Objective Coronary artery bypass grafting （CABG） is gradually increasing in the elderly population. We aimed to investigate the risk factors and the results of CABG along with the long term survival in patients at a...Objective Coronary artery bypass grafting （CABG） is gradually increasing in the elderly population. We aimed to investigate the risk factors and the results of CABG along with the long term survival in patients at an age of 80 and older. Methods Between Januaa-y 2002 and December 201 I, a total of i01 consecutive patients at an age of S0 and older who underwent CABG in our hospital were included in the study. The patients were followed and the long-term survival was estimated. Results The mean age of the patients was 82.98 ~ 2.27 years. Sixty-four （63.4%） were males and 37 （36.6%） were females. Emergency surgery, duration of cardiopulmonary bypass, the intensive care unit （ICU） stay, inotropic support, intra aortic balloon pulsation application, amount oferythrocyte transfusion and flesh frozen plasma transfusion and ventilation period were significantly higher in the patients who died in the hospital. The duration of cardiopulmonary bypass （CPB） was found to be an inde- pendent predictor of mortality （OR： 1.18, 95% CI 1.01-1.38, P = 0.034）. The in-hospital mortality was 16.8%. Kaplan-Meier analyses revealed a survival ratio of 91.3% at one year, 82.9% at three years and 69.0% at five years. Conclusions Patients at the age of 80 and older can be candidates for the CABG procedure bearing in mind that they may have a longer ventilation period and intensive care unit stay. The morbidity and mortality of this age group is considered within an acceptable range. Approaches to minimize CPB, or the choice of off-pump surgery, may be a preventive method to lower the incidence of mortality. Hence, CABG may be performed in this age group with a satisfactory survival ratio.展开更多
The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups, the p38 group of MAP kinases, serve...The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups, the p38 group of MAP kinases, serve as a nexus for signal transduction and play a vital role in numerous biological processes. In this review, we highlight the known characteristics and components of the p38 pathway along with the mechanism and consequences of p38 activation. We focus on the role of p38 as a signal transduction mediator and examine the evidence linking p38 to inflammation, cell cycle, cell death, development, cell differentiation, senescence and tumorigenesis in specific cell types. Upstream and downstream components of p38 are described and questions remaining to be answered are posed. Finally, we propose several directions for future research on p38.展开更多
Taiwan had officially entered aging society in 1993, and meantime the birthrate reaches its lowest point again and again. The constitution of population dramatically turns into an elder and low-birthrate society. Ther...Taiwan had officially entered aging society in 1993, and meantime the birthrate reaches its lowest point again and again. The constitution of population dramatically turns into an elder and low-birthrate society. Therefore, the ratio of elders living along is increasing yearly. When the elders need to deal the illness and go to hospital along, decays come from degeneration might have affect on their activity in accessible environment in hospital. Signs is a vital tool for delivering and communicating information in the road sign system. Whether the elders can identify the signs in hospital clearly becomes an important issue in the current research. To understand the affect of signs design in hospital to elders, the research reviewed and gained insight of degeneration in both physical and psychological of elders and the proper principal of signs design for elders. The research surveys in Taipei City, which has densest medical center, and mainly focus on National Taiwan University College of Medicine, which has hundred years of history （founded in 1895）. The research conducts field survey in both old and new buildings of National Taiwan University College of Medicine in August, 2015. The survey includes five types of signs design： Public Facilities, Prohibition, Safety, Warning, and Commercial Facilities. The result from article review indicates the most salient psychological degenerations includes the change in cognitive function, decay of memory, and deceleration of information processing; physical degenerations includes the decay of vision. As a result, the following properties should be taken into consideration when designing sings for elders： （1） The proper ratio of graphic and text. （2） Avoid using colors or matches difficult to identify by elders, like purple, blue, and green. （3） Take the visibility, legibility, identity, attention, and memory into consideration, there should be 70% differentiation in contrast between text of sign and background. （4） Avoid using multi-meaning graphic, keep the design simple. The result from the survey of National Yaiwan University College of Medicine indicates： （1） Using mainly on graphic and text as subsidiary, part of the sign design using both Chinese and English, and make sure the appropriateness of ratio between graphic and text. Use more of sans-serif font, which has better legibility. （2） Match the color mainly as yellow background with black graphic, blue background with white graphic, white background with black graphic, white background with blue graphic, a strong contrast between background and graphic on brightness and chroma matches the principle of visibility, legibility, and identity. （3） Simplify the signs design may safeguard its visibility. When elder need to handle illness comes from degeneration alone and go to large and complex hospitals frequently, the decay of their mental and physical might have a huge negative affect. Therefore, the signs design in hospital should understand their properties and design signs that match their requirement, to safeguard their live independency.展开更多
