48 patients with liver fibrosis due to hepatitis B were treated for 2 years with the drugs for tonifying the kidney, supplementing qi, cooling and invigorating the blood and detoxification. The symptoms were markedly ...48 patients with liver fibrosis due to hepatitis B were treated for 2 years with the drugs for tonifying the kidney, supplementing qi, cooling and invigorating the blood and detoxification. The symptoms were markedly improved, and serum ALT and bilirubin were recovered and kept normal in most of the cases. The mean levels of serum hyaluronic acid, procollagen peptide III and circulating immune complex were decreased and returned to normal after the treatment. B-ultrasonography showed that the portal vein kept in normal size in 82% of the patients, the enlarged portal vein diminished in diameter, and the enlarged spleen reduced.展开更多
I make an attempt in the paper to argue in favor of the person-centered view of good life, where becoming a good person involves seeking to qualitatively transform oneself into a worthy human being. I maintain that be...I make an attempt in the paper to argue in favor of the person-centered view of good life, where becoming a good person involves seeking to qualitatively transform oneself into a worthy human being. I maintain that becoming fully a person and respecting others as persons are achievements that are not assured for all of us. Thus, for the purpose I prepare the ground for an account of good life that rests on valuational consciousness. I propose that one may ascribe valuational consciousness to a person who is a value-sensitive rational being striving to attain a kind of inner transparency. Evidently, to say that a person has valuational consciousness is to stress the values, which are built into personal consciousness. The life of a person, whether that of truth, courage, nobility, justice, kindness, is a life marked by ego transcending personal consciousness that reaches out to humanity at large. And such a repository of values enables a human being to attain the ideal of good life. The ideal of good life, I contend, consists of attaining the higher order posture of selflessness--a posture of inner transparency. It is to shake off the egocentric partiality that characterizes our usual attitudinal stance towards one another.展开更多
The acrosome reaction （AR）, an absolute requirement for spermatozoa and egg fusion, requires the influx of Ca2＋ into the spermatozoa through voltage-dependent Ca2＋ channels and store-operated channels. Maitotoxin ...The acrosome reaction （AR）, an absolute requirement for spermatozoa and egg fusion, requires the influx of Ca2＋ into the spermatozoa through voltage-dependent Ca2＋ channels and store-operated channels. Maitotoxin （MTx）, a Ca2＋-mobilizing agent, has been shown to be a potent inducer of the mouse sperm AR, with a pharmacology similar to that of the zona pellucida （ZP）, possibly suggesting a common pathway for both inducers. Using recombinant human ZP3 （rhZP3）, mouse ZP and two MTx channel blockers （U73122 and U73343）, we investigated and compared the MTx- and ZP-induced ARs in human and mouse spermatozoa. Herein, we report that MTx induced AR and elevated intracellular Ca2＋ （[Ca2＋]~） in human spermatozoa, both of which were blocked by U73122 and U73343. These two compounds also inhibited the MTx-induced AR in mouse spermatozoa. In disagreement with our previous proposal, the AR triggered by rhZP3 or mouse ZP was not blocked by U73343, indicating that in human and mouse spermatozoa, the AR induction by the physiological ligands or by MTx occurred through distinct pathways. U73122, but not U73343 （inactive analogue）, can block phospholipase C （PLC）. Another PLC inhibitor, edelfosine, also blocked the rhZP3- and ZP-induced ARs. These findings confirmed the participation of a PLC-dependent signalling pathway in human and mouse zona protein-induced AR. Notably, edelfosine also inhibited the MTx-induced mouse sperm AR but not that of the human, suggesting that toxin-induced AR is PLC-dependent in mice and PLC-independent in humans.展开更多
In this paper, we conduct research on the literary reading and teaching form under the perspective of medical humanitiespermeation. The complex of human nature is that it not only has natural property, including socia...In this paper, we conduct research on the literary reading and teaching form under the perspective of medical humanitiespermeation. The complex of human nature is that it not only has natural property, including social and general spiritual attribute. Therefore,medical humanities connotation fi rstly embodies in the fear of life, love life and maintains the inherent in the human life and health. Literaryclassics is naturally formed in the process of human civilization and social development, it is carrying the human understanding of nature andsociety in history. This paper integrates the principles of the related issues to propose the new idea of the issue that will be the core meaning ofthe research.展开更多
Over the past few years, the rapid development of tactile sensing technology has contributed significantly to the realization of intuitional touch control and intelligent human-machine interaction. Apart from physical...Over the past few years, the rapid development of tactile sensing technology has contributed significantly to the realization of intuitional touch control and intelligent human-machine interaction. Apart from physical touch or pressure sensing, proximity sensing as a complementary function can extend the detection mode of common single functional tactile sensors. In this work, we present a transparent, matrix-structure dual functional capacitive sensor which integrates the capability of proximity and pressure sensing in one device, and the excellent spatial resolution offered by the isolated response of capacitive pixels enables us to realize precise location identification of approaching objects and loaded pressure with fast response, high stability and high reversibility.展开更多
文摘48 patients with liver fibrosis due to hepatitis B were treated for 2 years with the drugs for tonifying the kidney, supplementing qi, cooling and invigorating the blood and detoxification. The symptoms were markedly improved, and serum ALT and bilirubin were recovered and kept normal in most of the cases. The mean levels of serum hyaluronic acid, procollagen peptide III and circulating immune complex were decreased and returned to normal after the treatment. B-ultrasonography showed that the portal vein kept in normal size in 82% of the patients, the enlarged portal vein diminished in diameter, and the enlarged spleen reduced.
