AIM: To identify the factors associated with virologic breakthrough and to select a subgroup of patients who respond well to lamivudine without developing virologic breakthrough (VBT). METHODS: Of 79 patients who had ...AIM: To identify the factors associated with virologic breakthrough and to select a subgroup of patients who respond well to lamivudine without developing virologic breakthrough (VBT). METHODS: Of 79 patients who had received lamivudine therapy for 9-57 mo, 34 were HBeAg-positive and 45 were HBeAg-negative, 24 developed virologic breakthrough and 55 did not. Clinical and virologic factors were compared between the two groups. RESULTS: The median duration of therapy was 25 (9-57) mo. Virologic breakthrough was defined as a > 1 log HBV DNA increase following initial suppression. When several factors, including gender, duration of infection, baseline HBV DNA, and baseline ALT in HBeAg-positive chronic hepatitis patients were analyzed by logistic regression, the most important predictor of virologic breakthrough was the baseline HBV DNA (r2 = 0.12, P < 0.05). When HBeAg-postitive chronic hepatitis patients were divided into two groups by a point of 6.6 log HBV DNA, the incidence of virologic breakthough between two groups was significantly different. CONCLUSION: Lamivudine may remain an effective first line therapy for those HBeAg-positive patients with a baseline HBV DNA < 6.6 log10 copies/mL.展开更多
Dimensional analysis and numerical simulations were carried out to research prediction method of breakthrough time of horizontal wells in bottom water reservoir. Four dimensionless independent variables and dimensionl...Dimensional analysis and numerical simulations were carried out to research prediction method of breakthrough time of horizontal wells in bottom water reservoir. Four dimensionless independent variables and dimensionless time were derived from 10 influencing factors of the problem by using dimensional analysis. Simulations of horizontal well in reservoir with bottom water were run to find the prediction correlation. A general and concise functional relationship for predicting breakthrough time was established based on simulation results and theoretical analysis. The breakthrough time of one conceptual model predicted by the correlation is very close to the result by Eclipse with less than 2% error. The practical breakthrough time of one well in Helder oilfield is 10 d, and the predicted results by the method is 11.2 d, which is more accurate than the analytical result. Case study indicates that the method could predict breakthrough time of horizontal well under different reservoir conditions accurately. For its university and ease of use, the method is suitable for quick prediction of breakthrough time.展开更多
The Qinling tunnel with length of 18. 488km is located on the railway line from Xi’ an (Shanxi Province) to Ankan (Sichuan Province) in the middle of Qinling moun- tain. It is the longest double track railway tunnel ...The Qinling tunnel with length of 18. 488km is located on the railway line from Xi’ an (Shanxi Province) to Ankan (Sichuan Province) in the middle of Qinling moun- tain. It is the longest double track railway tunnel in China and takes the third place in the world. According to the design, the break-through error in vertical direction caused by the al- timetric control surveying is limited to 18mm for the case of one piercing face. Because the leveling route reaches over 120km in length and must go over two mountains in 2 800m height, the first-order precise leveling and precise gravity measurement should be carried out in the construction stage. In this paper the field leveling approach, the application of new technology,some experience as well as the office calculation with final results analysis are in- troduced. By meticulous planning, organization and observation, the final accuracy of vertical difference between two tunnel end points is only 8mm, and it provides reliable surveying guarantee for this great tunnel engineering. Finally it is pointed out that this vertical differ- ence distinguishes obviously from the primary measurement result as high as 114mm. It means that the primary result is not accurate enough.展开更多
Based on the damage analysis of elliptical aperture,the mechanism of coal damagein the developing process of coal and gas outburst was researched.The results show thatthe damage to coal by gas is mainly caused by the ...Based on the damage analysis of elliptical aperture,the mechanism of coal damagein the developing process of coal and gas outburst was researched.The results show thatthe damage to coal by gas is mainly caused by the concentrated tensile stress appearing nearthe endpoint of the pores.Fractures in coal,gas pressure,ground stress and the tensilestrength of the coal matrix are the major controlling factors of this kind of damage.When theground stress releases abruptly and the gas pressure is high,tensile failure will occur aroundthe endpoint of the small pores due to gas pressure,and the coal may be broken up like powder;this is called pulverization.Otherwise,when the gas pressure is low,the tensile stress canonly occur around the endpoint of the large pores and fractures due to gas pressure,the fracturesin coal extend and link together,the fracture extension direction is statistically perpendicularto the direction of the minor principal stress.This kind of damage is shown as the stratifiedspall around the outburst hole.展开更多
