Based on perturbation theory, the wave equation extrapolation operator with mixed domains has the ability to deal with lateral velocity variations. It is the image method that has undergone much research in seismology...Based on perturbation theory, the wave equation extrapolation operator with mixed domains has the ability to deal with lateral velocity variations. It is the image method that has undergone much research in seismology. All extrapolation operators face the problem of choosing the reference velocity due to continuation in depth. The wavefield extrapolation operator with a single reference velocity is suitable for media with weak lateral variation. The multi-reference velocity extrapolation operator can cope with severe lateral velocity variations and improve image accuracy. However, the calculation cost is large. We present a self-adaptive approach to automatically determine the number of selected reference velocities according to the complexity of structure and the given velocity threshold value. The approach can be used to construct the SSF, FFD, WXFD, and GSP multi-reference velocity wavefield extrapolation image algorithms. The result of a salt-dome model data test demonstrates that the self-adoptive multi-reference wavefield extrapolation algorithm has the ability to deal with severe lateral velocity variations and can also be used for structure edge detection. The method is flexible and computationally cost-effective.展开更多
Cancer immunotherapy has greatly advanced in recent years,and PD-1/PD-L1 blocking therapy has become a major pillar of immunotherapy.Successful clinical trials of PD-1/PD-L1 blocking therapies in cancer treatments hav...Cancer immunotherapy has greatly advanced in recent years,and PD-1/PD-L1 blocking therapy has become a major pillar of immunotherapy.Successful clinical trials of PD-1/PD-L1 blocking therapies in cancer treatments have benefited many patients,which promoted the Food and Drug Administration(FDA)approval of PD-1/PD-L1 blocking drugs.In this review,we provide a detailed introduction of five PD-1/PD-L1 blocking drugs,with indications and studies,as a valuable reference for doctors and medical investigators.Moreover,the characteristics of PD-1/PD-L1 blocking therapies,including their universality and sustainability,are discussed in this review.Furthermore,we also discuss and predict the possibility of PD-L1 as an indication marker of PD-1/PD-L1 blocking therapy for pan-cancer treatment,and the current status of combination therapies.展开更多
Theme is the point of departure of a message, and it is a textual phenomenon. It can interpret the comprehension and production of texts. This paper first makes a thematic analysis of the English original text and the...Theme is the point of departure of a message, and it is a textual phenomenon. It can interpret the comprehension and production of texts. This paper first makes a thematic analysis of the English original text and the Chinese target text, and then makes a comparative study of them in terms of the textual properties. It is found that in reproduction of target text, theme equivalence can not only help to realize the coherence of the target text with the same effect on receptors but also can save translation efforts. It is unnecessary to change the theme-rheme arrangements of the original unless it is required due to the social and cultural differences between English and Chinese.展开更多
基金The work is financially supported by the "973" project "Large-scale Scientific Calculation and its Use in the Petroleum Industry (G19990328)" by the "863" Project "High Accuracy Seismic Exploration Technologies in the Transition Area (2000AA602018)" also by the Geophysical Research Institute, Shengli Oilfield Ltd. SINOPEC.
文摘Based on perturbation theory, the wave equation extrapolation operator with mixed domains has the ability to deal with lateral velocity variations. It is the image method that has undergone much research in seismology. All extrapolation operators face the problem of choosing the reference velocity due to continuation in depth. The wavefield extrapolation operator with a single reference velocity is suitable for media with weak lateral variation. The multi-reference velocity extrapolation operator can cope with severe lateral velocity variations and improve image accuracy. However, the calculation cost is large. We present a self-adaptive approach to automatically determine the number of selected reference velocities according to the complexity of structure and the given velocity threshold value. The approach can be used to construct the SSF, FFD, WXFD, and GSP multi-reference velocity wavefield extrapolation image algorithms. The result of a salt-dome model data test demonstrates that the self-adoptive multi-reference wavefield extrapolation algorithm has the ability to deal with severe lateral velocity variations and can also be used for structure edge detection. The method is flexible and computationally cost-effective.
文摘Cancer immunotherapy has greatly advanced in recent years,and PD-1/PD-L1 blocking therapy has become a major pillar of immunotherapy.Successful clinical trials of PD-1/PD-L1 blocking therapies in cancer treatments have benefited many patients,which promoted the Food and Drug Administration(FDA)approval of PD-1/PD-L1 blocking drugs.In this review,we provide a detailed introduction of five PD-1/PD-L1 blocking drugs,with indications and studies,as a valuable reference for doctors and medical investigators.Moreover,the characteristics of PD-1/PD-L1 blocking therapies,including their universality and sustainability,are discussed in this review.Furthermore,we also discuss and predict the possibility of PD-L1 as an indication marker of PD-1/PD-L1 blocking therapy for pan-cancer treatment,and the current status of combination therapies.
文摘Theme is the point of departure of a message, and it is a textual phenomenon. It can interpret the comprehension and production of texts. This paper first makes a thematic analysis of the English original text and the Chinese target text, and then makes a comparative study of them in terms of the textual properties. It is found that in reproduction of target text, theme equivalence can not only help to realize the coherence of the target text with the same effect on receptors but also can save translation efforts. It is unnecessary to change the theme-rheme arrangements of the original unless it is required due to the social and cultural differences between English and Chinese.
