灵活

灵活是一种姿态。灵活更是一种智慧。我们欣赏柳条在微风轻拂下的婀娜之美，那是灵活；我们惊叹舞台上少女翩跹的舞姿，那是灵活；我们钦佩生活中有人能巧舌如簧．轻松化解一场又一场矛盾，那更是灵活。人生需要灵活的智慧。

Studies on Active Polysaccharides from Ganoderma lucidum vith Immune Activity

从云头状灵芝[Ganoderma Lucidum(Leyss.ex Fr.)Karst.]中分离得到三种灵芝多糖BN3A，BN3B及BN3C，它们均表现明显免疫调节作用。从灵芝多糖BN3B及BN3C中各分离得到四个多糖均一体，对其中主要成分BN3C1，BN3C3，BN3B1及BN3B3进行了物理及化学研究，它们的平均分子量依次为1.6×10^4，2.5×10^4，3.5×10^4及4.0×10^4。经完全酸水解、红外光谱测定、过碘酸氧化、甲酸生成、Smith降解等证明，BN3B1及BN3C1均为β－（1→6)(1→3）甙键相连的葡聚糖。BN3B3为阿拉伯半乳聚糖。BN3C3为由葡萄糖和阿拉伯糖组成的肽多糖。它们均为β－（1→6）（1→3）甙键相连。

基于网络药理学探讨活络效灵丹治疗冠心病的作用机制

目的基于网络药理学方法探讨活络效灵丹治疗冠心病的有效活性成分及靶点的作用机制。方法本研究运用TCMSP数据库结合筛选条件确定活络效灵丹的主要有效活性成分及其作用靶点。利用GeneCards数据库和OMIM数据库获取冠心病作用靶点,取活络效灵丹和冠心病作用靶点的交集,对交集靶点进行蛋白质互相作用网络分析、基因功能富集分析和信号通路富集分析。结果筛选主要有效活性成分118种,并获得药物靶点197个。通过GeneCards数据库和OMIM数据库共获得7266靶点,药物作用靶点与疾病作用靶点交集基因172个,PPI蛋白互作网络分析得出STAT3、AKT1、JUN、MAPK1、APP、ERLA、CXCL8、IL6、MAPK14、EGFR等可能是活络效灵丹治疗冠心病的核心靶点。GO功能富集分析得到163个条目,KEGG通路富集分析获得69条信号通路,其中富集排名靠前通路主要有IL-17信号通路TNF信号通路、HIF-1信号通路、内分泌抵抗、EGFR酪氨酸激酶抑制剂耐药、PI3K-Akt信号通路、铂耐药、细胞凋亡、C型凝集素受体信号通路、Th17细胞分化、Toll样受体信号通路等。结论活络效灵丹治疗动冠心病具有多途径、多靶点的作用特点,为探析中医治疗冠心病提供参考。

加味活络效灵丹对啤酒诱发痛风模型大鼠关节组织中IL-1β表达的影响

目的:通过观察活络效灵丹对啤酒诱发痛风模型大鼠的影响,对活络效灵丹治疗痛风的疗效及机制进行探索。方法:将60只雄性SD大鼠随机分为空白对照组,造模啤酒组,加味活络效灵丹高、中、低剂量组,每组12只。除空白对照组外,其余各组大鼠注射尿酸钠诱导痛风模型。空白对照组给予生理盐水灌胃,其余各组均给予啤酒灌胃,加味活络效灵丹高、中、低剂量组同时予以加味活络效灵丹汤液高、中、低剂量灌胃。观察各组大鼠的饮食、二便、毛色、精神状态及活动情况,受试关节周径变化;ELISA法检测关节组织中白细胞介素-1β(IL-1β)的水平。结果:与造模啤酒组比较,加味活络效灵丹高、中、低各剂量组大鼠的饮食、二便、毛色、精神状态及活动情况均有所改善。与空白对照组比较,造模啤酒组大鼠的受试关节周径有所增加(P<0.05);与造模啤酒组比较,加味活络效灵丹高、中、低各剂量组大鼠的受试关节周径均有所减少(P<0.05)。与空白对照组比较,造模啤酒组大鼠的关节组织中IL-1β的表达有所增加(P<0.05);与造模啤酒组比较,加味活络效灵丹高、中、低各剂量组大鼠的关节组织中IL-1β的表达均有所降低(P<0.05)。结论:加味活络效灵丹可通过降低关节组织中IL-1β的表达而起到治疗痛风的作用。

