AIM:To discuss the variations and distributions of authors who published their papers in World Journal of Gastroenterology (WJG) during 2001-2007 and evaluate the development of WJG and gastroenterology core journals ...AIM:To discuss the variations and distributions of authors who published their papers in World Journal of Gastroenterology (WJG) during 2001-2007 and evaluate the development of WJG and gastroenterology core journals in recent years by comparing the contributions of the authors. METHODS: WJG articles published in 2001-2007 were searched from MEDLINE database (by ISI Web of Knowledge). The variations (cooperation degree, cooperation rate) and distributions of the first authors were analyzed with bibliometric methods. SCIE was used to collect articles published in Am J Gastroenterol, Gastroenterology, Scand J Gastroenterol and WJG in 2007, and comparison of the data was made. Comparison indicators included the article number of annual journals, cooperation degree of authors, cooperation rate, mean number of articles published in each WJG issue, number of countries of the first WJG authors, geographical distribution and article contribution ratio of all WJG authors and domestic authors. RESULTS: Of the 5851 articles covered in MEDLINE, 173, 236, 633, 826, 1496, 1382 and 1105 articles were cited from 2001 to 2007. The cooperation degree was 5.11, 5.56, 5.75, 5.76, 6.31, 5.90 and 5.64 respectively. The cooperation rates was 94.80%, 99.15%, 98.89%, 98.55%, 99.13%, 96.67% and 95.66%, respectively. The mean number of articles published in each WJG issue from 2001 to 2007 was 28, 39, 52, 34, 31, 28 and 23, respectively. The number of countries of the first WJG authors was 8, 8, 27, 32, 49, 61 and 56, respectively. The first authors of WJG came from 3 continents in 2001 and covered 6 continents in 2006-2007. The number of articles written by Asian authors was 136 (79.07%), 227 (96.19%), 575 (90.98%), 713 (87.81%), 1111 (75.32%),712 (53.98%) and 555 (53.21%), respectively in 2001-2007. The number of articles written by European & American authors increased from 36 (20.93%) and 8 (3.39%) in 2001-2002 to 563 (42.68%) and 452(43.34%) in 2006-2007. The number of countries except for China contributing papers was increased. The number of articles written by first authors of Japan rose from 0 (0%) in 2001-2002 to 287 (12.15%) in 2006-2007. The number of articles written by American authors increased from 6 (1.47%) in 2001-2002 to 158 (6.69%) in 2006-2007. The number of articles written by Chinese authors was 136 (79.07%), 227 (96.19%), 548 (86.71%), 669 (82.39%), 884 (59.93%), 380 (28.81%) and 320 (30.68%), respectively, in 2001 to 2007. The number of articles published in Am J Gastroenterol, Gastroenterology, Scand J Gastroenterol and WJG was 565, 586, 238 and 1118, respectively in 2007. The cooperation degree was 4.77, 6.14, 5.95 and 5.64, respectively, in 2007. The cooperation rate was 95.40%, 84.18%, 96.63% and 95.66%, respectively, in 2007. The number of countries of authors contributing papers was 44, 35, 42 and 62, respectively, in 2007. CONCLUSION:The geographical distribution of WJG authors is wide for the past 2 years. WJG has made a step onto international publishing, and drawn even more attentions from gastroenterology researchers. Its authors are distributed over 74 countries in 6 global continents, and the journal has become the main intermediary for international gastroenterology researchers to demonstrate their research accomplishments.展开更多
Millions of people worldwide are exposed to harmful levels of noise daily in their work and leisure environment. This makes noise-induced hearing loss(NIHL) a major occupational health risk globally. NIHL is the secon...Millions of people worldwide are exposed to harmful levels of noise daily in their work and leisure environment. This makes noise-induced hearing loss(NIHL) a major occupational health risk globally. NIHL is the second most common form of acquired hearing loss after agerelated hearing loss and is itself a major contributing factor to presbycusis. Temporary threshold shifts, once thought to be relatively harmless and recoverable, are now known to cause permanent cochlear injury leading to permanent loss of hearing sensitivity. This article reviews the current understanding of the cellular and molecular pathophysiology of NIHL with latest findings from animal models. Therapeutic approaches to protect against or to mitigate NIHL are discussed based on their proposed action against these known mechanisms of cochlear injury. Successes in identifying genes that predispose individuals to NIHL by candidate gene association studies are discussed with matched gene knockout animal models. This links to exciting developments in experimental gene therapy to replace and regenerate lost hair cells and post-noise otoprotective therapies currently being investigated in clinical trials. The aim is to provide new insights into current and projected future strategies to manage NIHL; bench to bedside treatment is foreseeable in the next 5 to 10 years.展开更多
