS、Gd-IgA1和IgA水平(P<0.05);降低B细胞活化率及IgA前体B细胞比率(P<0.05),qRT-PCR和Western blot结果显示固本通络方能够显著降低小鼠粪便培养中菌落蛋白表达水平,上调Cosmc蛋白和Cosmc基因表达水平(P<0.05)。LPS水平与B细胞活化率及IgA前体B细胞比率均呈正相关(P<0.05)。结论固本通络方能有效降低IgA肾病小鼠蛋白尿及血清肌酐水平,减轻肾脏病理损伤及肾小球系膜区IgA沉积,其作用可能和固本通络方降低IgA肾病小鼠血清及肠道LPS水平,降低B淋巴细胞活化率,Cosmc表达上调相关。 展开更多
关键词 固本通络方 IGA肾病 糖基化缺陷IgA1 肠道细菌脂多糖
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金龙固本合剂对哮喘模型大鼠气道重塑及肺组织ET1、TFF2、IL-13表达水平的影响
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作者 黄文鑫 孙瑶 +2 位作者 迟映雪 田玉 石绍顺 《辽宁中医药大学学报》 CAS 2024年第2期37-42,共6页
目的观察金龙固本合剂对哮喘气道重塑大鼠肺组织内皮素1(ET1)、三叶因子2(TFF2)及白细胞介素-13(IL-13)表达水平的影响,并探讨抑制气道重塑的机制。方法将50只雄性大鼠随机分为中药低剂量组(A)、中药高剂量组(B)、地塞米松组(C)、模型... 目的观察金龙固本合剂对哮喘气道重塑大鼠肺组织内皮素1(ET1)、三叶因子2(TFF2)及白细胞介素-13(IL-13)表达水平的影响,并探讨抑制气道重塑的机制。方法将50只雄性大鼠随机分为中药低剂量组(A)、中药高剂量组(B)、地塞米松组(C)、模型对照组(D)、空白对照组(E),共5组,每组10只。腹腔注射卵蛋白致敏液构建大鼠气道重塑模型,观察各组大鼠症状及肺组织病理学形态改变。Western blot法检测肺组织ET1,ELISA法检测各组大鼠支气管肺泡灌洗液(bronchoalveolar lavage fluid,BALF)上清液中TFF2含量,实时荧光定量Q-PCR法检测各组大鼠肺组织IL-13 mRNA表达情况。结果各组大鼠肺组织ET1蛋白相对表达水平:与模型对照组比较,中药低剂量组ET1蛋白表达稍降低,中药高剂量组和地塞米松组ET1蛋白表达呈下降趋势,但差异均无统计学意义。各组大鼠BALF上清液中TFF2含量:与模型对照组比较,中药高剂量组和地塞米松组大鼠BALF上清液中TFF2含量显著降低(P<0.01),中药低剂量组大鼠BALF上清液中TFF2含量呈一定下降趋势,但差异无统计学意义。各组大鼠肺组织IL-13相对表达水平:与模型对照组比较,中药高剂量组大鼠肺组织IL-13 mRNA表达水平显著降低(P<0.05),地塞米松组大鼠肺组织IL-13 mRNA表达水平显著降低(P<0.01),中药低剂量组大鼠肺组织IL-13mRNA表达水平呈明显下降趋势,差异无统计学意义。结论金龙固本合剂可以改善哮喘模型大鼠气道重塑状态,其机制可能与调节ET1、TFF2、IL-13蛋白表达水平有关,为中医药治疗哮喘气道重塑提供理论基础,证明金龙固本合剂治疗哮喘气道重塑具有多途径多靶点的作用,具有临床推广应用的价值。 展开更多
关键词 金龙固本合剂 气道重塑 大鼠 内皮素1 三叶因子2 白细胞介素-13
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扶正固本方联合针刺对胃癌患者症状改善及抗氧化机制研究
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作者 丁铌 王苏 +1 位作者 郭曼 陈丽娟 《中华中医药学刊》 CAS 北大核心 2024年第8期81-84,共4页
目的分析扶正固本方联合针刺治疗胃癌的干预改善效果及对氧化应激水平的影响。方法纳入2022年9月—2023年6月医院收治的94例胃癌患者为研究对象,随机将其分为两组,47例对照组采用化疗治疗,47例观察组在此基础上予以扶正固本方联合针刺治... 目的分析扶正固本方联合针刺治疗胃癌的干预改善效果及对氧化应激水平的影响。方法纳入2022年9月—2023年6月医院收治的94例胃癌患者为研究对象,随机将其分为两组,47例对照组采用化疗治疗,47例观察组在此基础上予以扶正固本方联合针刺治疗,对比两组疗效差异、炎症因子水平、氧化应激水平、T细胞亚群指标水平变化情况等。结果观察组客观缓解率为40.43%(19/47),疾病控制率为93.62%(44/47),高于对照组的25.53%(12/47)、76.60%(36/47),组间比较差异有统计学意义(P<0.05);观察组谷胱甘肽过氧化酶(glutathione peroxidase,GSH-Px)、超氧化物歧化酶(superoxide dismutase,SOD)高于对照组,丙二醛(malondialdehyde,MDA)、血清活性氧(reactive oxygen species,ROS)水平低于对照组(P<0.05);观察组干扰素-γ(interferon gamma-γ,IFN-γ)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)高于对照组,白介素细胞-6(interleukin 6,IL-6)、白介素细胞-8(interleukin 8,IL-8)水平低于对照组、CD_(3)^(+)、CD_(4)^(+)/CD_(8)^(+)高于对照组,CD_(4)^(+)低于对照组(P<0.05)。结论对胃癌患者开展扶正固本方联合针刺治疗改善效果明确,有利于减轻机体炎症刺激反应,改善氧化应激水平,提高患者机体免疫功能,调节免疫失衡,对患者预后改善具有积极作用。 展开更多
关键词 胃癌 扶正固本方 针刺 炎性因子 氧化应激 免疫能力
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基于多任务学习的同行评审细粒度情感分析模型 被引量:1
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作者 朱金秋 檀健 +1 位作者 韩斌彬 殷秀秀 《中北大学学报(自然科学版)》 CAS 2024年第1期105-113,共9页