通脉活血灵胶囊的实验药效学研究

目的：观察通脉活血灵胶囊对实验性高粘血症家兔血液流变学的影响。方法：采用高脂饲料饲喂家兔８ 周，以造成高粘血症模型。在建立模型的同时，实验组给予不同剂量的通脉活血灵胶囊，然后取血测定各组动物血液流变学变化。并将通脉活血灵胶囊给大鼠灌胃，每日１ 次，连续７ 天，然后将大鼠麻醉，腹主动脉取血，测定各组动物的血小板聚集功能。结果：高脂饲料饲养家兔可导致高粘血症，通脉活血灵胶囊可明显改善各组动物的血液流变学指标，亦可明显抑制ＡＤＰ诱导的血小板聚集反应。

Antitumor Activity of the Ganoderma Lucidum Spore Alcohol Extract in Vitro

Several cancer cell lines(epithelioma cells or leukemia cells)from human being or mouse were first used to study the antitumor activity of the Ganoderma lucidum spore alcohol extract(GLSAE)in vitro by the MTT test A comparision was made between the sporodermbroken(SB)and sporoderm nonbroken(SN)GLSAE It was showed that both GLSAE SB and GLSAE SN could inhibit the proliferation of these cancer cells,but the activity of GLSAE SB was much higher than that of GLSAE SN These results suggested that Ganoderma lucidum spore could probably be used for tumor treatment

Flexibility of a 300 MW Arch Firing Boiler Burning Low Quality Coals

Experimental investigations on the flexibility of a 300 MW Arch Firing (AF) coal-fired boiler when burning low quality coals is reported. Measurements of gas temperature and species concentration and char sampling using a water-cooled suction pyrometer were carried out along the furnace elevation. The carbon content and the size distribu-tions of the char samples were obtained. The char morphology was examined using a field emission scanning electron microscope (FESEM). The char sampling was performed on this type of boiler for the first time. The results indicate that the flexibility of this boiler burning low quality coals under a moderate boiler load is better than its flexibility under a high boiler load. Because of the insufficient capacity of the coal pulverizers used,in case of low coal quality the pul-verized coal fineness will drastically decrease under high boiler loads. This causes an increase in the loss due to incom-plete mechanical and chemical combustion. This is the main cause of a low burnout degree of the pulverized coal and the decrease of the flexibility of this AF boiler under a high boiler load.

TCP performance evaluation over AODV and DSDV in RW and SN mobility models

This paper presents evaluation and comparison of the TCP performance in different mobile scenarios generated by Random Waypoint (RW) and Social Network (SN) mobility models. To our knowledge, TCP performance in SN mobility is discussed for the first time. The impact of AODV and DSDV routing protocols on the TCP goodput, delay and drop rate per- formance is also discussed. Extensive simulation results and analysis showed that TCP has better performance over AODV than over DSDV and has more stable performance in SN mobility than in RW mobility. We suggest using more mobility models, in particular, such as SN, in the evaluations of the transport layer or routing layer protocols because the mobility patterns have impacts on the protocol performance.