Vestibular evoked myogenic potential （VEMP）, is an electromyographic response of vestibular origin evoked by sound, vibration or electrical stimulation. VEMP is widely used as a clinical test of the otolith organs. ...Vestibular evoked myogenic potential （VEMP）, is an electromyographic response of vestibular origin evoked by sound, vibration or electrical stimulation. VEMP is widely used as a clinical test of the otolith organs. Now-adays, two kinds of VEMP, cervical VEMP （cVEMP） and ocular VEMP （oVEMP） are clinically used. cVEMP is a test of sacculo-collic refex while oVEMP is a test of utri-culo-ocular refex. Absence of responses, large interau-ral asymmetry of amplitudes, prolonged peak latencies, and abnormal thresholds of responses are regarded as abnormal responses. Clinical application to various diseases of the vestibular system was performed. Using VEMP, a new type of vestibular neuritis, inferior ves-tibular neuritis was established. A prominent feature of VEMP in Meniere’s disease is a shift of a preferred fre-quency in cVEMP. The whole aspects of VEMP fndings in patients with benign paroxysmal positional vertigo are not clarifed yet. Sensitivity of cVEMP to vestibular schwannoma was 80.0%, while specifcity was 52.7%. Concerning diagnosis of superior canal dehiscence syn-drome （SCDS）, oVEMP to air-conducted sound is the most helpful. Augmentation of oVEMP responses is a prominent feature in SCDS. I also presented “idiopathic otolithic vertigo”, which I proposed as a new clinical en-tity based on VEMP fndings. Some patients complained of lateral tilting sensation in the roll plane, or tilting or translational sensation in the pitch plane without rota-tory vertigo. Majority of patients with these symptoms had absent or decreased responses of oVEMP and/or cVEMP. I proposed that these patients could be diag-nosed as having “idiopathic otolithic vertigo”.展开更多
Hundreds of scientific journals are published in China. However, only scores of them are included in Science Citation Index by the Institute for Scientific Information, with impact factors of only 1 or less. Thus, how...Hundreds of scientific journals are published in China. However, only scores of them are included in Science Citation Index by the Institute for Scientific Information, with impact factors of only 1 or less. Thus, how to establish a first-class international scientific journal in China is an important but difficult topic that deserves extensive exploration. World Journal of Gastroenterology (WJG) sets a good example although it has experienced setbacks on the road towards success. Concepts and pursuits that affirm the overall development direction, innovation and dreams that provide impetus and aspiration for higher objectives, team work and unique pattern that assure excellent quality and service, and culture and environment that also determine the speed and direction of the development, are believed to be the major factors contributing to the success of WJG. It is recommended that the effective resolution to the above issue is to learn from Chinese examples such as WJG rather than from “how foreign journals do”.展开更多
AIM: To determine the citation status in 2004 and the citation trend of WJG by analyzing all articles cited by WJG and all WJG articles cited by SCI journals during 1998-2004.METHODS: The total number of published art...AIM: To determine the citation status in 2004 and the citation trend of WJG by analyzing all articles cited by WJG and all WJG articles cited by SCI journals during 1998-2004.METHODS: The total number of published articles and reference citations in WJG, authors' self-citations, WJG's self-citations, citations of WJG articles by SCI journals and inappropriate citations in WJG during 1998-2004 were statistically analyzed. Data on self-citations of the articles published between 1998 and August 2004 (Issues 1-16)were from ISI SCI-E, and data on self-citations of articles published after August 2004 (Issues 17-24) were from the WJG Editorial Office. Data on citations of WJG articles by other journals between 1998 and August 2004 were from ISI SCI-E.RESULTS: Annual number of published articles: WJG published 179, 144, 211, 174, 236, 634 and 830 articles,respectively, in 1998, 1999, 2000, 2001, 2002, 2003 and 2004. The number in 2004 increased by 594, compared to that in 2002, giving an increased rate of 251.7%. Annual references cited by WJG were 2 123, 2 125, 6 244,8 883, 11 442, 23 218 and 25 971, respectively, in 1998-2004.The average number was 31.3 per WJG article in 2004,which was less than that (48.5) in 2002, giving a reduction rate of 35.5%. Authors of WJG cited 125, 126, 343, 210,354, 310 and 470 of their