Exploring the vertical variation in volatile organic compounds(VOCs)in background regions can provide infor-mation on the spatial distribution of pollutants,providing a scientific basis for atmospheric pollution preve...Exploring the vertical variation in volatile organic compounds(VOCs)in background regions can provide infor-mation on the spatial distribution of pollutants,providing a scientific basis for atmospheric pollution prevention and control strategies.From 15 August to 5 September 2023,at the Southeast Tibet Mountain Comprehensive Environmental Observation Station(SETS),a tethered balloon was used to sample VOCs every 100 m from the ground to 1000 m.A total of 403 air bag samples were collected,and 39 vertical profiles of VOCs were obtained.Ninety-two VOC species were detected.The VOC concentration at the SETS did not change significantly verti-cally,and the average VOC concentration was 11.1±2.4 ppbv.The main components were alkanes(51.4%),alkenes(18.7%),and halohydrocarbons(18.1%).There was no obvious diurnal change in VOCs and no signif-icant difference between the different layers.When the surface VOC concentration was less than 10 ppbv,the concentrations,components,and sources of VOCs were evenly distributed vertically,and the main sources of VOCs at different heights were vehicle exhaust and background.When the surface VOC concentration exceeded 10 ppbv,the VOC concentration gradually decreased with height.The proportion of alkanes in surface VOCs in-creased,and the source was mainly vehicle exhaust.This study confirmed that VOCs are vertically homogeneous in the background of the Tibetan Plateau,emphasizing the importance of vehicle emissions as a potential source of VOCs.展开更多
The genomic fusions of the anaplastic lymphoma kinase(ALK)gene have been widely recognized as effective therapeutic targets for non-small cell lung carcinoma(NSCLC).The Second Xiangya Hospital of Central South Univers...The genomic fusions of the anaplastic lymphoma kinase(ALK)gene have been widely recognized as effective therapeutic targets for non-small cell lung carcinoma(NSCLC).The Second Xiangya Hospital of Central South University has treated 2 NSCLC patients with 2 distinct novel ALK gene fusions.Case 1 was a 55-year-old male with a solid nodule located in the right hilar lobe on enhanced CT scan.Case 2 was a 47-year-old female with enhanced CT showing involvement of the left upper lobe of lung.Histopathological examination of tumor tissues confirmed lung adenocarcinoma in both cases.Immunohistochemical(IHC)staining demonstrated positivity for thyroid transcription factor 1(TTF-1)and ALK-D5F3 in tumor cells,while negativity for P40.The next-generation sequencing(NGS)tests identified a PNPT1-ALK(Exon22:Exon20)fusion variant in case 1 and a TCEAL2-ALK(Exon3:Exon19)fusion variant in case 2.The TCEAL2-ALK fusion was further confirmed by amplification refractory mutation system(ARMS)-PCR at the mRNA level.Both patients were treated with oral alectinib at a dosage of 600 mg twice daily.The tumors in both patients were significantly decreased after alectinib treatment,achieving partial response.At the time of submission,there was an absence of disease progression and the progression-free survival(PFS)had surpassed 1 year.It offered compelling evidences that the individuals with NSCLC and harboring either a PNPT1-ALK(Exon22:Exon20)fusion or a TCEAL2-ALK(Exon3:Exon19)fusion,experience favorable therapeutic outcomes through the administration of alectinib.This study expands the known ALK fusion variants database and supports the precision treatment of NSCLC using ALK tyrosine kinase inhibitors(TKIs).展开更多
To protect carbon materials from oxidation, mullite/SiC coatings were prepared on graphite by chemical vapor reaction (CVR) and slurry sintering. The XRD analyses show that the phase of the outer-layer coating is comp...To protect carbon materials from oxidation, mullite/SiC coatings were prepared on graphite by chemical vapor reaction (CVR) and slurry sintering. The XRD analyses show that the phase of the outer-layer coating is composed of SiO2 and mullite, and the inner-layer coating is mainly composed of β-SiC. The anti-oxidation behavior of the coating and the Rockwell hardness (HRB) of the coating after oxidation were investigated. The oxidation test shows that the as-prepared multi-layer coating exhibits excellent antioxidation and thermal shock resistance at high temperature. After oxidation at 1150 ℃ for 109 h and thermal shock cycling between 1150 ℃ and room temperature for 12 times, the mass gain of the coated sample is 0.085%. Meanwhile, the indentation tests also demonstrate that the as-prepared coating has good bonding ability between the layers.展开更多