The effect of hamstring flexibility on peak hamstring muscle strain in sprinting

Background:The effect of hamstring flexibility on the peak hamstring muscle strains in sprinting,until now,remained unknown,which limited our understanding of risk factors of hamstring muscle strain injury(hamstring injury).As a continuation of our previous study,this study was aimed to examine the relationship between hamstring flexibility and peak hamstring muscle strains in sprinting.Methods:Ten male and 10 female college students participated in this study.Hamstring flexibility,isokinetic strength data,three-dimensional(3D)kinematic data in a hamstring isokinetic test,and kinematic data in a sprinting test were collected for each participant.The optimal hamstring muscle lengths and peak hamstring muscle strains in sprinting were determined for each participant.Results:The muscle strain of each of the 3 biarticulated hamstring muscles reached a peak during the late swing phase.Peak hamstring muscle strains were negatively correlated to hamstring flexibility(0.1179 ≤ R2≤ 0.4519,p = 0.001) but not to hip and knee joint positions at the time of peak hamstring muscle strains.Peak hamstring muscle strains were not different for different genders.Peak muscle strains of biceps long head(0.071 ± 0.059) and semitendinosus(0.070 ± 0.055) were significantly greater than that of semimembranosus(0.064 ± 0.054).Conclusion:A potential for hamstring injury exists during the late swing phase of sprinting.Peak hamstring muscle strains in sprinting are negatively correlated to hamstring flexibility across individuals.The magnitude of peak muscle strains is different among hamstring muscles in sprinting,which may explain the different injury rate among hamstring muscles.

Research on vibration characteristics of L-shaped plate using a mobility power flow approach

L-shaped plates have become an important focuses in structural vibration research. To determine their vibration characteristics, this paper applied a mobility power flow method. Firstly, the L-shaped plate was divided into two substructures to simplify analysis. The coupled bending moment was then deduced by applying a continuous vibration property on the common edge. Next, the response on any point of the plate and the input and transmitted power flow formulas were calculated. Numerical simulations showed the distribution of the coupled bending moment and the response of the whole structure. The validity of this method was verified by the SEA approach.

New flexible endoscopic controlled stapler technique for the treatment of Zenker's diverticulum:A case series

AIMTo report about the combination and advantages of a stapler-assisted diverticulotomy performed by flexible endoscopy.METHODSFrom November 2014 till December 2015 17 patients (8 female, 9 male, average age 69.8 years) with a symptomatic Zenker diverticulum (mean size 3.5 cm) were treated by inserting a new 5 mm fully rotatable surgical stapler (MicroCutter30 Xchange, Cardica Inc.) next to an ultrathin flexible endoscope through an overtube. The Patients were under conscious sedation with the head reclined in left position, the stapler placed centrally and pushed forward to the bottom of the diverticulum. The septum was divided by the staple rows under flexible endoscopic control.RESULTSIn eleven patients (64.7%) the stapler successfully divided the septum completely. Mean procedure time was 21 min, medium size of the septum was 2.8 cm (range 1.5 cm to 4 cm). In four patients the septum was shorter than 3 cm, in seven longer than 3 cm. To divide the septum, averagely 1.3 stapler cartridges were used. Two minor bleedings occurred. Major adverse events like perforation or secondary haemorrhage did not occur. After an average time of two days patients were discharged from the hospital. In 6 patients (35.3%) the stapler failed due to a thick septum or insufficient reclination of the head. Follow up endoscopy was performed after an average of two months in 9 patients; 4 patients (44.4%) were free of symptoms, 5 patients (55.6%) stated an improvement. A relapse of symptoms did not occur.CONCLUSIONFlexible endoscopic Zenker diverticulotomy by using a surgical stapler is a new, safe and efficient treatment modality. A simultaneously tissue opening and occlusion prevents major complications.

Turbine speed control system based on a fuzzy-PID

The flexibility demand of marine nuclear power plant is very high,the multiple parameters of the marine nuclear power plant with the once-through steam generator are strongly coupled,and the normal PID control of the turbine speed can't meet the control demand.This paper introduces a turbine speed Fuzzy-PID controller to coordinately control the steam pressure and thus realize the demand for quick tracking and steady state control over the turbine speed by using the Fuzzy control's quick dynamic response and PID control's steady state performance.The simulation shows the improvement of the response time and steady state performance of the control system.