own published articles,respectively, in 1998-2004. The average number of authors'self-citations was 0.57 per WJG article in 2004, which was decreased by 0.93 or 62.0%, compared with that in 2002.Annual numbers of journal's self-citations: Authors of WJG articles cited 5, 7, 373, 733, 1474, 1947 and 1412 of WJG articles, respectively, in 1998-2004. The average number of journal's self-citations was 1.70 per WJG article in 2004,which decreased by 4.55 or 72.8%. No WJG article was cited in 1998 by other SCI journals. However, the number of citations steadily increased afterwards, with 16, 18, 39,85, 372 and 580, respectively, in 1999-2004. The average number of citations by other SCI journals was 0.11, 0.09,0.22, 0.36, 0.59 and 1.06 per WJG article, respectively,1999-2004 (January-August). There was an increase by 582%, when comparing the citation numbers between 2004and 2002. Annual WJG self-citation rates and citation rates of WJG articles by other SCI journals: WJG self-citation rates were 30.43%, 95.40%, 95.07%, 94.55%, 83.96%and 67.47%, respectively, in 1999-2004 (January-August).Compared with 2002, the self-citation rate in 2004decreased by 26.87%. The citation rates of WJG articles by other SCI journals were 69.57%, 4.60%, 4.93%, 5.45%,16.04%, and 32.53%, respectively, in 1999-2004 (January-August). Compared with 2002, the citation rate in 2004decreased by 26.87%. There were 8, 19, 218, 274, 461,698 and 574 inappropriate citations, respectively, in 1998-2004.The average inappropriate citation in 2004 was 0.69 per article, which represents a decrease of 1.26, compared with that in 2002. Inappropriate citations were mostly those with the differences between the two sides of the hyphens of 5-9, and the proportions of inappropriate citations within the three subsections of the differences between the two sides of the hyphens (5-9, 10-19, and ＞=20) were approximately 7:2:1. In addition, inappropriate citations mostly occurred with frequencies of 1-3 in the articles,and the proportion of inappropriate citations within the two frequency subsections (1-3 and ＞3) have been approximately 4:1 since 1999.CONCLUSIONS: In 2004, the average number of reference citations, authors' self-citations and journal's self-citations were 31.3, 0.57 and 1.70 per article, respectively, which represents a decrease in the numbers by 35.5%. 62.0%,and 72.8% respectively compared to the corresponding numbers in 2002. WJG self-citation rate was 67.47% in 2004 (January-August), which was a decrease by26.87%,compared with 2002. The citation rate of WJG articles by other SCI journals was 32.53% in 2004 (January-August),an increase of 26.87%, compared to 2002. There were 574inappropriate citations in 2004, with an average of 0.69per article, which represents a decrease of 1.26, compared with that in 2002. These figures demonstrate that the overall citation status of WJG is improving.展开更多
Hearing loss is the most common sensory disability with considerable social and economic implications. According to recent World Health Organization estimates,360 million people worldwide suffer from moderate to profo...Hearing loss is the most common sensory disability with considerable social and economic implications. According to recent World Health Organization estimates,360 million people worldwide suffer from moderate to profound hearing loss. Exposure to excessive noise is one of the major causes of sensorineural hearing loss,secondary only to age-related hearing loss(presbyacusis). Since cochlear tissues have limited abilities of repair and regeneration, this damage can be irreversible, leading to cochlear dysfunction and permanent hearing loss. Recent studies have shown that cochlear inflammation can be induced by noise exposure and contribute to the overall pathogenesis of cochlear injury and hearing loss. The cochlea is separated from the systemic circulation by the blood-labyrinth barrier,which is physiologically similar to the blood-brain barrier of the central nervous system. Because of this feature, the cochlea was originally considered an immunologically privileged organ. However, this postulate has been challenged by the evidence of an inflammatory response in the cochlea in the presence of bacterial or viral pathogens or antigens that can cause labyrinthitis. Although the main purpose of the inflammatory reaction is to protect against invading pathogens, the inflammatory response can also cause significant bystander injury to the delicate structures of the cochlea. The cochlear inflammatory response is characterised by the generation of proinflammatory mediators(cytokines, chemokines and adhesion molecules), and the recruitment of inflammatory cells(leukocytes). Here, we present an overview of the current research on cochlear inflammation, with particular emphasis on noise-induced cochlear inflammation. We also discuss treatment strategies aimed at the suppression of inflammation, which may potentially lead to mitigation of hearing loss.展开更多