学术论文同行评审能够直接反映审稿人对论文的主观评价,对审稿文本进行情感分析有利于挖掘审稿人对论文多维度的评价信息。现有的情感分析模型仅能挖掘专家单一的评审维度和相应的情感倾向,本文提出了一种基于多任务学习的同行评审细粒... 学术论文同行评审能够直接反映审稿人对论文的主观评价,对审稿文本进行情感分析有利于挖掘审稿人对论文多维度的评价信息。现有的情感分析模型仅能挖掘专家单一的评审维度和相应的情感倾向,本文提出了一种基于多任务学习的同行评审细粒度情感分析模型。该模型在多任务学习框架下,通过在BERT-LCF模型的基础上增加BiLSTM-CRF模块,使其具备了同时完成属性词抽取和细粒度情感分析任务的能力。与传统的基于Pipeline模式的单任务细粒度情感分析模型相比,本模型在保证精度的情况下可以同时完成评审属性提取和情感分析任务。在这两项任务中,所提出模型的F1分数分别达到了89.01%和90.71%。对比实验证明,在多任务场景下,引入BiLSTM-CRF模块对评审文本属性词提取任务有一定的提升作用。 展开更多
关键词 同行评审 多任务学习 属性词抽取 细粒度情感分析 BiLSTM-CRF
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Design and implementation of low-cost geomagnetic field monitoring equipment for high-density deployment
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作者 Sun Lu-Qiang Bai Xian-Fu +3 位作者 Kang Jian Zeng Ning Zhu Hong Zhang Ming-Dong 《Applied Geophysics》 SCIE CSCD 2024年第3期505-512,618,共9页
The observation of geomagnetic field variations is an important approach to studying earthquake precursors.Since 1987,the China Earthquake Administration has explored this seismomagnetic relationship.In particular,the... The observation of geomagnetic field variations is an important approach to studying earthquake precursors.Since 1987,the China Earthquake Administration has explored this seismomagnetic relationship.In particular,they studied local magnetic field anomalies over the Chinese mainland for earthquake prediction.Owing to the years of research on the seismomagnetic relationship,earthquake prediction experts have concluded that the compressive magnetic effect,tectonic magnetic effect,electric magnetic fluid effect,and other factors contribute to preearthquake magnetic anomalies.However,this involves a small magnitude of magnetic field changes.It is difficult to relate them to the abnormal changes of the extremely large magnetic field in regions with extreme earthquakes owing to the high cost of professional geomagnetic equipment,thereby limiting large-scale deployment.Moreover,it is difficult to obtain strong magnetic field changes before an earthquake.The Tianjin Earthquake Agency has developed low-cost geomagnetic field observation equipment through the Beijing–Tianjin–Hebei geomagnetic equipment test project.The new system was used to test the availability of equipment and determine the findings based on big data.. 展开更多
关键词 geomagnetic field earthquake prediction low cost high density big data
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Ultrafast pulse wave velocity technique for evaluating changes of carotid artery elasticity in Hashimoto thyroiditis patients with euthyroidism
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作者 JIANG Yanhui LIU Meiling +1 位作者 XIE Jingwen ZHANG Jianxing 《中国医学影像技术》 CSCD 北大核心 2024年第8期1179-1182,共4页