Psychological effects of colorectal cancer screening: Participants vs individuals not invited

AIM To investigate the possible long-term psychological harm of participating in colorectal cancer(CRC)screening in Norway.METHODS In a prospective, randomized trial, 14294 participants(aged 50-74 years) were invited to either flexible sigmoidoscopy(FS) screening, or a faecal immunochemical test(FIT)(1:1). In total, 4422 screening participants(32%) completed the questionnaire, which consisted of the Hospital Anxiety and Depression Scale and the SF-12, a generic health-related quality of life(HRQOL) measurement, when invited to screening and one year after the invitation. A control group of 7650 individuals was invited to complete the questionnaire only, at baseline and one year after, and 1911(25%) completed the questionnaires.RESULTS Receiving a positive or negative screening result and participating in the two different screening modalities did not cause clinically relevant mean changes in anxiety, depression or HRQOL after one year. FS screening, but not FIT, was associated with an increased probability of being an anxiety case(score ≥ 8) at the one-year follow-up(5.6% of FS participants transitioned from being not anxious to anxious, while 3.0% experienced the reverse). This increase was moderately significantly different from the changes in the control group(in which the corresponding numbers were 4.8% and 4.5%, respectively), P = 0.06. CONCLUSION Most individuals do not experience psychological effects of CRC screening participation after one year, while FS participation is associated with increased anxiety for a smaller group.

Role of new endoscopic techniques in inflammatory bowel disease management: Has the change come?

Despite significant therapeutic progress in recent years,inflammatory bowel disease(IBD),which includes Crohn’s disease and ulcerative colitis,remains a challenge regarding its pathogenesis and long-term complications.New concepts have emerged in the management of this disease,such as the"treat-totarget"concept,in which mucosal healing plays a key role in the evolution of IBD,the risk of recurrence and the need for surgery.Endoscopy is essential for the assessment of mucosal inflammation and plays a pivotal role in the analysis of mucosal healing in patients with IBD.Endoscopy is also essential in the detection of dysplasia and in the identification of the risk of colon cancer.The current surveillance strategy for dysplasia in IBD patients indicates white-light endoscopy with non-targeted biopsies.The new chromoendoscopy techniques provide substantial benefits for both clinicians and patients.Narrow-band imaging(NBI)has similar rates of dysplastic lesion detection as whitelight endoscopy,and it seems that NBI identifies more adenoma-like lesions.Because it is used instinctively by many endoscopists,the combination of these two techniques might improve the rate of dysplasia detection.Flexible spectral imaging color enhancement can help differentiate dysplastic and non-dysplastic lesions and can also predict the risk of recurrence,which allows us to modulate the treatment to gain better control of the disease.The combination of noninvasive serum and stool biomarkers with endoscopy will improve the monitoring and limit the evolution of IBD because it enables the use of a personalized approach to each patient based on that patient’s history and risk factors.

Thyristor Controlled Phase Shifter:A Comprehensive Survey

Thyristor control phase shifter (TCPS) is one of the new facilities implemented in power network, leading to the development of economically efficient and technically reliable system. This paper introduces the function of TCPS in power system, describes its working principle and structure, and suggests some simple models used in its study and briefly presents the comparison between different types of TCPSs and their applications.

Comparison between PCA and KPCA methods in comprehensive evaluation of robotic kinematic dexterity

Due to the correlation and diversity of robotic kinematic dexterity indexes, the principal component analysis （PCA） and kernel principal component analysis （KPCA） based on linear dimension reduction and nonlinear dimension reduction principle could be respectively introduced into comprehensive kinematic dexterity performance evaluation of space 3R robot of different tasks. By comparing different dimension reduction effects, the KPCA method could deal more effectively with the nonlinear relationship among different single kinematic dexterity indexes, and its calculation result is more reasonable for containing more comprehensive information. KPCA＇ s calculation provides scientific basis for optimum order of robotic tasks, and furthermore a new optimization method for robotic task selection is proposed based on various performance indexes.

