AIM: To study whether N-acetyltransferase 2 (NAT2) genotypes and phenotypes are associated with increased risk factor for gastric cancer in Omani patients and to study the clinico-pathological correlations and the ...AIM: To study whether N-acetyltransferase 2 (NAT2) genotypes and phenotypes are associated with increased risk factor for gastric cancer in Omani patients and to study the clinico-pathological correlations and the prognostic significance of NAT2. METHODS: Genomic DNA was extracted from peripheral blood of 100 gastric cancer patients and 100 control subjects. NAT2 genotyping was performed using DNA sequencing. The prognostic significance of NAT2 and other clinicopathological features was assessed by univariate and multivariate analyses. RESULTS: We observed no significant association between NAT2 genotypes and phenotypes and gastric cancer risk. The IVAT2 phenotype polymorphisms and gastric cancer risk predisposition were not modified by concomitant Hpylori infection and smoking. There was no significant association between NAT2 and clinicopathological features, and NAT2 had no independent prognostic significance. CONCLUSION: In the current study, NAT2 genotypes and phenotypes are not associated with gastric cancer risk predisposition. Moreover NAT2 phenotypes had no clinicopathological associations or prognostic significance.展开更多
AIM: To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR). METHODS: According to GCIR, 191 Helicobacter pylori (H pylori)-positive patients ...AIM: To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR). METHODS: According to GCIR, 191 Helicobacter pylori (H pylori)-positive patients were classified into groups A (high GCIR, n = 101) and B (low GCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1β and IL-10 by PCRRFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 GC patients was utilized for comparative purposes. RESULTS: Cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach (mixed strain infection) were more frequently found in group A than in group B, and cagA and vacA s1b were significantly associated with high GCIR (P = 0.026 and 0.041, respectively). IL- 1β+3954_T/C (OR 2.1, 1.0-4.3), IL-1RN^*2/L (OR 3.5, 1.7-7.3) and IL-10-592_C/A (OR 3.2, 1.5-6.8) were individually associated with GC, and a combination of these cytokine polymorphisms with Hpylori vacA slb and ml further increased the risk (OR 7.2, 1.4-36.4). CONCLUSION: Although a proinflammatory cytokine genetic profile showed an increased risk for developing GC, the characteristics of Hpylori infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica.展开更多
This study presents a robust design method for autonomous photovoltaic (PV)-wind hybrid power systems to obtain an optimum system configuration insensitive to design variable variations. This issue has been formulated...This study presents a robust design method for autonomous photovoltaic (PV)-wind hybrid power systems to obtain an optimum system configuration insensitive to design variable variations. This issue has been formulated as a constraint multi-objective optimization problem, which is solved by a multi-objective genetic algorithm, NSGA-II. Monte Carlo Simulation (MCS) method, combined with Latin Hypercube Sampling (LHS), is applied to evaluate the stochastic system performance. The potential of the proposed method has been demonstrated by a conceptual system design. A comparative study between the proposed robust method and the deterministic method presented in literature has been conducted. The results indicate that the proposed method can find a large mount of Pareto optimal system configurations with better compromising performance than the deterministic method. The trade-off information may be derived by a systematical comparison of these configurations. The proposed robust design method should be useful for hybrid power systems that require both optimality and robustness.展开更多
In order to reduce the probability of fault occurrence of local ventilation system in coal mine and prevent gas from exceeding the standard limit, an approach incorporating the reliability analysis, rough set theory, ...In order to reduce the probability of fault occurrence of local ventilation system in coal mine and prevent gas from exceeding the standard limit, an approach incorporating the reliability analysis, rough set theory, genetic algorithm (GA), and intelligent decision support system (IDSS) was used to establish and develop a fault diagnosis system of local ventilation in coal mine. Fault tree model was established and its reliability analysis was performed. The algorithms and software of key fault symptom and fault diagnosis rule acquiring were also analyzed and developed. Finally, a prototype system was developed and demonstrated by a mine instance. The research results indicate that the proposed approach in this paper can accurately and quickly find the fault reason in a local ventilation system of coal mines and can reduce difficulty of the fault diagnosis of the local ventilation system, which is significant to decrease gas exploding accidents in coal mines.展开更多