Although the pectoralis major myocutaneous flap is often used in head and neck reconstruction, the extension of the skin paddle beyond the inferior limits of the muscle has not been well described. We aim to clarify t...Although the pectoralis major myocutaneous flap is often used in head and neck reconstruction, the extension of the skin paddle beyond the inferior limits of the muscle has not been well described. We aim to clarify the design and application of this extended flap in head and neck reconstruction. In this retrospective study, consecutive cases of extended pectoralis major myocutaneous flap reconstruction of post-ablative head and neck defects at a single tertiary referral center were included for analysis. In 7 cases an extended pectoralis major flap was utilized, in which the skin paddle was extended beyond the inferior border of the pectoralis major to include the rectus sheath. Skin and soft tissue as well as composite defects of the oral cavity, parotid/temporal region and neck were reconstructed. All flaps healed satisfactorily with no loss of skin viability. The extended pectoralis major myocutaneous flap is robust and has versatile applications for reconstruction of large, high and three dimensionally complex defects in the head and neck region.展开更多
Many reviewers have contributed their expertise and time to the peer review, a critical process to ensure the quality of World Journal of Gastroenterology. The editors and authors of the articles submitted to the jour...Many reviewers have contributed their expertise and time to the peer review, a critical process to ensure the quality of World Journal of Gastroenterology. The editors and authors of the articles submitted to the journal are grateful to the following reviewers for evaluating the articles (including those published in this issue and those rejected for this issue) during the last editing time period.展开更多
The peer review policy of the World Journal of Gastroenterology （WJG） states that all articles received are subjected to peer review. Normally, three experts are invited to review each article. Decision for acceptan...The peer review policy of the World Journal of Gastroenterology （WJG） states that all articles received are subjected to peer review. Normally, three experts are invited to review each article. Decision for acceptance is made only when at least two experts recommend. Otherwise, the article is rejected. This is to ensure that high standards are maintained and the work is original. In medical sciences, there is a tendency for work to be incremental, ideas being developed gradually, with major breakthroughs being relatively rare. Consequently there tends to be significant overlap in which a field already investigated is researched from a different angle or using alternative methods.展开更多
Gene therapy is a promising technology with potential applications in the treatment of medical conditions, both congenital and acquired. Despite its label as breakthrough technology for the 21st century, the simple co...Gene therapy is a promising technology with potential applications in the treatment of medical conditions, both congenital and acquired. Despite its label as breakthrough technology for the 21st century, the simple concept of gene therapy - the introduction of a functional copy of desired genes in affected individuals - is proving to be more challenging than expected. Oral gene delivery has shown intriguing results and warrants further exploration. In particular, oral administration of chitosan DNA nano-particles, one the most commonly used formulations of therapeutic DNA, has repeatedly demonstrated successful in vitro and in vivo gene transfection. While oral gene therapy has shown immense promise as treatment options in a variety of diseases, there are still signifcant barriers to overcome before it can be considered for clinical applications. In this review we provide an over-view of the physiologic challenges facing the use of chitosan DNA nanoparticles for oral gene delivery at both the extracellular and intracellular level. From administration at the oral cavity, chitosan nanoparticles must traverse the gastrointestinal tract and protect its DNA contents from signifcant jumps in pH levels, various intestinal digestive enzymes, thick mucus layers with high turnover, and a proteinaceous glycocalyx meshwork. Once these extracellular barriers are overcome, chitosan DNA nanoparticles must enter intestinal cells, escape endolysosomes, and disassociate from genetic material at the appropriate time allowing transport of genetic material into the nucleus to deliver a therapeutic ef-fect. The properties of chitosan nanoparticles and modified nanoparticles are discussed in this review. An understanding of the barriers to oral gene delivery and how to overcome them would be invaluable for future gene therapy development.展开更多