Objective To explore the value of ultrafast pulse wave velocity(UFPWV)technique for evaluating changes of carotid artery elasticity in Hashimoto thyroiditis(HT)patients with euthyroidism.Methods Conventional ultrasoun... Objective To explore the value of ultrafast pulse wave velocity(UFPWV)technique for evaluating changes of carotid artery elasticity in Hashimoto thyroiditis(HT)patients with euthyroidism.Methods Conventional ultrasound and UFPWV for carotid artery were prospectively performed in 91 HT patients with euthyroidism(HT group)and 81 healthy subjects(control group).Clinical data and ultrasonic parameters were compared between groups.Spearman correlation analysis was performed to observe the correlations of carotid pulse wave velocity in end of systole(PWV-ES)with clinical indexes and other ultrasonic parameters in HT group.Multiple stepwise linear regression analysis was used to screen the independent impact factors of increased carotid PWV-ES in HT group.Results Significant differences of thyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TgAb),total cholesterol(TC),low density lipoprotein and neutrophil-lymphocyte ratio(NLR)were found between groups(all P<0.05).The carotid PWV-ES in HT group was significantly higher than that in control group(P<0.05),while no significant difference of carotid artery intima-media thickness(CIMT)nor carotid pulse wave velocity in beginning of systole(PWV-BS)was found between groups(both P>0.05).Carotid PWV-ES in HT group was positively correlated with patients'age,body mass index,TPOAb,TC,triglyceride,NLR and CIMT(r=0.217—0.707,all P<0.05).Patients'age,TPOAb and NLR were all independent impact factors of increased carotid PWV-ES in HT patients with euthyroidism(all P<0.05).Conclusion UFPWV technique could be used to evaluate changes of carotid artery elasticity in HT patients with euthyroidism,among which PWV-ES was relatively sensitive. 展开更多
关键词 Hashimoto disease carotid arteries ULTRASONOGRAPHY prospective studies
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A whole process damage constitutive model for layered sandstone under uniaxial compression based on Logistic function
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作者 LIU Dong-qiao GUO Yun-peng +1 位作者 LING Kai LI Jie-yu 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第7期2411-2430,共20页
Bedding structural planes significantly influence the mechanical properties and stability of engineering rock masses.This study conducts uniaxial compression tests on layered sandstone with various bedding angles(0... Bedding structural planes significantly influence the mechanical properties and stability of engineering rock masses.This study conducts uniaxial compression tests on layered sandstone with various bedding angles(0°,15°,30°,45°,60°,75°and 90°)to explore the impact of bedding angle on the deformational mechanical response,failure mode,and damage evolution processes of rocks.It develops a damage model based on the Logistic equation derived from the modulus’s degradation considering the combined effect of the sandstone bedding dip angle and load.This model is employed to study the damage accumulation state and its evolution within the layered rock mass.This research also introduces a piecewise constitutive model that considers the initial compaction characteristics