Non-alcoholic fatty liver disease(NAFLD) has a prevalence of approximately 30% in western countries, and is emerging as the first cause of liver cirrhosis and hepatocellular carcinoma(HCC). Therefore, risk stratificat...Non-alcoholic fatty liver disease(NAFLD) has a prevalence of approximately 30% in western countries, and is emerging as the first cause of liver cirrhosis and hepatocellular carcinoma(HCC). Therefore, risk stratification emerges as fundamental in order to optimize human and economic resources, and genetics displays intrinsic characteristics suitable to fulfill this task. According to the available data, heritability estimates for hepatic fat content range from 20% to 70%, and an almost 80% of shared heritability has been found between hepatic fat content and fibrosis. The rs738409 single nucleotide polymorphism(SNP) in patatin-like phospholipase domain-containing protein 3 gene and the rs58542926 SNP in transmembrane 6 superfamily member 2 gene have been robustly associated with NAFLD and with its progression, but promising results have been obtained with many other SNPs. Moreover, there has been proof of the additive role of the different SNPs in determining liver damage, and there have been preliminary experiences in which risk scores created through a few genetic variants, alone or in combination with clinical variables, were associated with a strongly potentiated risk of NAFLD, non-alcoholic steatohepatitis(NASH), NASH fibrosis or NAFLD-HCC. However, to date, clinical translation of genetics in the field of NAFLD has been poor or absent. Fortunately, the research we have done seems to have placed us on the right path: We should rely on longitudinal rather than on cross-sectional studies; we should focus on relevant outcomes rather than on simple liver fat accumulation; and we should put together the genetic and clinical information. The hope is that combined genetic/clinical scores, derived from longitudinal studies and built on a few strong genetic variants and relevant clinical variables, will reach a significant predictive power, such as to have clinical utility for risk stratification at the single patient level and even to esteem the impact of intervention on the risk of disease-related outcomes. Well-structured future studies would demonstrate if this vision can become a reality.展开更多
Variable-air-volume (VAV) air-conditioning system is a multi-variable system and has multi coupling control loops. While all of the control loops are working together, they interfere and influence each other. A multiv...Variable-air-volume (VAV) air-conditioning system is a multi-variable system and has multi coupling control loops. While all of the control loops are working together, they interfere and influence each other. A multivariable decoupling PID controller is designed for VAV air-conditioning system. Diagonal matrix decoupling method is employed to eliminate the coupling between the loop of supply air temperature and that of thermal-space air temperature. The PID controller parameters are optimized by means of an improved genetic algorithm in floating point representations to obtain better performance. The population in the improved genetic algorithm mutates before crossover, which is helpful for the convergence. Additionally the micro mutation algorithm is proposed and applied to improve the convergence during the later evolution. To search the best parameters, the optimized parameters ranges should be amplified 10 times the initial ideal parameters. The simulation and experiment results show that the decoupling control system is effective and feasible. The method can overcome the strong coupling feature of the system and has shorter governing time and less over-shoot than non-optimization PID control.展开更多
Intramuscular fat (IMF), an important flavor precursor of porcine meat, is closely related to pork quality traits such as pH, color, tenderness, water-holding capacity (WHC) and juiciness, and thus is one of the i...Intramuscular fat (IMF), an important flavor precursor of porcine meat, is closely related to pork quality traits such as pH, color, tenderness, water-holding capacity (WHC) and juiciness, and thus is one of the important factors affecting pork quality. Pork IMF content is not only associated with swine breed on heredity, but also influenced by the alteration of nutrients in diet. These may give a possibility for researchers to improve the IMF content and pork quality by their work on swine breed or heredity, and nutrition regulation in diet. Therefore, this article summarizes the effects of swine breed and nutrition regulation on IMF content briefly to provide some information for future researches.展开更多