Global Collaboration for Gastroenterology For the first time in the history of gastroenterology, an international conference will take place which joins together the forces of four pre-eminent organisations： Gastro ...Global Collaboration for Gastroenterology For the first time in the history of gastroenterology, an international conference will take place which joins together the forces of four pre-eminent organisations： Gastro 2009, UEGW/WCOG London. The United European Gastroenterology Federation （UEGF） and the World Gastroenterology Organisation （WGO）, together with the World Organisation of Digestive Endoscopy （OMED） and the British Society of Gastroenterology （BSG）, are jointly organising a landmark meeting in London from November 21-25, 2009. This collaboration will ensure the perfect balance of basic science and clinical practice, will cover all disciplines in gastroenterology （endoscopy, digestive oncology, nutrition, digestive surgery, hepatology, gastroenterology） and ensure a truly global context; all presented in the exciting setting of the city of London. Attendance is expected to reach record heights as participants are provided with a compact “all-in-one” programme merging the best of several GI meetings. Faculty and participants from all corners of the earth will merge to provide a truly global environment conducive to the exchange of ideas and the forming of friendships and collaborations.展开更多
基金The Education Department of Liaoning Province, No. 05W238
文摘AIM:To discuss the variations and distributions of authors who published their papers in World Journal of Gastroenterology (WJG) during 2001-2007 and evaluate the development of WJG and gastroenterology core journals in recent years by comparing the contributions of the authors. METHODS: WJG articles published in 2001-2007 were searched from MEDLINE database (by ISI Web of Knowledge). The variations (cooperation degree, cooperation rate) and distributions of the first authors were analyzed with bibliometric methods. SCIE was used to collect articles published in Am J Gastroenterol, Gastroenterology, Scand J Gastroenterol and WJG in 2007, and comparison of the data was made. Comparison indicators included the article number of annual journals, cooperation degree of authors, cooperation rate, mean number of articles published in each WJG issue, number of countries of the first WJG authors, geographical distribution and article contribution ratio of all WJG authors and domestic authors. RESULTS: Of the 5851 articles covered in MEDLINE, 173, 236, 633, 826, 1496, 1382 and 1105 articles were cited from 2001 to 2007. The cooperation degree was 5.11, 5.56, 5.75, 5.76, 6.31, 5.90 and 5.64 respectively. The cooperation rates was 94.80%, 99.15%, 98.89%, 98.55%, 99.13%, 96.67% and 95.66%, respectively. The mean number of articles published in each WJG issue from 2001 to 2007 was 28, 39, 52, 34, 31, 28 and 23, respectively. The number of countries of the first WJG authors was 8, 8, 27, 32, 49, 61 and 56, respectively. The first authors of WJG came from 3 continents in 2001 and covered 6 continents in 2006-2007. The number of articles written by Asian authors was 136 (79.07%), 227 (96.19%), 575 (90.98%), 713 (87.81%), 1111 (75.32%),712 (53.98%) and 555 (53.21%), respectively in 2001-2007. The number of articles written by European & American authors increased from 36 (20.93%) and 8 (3.39%) in 2001-2002 to 563 (42.68%) and 452(43.34%) in 2006-2007. The number of countries except for China contributing papers was increased. The number of articles written by first authors of Japan rose from 0 (0%) in 2001-2002 to 287 (12.15%) in 2006-2007. The number of articles written by American authors increased from 6 (1.47%) in 2001-2002 to 158 (6.69%) in 2006-2007. The number of articles written by Chinese authors was 136 (79.07%), 227 (96.19%), 548 (86.71%), 669 (82.39%), 884 (59.93%), 380 (28.81%) and 320 (30.68%), respectively, in 2001 to 2007. The number of articles published in Am J Gastroenterol, Gastroenterology, Scand J Gastroenterol and WJG was 565, 586, 238 and 1118, respectively in 2007. The cooperation degree was 4.77, 6.14, 5.95 and 5.64, respectively, in 2007. The cooperation rate was 95.40%, 84.18%, 96.63% and 95.66%, respectively, in 2007. The number of countries of authors contributing papers was 44, 35, 42 and 62, respectively, in 2007. CONCLUSION:The geographical distribution of WJG authors is wide for the past 2 years. WJG has made a step onto international publishing, and drawn even more attentions from gastroenterology researchers. Its authors are distributed over 74 countries in 6 global continents, and the journal has become the main intermediary for international gastroenterology researchers to demonstrate their research accomplishments.