Objectives To investigate the procedure characteristics and long term follow-up ofpercutaneous coronary intervention （PCI） for sa phaneous vein graft （SVG） lesions in the elderly patients. Methods From December 20...Objectives To investigate the procedure characteristics and long term follow-up ofpercutaneous coronary intervention （PCI） for sa phaneous vein graft （SVG） lesions in the elderly patients. Methods From December 2005 to December 201 l, 84 graft lesions were treated percumneously. Seventeen were located at proximal anastomosis, 48 were located at SVG body, 19 were located at distal anastomosis. Pri mary endpoint was defined as major adverse cardiovascular events （MACE, composite of cardiac death, target vessel revascularization, acute myocardial infarction）. Results The graft age was 6.7 i 4.0 years. Most anastomosis lesions （80.0%） presented within one year post coro-nary artery bypass grafting （CABG）. Proximal anastomosis lesion had the lowest successful rate for PCI compared with graft body and distal anastomosis lesions （70.6% vs. 91.7%, 79.0%, P 〈 0.05）. The distal embolic protection device was used in 19.1% of patients, most frequently used in body graft PCI （29.2%, P 〈 0.01）. The diameter of the stent was smallest in distal anastomosis group （2.9 ±0.4 mm, P 〈 0.05）. The highest post dilatation pressure was required in the proximal anastomosis （17.8 ± 2.7 atm, P 〈 0.05）. The patients were followed up for 24.3 ±16.9 months. MACE occurred in 18.57% of patients. Incidence of MACE was highest among proximal anastomosis PCI （47.1% vs. body graft PCI 16.7%, distal anastomosis PCI 21.1%; P 〈 0.05）. Old myocardial infarction was the predictive factor for the poor clinical outcomes （P〈 0.04）. Conclusions PCI of SVG lesions is feasible with lower success rate. PCI of ostial graft anastomosis lesions had the lowest procedure success rate and highest MACE rate compared with graft body and distal anastomosis lesions. Old myocardial infarction was a predictive factor of poor outcomes.展开更多
With the aging process, people been looked after properly in the old age has already become an important index to the national happiness index. Nowadays, government has a increasingly clear roadmap in promoting the de...With the aging process, people been looked after properly in the old age has already become an important index to the national happiness index. Nowadays, government has a increasingly clear roadmap in promoting the development of pension system. Pension system unification refers to the same pension system for workers in public institutions and enterprises. It is a relative concept to the dual pension system. It has positive effect on social equity. But it also has many problems. In this article, author explained the relation between pension system unification and social equity on the basic of analyzing viewpoints of several scholars. And make comments by extending it and analyzing it.展开更多
In nanoscale technology, transistor aging is one of the most critical problems that impact on the reliability of circuits. Aging sensor is a good online way to detect the circuit aging, which performs during the opera...In nanoscale technology, transistor aging is one of the most critical problems that impact on the reliability of circuits. Aging sensor is a good online way to detect the circuit aging, which performs during the operating time with no influence of the normal operation of circuits. In this paper, a Dou- ble-edge-triggered Detection Sensor for circuit Aging （DSDA） is proposed, which employs data signal of logic circuits as its clock to control the sampling process. The simulation is done by Hspice using 45 nm technology. The results show that this technique is not case of the detection precision is more than 80% under aging fault effectively with the 8% power cost and 30% sensitive to the process variations. The worst the different process variations. It can detect performance cost.展开更多
The value of social security funds, has always been an important part of our country social security enterprise as a whole, it is the one of the main ways to realize the social stability and national economic income. ...The value of social security funds, has always been an important part of our country social security enterprise as a whole, it is the one of the main ways to realize the social stability and national economic income. In the triple pressure with ageing population, inflation and social security transition, the value of the social security fund in our country is particularly acute. Analyses the receipts and expenditures of social security funds, investment and operation structure and put forward some rationalization proposal, which has significant meaning for a better play to the role of the social security fund and actively promote the innovation and development of China＇s social security fund management.展开更多