Objective: To observe the effect of acupuncture on blood oxygen free radical (OFR) and nitric oxide (NO) levels in the treatment of apoplectic sequelae. Methods: A total of 61 cases of apoplectic patients were subject...Objective: To observe the effect of acupuncture on blood oxygen free radical (OFR) and nitric oxide (NO) levels in the treatment of apoplectic sequelae. Methods: A total of 61 cases of apoplectic patients were subjected into this study and randomly divided into "JIN San Zhen" group (n=30) and control group (n=31). Blood lipid peroxidase (LPO), superoxide dismutase (SOD), glutathione peroxidase(GSH Px) and nitric oxide (NO) contents before and after acupuncture treatment were determined with radioimmunoassay. In both groups, acupuncture was given once daily, six times a week, with 4 weeks being a therapeutic course and with the interval between two weeks being a week, 3 courses all together. In "JIN San Zhen" group, acupoints of "JIN San Zhen" were used predominately, while in control group, scalp point Motor Sensory Area (MS 8) was used as the main point. Results: Self comparison showed that after 3 courses of treatment, in both groups, LPO and NO levels decreased significantly (P<0.05-0.01), SOD and GST Px values increased considerably (P<0.05-0.01). Comparison between two groups indicated that the effects of "JIN San Zhen" group are significantly superior to those of control group in raising blood SOD and GST Px levels (P<0.05-0.01) and in lowering blood NO content (P<0.01). Analysis on the correlation between the restoration of neural function and the changes of LPO, SOD and GST Px levels suggested that the effect of acupuncture in improving neural function may be related to changes of the aforementioned indexes. Conclusion: Acupuncture therapy can significantly lower blood LPO and NO levels and evidently raise blood SOD and GST Px levels in stroke patients.展开更多
Many scientific and irrational factors exist in the cultural development of the country, in the current housing reconstruction project in the village, residential style, building materials, and architectural culture a...Many scientific and irrational factors exist in the cultural development of the country, in the current housing reconstruction project in the village, residential style, building materials, and architectural culture are not conducive to the Wa architectural culture, history, culture and home and other cultural heritage' s protection and development, there is lack of integrity, long-term, historical, cultural, ethnic, heritage qualities and so on. Increased emphasis is on the development of national culture, implementing the development of a good culture, protection, inheritance. Development of national culture is a broad and urgent and we need to address issues that require more in-depth study of scholars and experts, and play to their strengths to further increase the cultural industry development.展开更多
Telomere maintenance genes play an important role in maintaining the integrity of the telomere structure that protects chromosome ends,and telomere dysfunction may lead to tumorigenesis.Genetic variation in telomere m...Telomere maintenance genes play an important role in maintaining the integrity of the telomere structure that protects chromosome ends,and telomere dysfunction may lead to tumorigenesis.Genetic variation in telomere maintenance genes has been confirmed.Cumulative evidence shows that the difference of telomere length and stability among the individual depends on the genetic variants of telomere maintenance genes.Genetic variants in telomere maintenance genes may affect telomere length and stability,thus the increased cancer risk.This review intends to summarize the association of genetic variants in telomere maintenance genes with bladder cancer risk.展开更多
This study discusses the analysis of various modeling approaches such as genetic algorithms, fuzzy logic and evidential reasoning, and maintenance techniques applicable to the liquefied natural gas (LNG) carrier ope...This study discusses the analysis of various modeling approaches such as genetic algorithms, fuzzy logic and evidential reasoning, and maintenance techniques applicable to the liquefied natural gas (LNG) carrier operations in the maritime environment. The usefulness of these algorithms in the LNG carrier industry in the areas of risk assessment and maintenance modeling as a standalone or hybrid algorithm are identified. This is evidenced with illustrative case studies.展开更多