文摘Millions of people worldwide are exposed to harmful levels of noise daily in their work and leisure environment. This makes noise-induced hearing loss(NIHL) a major occupational health risk globally. NIHL is the second most common form of acquired hearing loss after agerelated hearing loss and is itself a major contributing factor to presbycusis. Temporary threshold shifts, once thought to be relatively harmless and recoverable, are now known to cause permanent cochlear injury leading to permanent loss of hearing sensitivity. This article reviews the current understanding of the cellular and molecular pathophysiology of NIHL with latest findings from animal models. Therapeutic approaches to protect against or to mitigate NIHL are discussed based on their proposed action against these known mechanisms of cochlear injury. Successes in identifying genes that predispose individuals to NIHL by candidate gene association studies are discussed with matched gene knockout animal models. This links to exciting developments in experimental gene therapy to replace and regenerate lost hair cells and post-noise otoprotective therapies currently being investigated in clinical trials. The aim is to provide new insights into current and projected future strategies to manage NIHL; bench to bedside treatment is foreseeable in the next 5 to 10 years.
文摘Vestibular evoked myogenic potential （VEMP）, is an electromyographic response of vestibular origin evoked by sound, vibration or electrical stimulation. VEMP is widely used as a clinical test of the otolith organs. Now-adays, two kinds of VEMP, cervical VEMP （cVEMP） and ocular VEMP （oVEMP） are clinically used. cVEMP is a test of sacculo-collic refex while oVEMP is a test of utri-culo-ocular refex. Absence of responses, large interau-ral asymmetry of amplitudes, prolonged peak latencies, and abnormal thresholds of responses are regarded as abnormal responses. Clinical application to various diseases of the vestibular system was performed. Using VEMP, a new type of vestibular neuritis, inferior ves-tibular neuritis was established. A prominent feature of VEMP in Meniere’s disease is a shift of a preferred fre-quency in cVEMP. The whole aspects of VEMP fndings in patients with benign paroxysmal positional vertigo are not clarifed yet. Sensitivity of cVEMP to vestibular schwannoma was 80.0%, while specifcity was 52.7%. Concerning diagnosis of superior canal dehiscence syn-drome （SCDS）, oVEMP to air-conducted sound is the most helpful. Augmentation of oVEMP responses is a prominent feature in SCDS. I also presented “idiopathic otolithic vertigo”, which I proposed as a new clinical en-tity based on VEMP fndings. Some patients complained of lateral tilting sensation in the roll plane, or tilting or translational sensation in the pitch plane without rota-tory vertigo. Majority of patients with these symptoms had absent or decreased responses of oVEMP and/or cVEMP. I proposed that these patients could be diag-nosed as having “idiopathic otolithic vertigo”.
文摘Hundreds of scientific journals are published in China. However, only scores of them are included in Science Citation Index by the Institute for Scientific Information, with impact factors of only 1 or less. Thus, how to establish a first-class international scientific journal in China is an important but difficult topic that deserves extensive exploration. World Journal of Gastroenterology (WJG) sets a good example although it has experienced setbacks on the road towards success. Concepts and pursuits that affirm the overall development direction, innovation and dreams that provide impetus and aspiration for higher objectives, team work and unique pattern that assure excellent quality and service, and culture and environment that also determine the speed and direction of the development, are believed to be the major factors contributing to the success of WJG. It is recommended that the effective resolution to the above issue is to learn from Chinese examples such as WJG rather than from “how foreign journals do”.