Geriatric patients affected by stable multi-vessel coronary artery disease （CAD） are at the crossroad： they can live with the risks of acute coronary syndrome, malignant arrhythmias or heart failure, or they can un...Geriatric patients affected by stable multi-vessel coronary artery disease （CAD） are at the crossroad： they can live with the risks of acute coronary syndrome, malignant arrhythmias or heart failure, or they can undergo a rapid evaluation for myocardial revascularization.展开更多
Drainage layers provide permanent relief of hydrostatic water pressure, while the waterproof liner prevents any ingress of water into the tunnel. The durability and aging resistance of drainage membranes are of primar...Drainage layers provide permanent relief of hydrostatic water pressure, while the waterproof liner prevents any ingress of water into the tunnel. The durability and aging resistance of drainage membranes are of primary concern. This paper describes advantages and concerns related to the usage of, and the design with, polymeric drainboards in tunnel construction. Common degradation mechanisms associated with HDPE （high density polyethylene） sheets are described. The stringent requirements for the Gotthard Alpine Railway Tunnel through the Swiss Alps, e.g., high ambient temperatures of up to 45 ℃ and an expected service life of up to 100 years require outstanding aging resistance of polymeric drainage materials. The paper describes the methods deployed to investigate the long-term performance of HDPE drainboards, focusing on aging mechanisms. Details associated with the test procedures developed to reflect the specific properties of drainboards, as well as the results obtained, are presented. A summary table shows recommended product specifications needed to confine the aging properties of drainboards and to design a system performing adequately during the entire lifetime of the structure.展开更多
When a liquid is supercooled,its structural equilibration timeτeqincreases sharply approaching the glass transition temperature Tg,below which it is kinetically arrested in the out of equilibrium glassy state.Upon an...When a liquid is supercooled,its structural equilibration timeτeqincreases sharply approaching the glass transition temperature Tg,below which it is kinetically arrested in the out of equilibrium glassy state.Upon annealing below Tg,such glassy state relaxes toward the equilibrium state.There is growing evidence that such relaxation process is quite complex,influenced by the complexity of the potential energy landscape.Here we report the observation of a hierarchical aging pathway in the process of the glass-to-supercooled liquid transition in various molecular glass forming systems.Differential scanning calorimetry reveals that the glassy state upon annealing below Tgfirstly enters a transient metastable supercooled liquid state with slightly higher enthalpies than that of the equilibrium supercooled liquid state when extrapolated to below Tg.This observation is also confirmed by structural measurements via Raman scattering.The dynamics of the transient metastable-to-stable supercooled liquid transition exhibits characteristics of thermodynamic transition at spinodal temperature Tspslightly above Tg,leading to anomalous behaviors such as the appearance of a transition-like behavior in the plot of fragility measurements.These observations imply that the free energy landscape of the supercooled liquid develops complexity with qualitative changes approaching Tgand could have strong influence on the process of the glass transition.展开更多
：Objective：To study the epidemiologic characteristics of traffic injuries among people over 60 years old in the Nan＇ an district（urban）and Jiangjin district（rural）of Chongqing,and to discuss the corresponding s...：Objective：To study the epidemiologic characteristics of traffic injuries among people over 60 years old in the Nan＇ an district（urban）and Jiangjin district（rural）of Chongqing,and to discuss the corresponding strategies for its prevention and cure.Methods：Records of traffic injuries in people over 60 years old registered by the traffic police between 2000 and 2006 in Nan＇an district and Jiangjin district were collected in the Database of Road Traffic Accidents and Traffic Injuries.Epidemiologic characteristics of traffic injuries among the aged people were analyzed and compared.Results：Between the year 2000 and 2006,the average annual incidence of traffic injuries and mortality rate in the aged people in Nan＇ an district were 124.62/100 000 and 13.85/100 000 respectively,higher than that in Jiangjin district（27.49/100 000,7.13/100 000,P〈0.01）.However,the mortality rate for the aged people who were involved in traffic injuries in Jiangjin district was 20.60%,higher than that in Nan＇an district（10.00%,P〈0.01）.Head injury was the primary cause of death.Totally 76.58% of casualties were pedestrians.Over 90% of the traffic accidents occurred in the areas with no traffic signal or traffic control system.Conclusions：The traffic environment is unfavorable to the aged people.It is important to enhance traffic safety consciousness of drivers and the elderly and to strengthen traffic safety system and traffic law,so as to provide a safe road traffic environment for the aged people.展开更多