Layered structures with upper porous and lower fractured media are widely distributed in the world. An experimen- tal investigation on rainfall infiltration and solute transport in such layered structures can provide ...Layered structures with upper porous and lower fractured media are widely distributed in the world. An experimen- tal investigation on rainfall infiltration and solute transport in such layered structures can provide the necessary foundation for effectively preventing and forecasting water bursting in mines, controlling contamination of mine water, and accomplishing ecological restoration of mining areas. A typical physical model of the layered structures with porous and fractured media was created in this study. Then rainfall infiltration experiments were conducted after salt solution was sprayed on the surface of the layered structure. The volumetric water content and concentration of chlorine ions at different specified positions along the profile of the experiment system were measured in real-time. The experimental results showed that the lower fractured media, with a considerably higher permeability than that of the upper porous media, had significant effects on preventing water infil- tration. Moreover, although the porous media were homogeneous statistically in the whole domain, spatial variations in the features of effluent concentrations with regards to time, or so called breakthrough curves, at various sampling points located at the horizontal plane in the porous media near the porous-fractured interface were observed, indicating the diversity of solute transport at small scales. Furthermore, the breakthrough curves of the outflow at the bottom, located beneath the underlying fractured rock, were able to capture and integrate features of the breakthrough curves of both the upper porous and fractured media, which exhibited multiple peaks, while the peak values were reduced one by one with time.展开更多
In recent years,air-foam combining the advantages of both liquid and air drilling has been utilized as a drilling medium. Air-foam drilling has proved its efficiency in numerous situations where serious problems were ...In recent years,air-foam combining the advantages of both liquid and air drilling has been utilized as a drilling medium. Air-foam drilling has proved its efficiency in numerous situations where serious problems were encountered,such as in fractured formations and depleted or high permeable zones. However,the major disadvantage of air-foam drilling system is that the foam can only be used once,so that an extremely large pit is required to contain the foam to allow sufficient room for cuttings and for the foam to dissipate. Moreover,it needs enormous volume prepared,consuming abundance of water and ingredient additives,which results in the high cost of foam drilling. The recycling foam fluid by using foam breaking technology is the only effective method to solve these problems associated with the known foam drilling. Various types of equipment and technique have been employed to suppress foam formation in biological and process equipment in foam drilling. The study described various methods of foam breaking technology,and the trend of the foam breaking technology for foam drilling is discussed.展开更多
Up to now there is no specification about the allowance of lateral breakthrough error for super long tunnel from 20 km to 50 km. On the basis of the design of GPS networks located outside and inside tunnel traverse ne...Up to now there is no specification about the allowance of lateral breakthrough error for super long tunnel from 20 km to 50 km. On the basis of the design of GPS networks located outside and inside tunnel traverse network, we propose a method for calculating the influence value caused by control surveying errors. Through a lot of simulative calculations and combination with piercing practice of super tunnels in Wan Jiazai Project, Shanxi province, we present an allowance table of lateral breakthrough error for super long tunnels from 20 km to 50 km.展开更多
Accurate physical and chemical properties of adsorbents are required for the efficient design of fixed bed adsorbers. The bed void and particle void are significant physical properties. One of the experimentally deter...Accurate physical and chemical properties of adsorbents are required for the efficient design of fixed bed adsorbers. The bed void and particle void are significant physical properties. One of the experimentally determination technique for the bed void is a breakthrough curve method. In the present paper, experimental conditions for determining the bed void from breakthrough curve were investigated because complex conditions are required. The values of bed void were determined from theoretical elution curve at the point of c/c0 = 0.5 under the condition of negligible amount adsorbed. The bed void value determined from elution curve was clearly affected by particle void and fluid velocity, and regarded as ＂apparent＂ bed void values. For large porosity particles, it was difficult to determine the true bed void value due to the effect of penetration into macro pores. Then, the bed void fraction can be determined safely from breakthrough curve when particles possessing small particle void are used.展开更多