to simulate the whole deformation process of layered sandstone under uniaxial compression.The results revealed that as the bedding angle increases from 0°to 90°,the uniaxial compressive strength and elastic modulus of layered sandstone significantly decrease,slightly increase,and then decline again.The corresponding failure modes transition from splitting tensile failure to slipping shear failure and back to splitting tensile failure.As indicated by the modulus’s degradation,the damage characteristics can be categorized into four stages:initial no damage,damage initiation,damage acceleration,and damage deceleration termination.The theoretical damage model based on the Logistic equation effectively simulates and predicts the entire damage evolution process.Moreover,the theoretical constitutive model curves closely align with the actual stress−strain curves of layered sandstone under uniaxial compression.The introduced constitutive model is concise,with fewer parameters,a straightforward parameter determination process,and a clear physical interpretation.This study offers valuable insights into the theory of layered rock mechanics and holds implications for ensuring the safety of rock engineering. 展开更多
关键词 layered sandstone uniaxial compression damage evolution Logistic function constitutive model
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The Use of Hand Stamps in the Manuscript Maps Drawn by East Asian Countries in the Eighteenth and Nineteenth Centuries
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作者 WANG Yao 《Chinese Annals of History of Science and Technology》 2024年第1期57-77,共21页
It was generally accepted that manuscript maps,as distinct from printed maps,exhibited no signs of printing and were entirely hand-drawn.Western scholars Christopher Terrell and Tony Campbell were the first to break t... It was generally accepted that manuscript maps,as distinct from printed maps,exhibited no signs of printing and were entirely hand-drawn.Western scholars Christopher Terrell and Tony Campbell were the first to break this stereotype in 1987,followed by Catherine Delano-Smith and Chet Van Duzer who discovered a few Renaissance maps and two Qing dynasty maps that showed use of hand stamps.Inspired by these findings,this paper explores the stamped map signs in ten Chinese maps,three Japanese maps,and three Korean maps.By analyzing each map and each type of stamp,this paper provides more examples of this research,broadens the research horizons and geographical area,and demonstrates that use of stamps in manuscript maps was invented independently among people of different regions and civilizations as a result of human nature. 展开更多
关键词 history of cartography East Asia manuscript maps STAMPS printing technique(nayin)
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《广韵》206韵来源考
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作者 丁治民 《长江学术》 2024年第1期107-115,共9页