文摘Objective Coronary artery bypass grafting （CABG） is gradually increasing in the elderly population. We aimed to investigate the risk factors and the results of CABG along with the long term survival in patients at an age of 80 and older. Methods Between Januaa-y 2002 and December 201 I, a total of i01 consecutive patients at an age of S0 and older who underwent CABG in our hospital were included in the study. The patients were followed and the long-term survival was estimated. Results The mean age of the patients was 82.98 ~ 2.27 years. Sixty-four （63.4%） were males and 37 （36.6%） were females. Emergency surgery, duration of cardiopulmonary bypass, the intensive care unit （ICU） stay, inotropic support, intra aortic balloon pulsation application, amount oferythrocyte transfusion and flesh frozen plasma transfusion and ventilation period were significantly higher in the patients who died in the hospital. The duration of cardiopulmonary bypass （CPB） was found to be an inde- pendent predictor of mortality （OR： 1.18, 95% CI 1.01-1.38, P = 0.034）. The in-hospital mortality was 16.8%. Kaplan-Meier analyses revealed a survival ratio of 91.3% at one year, 82.9% at three years and 69.0% at five years. Conclusions Patients at the age of 80 and older can be candidates for the CABG procedure bearing in mind that they may have a longer ventilation period and intensive care unit stay. The morbidity and mortality of this age group is considered within an acceptable range. Approaches to minimize CPB, or the choice of off-pump surgery, may be a preventive method to lower the incidence of mortality. Hence, CABG may be performed in this age group with a satisfactory survival ratio.
文摘The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups, the p38 group of MAP kinases, serve as a nexus for signal transduction and play a vital role in numerous biological processes. In this review, we highlight the known characteristics and components of the p38 pathway along with the mechanism and consequences of p38 activation. We focus on the role of p38 as a signal transduction mediator and examine the evidence linking p38 to inflammation, cell cycle, cell death, development, cell differentiation, senescence and tumorigenesis in specific cell types. Upstream and downstream components of p38 are described and questions remaining to be answered are posed. Finally, we propose several directions for future research on p38.
文摘Taiwan had officially entered aging society in 1993, and meantime the birthrate reaches its lowest point again and again. The constitution of population dramatically turns into an elder and low-birthrate society. Therefore, the ratio of elders living along is increasing yearly. When the elders need to deal the illness and go to hospital along, decays come from degeneration might have affect on their activity in accessible environment in hospital. Signs is a vital tool for delivering and communicating information in the road sign system. Whether the elders can identify the signs in hospital clearly becomes an important issue in the current research. To understand the affect of signs design in hospital to elders, the research reviewed and gained insight of degeneration in both physical and psychological of elders and the proper principal of signs design for elders. The research surveys in Taipei City, which has densest medical center, and mainly focus on National Taiwan University College of Medicine, which has hundred years of history （founded in 1895）. The research conducts field survey in both old and new buildings of National Taiwan University College of Medicine in August, 2015. The survey includes five types of signs design： Public Facilities, Prohibition, Safety, Warning, and Commercial Facilities. The result from article review indicates the most salient psychological degenerations includes the change in cognitive function, decay of memory, and deceleration of information processing; physical degenerations includes the decay of vision. As a result, the following properties should be taken into consideration when designing sings for elders： （1） The proper ratio of graphic and text. （2） Avoid using colors or matches difficult to identify by elders, like purple, blue, and green. （3） Take the visibility, legibility, identity, attention, and memory into consideration, there should be 70% differentiation in contrast between text of sign and background. （4） Avoid using multi-meaning graphic, keep the design simple. The result from the survey of National Yaiwan University College of Medicine indicates： （1） Using mainly on graphic and text as subsidiary, part of the sign design using both Chinese and English, and make sure the appropriateness of ratio between graphic and text. Use more of sans-serif font, which has better legibility. （2） Match the color mainly as yellow background with black graphic, blue background with white graphic, white background with black graphic, white background with blue graphic, a strong contrast between background and graphic on brightness and chroma matches the principle of visibility, legibility, and identity. （3） Simplify the signs design may safeguard its visibility. When elder need to handle illness comes from degeneration alone and go to large and complex hospitals frequently, the decay of their mental and physical might have a huge negative affect. Therefore, the signs design in hospital should understand their properties and design signs that match their requirement, to safeguard their live independency.
