AIM To investigate histologic abnormalities in the gastric smooth muscle of patients with diabetes mellitus(DM).METHODS Full-thickness gastric specimens were obtained from patients undergoing surgery for gastric cance...AIM To investigate histologic abnormalities in the gastric smooth muscle of patients with diabetes mellitus(DM).METHODS Full-thickness gastric specimens were obtained from patients undergoing surgery for gastric cancer. H&E stain and Masson's Trichrome stain were performed to assess the degree of fibrosis. Immunohistochemical staining using various antibodies was also performed [antibodies against protein gene product 9.5(PGP9.5), neuronal nitric oxide synthase(n NOS), vasoactive intestinal peptide(VIP), neurokinin-1(NK1) receptor, c-Kit, and platelet-derived growth factor receptor-alpha,(PDGFRα)]. Immunofluorescent staining and evaluation with confocal microscopy were also conducted.RESULTS Twenty-six controls and 35 diabetic patients(21 shortduration patients and 14 long-duration patients) were included. There were no significant differences in basic demographics between the two groups except in mean body mass index(BMI)(higher in the DM group). Proportions of moderate-to-severe intercellular fibrosis in the muscle layer were significantly higher in the DM group than in the control group(P < 0.01). On immunohistochemical staining, c-Kit- and PDGFRα-positive immunoreactivity were significantly decreased in the DM group compared with the control group(P < 0.05). There were no statistically significant differences in PGP9.5, n NOS, VIP, and neurokinin 1 expression. On immunofluorescent staining, cellularity of interstitial cells of Cajal(ICC) was observed to decrease with increasing duration of DM.CONCLUSION Our study suggests that increased intercellular fibrosis, loss of ICC, and loss of fibroblast-like cells are found in the smooth muscle of DM patients. These abnormalities may contribute to changes in gastric motor activity in patients with DM.展开更多
Aiming at the shallow depth seam proximity beneath a room mining goaf, due to that the shallow depth seam is exploited using the longwall mining and overlain by thin bedrock and thick loose sands, many accidents are l...Aiming at the shallow depth seam proximity beneath a room mining goaf, due to that the shallow depth seam is exploited using the longwall mining and overlain by thin bedrock and thick loose sands, many accidents are likely to occur, including roof structure instability, roof step subsidence, damages of shield supports, and the face bumps triggered by the large area roof weighting, resulting in serious threats to the safety of underground miners and equipment. This paper analyses the overlying strata movement rules for the shallow seams using the physical simulation, the 3DEC numerical simulation and the field mea- surements. The results show that, in shallow seam mining, the overburden movement forms caved zone and fractured zone, the cracks develop continuously and reach the surface with the face advancing, and the development of surface cracks generally goes through four stages. With the application of loose blast- ing of residual pillars, reasonable mining height, and roof support and management, the safe, efficient and high recovery rate mining has been achieved in the shallow depth seam proximity beneath a room min ing goal.展开更多
Neuroendocrine tumors represent a heterogeneous group of neoplasms that arise from neuroendocrine cells and secrete various peptides and bioamines. While gastrointestinal neuroendocrine tumors,commonly called carcinoi...Neuroendocrine tumors represent a heterogeneous group of neoplasms that arise from neuroendocrine cells and secrete various peptides and bioamines. While gastrointestinal neuroendocrine tumors,commonly called carcinoids,account for about 2/3 of all neuroendocrine tumors,they are relatively rare. Small intestine neuroendocrine tumors originate from intestinal enterochromaffin cells and represent about 1/4 of small intestine neoplasms. They can be asymptomatic or cause nonspecific symptoms,which usually leads to a delayed diagnosis. Imaging modalities can aid diagnosis and surgery remains the mainstay of treatment. We present a case of a jejunal neuroendocrine tumor that caused nonspecific symptoms for about 1 year before manifesting with acute mesenteric ischemia. Abdominal X-rays revealed pneumatosis intestinalis and an abdominal ultrasound and computed tomography confirmed the diagnosis. The patient was submitted to segmental enterectomy. Histopathological study demonstrated a neuroendocrine tumor with perineural and arterial infiltration and lymph node metastasis. The postoperative course was uneventful and the patient denied any adjuvant treatment.展开更多