《广韵》206韵是怎么来的?历来聚讼纷纭,经分类详列各家的观点,再比较现有材料,得出结论如下:《广韵》是以开元本孙愐《唐韵》204韵,再加上敦煌本王仁昫《刊谬补缺切韵》上声五十一广与去声五十六严两韵而来的;《广韵》的韵数发展历程... 《广韵》206韵是怎么来的?历来聚讼纷纭,经分类详列各家的观点,再比较现有材料,得出结论如下:《广韵》是以开元本孙愐《唐韵》204韵,再加上敦煌本王仁昫《刊谬补缺切韵》上声五十一广与去声五十六严两韵而来的;《广韵》的韵数发展历程应为“193-204-206”,而非其他。 展开更多
关键词 《广韵》 206韵 开元本《唐韵》 敦煌本王韵
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Ground response and failure mechanism of gob-side entry by roof cutting with hard main roof
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作者 ZHU Heng-zhong XU Lei WEN Zhi-jie 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第7期2488-2512,共25页
This study is the result of long-term efforts of the authors’team to assess ground response of gob-side entry by roof cutting(GSERC)with hard main roof,aiming at scientific control for GSERC deformation.A comprehensi... This study is the result of long-term efforts of the authors’team to assess ground response of gob-side entry by roof cutting(GSERC)with hard main roof,aiming at scientific control for GSERC deformation.A comprehensive field measurement program was conducted to determine entry deformation,roof fracture zone,and anchor bolt(cable)loading.The results indicate that GSERC deformation presents asymmetric characteristics.The maximum convergence near roof cutting side is 458 mm during the primary use process and 1120 mm during the secondary reuse process.The entry deformation is closely associated with the primary development stage,primary use stage,and secondary reuse stage.The key block movement of roof cutting structure,a complex stress environment,and a mismatch in the supporting design scheme are the failure mechanism of GSERC.A controlling ideology for mining states,including regional and stage divisions,was proposed.Both dynamic and permanent support schemes have been implemented in the field.Engineering practice results indicate that the new support scheme can efficiently ensure long-term entry safety and could be a reliable approach for other engineering practices. 展开更多
关键词 gob-side entry by roof cutting ground response failure mechanism following mining states control hard main roof
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Region-Aware Fashion Contrastive Learning for Unified Attribute Recognition and Composed Retrieval
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作者 WANG Kangping ZHAO Mingbo 《Journal of Donghua University(English Edition)》 CAS 2024年第4期405-415,共11页
Clothing attribute recognition has become an essential technology,which enables users to automatically identify the characteristics of clothes and search for clothing images with similar attributes.However,existing me... Clothing attribute recognition has become an essential technology,which enables users to automatically identify the characteristics of clothes and search for clothing images with similar attributes.However,existing methods cannot recognize newly added attributes and may fail to capture