Hot spinning process has attracted significant attention because it can be used to manufacture complex parts, extend the forming limit of materials, decrease forming forces and reduce process chains. In this paper, we...Hot spinning process has attracted significant attention because it can be used to manufacture complex parts, extend the forming limit of materials, decrease forming forces and reduce process chains. In this paper, we review researches on lightweight metals spun at elevated temperatures since they are difficult to deform at room temperature. These metals include light alloys, such as titanium, magnesium and aluminum alloys, and metal composites. Then, the heating methods used in the hot spinning process and the treatment methods employed for the temperature boundary condition in finite element analyses for the process were discussed. Finally, the future development directions for the hot spinning process of lightweight but difficult-to-deform alloys were highlighted.展开更多
Pure compounds and kaolin were employed to investigate the reaction behavior of ferric oxide in thetrinarysystem Fe2O3?SiO2?Al2O3 during reductive sintering process. The thermodynamic analyses and reductive sintering ...Pure compounds and kaolin were employed to investigate the reaction behavior of ferric oxide in thetrinarysystem Fe2O3?SiO2?Al2O3 during reductive sintering process. The thermodynamic analyses and reductive sintering experimental results show that ferrous oxide generated from the reduction of ferric oxide by carbon can react with silicon dioxide and aluminum oxide to form ferrous silicate and hercynite at 1173 K, respectively. In the trinary system Fe2O3?SiO2?Al2O3, ferrous oxide obtained from ferric oxide reduction preferentially reacts with aluminum oxide to form hercynite, and the reaction of ferrous oxide with silicon dioxide occurs only when there is surplus ferrous oxide after the exhaustion of aluminum oxide. When sintering temperature rises to 1473 K, hercynite further reacts with silicon dioxide to form mullite and ferrous oxide. Results presented in this work may throw a new light upon the separation of alumina and silica present in Al/Fe-bearing materials with low mass ratio of alumina to silica in alumina production.展开更多
Non-tobacco related materials （NTRM） come from field production, tobacco stringing, grading and purchasing, affecting cigarette quality and having potential safety hazard. The research reviewed control on NTRM from ...Non-tobacco related materials （NTRM） come from field production, tobacco stringing, grading and purchasing, affecting cigarette quality and having potential safety hazard. The research reviewed control on NTRM from source, production and processing to enhance use efficiency of raw materials and guarantee raw material safety.展开更多
Objective: To investigate the relationship between peroxisomeproliferators-activated receptor-gamma (PPAR-γ) and clinical pathology of lung cancer, and to studythe inhibitory effect of PPAR-γ activators on lung canc...Objective: To investigate the relationship between peroxisomeproliferators-activated receptor-gamma (PPAR-γ) and clinical pathology of lung cancer, and to studythe inhibitory effect of PPAR-γ activators on lung cancer growth and the mechanism of inducingapoptosis of lung cancer. Methods: Expression of PPAR-γ in 15 cases of non-cancerous lung tissuesand 64 cases of lung cancer tissues was detected by using immunohistochemistry. The average A valueswere measured by using image analysis. The expression of PPAR-γ in lung cancer cells was detectedby using RT-PCR. After being treated with PPAR-γ activators, apoptosis was detected by using flowcytometry, and meanwhile, the change in caspase-3 activity was detected by caspase-3 kits. Results:Expression levels of PPAR-γ in cancerous tissues were higher than those in non-cancerous lungtissues. In four types of lung cancer, the sequence of PPAR-γ expression from high to low levelswas small-cell lung cancer, squamous carcinom, large-cell lung cancer, adenocarcinoma in turns. Theexpression of PPAR-γ was correlated with differentiation and postoperative TNM staging of lungcancer tissues, but not with lymph node metastasis. PPAR-γ expressed in two lung cancer cell lines,which could induce apoptosis of lung cancer cells after being treated with PPAR-γ activators, andcaspase-3 activity in cells treated with PPAR-γ activators was significantly increased. Conclusion:PPAR-γ is correlated with clinical pathology and apoptosis of lung cancer closely, and activatedPPAR-γ can increase caspase-3 activity to induce cells apoptosis. PPAR-γ will be able to become anew target for therapy of lung cancer in the future.展开更多
JCOMM has strategy to establish the network of WMO-IOC Centres for Marine-meteorological and Oceanographic Climate Data （CMOCs） under the new Marine Climate Data System （MCDS） in 2012 for improving the quality and...JCOMM has strategy to establish the network of WMO-IOC Centres for Marine-meteorological and Oceanographic Climate Data （CMOCs） under the new Marine Climate Data System （MCDS） in 2012 for improving the quality and timeliness of the marine-meteorological and oceanographic data, metadata and products available to end users. China as a candidate of CMOC China has been approved to run on a trial basis after the 4th Meeting of the Joint IOC/WMO Technical Commission for Oceanography and Marine Meteorology （JCOMM）. This article states the developing intention of CMOC China in the next few years through the brief introduction to critical marine data, products and service system and cooperation projects in the world.展开更多