Implication of Surface Fractal Analysis to Evaluate the Relative Sensitivity of Topography to Active Tectonics,Zagros Mountains, Iran

Fractal geometry is increasingly becoming a useful tool for modeling and quantifying the complex patterns of natural phenomena. The Earth's topography is one of these phenomena that have fractal characteristics. This paper investigates the relative sensitivity of topography to active tectonics using ASTER Global Digital Elevation Model. The covering divider method was used for direct extraction of surface fractal dimension(D surf) to estimate the roughness-surface of topography with aid of geographic information system(GIS)techniques. This evaluation let us highlight the role of the geomorphic and tectonic processes on the spatial variability of fractal properties of natural landforms.Geomorphic zones can be delineated using fractal dimension mapping in which variability of surface fractal dimension reflects the roughness of the landform surface and is a measure of topography texture. Obtained results showed this method can be a quick and easy way to assess the distribution of land surface deformation in different tectonic settings. The loose alluvial deposits and irregularities derived by tectonic activity have high fractal dimensions whereas the competent formations and higher wavelength folded surfaces have lower fractal dimensions.According to the obtained results, the Kazerun Fault Zone has a crucial role in the separation of the Zagros Mountain Ranges into the different lithological,geomorphological and structural zones.

Research on Miniature Hexapod Bio-robot

This paper described the structure and control of a new kind of miniature hexap od bio-robot, analyzed the moving principle of the robot. The robot is based on the principle of bionics, its structure is simple, design novel, unique. It can mov e forwards and backwards. The external dimensions of bio-robot is: length 30 mm , width 40 mm, height 20 mm, weight 6.3 g. Some tests about the model robot were made. The experimental results show that the robot has good mobility.

Variable structure attitude maneuver and vibration control of flexible spacecraft

A dual-stage control system design method is presented for the three-axis-rotational maneuver and vibration stabilization of a spacecraft with flexible appendages embedded with piezoceramics as sensor and actuator. In this design approach, the attitude control and the vibration suppression sub-systems are designed separately using the lower order model. The design of attitude controller is based on the variable structure control (VSC) theory leading to a discontinuous control law. This controller accomplishes asymptotic attitude maneuvering in the closed-loop system and is insensitive to the interaction of elastic modes and uncertainty in the system. To actively suppress the flexible vibrations, the modal velocity feedback control method is presented by using piezoelectric materials as additional sensor and actuator bonded on the surface of the flexible appendages. In addition, a special configuration of actuators for three-axis attitude control is also investigated: the pitch attitude controlled by a momentum wheel, and the roll/yaw control achieved by on-off thrusters, which is modulated by pulse width pulse frequency modulation technique to construct the proper control torque history. Numerical simulations performed show that the rotational maneuver and vibration suppression are accomplished in spite of the presence of disturbance torque and parameter uncertainty.

Impact of Capacity Parameters on Flexible Inventory Control Decision Model

From the mathematical point of view,the flexible inventory control model is proved in the practical problem application and the rationality of the capacity parameter selection and calculation.The purpose is to actively respond to demand fluctuations when there is a demand forecast error or a missing part of the demand information,and to avoid the risk of passive variable demand forecasting to set the immutable inventory capacity.At the same time,the game is controlled by the flexible and variable inventory control strategy and the customer’s willingness to demand.The paper mainly studies the influence of the setting of capacity parameters on the booking-limit decision and its benefits under the control of flexible space with variable total capacity.Through the two trends of capacity increase flexibility and capacity reduction flexibility in the flexible inventory control model,the mathematical performance and marginal utility methods are introduced to change the performance of the booking-limit control decision model under different scenarios.The correlation analysis between the capacity limit level and the return under the optimal Bookinglimit decision,and the above two flexibility parameters are obtained.