region-level visual features.To address the aforementioned issues,a region-aware fashion contrastive language-image pre-training(RaF-CLIP)model was proposed.This model aligned cropped and segmented images with category and multiple fine-grained attribute texts,achieving the matching of fashion region and corresponding texts through contrastive learning.Clothing retrieval found suitable clothing based on the user-specified clothing categories and attributes,and to further improve the accuracy of retrieval,an attribute-guided composed network(AGCN)as an additional component on RaF-CLIP was introduced,specifically designed for composed image retrieval.This task aimed to modify the reference image based on textual expressions to retrieve the expected target.By adopting a transformer-based bidirectional attention and gating mechanism,it realized the fusion and selection of image features and attribute text features.Experimental results show that the proposed model achieves a mean precision of 0.6633 for attribute recognition tasks and a recall@10(recall@k is defined as the percentage of correct samples appearing in the top k retrieval results)of 39.18 for composed image retrieval task,satisfying user needs for freely searching for clothing through images and texts. 展开更多
关键词 attribute recognition image retrieval contrastive language-image pre-training(CLIP) image text matching transformer
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Prediction of Hot Deformation Behavior of 7Mo Super Austenitic Stainless Steel Based on Back Propagation Neural Network
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作者 WANG Fan WANG Xitao +1 位作者 XU Shiguang HE Jinshan 《材料导报》 EI CAS CSCD 北大核心 2024年第17期165-171,共7页
The hot compression tests of 7Mo super austenitic stainless(SASS)were conducted to obtain flow curves at the temperature of 1000-1200℃and strain rate of 0.001 s^(-1)to 1 s^(-1).To predict the non-linear hot deformati... The hot compression tests of 7Mo super austenitic stainless(SASS)were conducted to obtain flow curves at the temperature of 1000-1200℃and strain rate of 0.001 s^(-1)to 1 s^(-1).To predict the non-linear hot deformation behaviors of the steel,back propagation-artificial neural network(BP-ANN)with 16×8×8 hidden layer neurons was proposed.The predictability of the ANN model is evaluated according to the distribution of mean absolute error(MAE)and relative error.The relative error of 85%data for the BP-ANN model is among±5%while only 42.5%data predicted by the Arrhenius constitutive equation is in this range.Especially,at high strain rate and low temperature,the MAE of the ANN model is 2.49%,which has decreases for 18.78%,compared with conventional Arrhenius constitutive equation. 展开更多
关键词 7Mo super austenitic stainless steel hot deformation behavior flow stress BP-ANN Arrhenius constitutive equation
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Text Difficulty,Working Memory Capacity and Mind Wandering During Chinese EFL Learners’Reading