基金supported by the second Tibetan Plateau Scientific Expedition and Research Program[No.2019QZKK0604]the National Natural Science Foundation of China[Nos.42177081 and 42171450]the Youth Cross Team Scientific Research Project of the Chinese Academy of Sciences[No.JCTD-2021–10]。
文摘Exploring the vertical variation in volatile organic compounds(VOCs)in background regions can provide infor-mation on the spatial distribution of pollutants,providing a scientific basis for atmospheric pollution prevention and control strategies.From 15 August to 5 September 2023,at the Southeast Tibet Mountain Comprehensive Environmental Observation Station(SETS),a tethered balloon was used to sample VOCs every 100 m from the ground to 1000 m.A total of 403 air bag samples were collected,and 39 vertical profiles of VOCs were obtained.Ninety-two VOC species were detected.The VOC concentration at the SETS did not change significantly verti-cally,and the average VOC concentration was 11.1±2.4 ppbv.The main components were alkanes(51.4%),alkenes(18.7%),and halohydrocarbons(18.1%).There was no obvious diurnal change in VOCs and no signif-icant difference between the different layers.When the surface VOC concentration was less than 10 ppbv,the concentrations,components,and sources of VOCs were evenly distributed vertically,and the main sources of VOCs at different heights were vehicle exhaust and background.When the surface VOC concentration exceeded 10 ppbv,the VOC concentration gradually decreased with height.The proportion of alkanes in surface VOCs in-creased,and the source was mainly vehicle exhaust.This study confirmed that VOCs are vertically homogeneous in the background of the Tibetan Plateau,emphasizing the importance of vehicle emissions as a potential source of VOCs.
基金supported by the National Natural Science Foundation(81900070)the Natural Science Foundation of Hunan Province(2020JJ5813)China。
文摘The genomic fusions of the anaplastic lymphoma kinase(ALK)gene have been widely recognized as effective therapeutic targets for non-small cell lung carcinoma(NSCLC).The Second Xiangya Hospital of Central South University has treated 2 NSCLC patients with 2 distinct novel ALK gene fusions.Case 1 was a 55-year-old male with a solid nodule located in the right hilar lobe on enhanced CT scan.Case 2 was a 47-year-old female with enhanced CT showing involvement of the left upper lobe of lung.Histopathological examination of tumor tissues confirmed lung adenocarcinoma in both cases.Immunohistochemical(IHC)staining demonstrated positivity for thyroid transcription factor 1(TTF-1)and ALK-D5F3 in tumor cells,while negativity for P40.The next-generation sequencing(NGS)tests identified a PNPT1-ALK(Exon22:Exon20)fusion variant in case 1 and a TCEAL2-ALK(Exon3:Exon19)fusion variant in case 2.The TCEAL2-ALK fusion was further confirmed by amplification refractory mutation system(ARMS)-PCR at the mRNA level.Both patients were treated with oral alectinib at a dosage of 600 mg twice daily.The tumors in both patients were significantly decreased after alectinib treatment,achieving partial response.At the time of submission,there was an absence of disease progression and the progression-free survival(PFS)had surpassed 1 year.It offered compelling evidences that the individuals with NSCLC and harboring either a PNPT1-ALK(Exon22:Exon20)fusion or a TCEAL2-ALK(Exon3:Exon19)fusion,experience favorable therapeutic outcomes through the administration of alectinib.This study expands the known ALK fusion variants database and supports the precision treatment of NSCLC using ALK tyrosine kinase inhibitors(TKIs).
基金Project (2012M511752) supported by China Postdoctoral Science FoundationProject (2011CB605801) supported by the National Basical Research Program of China+3 种基金Project (2012QNZT004) supported by the Fundamental Research Funds of the Central Universities, ChinaProject supported by the Freedom Explore Program of Central South University, ChinaProject (CSUZC2012026) supported by the Open-End Fund for the Valuable and Precision Instruments of Central South University, ChinaProject supported by the Postdoctoral Science Foundation of Central South University, China
文摘To protect carbon materials from oxidation, mullite/SiC coatings were prepared on graphite by chemical vapor reaction (CVR) and slurry sintering. The XRD analyses show that the phase of the outer-layer coating is composed of SiO2 and mullite, and the inner-layer coating is mainly composed of β-SiC. The anti-oxidation behavior of the coating and the Rockwell hardness (HRB) of the coating after oxidation were investigated. The oxidation test shows that the as-prepared multi-layer coating exhibits excellent antioxidation and thermal shock resistance at high temperature. After oxidation at 1150 ℃ for 109 h and thermal shock cycling between 1150 ℃ and room temperature for 12 times, the mass gain of the coated sample is 0.085%. Meanwhile, the indentation tests also demonstrate that the as-prepared coating has good bonding ability between the layers.