Dongjiahe Coal Mine belongs to the Carboniferous Permian coal field which has a high degree of karst and fissure development.This paper takes the working face of Dongjiahe Coal Mine as an example;through the microseis...Dongjiahe Coal Mine belongs to the Carboniferous Permian coal field which has a high degree of karst and fissure development.This paper takes the working face of Dongjiahe Coal Mine as an example;through the microseismic(MS)monitoring system arranged on the working face,the moment tensor theory was used to invert the focal mechanism solution of the anomalous area of the floor MS event;combining the numerical simulation and field data,the underlying floor faults were identified by the stress inversion method.The results show that:1)Moment tensors were decomposed into three components and the main type of rupture in this area is mixed failure according to the relative criterion;2)The hidden fault belongs to the reversed fault,its dip angle is approximately 70°,and the rupture length is 21 m determined by the inversion method of the initial dynamic polarity and stress in the focal mechanism;3)The failure process of the fault is divided into three stages by numerical simulation method combined with the temporal and spatial distribution of MS events.The results can provide a reference for early warning and evaluation of similar coal mine water inrush risks.展开更多
基金Supported by the research grant of the Chungbuk National University in 2004
文摘AIM: To identify the factors associated with virologic breakthrough and to select a subgroup of patients who respond well to lamivudine without developing virologic breakthrough (VBT). METHODS: Of 79 patients who had received lamivudine therapy for 9-57 mo, 34 were HBeAg-positive and 45 were HBeAg-negative, 24 developed virologic breakthrough and 55 did not. Clinical and virologic factors were compared between the two groups. RESULTS: The median duration of therapy was 25 (9-57) mo. Virologic breakthrough was defined as a > 1 log HBV DNA increase following initial suppression. When several factors, including gender, duration of infection, baseline HBV DNA, and baseline ALT in HBeAg-positive chronic hepatitis patients were analyzed by logistic regression, the most important predictor of virologic breakthrough was the baseline HBV DNA (r2 = 0.12, P < 0.05). When HBeAg-postitive chronic hepatitis patients were divided into two groups by a point of 6.6 log HBV DNA, the incidence of virologic breakthough between two groups was significantly different. CONCLUSION: Lamivudine may remain an effective first line therapy for those HBeAg-positive patients with a baseline HBV DNA < 6.6 log10 copies/mL.
基金Project(2011ZX05009-004)supported by the National Science and Technology Major Projects of China
文摘Dimensional analysis and numerical simulations were carried out to research prediction method of breakthrough time of horizontal wells in bottom water reservoir. Four dimensionless independent variables and dimensionless time were derived from 10 influencing factors of the problem by using dimensional analysis. Simulations of horizontal well in reservoir with bottom water were run to find the prediction correlation. A general and concise functional relationship for predicting breakthrough time was established based on simulation results and theoretical analysis. The breakthrough time of one conceptual model predicted by the correlation is very close to the result by Eclipse with less than 2% error. The practical breakthrough time of one well in Helder oilfield is 10 d, and the predicted results by the method is 11.2 d, which is more accurate than the analytical result. Case study indicates that the method could predict breakthrough time of horizontal well under different reservoir conditions accurately. For its university and ease of use, the method is suitable for quick prediction of breakthrough time.
文摘The Qinling tunnel with length of 18. 488km is located on the railway line from Xi’ an (Shanxi Province) to Ankan (Sichuan Province) in the middle of Qinling moun- tain. It is the longest double track railway tunnel in China and takes the third place in the world. According to the design, the break-through error in vertical direction caused by the al- timetric control surveying is limited to 18mm for the case of one piercing face. Because the leveling route reaches over 120km in length and must go over two mountains in 2 800m height, the first-order precise leveling and precise gravity measurement should be carried out in the construction stage. In this paper the field leveling approach, the application of new technology,some experience as well as the office calculation with final results analysis are in- troduced. By meticulous planning, organization and observation, the final accuracy of vertical difference between two tunnel end points is only 8mm, and it provides reliable surveying guarantee for this great tunnel engineering. Finally it is pointed out that this vertical differ- ence distinguishes obviously from the primary measurement result as high as 114mm. It means that the primary result is not accurate enough.
基金Supported by the National Basic Research Program(973)of China(2005CB221503)the Key Project of Natural Science Foundation of China(50534080)
文摘Based on the damage analysis of elliptical aperture,the mechanism of coal damagein the developing process of coal and gas outburst was researched.The results show thatthe damage to coal by gas is mainly caused by the concentrated tensile stress appearing nearthe endpoint of the pores.Fractures in coal,gas pressure,ground stress and the tensilestrength of the coal matrix are the major controlling factors of this kind of damage.When theground stress releases abruptly and the gas pressure is high,tensile failure will occur aroundthe endpoint of the small pores due to gas pressure,and the coal may be broken up like powder;this is called pulverization.Otherwise,when the gas pressure is low,the tensile stress canonly occur around the endpoint of the large pores and fractures due to gas pressure,the fracturesin coal extend and link together,the fracture extension direction is statistically perpendicularto the direction of the minor principal stress.This kind of damage is shown as the stratifiedspall around the outburst hole.