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作者 Xianli GAO Li LI 《Chinese Journal of Applied Linguistics》 2024年第3期433-449,525,共18页
This experimental study investigated how text difficulty and different working memory capacity(WMC)affected Chinese EFL learners’reading comprehension and their tendency to engage in task-unrelated thoughts,that is,m... This experimental study investigated how text difficulty and different working memory capacity(WMC)affected Chinese EFL learners’reading comprehension and their tendency to engage in task-unrelated thoughts,that is,mind wandering(MW),in the course of reading.Sixty first-year university non-English majors participated in the study.A two-factor mixed experimental design of 2(text difficulty:difficult and simple)×2(WMC:high/large and low/small)was employed.Results revealed that 1)the main and interaction effects of WMC and text difficulty on voluntary MW were significant,whereas those on involuntary MW were not;2)while reading the easy texts,the involuntary MW of high-WMC individuals was less frequent than that of low-WMC ones,whereas while reading the difficult ones,the direct relationship between WMC and involuntary MW was not found;and that 3)high-WMC individuals had a lower overall rate of MW and better reading performance than low-WMC individuals did,but with increasing text difficulty,their rates of overall MW and voluntary MW were getting higher and higher,and the reading performance was getting lower and lower.These results lend support to WM theory and have pedagogical implications for the instruction of L2 reading. 展开更多
关键词 text difficulty working memory capacity reading mind wandering voluntary mind wandering involuntary mind wandering reading comprehension
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基于数据挖掘的《本草纲目》中鲜药应用的规律及特点分析 被引量:4
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作者 张亚楠 惠香香 +3 位作者 秦格 赵艳媛 苗明三 白明 《中药药理与临床》 CAS CSCD 北大核心 2023年第4期97-101,共5页
目的:本文通过对李时珍《本草纲目》中使用鲜药的规律和特点进行了分析和总结,为临床使用鲜药提供数据支撑及参考。方法:通过查阅总结《本草纲目》中关于中药鲜药的临床应用,输入Excel 2016软件中建立数据库,对药物的使用频数、性味、... 目的:本文通过对李时珍《本草纲目》中使用鲜药的规律和特点进行了分析和总结,为临床使用鲜药提供数据支撑及参考。方法:通过查阅总结《本草纲目》中关于中药鲜药的临床应用,输入Excel 2016软件中建立数据库,对药物的使用频数、性味、归经等信息进行统计分析。结果:《本草纲目》中共记载药物1 892种,发现鲜药品种总计达292种,其中鲜药植物药258种,鲜药动物药34种;鲜药的使用频次共为1 016次;鲜药的药性以寒、平居多,药味以苦、甘为主,鲜药的归经以肝经、肺经为主;在古方的应用中,使用鲜药频次最高的是内科疾病(350次,34.4%)、外科疾病(337次,33.2%)。结论:《本草纲目》是16世纪中国的百科全书,所记载的药方应用鲜药的方子颇多,鲜药来源广泛,代表性高,且多为地产药材,临床应用广泛,不只用于内科,还用于外科、妇科、儿科、皮肤科、耳鼻喉;不只用于一般疾病,还用于疑难杂症、危重症以及急性传染病,对鲜药的文献考究,必将加深人们对鲜药特点的理解和认识,也为鲜药的现代研究提供文献依据。 展开更多
关键词 李时珍 《本草纲目》 鲜药 文献研究 临床应用
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《唐诗近体》的曲折境遇与编选旨趣
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作者 张蕾 《河北师范大学学报(哲学社会科学版)》 2023年第5期92-99,共8页
