The paper analyzes John Presper Eckert and John William Mauchly＇s endeavours to design, sell, and build the revolutionary new technology of the first-large and commercial computers. It discusses how Eckert and Mauchl...The paper analyzes John Presper Eckert and John William Mauchly＇s endeavours to design, sell, and build the revolutionary new technology of the first-large and commercial computers. It discusses how Eckert and Mauchly＇s conceptualization of the computer grew out of their Electronic Numerical Integrator and Calculator （ENIAC） and Electronic Discrete Variable Automatic Computer （EDVAC） projects at University of Pennsylvania. They incorporated their own business to gain profit from production and attain the freedom needed to develop their revolutionary new computer technology through a series of small and separate computer projects with private and government customers. The paper approaches innovation as a chaotic process and uses uncertainty to conceptualize the basic relations between actors and organizations.展开更多
Marcel Proust is an author of global significance and renown. Trans- lations into Chinese and Korean of A la recherche du temps perdu are ongoing. The Gallica online library of France＇s Bibliothbque nationale makes t...Marcel Proust is an author of global significance and renown. Trans- lations into Chinese and Korean of A la recherche du temps perdu are ongoing. The Gallica online library of France＇s Bibliothbque nationale makes the notebooks from which Proust＇s novel emerged between 1908 and 1922 digitally accessible any- where in the world. It is well known that Proust has been adapted to graphic novel format, individual volumes of his novel have been adapted for cinema, inspired ballet and musical theatre and his characters＇ lives have fuelled works of fiction by contemporary creative writers. This paper considers a very recent instance of Proust＇s reception and adaptation： ＂Works in Fiber, Paper and Proust＂ created by the critic and theorist Eve Kosofsky Sedgwick （1950-2009） and first exhibited at Harvard University in 2005. These remarkable objects--including what Sedgwick calls an ＂accordion-book＂ and a ＂loom-book＂--give a woven, layered physicality to Proust＇s words and remobilise them in ways that force us to reconfigure our understanding of the text-reader relation. Sedgwick＇s visual, textile artworks are the products of creative, adaptive practices undertaken as a sort of therapy that was instrumental in her coming to terms with the terminal cancer diagnosis she received in 1996. My paper explores Sedgwick＇s adaptive practice and interrogates the in- sights their challenging hybridity offers us into the ongoing transmission of Proust＇s work.展开更多
OBJECTIVE: To study the daily administration times of Canhuang tablet(CHT) for treating jaundice in rats based on a pharmacodynamic/ pharmacokinetic model.METHODS: Rats were modeled by 4% 1-Naphthylisothiocyanate(75 m...OBJECTIVE: To study the daily administration times of Canhuang tablet(CHT) for treating jaundice in rats based on a pharmacodynamic/ pharmacokinetic model.METHODS: Rats were modeled by 4% 1-Naphthylisothiocyanate(75 mg/kg, p.o.). After 48 h, CHT was given(p.o.) at 0.75 g/kg once a day, 0.375 g/kg twice a day, and 0.25 g/kg three times a day. Blood was collected from the orbital sinus at different intervals. Levels of liver enzymes and bilirubin were detected using these blood samples. Bile was collected and determined after the first administration of CHT. High-performance liquid chromatography was used to determine the concentration of berberine in bile simultaneously. Time-effect and time-dose curves were then obtained.RESULTS: Compared with rats taking CHT twiceand three times a day, the total amount of bile within 10 h of rats taking CHT once a day were 1.32-and 1.47-fold higher, respectively. There was good consistency between the pharmacokinetics of berberine and the pharmacodynamics of the effect on liver enzymes and bilirubin in vivo. The pharmacokinetic analyses showed that rats administered CHT once daily maintained a higher concentration of berberine in bile for a longer period than rats administered CHT two- and three-times daily.CONCLUSION: In jaundiced rats, taking CHT once a day is better than taking CHT twice or three times a day. These data may provide a reference for the clinical application of CHT.展开更多
文摘The paper analyzes John Presper Eckert and John William Mauchly＇s endeavours to design, sell, and build the revolutionary new technology of the first-large and commercial computers. It discusses how Eckert and Mauchly＇s conceptualization of the computer grew out of their Electronic Numerical Integrator and Calculator （ENIAC） and Electronic Discrete Variable Automatic Computer （EDVAC） projects at University of Pennsylvania. They incorporated their own business to gain profit from production and attain the freedom needed to develop their revolutionary new computer technology through a series of small and separate computer projects with private and government customers. The paper approaches innovation as a chaotic process and uses uncertainty to conceptualize the basic relations between actors and organizations.
文摘Marcel Proust is an author of global significance and renown. Trans- lations into Chinese and Korean of A la recherche du temps perdu are ongoing. The Gallica online library of France＇s Bibliothbque nationale makes the notebooks from which Proust＇s novel emerged between 1908 and 1922 digitally accessible any- where in the world. It is well known that Proust has been adapted to graphic novel format, individual volumes of his novel have been adapted for cinema, inspired ballet and musical theatre and his characters＇ lives have fuelled works of fiction by contemporary creative writers. This paper considers a very recent instance of Proust＇s reception and adaptation： ＂Works in Fiber, Paper and Proust＂ created by the critic and theorist Eve Kosofsky Sedgwick （1950-2009） and first exhibited at Harvard University in 2005. These remarkable objects--including what Sedgwick calls an ＂accordion-book＂ and a ＂loom-book＂--give a woven, layered physicality to Proust＇s words and remobilise them in ways that force us to reconfigure our understanding of the text-reader relation. Sedgwick＇s visual, textile artworks are the products of creative, adaptive practices undertaken as a sort of therapy that was instrumental in her coming to terms with the terminal cancer diagnosis she received in 1996. My paper explores Sedgwick＇s adaptive practice and interrogates the in- sights their challenging hybridity offers us into the ongoing transmission of Proust＇s work.
基金Supported by the Shibingshiyao Program of Beijing Municipal Science and Technology Commission(No.Z131100002513005)
文摘OBJECTIVE: To study the daily administration times of Canhuang tablet(CHT) for treating jaundice in rats based on a pharmacodynamic/ pharmacokinetic model.METHODS: Rats were modeled by 4% 1-Naphthylisothiocyanate(75 mg/kg, p.o.). After 48 h, CHT was given(p.o.) at 0.75 g/kg once a day, 0.375 g/kg twice a day, and 0.25 g/kg three times a day. Blood was collected from the orbital sinus at different intervals. Levels of liver enzymes and bilirubin were detected using these blood samples. Bile was collected and determined after the first administration of CHT. High-performance liquid chromatography was used to determine the concentration of berberine in bile simultaneously. Time-effect and time-dose curves were then obtained.RESULTS: Compared with rats taking CHT twiceand three times a day, the total amount of bile within 10 h of rats taking CHT once a day were 1.32-and 1.47-fold higher, respectively. There was good consistency between the pharmacokinetics of berberine and the pharmacodynamics of the effect on liver enzymes and bilirubin in vivo. The pharmacokinetic analyses showed that rats administered CHT once daily maintained a higher concentration of berberine in bile for a longer period than rats administered CHT two- and three-times daily.CONCLUSION: In jaundiced rats, taking CHT once a day is better than taking CHT twice or three times a day. These data may provide a reference for the clinical application of CHT.