基金Project(51222509) supported by the National Science Fund for Excellent Young Scholars of ChinaProject(51175429) supported by the National Natural Science Foundation of ChinaProjects(97-QZ-2014,90-QP-2013) supported by the Research Fund of the State Key Laboratory of Solidification Processing(NWPU) of China
文摘Hot spinning process has attracted significant attention because it can be used to manufacture complex parts, extend the forming limit of materials, decrease forming forces and reduce process chains. In this paper, we review researches on lightweight metals spun at elevated temperatures since they are difficult to deform at room temperature. These metals include light alloys, such as titanium, magnesium and aluminum alloys, and metal composites. Then, the heating methods used in the hot spinning process and the treatment methods employed for the temperature boundary condition in finite element analyses for the process were discussed. Finally, the future development directions for the hot spinning process of lightweight but difficult-to-deform alloys were highlighted.
基金Project(51274243)supported by the National Natural Science Foundation of China
文摘Pure compounds and kaolin were employed to investigate the reaction behavior of ferric oxide in thetrinarysystem Fe2O3?SiO2?Al2O3 during reductive sintering process. The thermodynamic analyses and reductive sintering experimental results show that ferrous oxide generated from the reduction of ferric oxide by carbon can react with silicon dioxide and aluminum oxide to form ferrous silicate and hercynite at 1173 K, respectively. In the trinary system Fe2O3?SiO2?Al2O3, ferrous oxide obtained from ferric oxide reduction preferentially reacts with aluminum oxide to form hercynite, and the reaction of ferrous oxide with silicon dioxide occurs only when there is surplus ferrous oxide after the exhaustion of aluminum oxide. When sintering temperature rises to 1473 K, hercynite further reacts with silicon dioxide to form mullite and ferrous oxide. Results presented in this work may throw a new light upon the separation of alumina and silica present in Al/Fe-bearing materials with low mass ratio of alumina to silica in alumina production.
文摘Non-tobacco related materials （NTRM） come from field production, tobacco stringing, grading and purchasing, affecting cigarette quality and having potential safety hazard. The research reviewed control on NTRM from source, production and processing to enhance use efficiency of raw materials and guarantee raw material safety.
文摘Objective: To investigate the relationship between peroxisomeproliferators-activated receptor-gamma (PPAR-γ) and clinical pathology of lung cancer, and to studythe inhibitory effect of PPAR-γ activators on lung cancer growth and the mechanism of inducingapoptosis of lung cancer. Methods: Expression of PPAR-γ in 15 cases of non-cancerous lung tissuesand 64 cases of lung cancer tissues was detected by using immunohistochemistry. The average A valueswere measured by using image analysis. The expression of PPAR-γ in lung cancer cells was detectedby using RT-PCR. After being treated with PPAR-γ activators, apoptosis was detected by using flowcytometry, and meanwhile, the change in caspase-3 activity was detected by caspase-3 kits. Results:Expression levels of PPAR-γ in cancerous tissues were higher than those in non-cancerous lungtissues. In four types of lung cancer, the sequence of PPAR-γ expression from high to low levelswas small-cell lung cancer, squamous carcinom, large-cell lung cancer, adenocarcinoma in turns. Theexpression of PPAR-γ was correlated with differentiation and postoperative TNM staging of lungcancer tissues, but not with lymph node metastasis. PPAR-γ expressed in two lung cancer cell lines,which could induce apoptosis of lung cancer cells after being treated with PPAR-γ activators, andcaspase-3 activity in cells treated with PPAR-γ activators was significantly increased. Conclusion:PPAR-γ is correlated with clinical pathology and apoptosis of lung cancer closely, and activatedPPAR-γ can increase caspase-3 activity to induce cells apoptosis. PPAR-γ will be able to become anew target for therapy of lung cancer in the future.
文摘JCOMM has strategy to establish the network of WMO-IOC Centres for Marine-meteorological and Oceanographic Climate Data （CMOCs） under the new Marine Climate Data System （MCDS） in 2012 for improving the quality and timeliness of the marine-meteorological and oceanographic data, metadata and products available to end users. China as a candidate of CMOC China has been approved to run on a trial basis after the 4th Meeting of the Joint IOC/WMO Technical Commission for Oceanography and Marine Meteorology （JCOMM）. This article states the developing intention of CMOC China in the next few years through the brief introduction to critical marine data, products and service system and cooperation projects in the world.