基金Supported by ihe Major State Basic Research Development Program of China （973 Program） （2010CB428801, 2010CB428804） the National Science Foundation of China （40972166）+1 种基金 the Major Science and Technology Program for Water Pollution Control and Treatment （2009ZX07212-003） the Technology Development and Applications for Ecology System Reconstruction and Restoration of Yongding River （D08040903700000）
文摘Layered structures with upper porous and lower fractured media are widely distributed in the world. An experimen- tal investigation on rainfall infiltration and solute transport in such layered structures can provide the necessary foundation for effectively preventing and forecasting water bursting in mines, controlling contamination of mine water, and accomplishing ecological restoration of mining areas. A typical physical model of the layered structures with porous and fractured media was created in this study. Then rainfall infiltration experiments were conducted after salt solution was sprayed on the surface of the layered structure. The volumetric water content and concentration of chlorine ions at different specified positions along the profile of the experiment system were measured in real-time. The experimental results showed that the lower fractured media, with a considerably higher permeability than that of the upper porous media, had significant effects on preventing water infil- tration. Moreover, although the porous media were homogeneous statistically in the whole domain, spatial variations in the features of effluent concentrations with regards to time, or so called breakthrough curves, at various sampling points located at the horizontal plane in the porous media near the porous-fractured interface were observed, indicating the diversity of solute transport at small scales. Furthermore, the breakthrough curves of the outflow at the bottom, located beneath the underlying fractured rock, were able to capture and integrate features of the breakthrough curves of both the upper porous and fractured media, which exhibited multiple peaks, while the peak values were reduced one by one with time.
基金Project supported by the Key Science &Technology Research Program of Zhongyuan Petroleum Exploration Bureau (No.20083022)
文摘In recent years,air-foam combining the advantages of both liquid and air drilling has been utilized as a drilling medium. Air-foam drilling has proved its efficiency in numerous situations where serious problems were encountered,such as in fractured formations and depleted or high permeable zones. However,the major disadvantage of air-foam drilling system is that the foam can only be used once,so that an extremely large pit is required to contain the foam to allow sufficient room for cuttings and for the foam to dissipate. Moreover,it needs enormous volume prepared,consuming abundance of water and ingredient additives,which results in the high cost of foam drilling. The recycling foam fluid by using foam breaking technology is the only effective method to solve these problems associated with the known foam drilling. Various types of equipment and technique have been employed to suppress foam formation in biological and process equipment in foam drilling. The study described various methods of foam breaking technology,and the trend of the foam breaking technology for foam drilling is discussed.
文摘Up to now there is no specification about the allowance of lateral breakthrough error for super long tunnel from 20 km to 50 km. On the basis of the design of GPS networks located outside and inside tunnel traverse network, we propose a method for calculating the influence value caused by control surveying errors. Through a lot of simulative calculations and combination with piercing practice of super tunnels in Wan Jiazai Project, Shanxi province, we present an allowance table of lateral breakthrough error for super long tunnels from 20 km to 50 km.
文摘Accurate physical and chemical properties of adsorbents are required for the efficient design of fixed bed adsorbers. The bed void and particle void are significant physical properties. One of the experimentally determination technique for the bed void is a breakthrough curve method. In the present paper, experimental conditions for determining the bed void from breakthrough curve were investigated because complex conditions are required. The values of bed void were determined from theoretical elution curve at the point of c/c0 = 0.5 under the condition of negligible amount adsorbed. The bed void value determined from elution curve was clearly affected by particle void and fluid velocity, and regarded as ＂apparent＂ bed void values. For large porosity particles, it was difficult to determine the true bed void value due to the effect of penetration into macro pores. Then, the bed void fraction can be determined safely from breakthrough curve when particles possessing small particle void are used.
基金Project(2017YFC1503103)supported by the National Key Research and Development Plan of ChinaProjects(51774064,51974055,41941018)supported by the National Natural Science Foundation of China+1 种基金Project(DUT20GJ216)supported by the Fundamental Research Funds for the Central Universities,ChinaProject(51627804)supported by the Special-Funded Program on National Key Scientific Instruments and Equipment Development,China。
文摘Dongjiahe Coal Mine belongs to the Carboniferous Permian coal field which has a high degree of karst and fissure development.This paper takes the working face of Dongjiahe Coal Mine as an example;through the microseismic(MS)monitoring system arranged on the working face,the moment tensor theory was used to invert the focal mechanism solution of the anomalous area of the floor MS event;combining the numerical simulation and field data,the underlying floor faults were identified by the stress inversion method.The results show that:1)Moment tensors were decomposed into three components and the main type of rupture in this area is mixed failure according to the relative criterion;2)The hidden fault belongs to the reversed fault,its dip angle is approximately 70°,and the rupture length is 21 m determined by the inversion method of the initial dynamic polarity and stress in the focal mechanism;3)The failure process of the fault is divided into three stages by numerical simulation method combined with the temporal and spatial distribution of MS events.The results can provide a reference for early warning and evaluation of similar coal mine water inrush risks.