A new air distribution pattern,air curtain jet ventilation was presented.The ventilation or airflow patterns and the air velocity produced by air curtain jet were investigated in detail.To identify the airflow charact...A new air distribution pattern,air curtain jet ventilation was presented.The ventilation or airflow patterns and the air velocity produced by air curtain jet were investigated in detail.To identify the airflow characteristics of this novel air curtain jet ventilation system,a full-scale room was used to measure the jet velocity with a slot-ventilated supply device,with regards to the airflow fields along the vertical wall as well as on the horizontal floor zones.The airflow fields under three supply air velocities,1.0,1.5 and 2.0 m/s,were carried out in the full-scale room.The experimental results show the velocity profiles of air distribution,the airflow fields along the attached vertical wall and the air lake zones on the floor,respectively.The current experimental research is helpful for heating,ventilation and air conditioning(HVAC) engineers to design better air distribution in rooms.展开更多
With the urban expansion and economic restructuring, the jobs-housing relationship has become an important issue in studies on urban spatial structure. This paper employed a job accessibility model, which is an evalua...With the urban expansion and economic restructuring, the jobs-housing relationship has become an important issue in studies on urban spatial structure. This paper employed a job accessibility model, which is an evaluation instrument to measure the jobs-housing relationship in Beijing Metropolitan Area from a job accessibility perspective. The results indicate that the population in the central city is declining, whereas the population in the suburbs is consistently growing and forming new population centers. However, the distribution pattern of employment is still highly centralized. Job accessibility varies in different locations, but the inner-city areas(within the Third Ring road) have seen improved job accessibility over time while job accessibility in the suburbs(especially outside the Fourth Ring road) has decreased, and this has led it to become a primary area of residential and employment mismatch. At the same time, the new towns in the outer suburbs have not yet demonstrated great potential to attract more jobs. In addition we find that, to some extent, urban planning changes the jobs-housing relationship, but a polycentric urban spatial structure is not yet evident. The floating population and related housing policy also affect the jobs-housing relationship. We propose some measures to resolve the spatial mismatch as well as some future research directions.展开更多
In this paper, the author focuses on spaces used for personal hygiene--the bathroom. The paper begins with a description of the hygienic movement in the late 19th century. At that time, urinating took place in semi-pu...In this paper, the author focuses on spaces used for personal hygiene--the bathroom. The paper begins with a description of the hygienic movement in the late 19th century. At that time, urinating took place in semi-public spaces outside the dwelling. Today, the WC has moved well into the dwelling, and in many dwellings, the bathroom has developed as the most private space. Thus, the bathroom can be regarded as the last domain of privacy in today＇s housing, and in a number of new dwellings this quality is exploited in new ways. The development of ＂space for hygiene＂ in the 20th century will be studied by analyzing the spatial organization of dwellings.展开更多
基金Supported by the National Research Foundation of Korea Grant funded by the Korean Government,No.2014R1A5A2010008
文摘AIM To investigate histologic abnormalities in the gastric smooth muscle of patients with diabetes mellitus(DM).METHODS Full-thickness gastric specimens were obtained from patients undergoing surgery for gastric cancer. H&E stain and Masson's Trichrome stain were performed to assess the degree of fibrosis. Immunohistochemical staining using various antibodies was also performed [antibodies against protein gene product 9.5(PGP9.5), neuronal nitric oxide synthase(n NOS), vasoactive intestinal peptide(VIP), neurokinin-1(NK1) receptor, c-Kit, and platelet-derived growth factor receptor-alpha,(PDGFRα)]. Immunofluorescent staining and evaluation with confocal microscopy were also conducted.RESULTS Twenty-six controls and 35 diabetic patients(21 shortduration patients and 14 long-duration patients) were included. There were no significant differences in basic demographics between the two groups except in mean body mass index(BMI)(higher in the DM group). Proportions of moderate-to-severe intercellular fibrosis in the muscle layer were significantly higher in the DM group than in the control group(P < 0.01). On immunohistochemical staining, c-Kit- and PDGFRα-positive immunoreactivity were significantly decreased in the DM group compared with the control group(P < 0.05). There were no statistically significant differences in PGP9.5, n NOS, VIP, and neurokinin 1 expression. On immunofluorescent staining, cellularity of interstitial cells of Cajal(ICC) was observed to decrease with increasing duration of DM.CONCLUSION Our study suggests that increased intercellular fibrosis, loss of ICC, and loss of fibroblast-like cells are found in the smooth muscle of DM patients. These abnormalities may contribute to changes in gastric motor activity in patients with DM.