胡本渊所编《唐诗近体》具有明确的编纂动机与读者定位意识。因其适用,问世不久即遭攘窃,遂长期亦以攘窃者之名刊行,此本弥补《唐诗三百首》近体诗入选过少的缺憾,助益童蒙学诗从近体入门。《唐诗近体》选诗以杜甫为中心,建立起唐代近... 胡本渊所编《唐诗近体》具有明确的编纂动机与读者定位意识。因其适用,问世不久即遭攘窃,遂长期亦以攘窃者之名刊行,此本弥补《唐诗三百首》近体诗入选过少的缺憾,助益童蒙学诗从近体入门。《唐诗近体》选诗以杜甫为中心,建立起唐代近体诗的品第层级;评点博采众家,尤其宪章《唐诗别裁集》,使得本为面向童蒙的普及读本足以进阶为学术研究的对象。《唐诗近体》曾被攘窃的境遇,反而助其广为流传。存世版本可据署名不同区分出两个系统,某些版本还标记了使用过程中的心得,或可视为其在民间被研读、接受的依据,昭示了此选本的生命力所在。尽管在很长的时段里,选家的贡献、声名被遮蔽、忽略,但真相终将被还原。曲折的境遇激发的探究欲望,为我们对唐诗选本经典化途径的思考提供了更多向面。 展开更多
关键词 胡本渊 《唐诗近体》 攘窃 编选旨趣
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基于肠道菌群探讨四四固本颗粒对IBS-D(脾肾阳虚型)大鼠短链脂肪酸(SCFAs)含量影响 被引量:6
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作者 许云姣 蔡悦青 +4 位作者 姜莉云 张志毕 周瑞彬 杨翼豪 吴文笛 《辽宁中医药大学学报》 CAS 2023年第2期18-23,共6页
目的观察“四四固本颗粒”对脾肾阳虚型IBS-D模型大鼠肠道菌群及其代谢产物短链脂肪酸(SCFAs)的影响,从“肠道菌群”角度揭示“四四固本颗粒”对IBS-D防治作用及其作用机制。方法将60只SPF级SD雄性大鼠随机分为6组,采用番泻叶灌胃+避水... 目的观察“四四固本颗粒”对脾肾阳虚型IBS-D模型大鼠肠道菌群及其代谢产物短链脂肪酸(SCFAs)的影响,从“肠道菌群”角度揭示“四四固本颗粒”对IBS-D防治作用及其作用机制。方法将60只SPF级SD雄性大鼠随机分为6组,采用番泻叶灌胃+避水应激方法建立脾肾阳虚证IBS-D大鼠模型,造模后各组大鼠给予相应药物,采用高通量测序检测大鼠肠道菌群,使用气相色谱-质谱联用(GC-MS)检测肠道内容物菌群关键代谢产物短链脂肪酸表达。结果与模型组比较,SSGB组大鼠粪便Bristol评分均显著降低(P<0.05);阳性药组和SSGB-H组AWR显著降低(P<0.05);SSGB-H/M/L组D-木糖、ACTH、CORT、尿17-OHCS含量均有不同程度增加;SSGB组Shannon指数显著增加(P<0.05),Simpson指数显著降低(P<0.05);SSGB-H组厚壁菌门和变形菌门丰度都显著降低(P<0.05),拟杆菌门丰度显著升高(P<0.05),而SSGB-M/L组放线菌门丰度显著升高(P<0.05);SSGB组在SCFAs总酸、丙酸、乙酸都显著低于模型组(P<0.05)。结论SSGB能够明显改善大鼠脾肾阳虚症状,降低大鼠内脏敏感性,增加IBS-D大鼠肠道菌群多样性,有效逆转IBS-D大鼠肠道菌紊乱,提高益生菌丰度,降低致病菌丰度,促进肠道菌群代谢产物短链脂肪酸吸收,进而调节肠道菌群。 展开更多
关键词 腹泻型肠易激综合征 肠道菌群 短链脂肪酸 四四固本颗粒 升举三阴
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裴务齐正字本《刊谬补缺切韵》同形字辨析十则
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作者 刘亚丽 《现代语文》 2023年第6期34-38,共5页
作为《切韵》系韵书的一种,裴务齐正字本《刊谬补缺切韵》收录了部分字形相同而音义不同的同形字。利用传世文献和字典辞书,依据汉字形体演变和书写变异规律,对“亢、攲、茈、眙、椁、侘、翙、汨、舌、腊”等10组同形字进行辨析。通过... 作为《切韵》系韵书的一种,裴务齐正字本《刊谬补缺切韵》收录了部分字形相同而音义不同的同形字。利用传世文献和字典辞书,依据汉字形体演变和书写变异规律,对“亢、攲、茈、眙、椁、侘、翙、汨、舌、腊”等10组同形字进行辨析。通过这一个案研究,不仅可以规范同形字的音义关系,还可以为汉字俗体的演变及书写变异规律的研究提供字形材料。 展开更多
关键词 裴务齐正字本 《刊谬补缺切韵》 同形字 《切韵》 辨析
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从肿瘤干细胞Wnt通路探讨固本清源方药联合雄激素剥夺治疗控制去势抵抗性前列腺癌 被引量:2
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作者 陈浩然 方素萍 +3 位作者 张迪 王家政 陈亚飞 刘浩 《中华中医药学刊》 CAS 北大核心 2023年第3期111-115,I0027,共6页
目的从肿瘤干细胞Wnt通路探讨固本清源方药联合雄激素剥夺治疗控制去势抵抗性前列腺癌的作用机制。方法采用流式细胞术从前列腺癌PC-3细胞中分选出CD44+CD133+PC-3细胞并验证其肿瘤干细胞特性。将36只雄性裸鼠随机分为A~F组,每组6只,除... 目的从肿瘤干细胞Wnt通路探讨固本清源方药联合雄激素剥夺治疗控制去势抵抗性前列腺癌的作用机制。方法采用流式细胞术从前列腺癌PC-3细胞中分选出CD44+CD133+PC-3细胞并验证其肿瘤干细胞特性。将36只雄性裸鼠随机分为A~F组,每组6只,除A组接种前列腺癌PC-3细胞外,其他各组接种前列腺癌干细胞;除A、B组均给予氯化钠溶液外,其余组均给予醋酸戈舍瑞林缓释植入剂0.36 mg·kg^(-1),腹腔注射1次/25 d;比卡鲁胺片5 mg·kg^(-1),灌胃1次/d;其中D-F组在上述基础上进一步分别给予2.5 g·kg^(-1)、25 g·kg^(-1)、50 g·kg^(-1)固本清源方药,灌胃2次/d;观察荷瘤小鼠肿瘤的生长情况,连续给药32 d后剥离瘤组织,计算肿瘤抑制率;采用Western blot法分别检测肿瘤组织中Wnt、β-catenin的蛋白表达。结果从PC-3细胞中分选出的CD44+CD133+PC-3细胞亚群具有前列腺癌干细胞特性;低、中、高剂量固本清源方联合雄激素剥夺治疗对前列腺癌干细胞荷瘤小鼠的抑瘤率分别为24.58%,36.67%,40.24%,与单纯雄激素剥夺治疗组比较差异具有统计学意义(P<0.05),进一步研究显示低、中、高剂量固本清源方联合雄激素剥夺治疗能下调Wnt、β-catenin的蛋白表达水平,与雄激素剥夺治疗组比较差异有统计学意义(P<0.05)。结论固本清源方联合雄激素剥夺治疗能够抑制前列腺癌干细胞荷瘤小鼠肿瘤生长,其作用机制与调控前列腺癌干细胞Wnt/β-catenin信号通路有关。 展开更多
关键词 去势抵抗性前列腺癌 荷瘤小鼠 肿瘤干细胞 WNT通路 固本清源方
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