文摘Objectives To investigate the procedure characteristics and long term follow-up ofpercutaneous coronary intervention （PCI） for sa phaneous vein graft （SVG） lesions in the elderly patients. Methods From December 2005 to December 201 l, 84 graft lesions were treated percumneously. Seventeen were located at proximal anastomosis, 48 were located at SVG body, 19 were located at distal anastomosis. Pri mary endpoint was defined as major adverse cardiovascular events （MACE, composite of cardiac death, target vessel revascularization, acute myocardial infarction）. Results The graft age was 6.7 i 4.0 years. Most anastomosis lesions （80.0%） presented within one year post coro-nary artery bypass grafting （CABG）. Proximal anastomosis lesion had the lowest successful rate for PCI compared with graft body and distal anastomosis lesions （70.6% vs. 91.7%, 79.0%, P 〈 0.05）. The distal embolic protection device was used in 19.1% of patients, most frequently used in body graft PCI （29.2%, P 〈 0.01）. The diameter of the stent was smallest in distal anastomosis group （2.9 ±0.4 mm, P 〈 0.05）. The highest post dilatation pressure was required in the proximal anastomosis （17.8 ± 2.7 atm, P 〈 0.05）. The patients were followed up for 24.3 ±16.9 months. MACE occurred in 18.57% of patients. Incidence of MACE was highest among proximal anastomosis PCI （47.1% vs. body graft PCI 16.7%, distal anastomosis PCI 21.1%; P 〈 0.05）. Old myocardial infarction was the predictive factor for the poor clinical outcomes （P〈 0.04）. Conclusions PCI of SVG lesions is feasible with lower success rate. PCI of ostial graft anastomosis lesions had the lowest procedure success rate and highest MACE rate compared with graft body and distal anastomosis lesions. Old myocardial infarction was a predictive factor of poor outcomes.
文摘With the aging process, people been looked after properly in the old age has already become an important index to the national happiness index. Nowadays, government has a increasingly clear roadmap in promoting the development of pension system. Pension system unification refers to the same pension system for workers in public institutions and enterprises. It is a relative concept to the dual pension system. It has positive effect on social equity. But it also has many problems. In this article, author explained the relation between pension system unification and social equity on the basic of analyzing viewpoints of several scholars. And make comments by extending it and analyzing it.
基金Supported by the National Natural Science Foundation of China (No.61274036 and 61106038)Anhui Provincial Natural Science Foundation of China (No.090412034)
文摘In nanoscale technology, transistor aging is one of the most critical problems that impact on the reliability of circuits. Aging sensor is a good online way to detect the circuit aging, which performs during the operating time with no influence of the normal operation of circuits. In this paper, a Dou- ble-edge-triggered Detection Sensor for circuit Aging （DSDA） is proposed, which employs data signal of logic circuits as its clock to control the sampling process. The simulation is done by Hspice using 45 nm technology. The results show that this technique is not case of the detection precision is more than 80% under aging fault effectively with the 8% power cost and 30% sensitive to the process variations. The worst the different process variations. It can detect performance cost.