基金Supported by the National Natural Science Foundation of China,No.30224801
文摘AIM: To determine the citation status in 2004 and the citation trend of WJG by analyzing all articles cited by WJG and all WJG articles cited by SCI journals during 1998-2004.METHODS: The total number of published articles and reference citations in WJG, authors' self-citations, WJG's self-citations, citations of WJG articles by SCI journals and inappropriate citations in WJG during 1998-2004 were statistically analyzed. Data on self-citations of the articles published between 1998 and August 2004 (Issues 1-16)were from ISI SCI-E, and data on self-citations of articles published after August 2004 (Issues 17-24) were from the WJG Editorial Office. Data on citations of WJG articles by other journals between 1998 and August 2004 were from ISI SCI-E.RESULTS: Annual number of published articles: WJG published 179, 144, 211, 174, 236, 634 and 830 articles,respectively, in 1998, 1999, 2000, 2001, 2002, 2003 and 2004. The number in 2004 increased by 594, compared to that in 2002, giving an increased rate of 251.7%. Annual references cited by WJG were 2 123, 2 125, 6 244,8 883, 11 442, 23 218 and 25 971, respectively, in 1998-2004.The average number was 31.3 per WJG article in 2004,which was less than that (48.5) in 2002, giving a reduction rate of 35.5%. Authors of WJG cited 125, 126, 343, 210,354, 310 and 470 of their own published articles,respectively, in 1998-2004. The average number of authors'self-citations was 0.57 per WJG article in 2004, which was decreased by 0.93 or 62.0%, compared with that in 2002.Annual numbers of journal's self-citations: Authors of WJG articles cited 5, 7, 373, 733, 1474, 1947 and 1412 of WJG articles, respectively, in 1998-2004. The average number of journal's self-citations was 1.70 per WJG article in 2004,which decreased by 4.55 or 72.8%. No WJG article was cited in 1998 by other SCI journals. However, the number of citations steadily increased afterwards, with 16, 18, 39,85, 372 and 580, respectively, in 1999-2004. The average number of citations by other SCI journals was 0.11, 0.09,0.22, 0.36, 0.59 and 1.06 per WJG article, respectively,1999-2004 (January-August). There was an increase by 582%, when comparing the citation numbers between 2004and 2002. Annual WJG self-citation rates and citation rates of WJG articles by other SCI journals: WJG self-citation rates were 30.43%, 95.40%, 95.07%, 94.55%, 83.96%and 67.47%, respectively, in 1999-2004 (January-August).Compared with 2002, the self-citation rate in 2004decreased by 26.87%. The citation rates of WJG articles by other SCI journals were 69.57%, 4.60%, 4.93%, 5.45%,16.04%, and 32.53%, respectively, in 1999-2004 (January-August). Compared with 2002, the citation rate in 2004decreased by 26.87%. There were 8, 19, 218, 274, 461,698 and 574 inappropriate citations, respectively, in 1998-2004.The average inappropriate citation in 2004 was 0.69 per article, which represents a decrease of 1.26, compared with that in 2002. Inappropriate citations were mostly those with the differences between the two sides of the hyphens of 5-9, and the proportions of inappropriate citations within the three subsections of the differences between the two sides of the hyphens (5-9, 10-19, and ＞=20) were approximately 7:2:1. In addition, inappropriate citations mostly occurred with frequencies of 1-3 in the articles,and the proportion of inappropriate citations within the two frequency subsections (1-3 and ＞3) have been approximately 4:1 since 1999.CONCLUSIONS: In 2004, the average number of reference citations, authors' self-citations and journal's self-citations were 31.3, 0.57 and 1.70 per article, respectively, which represents a decrease in the numbers by 35.5%. 62.0%,and 72.8% respectively compared to the corresponding numbers in 2002. WJG self-citation rate was 67.47% in 2004 (January-August), which was a decrease by26.87%,compared with 2002. The citation rate of WJG articles by other SCI journals was 32.53% in 2004 (January-August),an increase of 26.87%, compared to 2002. There were 574inappropriate citations in 2004, with an average of 0.69per article, which represents a decrease of 1.26, compared with that in 2002. These figures demonstrate that the overall citation status of WJG is improving.
基金Supported by The Auckland Medical Research Foundationthe University of Auckland Doctoral Scholarship to Tan WJT
文摘Hearing loss is the most common sensory disability with considerable social and economic implications. According to recent World Health Organization estimates,360 million people worldwide suffer from moderate to profound hearing loss. Exposure to excessive noise is one of the major causes of sensorineural hearing loss,secondary only to age-related hearing loss(presbyacusis). Since cochlear tissues have limited abilities of repair and regeneration, this damage can be irreversible, leading to cochlear dysfunction and permanent hearing loss. Recent studies have shown that cochlear inflammation can be induced by noise exposure and contribute to the overall pathogenesis of cochlear injury and hearing loss. The cochlea is separated from the systemic circulation by the blood-labyrinth barrier,which is physiologically similar to the blood-brain barrier of the central nervous system. Because of this feature, the cochlea was originally considered an immunologically privileged organ. However, this postulate has been challenged by the evidence of an inflammatory response in the cochlea in the presence of bacterial or viral pathogens or antigens that can cause labyrinthitis. Although the main purpose of the inflammatory reaction is to protect against invading pathogens, the inflammatory response can also cause significant bystander injury to the delicate structures of the cochlea. The cochlear inflammatory response is characterised by the generation of proinflammatory mediators(cytokines, chemokines and adhesion molecules), and the recruitment of inflammatory cells(leukocytes). Here, we present an overview of the current research on cochlear inflammation, with particular emphasis on noise-induced cochlear inflammation. We also discuss treatment strategies aimed at the suppression of inflammation, which may potentially lead to mitigation of hearing loss.