文摘I make an attempt in the paper to argue in favor of the person-centered view of good life, where becoming a good person involves seeking to qualitatively transform oneself into a worthy human being. I maintain that becoming fully a person and respecting others as persons are achievements that are not assured for all of us. Thus, for the purpose I prepare the ground for an account of good life that rests on valuational consciousness. I propose that one may ascribe valuational consciousness to a person who is a value-sensitive rational being striving to attain a kind of inner transparency. Evidently, to say that a person has valuational consciousness is to stress the values, which are built into personal consciousness. The life of a person, whether that of truth, courage, nobility, justice, kindness, is a life marked by ego transcending personal consciousness that reaches out to humanity at large. And such a repository of values enables a human being to attain the ideal of good life. The ideal of good life, I contend, consists of attaining the higher order posture of selflessness--a posture of inner transparency. It is to shake off the egocentric partiality that characterizes our usual attitudinal stance towards one another.
文摘The acrosome reaction （AR）, an absolute requirement for spermatozoa and egg fusion, requires the influx of Ca2＋ into the spermatozoa through voltage-dependent Ca2＋ channels and store-operated channels. Maitotoxin （MTx）, a Ca2＋-mobilizing agent, has been shown to be a potent inducer of the mouse sperm AR, with a pharmacology similar to that of the zona pellucida （ZP）, possibly suggesting a common pathway for both inducers. Using recombinant human ZP3 （rhZP3）, mouse ZP and two MTx channel blockers （U73122 and U73343）, we investigated and compared the MTx- and ZP-induced ARs in human and mouse spermatozoa. Herein, we report that MTx induced AR and elevated intracellular Ca2＋ （[Ca2＋]~） in human spermatozoa, both of which were blocked by U73122 and U73343. These two compounds also inhibited the MTx-induced AR in mouse spermatozoa. In disagreement with our previous proposal, the AR triggered by rhZP3 or mouse ZP was not blocked by U73343, indicating that in human and mouse spermatozoa, the AR induction by the physiological ligands or by MTx occurred through distinct pathways. U73122, but not U73343 （inactive analogue）, can block phospholipase C （PLC）. Another PLC inhibitor, edelfosine, also blocked the rhZP3- and ZP-induced ARs. These findings confirmed the participation of a PLC-dependent signalling pathway in human and mouse zona protein-induced AR. Notably, edelfosine also inhibited the MTx-induced mouse sperm AR but not that of the human, suggesting that toxin-induced AR is PLC-dependent in mice and PLC-independent in humans.
文摘In this paper, we conduct research on the literary reading and teaching form under the perspective of medical humanitiespermeation. The complex of human nature is that it not only has natural property, including social and general spiritual attribute. Therefore,medical humanities connotation fi rstly embodies in the fear of life, love life and maintains the inherent in the human life and health. Literaryclassics is naturally formed in the process of human civilization and social development, it is carrying the human understanding of nature andsociety in history. This paper integrates the principles of the related issues to propose the new idea of the issue that will be the core meaning ofthe research.
基金This work was supported by the National Natural Science Foundation of China （No. 61204001）, and the Fundamental Research Funds for the Central Universities of China （No. 2014QN013）. We also thank the Center for Nanoscale Characterization ＆ Devices （CNCD）, WNLO of HUST for the use of facilities in support of this work.
文摘Over the past few years, the rapid development of tactile sensing technology has contributed significantly to the realization of intuitional touch control and intelligent human-machine interaction. Apart from physical touch or pressure sensing, proximity sensing as a complementary function can extend the detection mode of common single functional tactile sensors. In this work, we present a transparent, matrix-structure dual functional capacitive sensor which integrates the capability of proximity and pressure sensing in one device, and the excellent spatial resolution offered by the isolated response of capacitive pixels enables us to realize precise location identification of approaching objects and loaded pressure with fast response, high stability and high reversibility.