文摘The value of social security funds, has always been an important part of our country social security enterprise as a whole, it is the one of the main ways to realize the social stability and national economic income. In the triple pressure with ageing population, inflation and social security transition, the value of the social security fund in our country is particularly acute. Analyses the receipts and expenditures of social security funds, investment and operation structure and put forward some rationalization proposal, which has significant meaning for a better play to the role of the social security fund and actively promote the innovation and development of China＇s social security fund management.
文摘Geriatric patients affected by stable multi-vessel coronary artery disease （CAD） are at the crossroad： they can live with the risks of acute coronary syndrome, malignant arrhythmias or heart failure, or they can undergo a rapid evaluation for myocardial revascularization.
文摘Drainage layers provide permanent relief of hydrostatic water pressure, while the waterproof liner prevents any ingress of water into the tunnel. The durability and aging resistance of drainage membranes are of primary concern. This paper describes advantages and concerns related to the usage of, and the design with, polymeric drainboards in tunnel construction. Common degradation mechanisms associated with HDPE （high density polyethylene） sheets are described. The stringent requirements for the Gotthard Alpine Railway Tunnel through the Swiss Alps, e.g., high ambient temperatures of up to 45 ℃ and an expected service life of up to 100 years require outstanding aging resistance of polymeric drainage materials. The paper describes the methods deployed to investigate the long-term performance of HDPE drainboards, focusing on aging mechanisms. Details associated with the test procedures developed to reflect the specific properties of drainboards, as well as the results obtained, are presented. A summary table shows recommended product specifications needed to confine the aging properties of drainboards and to design a system performing adequately during the entire lifetime of the structure.
基金supported by the National Basic Research Program of China (2015CB856801)
文摘When a liquid is supercooled,its structural equilibration timeτeqincreases sharply approaching the glass transition temperature Tg,below which it is kinetically arrested in the out of equilibrium glassy state.Upon annealing below Tg,such glassy state relaxes toward the equilibrium state.There is growing evidence that such relaxation process is quite complex,influenced by the complexity of the potential energy landscape.Here we report the observation of a hierarchical aging pathway in the process of the glass-to-supercooled liquid transition in various molecular glass forming systems.Differential scanning calorimetry reveals that the glassy state upon annealing below Tgfirstly enters a transient metastable supercooled liquid state with slightly higher enthalpies than that of the equilibrium supercooled liquid state when extrapolated to below Tg.This observation is also confirmed by structural measurements via Raman scattering.The dynamics of the transient metastable-to-stable supercooled liquid transition exhibits characteristics of thermodynamic transition at spinodal temperature Tspslightly above Tg,leading to anomalous behaviors such as the appearance of a transition-like behavior in the plot of fragility measurements.These observations imply that the free energy landscape of the supercooled liquid develops complexity with qualitative changes approaching Tgand could have strong influence on the process of the glass transition.
文摘：Objective：To study the epidemiologic characteristics of traffic injuries among people over 60 years old in the Nan＇ an district（urban）and Jiangjin district（rural）of Chongqing,and to discuss the corresponding strategies for its prevention and cure.Methods：Records of traffic injuries in people over 60 years old registered by the traffic police between 2000 and 2006 in Nan＇an district and Jiangjin district were collected in the Database of Road Traffic Accidents and Traffic Injuries.Epidemiologic characteristics of traffic injuries among the aged people were analyzed and compared.Results：Between the year 2000 and 2006,the average annual incidence of traffic injuries and mortality rate in the aged people in Nan＇ an district were 124.62/100 000 and 13.85/100 000 respectively,higher than that in Jiangjin district（27.49/100 000,7.13/100 000,P〈0.01）.However,the mortality rate for the aged people who were involved in traffic injuries in Jiangjin district was 20.60%,higher than that in Nan＇an district（10.00%,P〈0.01）.Head injury was the primary cause of death.Totally 76.58% of casualties were pedestrians.Over 90% of the traffic accidents occurred in the areas with no traffic signal or traffic control system.Conclusions：The traffic environment is unfavorable to the aged people.It is important to enhance traffic safety consciousness of drivers and the elderly and to strengthen traffic safety system and traffic law,so as to provide a safe road traffic environment for the aged people.