文摘Although the pectoralis major myocutaneous flap is often used in head and neck reconstruction, the extension of the skin paddle beyond the inferior limits of the muscle has not been well described. We aim to clarify the design and application of this extended flap in head and neck reconstruction. In this retrospective study, consecutive cases of extended pectoralis major myocutaneous flap reconstruction of post-ablative head and neck defects at a single tertiary referral center were included for analysis. In 7 cases an extended pectoralis major flap was utilized, in which the skin paddle was extended beyond the inferior border of the pectoralis major to include the rectus sheath. Skin and soft tissue as well as composite defects of the oral cavity, parotid/temporal region and neck were reconstructed. All flaps healed satisfactorily with no loss of skin viability. The extended pectoralis major myocutaneous flap is robust and has versatile applications for reconstruction of large, high and three dimensionally complex defects in the head and neck region.
文摘Many reviewers have contributed their expertise and time to the peer review, a critical process to ensure the quality of World Journal of Gastroenterology. The editors and authors of the articles submitted to the journal are grateful to the following reviewers for evaluating the articles (including those published in this issue and those rejected for this issue) during the last editing time period.
文摘The peer review policy of the World Journal of Gastroenterology （WJG） states that all articles received are subjected to peer review. Normally, three experts are invited to review each article. Decision for acceptance is made only when at least two experts recommend. Otherwise, the article is rejected. This is to ensure that high standards are maintained and the work is original. In medical sciences, there is a tendency for work to be incremental, ideas being developed gradually, with major breakthroughs being relatively rare. Consequently there tends to be significant overlap in which a field already investigated is researched from a different angle or using alternative methods.
基金the Canadian Hemophilia Society Bayer IncNazarbayev University ORAU for their supporting to this work
文摘Gene therapy is a promising technology with potential applications in the treatment of medical conditions, both congenital and acquired. Despite its label as breakthrough technology for the 21st century, the simple concept of gene therapy - the introduction of a functional copy of desired genes in affected individuals - is proving to be more challenging than expected. Oral gene delivery has shown intriguing results and warrants further exploration. In particular, oral administration of chitosan DNA nano-particles, one the most commonly used formulations of therapeutic DNA, has repeatedly demonstrated successful in vitro and in vivo gene transfection. While oral gene therapy has shown immense promise as treatment options in a variety of diseases, there are still signifcant barriers to overcome before it can be considered for clinical applications. In this review we provide an over-view of the physiologic challenges facing the use of chitosan DNA nanoparticles for oral gene delivery at both the extracellular and intracellular level. From administration at the oral cavity, chitosan nanoparticles must traverse the gastrointestinal tract and protect its DNA contents from signifcant jumps in pH levels, various intestinal digestive enzymes, thick mucus layers with high turnover, and a proteinaceous glycocalyx meshwork. Once these extracellular barriers are overcome, chitosan DNA nanoparticles must enter intestinal cells, escape endolysosomes, and disassociate from genetic material at the appropriate time allowing transport of genetic material into the nucleus to deliver a therapeutic ef-fect. The properties of chitosan nanoparticles and modified nanoparticles are discussed in this review. An understanding of the barriers to oral gene delivery and how to overcome them would be invaluable for future gene therapy development.
文摘Global Collaboration for Gastroenterology For the first time in the history of gastroenterology, an international conference will take place which joins together the forces of four pre-eminent organisations： Gastro 2009, UEGW/WCOG London. The United European Gastroenterology Federation （UEGF） and the World Gastroenterology Organisation （WGO）, together with the World Organisation of Digestive Endoscopy （OMED） and the British Society of Gastroenterology （BSG）, are jointly organising a landmark meeting in London from November 21-25, 2009. This collaboration will ensure the perfect balance of basic science and clinical practice, will cover all disciplines in gastroenterology （endoscopy, digestive oncology, nutrition, digestive surgery, hepatology, gastroenterology） and ensure a truly global context; all presented in the exciting setting of the city of London. Attendance is expected to reach record heights as participants are provided with a compact “all-in-one” programme merging the best of several GI meetings. Faculty and participants from all corners of the earth will merge to provide a truly global environment conducive to the exchange of ideas and the forming of friendships and collaborations.