基金provided by the National Natural Science Foundation of China (No. 51304202)the Natural Science Foundation of Jiangsu Province of China (No. BK20130190)+1 种基金the Fundamental Research Funds for the Central Universities (No. 2013QNA28)the Priority Academic Program Development of Jiangsu Higher Education Institutions (No. SZBF2011-6-B35)
文摘Aiming at the shallow depth seam proximity beneath a room mining goaf, due to that the shallow depth seam is exploited using the longwall mining and overlain by thin bedrock and thick loose sands, many accidents are likely to occur, including roof structure instability, roof step subsidence, damages of shield supports, and the face bumps triggered by the large area roof weighting, resulting in serious threats to the safety of underground miners and equipment. This paper analyses the overlying strata movement rules for the shallow seams using the physical simulation, the 3DEC numerical simulation and the field mea- surements. The results show that, in shallow seam mining, the overburden movement forms caved zone and fractured zone, the cracks develop continuously and reach the surface with the face advancing, and the development of surface cracks generally goes through four stages. With the application of loose blast- ing of residual pillars, reasonable mining height, and roof support and management, the safe, efficient and high recovery rate mining has been achieved in the shallow depth seam proximity beneath a room min ing goal.
文摘Neuroendocrine tumors represent a heterogeneous group of neoplasms that arise from neuroendocrine cells and secrete various peptides and bioamines. While gastrointestinal neuroendocrine tumors,commonly called carcinoids,account for about 2/3 of all neuroendocrine tumors,they are relatively rare. Small intestine neuroendocrine tumors originate from intestinal enterochromaffin cells and represent about 1/4 of small intestine neoplasms. They can be asymptomatic or cause nonspecific symptoms,which usually leads to a delayed diagnosis. Imaging modalities can aid diagnosis and surgery remains the mainstay of treatment. We present a case of a jejunal neuroendocrine tumor that caused nonspecific symptoms for about 1 year before manifesting with acute mesenteric ischemia. Abdominal X-rays revealed pneumatosis intestinalis and an abdominal ultrasound and computed tomography confirmed the diagnosis. The patient was submitted to segmental enterectomy. Histopathological study demonstrated a neuroendocrine tumor with perineural and arterial infiltration and lymph node metastasis. The postoperative course was uneventful and the patient denied any adjuvant treatment.
基金Projects(50778145, 50278025) supported by the National Natural Science Foundation of ChinaProject(2009ZDKG-47) supported by "13115" Science and Technology Innovation Program of Shaanxi Province, China
文摘A new air distribution pattern,air curtain jet ventilation was presented.The ventilation or airflow patterns and the air velocity produced by air curtain jet were investigated in detail.To identify the airflow characteristics of this novel air curtain jet ventilation system,a full-scale room was used to measure the jet velocity with a slot-ventilated supply device,with regards to the airflow fields along the vertical wall as well as on the horizontal floor zones.The airflow fields under three supply air velocities,1.0,1.5 and 2.0 m/s,were carried out in the full-scale room.The experimental results show the velocity profiles of air distribution,the airflow fields along the attached vertical wall and the air lake zones on the floor,respectively.The current experimental research is helpful for heating,ventilation and air conditioning(HVAC) engineers to design better air distribution in rooms.
基金Under the auspices of National Natural Science Foundation of China(No.41271132)
文摘With the urban expansion and economic restructuring, the jobs-housing relationship has become an important issue in studies on urban spatial structure. This paper employed a job accessibility model, which is an evaluation instrument to measure the jobs-housing relationship in Beijing Metropolitan Area from a job accessibility perspective. The results indicate that the population in the central city is declining, whereas the population in the suburbs is consistently growing and forming new population centers. However, the distribution pattern of employment is still highly centralized. Job accessibility varies in different locations, but the inner-city areas(within the Third Ring road) have seen improved job accessibility over time while job accessibility in the suburbs(especially outside the Fourth Ring road) has decreased, and this has led it to become a primary area of residential and employment mismatch. At the same time, the new towns in the outer suburbs have not yet demonstrated great potential to attract more jobs. In addition we find that, to some extent, urban planning changes the jobs-housing relationship, but a polycentric urban spatial structure is not yet evident. The floating population and related housing policy also affect the jobs-housing relationship. We propose some measures to resolve the spatial mismatch as well as some future research directions.
文摘In this paper, the author focuses on spaces used for personal hygiene--the bathroom. The paper begins with a description of the hygienic movement in the late 19th century. At that time, urinating took place in semi-public spaces outside the dwelling. Today, the WC has moved well into the dwelling, and in many dwellings, the bathroom has developed as the most private space. Thus, the bathroom can be regarded as the last domain of privacy in today＇s housing, and in a number of new dwellings this quality is exploited in new ways. The development of ＂space for hygiene＂ in the 20th century will be studied by analyzing the spatial organization of dwellings.
