The localization for mine rescue robot in unknown space of coal mine emer- gency was researched,basing on the requirement of mine rescue robot localization which enters the scene of the coal mine accident,unknown circ...The localization for mine rescue robot in unknown space of coal mine emer- gency was researched,basing on the requirement of mine rescue robot localization which enters the scene of the coal mine accident,unknown circumstance,the unstructured, non-Gaussian and nonlinear work-space for robot works.The localization using particle filter was proposed to which is applied in mine rescue robot in unknown under-ground space.Meanwhile,focusing on severe particle sample degeneracy in the primary particle filter,an improved particle filter was proposed to reinforce the stability of particle filter.Be- ing compared with localization using extended Kalman filter through simulation experiment the localization using particle filter is proved to have more locating accuracy in unknown underground space and better computational real-time ability,which solves the pre-local- ization problem of robot underground.展开更多
Several high-profile coal mining accidents since 2006 that killed 27 coal miners have prompted the passing of the Mine Improvement and New Emergency Response Act of 2006 (MINER Act) which was signed into law in 2006,a...Several high-profile coal mining accidents since 2006 that killed 27 coal miners have prompted the passing of the Mine Improvement and New Emergency Response Act of 2006 (MINER Act) which was signed into law in 2006,and the proposed S-MINER Act of 2007,which passed the House of Representative in early 2008.The four coal mining accidents are described that are believed to be responsible for both the MINER Act and proposed S-MINER Act,and their potential impacts on the U.S.mining industry.展开更多
The rescue work of our country is facing with huge moral risk, the problem that the waste and the lack of resistance resources exist at the same time commands the realization of the accurate allocation of assistance r...The rescue work of our country is facing with huge moral risk, the problem that the waste and the lack of resistance resources exist at the same time commands the realization of the accurate allocation of assistance resources. Basing on the analysis of the characteristics and hazards of this population, the writer puts forward the suggestions to construct the urban vagrants＇ accurate rescue system with the relevant suggestions： perfecting the relief systern, fulfilling the basic functions of the relief management station, setting up an environment of sound laws and regulations. Take the temporary solution as the way and the permanent cure as the goal, not only achieve the resolve of the matter on surface, but also the matter of essence, enhance the overall viability of the urban wandering population.展开更多
Dystrobrevin-binding protein 1 （Dtnbp1） is one of the earliest identified schizophrenia susceptibility genes. Reduced expression of DTNBP1 is commonly found in brain areas of schizophrenic patients. Dtnbp1-nuU mutan...Dystrobrevin-binding protein 1 （Dtnbp1） is one of the earliest identified schizophrenia susceptibility genes. Reduced expression of DTNBP1 is commonly found in brain areas of schizophrenic patients. Dtnbp1-nuU mutant mice exhibit abnormalities in beha- viors and impairments in neuronal activities. However, how diminished DTNBP1 expression contributes to clinical relevant fea- tures of schizophrenia remains to be illustrated. Here, using a conditional Dtnbp1 knockout mouse line, we identified an in vivo schizophrenia-relevant function of DTNBP1 in pyramidal neurons of the medial prefrontal cortex （mPFC）. We demonstrated that DTNBP1 elimination specifically in pyramidal neurons of the mPFC impaired mouse pre-pu[se inhibition （PPI） behavior and reduced perisomatic GABAergic synapses. We further revealed that loss of DTNBP1 in pyramidal neurons diminished activity- dependent secretion of brain-derived neurotrophic factor （BDNF）. Finally, we showed that chronic BDNF infusion in the mPFC fully rescued both GABAergic synaptic dysfunction and PPI behavioral deficit induced by DTNBP1 elimination from pyramidal neurons. Our findings highlight brain region- and cell type-specific functions of DTNBP1 in the pathogenesis of schizophrenia, and under- score BDNF restoration as a potential therapeutic strategy for schizophrenia.展开更多
基金the National Natural Science Foundation of China(50674075)
文摘The localization for mine rescue robot in unknown space of coal mine emer- gency was researched,basing on the requirement of mine rescue robot localization which enters the scene of the coal mine accident,unknown circumstance,the unstructured, non-Gaussian and nonlinear work-space for robot works.The localization using particle filter was proposed to which is applied in mine rescue robot in unknown under-ground space.Meanwhile,focusing on severe particle sample degeneracy in the primary particle filter,an improved particle filter was proposed to reinforce the stability of particle filter.Be- ing compared with localization using extended Kalman filter through simulation experiment the localization using particle filter is proved to have more locating accuracy in unknown underground space and better computational real-time ability,which solves the pre-local- ization problem of robot underground.
文摘Several high-profile coal mining accidents since 2006 that killed 27 coal miners have prompted the passing of the Mine Improvement and New Emergency Response Act of 2006 (MINER Act) which was signed into law in 2006,and the proposed S-MINER Act of 2007,which passed the House of Representative in early 2008.The four coal mining accidents are described that are believed to be responsible for both the MINER Act and proposed S-MINER Act,and their potential impacts on the U.S.mining industry.
文摘The rescue work of our country is facing with huge moral risk, the problem that the waste and the lack of resistance resources exist at the same time commands the realization of the accurate allocation of assistance resources. Basing on the analysis of the characteristics and hazards of this population, the writer puts forward the suggestions to construct the urban vagrants＇ accurate rescue system with the relevant suggestions： perfecting the relief systern, fulfilling the basic functions of the relief management station, setting up an environment of sound laws and regulations. Take the temporary solution as the way and the permanent cure as the goal, not only achieve the resolve of the matter on surface, but also the matter of essence, enhance the overall viability of the urban wandering population.
文摘Dystrobrevin-binding protein 1 （Dtnbp1） is one of the earliest identified schizophrenia susceptibility genes. Reduced expression of DTNBP1 is commonly found in brain areas of schizophrenic patients. Dtnbp1-nuU mutant mice exhibit abnormalities in beha- viors and impairments in neuronal activities. However, how diminished DTNBP1 expression contributes to clinical relevant fea- tures of schizophrenia remains to be illustrated. Here, using a conditional Dtnbp1 knockout mouse line, we identified an in vivo schizophrenia-relevant function of DTNBP1 in pyramidal neurons of the medial prefrontal cortex （mPFC）. We demonstrated that DTNBP1 elimination specifically in pyramidal neurons of the mPFC impaired mouse pre-pu[se inhibition （PPI） behavior and reduced perisomatic GABAergic synapses. We further revealed that loss of DTNBP1 in pyramidal neurons diminished activity- dependent secretion of brain-derived neurotrophic factor （BDNF）. Finally, we showed that chronic BDNF infusion in the mPFC fully rescued both GABAergic synaptic dysfunction and PPI behavioral deficit induced by DTNBP1 elimination from pyramidal neurons. Our findings highlight brain region- and cell type-specific functions of DTNBP1 in the pathogenesis of schizophrenia, and under- score BDNF restoration as a potential therapeutic strategy for schizophrenia.