Used genetic algorithm (GA) to optimize the network of ventilation in order toavoid artificial convergence and speed up the convergence rate to introduce the Powellalgorithm. The Powell algorithm had been integrated i...Used genetic algorithm (GA) to optimize the network of ventilation in order toavoid artificial convergence and speed up the convergence rate to introduce the Powellalgorithm. The Powell algorithm had been integrated into GA. Powell had the effectivecapacity of solving the local optimal solution. Powell and the cross as a method ofchoice, a variation of the parallel operator, can be a better solution to the prematureconvergence of the GA problem. The two methods will be improved to make it an effective combination of hybrid GA called hybrid genetic algorithm (HGA) for the introductionof mine ventilation network optimization and to be used to solve the problem of regulating mine optimization.展开更多
The greater part of urban heritage, especially of the medium and small Algerian cities, is subject to a major seismic risk. The probability of a happening earthquake is strong, and the territories vulnerability is gre...The greater part of urban heritage, especially of the medium and small Algerian cities, is subject to a major seismic risk. The probability of a happening earthquake is strong, and the territories vulnerability is great. Legislative procedures are implemented to support urban heritage and managing natural disasters. In fact, the PPSMVSS (permanent plan of safeguard and enhancement of saved sectors) as an instrument of protection, preservation and enhancement of this heritage, in its content, does not guide decision makers on how to manage the vulnerability of preserved areas from the earthquake. After the disaster of the earthquake that hit the Algerian Centre (wilaya of Boumerdes) in 2003. A legislative framework was created while other texts have been adapted. Emergency measures operations are launched to preserve the under threat monuments and protected areas. Saved sectors of Dellys, in the wilaya of Boumerdes and T6n^s in the wilaya of Chlef, are all the time subjected to seismic risk. This article presents a comparative study of two PPSMVSS, Dellys and T6n6s, and the management of the vulnerability of their two safeguarded areas. As a result of this study, some indicators were identified to allow the development of plans for the protection and management natural risks of these protected areas.展开更多
Objective:To observe the clinical efficacy of body acupuncture combined with FANG’s scalp acupuncture in treating limb dysfunction in the remission stage of stroke and explore the mechanism.Methods:Sixty patients in ...Objective:To observe the clinical efficacy of body acupuncture combined with FANG’s scalp acupuncture in treating limb dysfunction in the remission stage of stroke and explore the mechanism.Methods:Sixty patients in the remission stage of stroke with limb dysfunction were divided into a control group and a treatment group using the random number table method,with 30 cases in each group.The control group was treated with ordinary acupuncture based on the conventional rehabilitation treatment,and the treatment group was additionally offered FANG’s scalp acupuncture.The interventions were conducted once daily with 10 sessions as 1 course.The Fugl-Meyer assessment(FMA)and Barthel index(BI)scores and serum malondialdehyde(MDA)and superoxide dismutase(SOD)levels were compared after 2 treatment courses,and the clinical efficacy was evaluated.Results:After treatment,the FMA and BI scores increased in both groups(P<0.05)and were higher in the treatment group than in the control group(P<0.05).Both groups showed a decreased MDA level and an increased SOD level after the intervention,all showing statistical significance(P<0.05);there were significant differences between the two groups(P<0.05).Conclusion:Based on the conventional rehabilitation treatment,ordinary acupuncture used alone or in combination with FANG’s scalp acupuncture can lower the oxidative stress level and improve limb function in treating limb dysfunction in the remission stage of stroke;body acupuncture plus FANG’s scalp acupuncture can produce better results.展开更多
Objective To explore the effect of meridian sinew row needling combined with dermal needling on spasticity of post-stroke patients with upper limb hemiparalysis. Methods Four hundred and eighty-eight cases of post-str...Objective To explore the effect of meridian sinew row needling combined with dermal needling on spasticity of post-stroke patients with upper limb hemiparalysis. Methods Four hundred and eighty-eight cases of post-stroke patients with upper limb spasticity were randomly divided into two groups at the ratio of 1: 1, the group of meridian sinew row needling combined with dermal needling (group A, 244 cases) and western medication group (group B, 244 cases). Coupled with rehabilitation, the patients in the group A were given meridian sinew row needling combined with dermal needling where five shu points were specifically selected, and three yang meridians of the hand were treated with acupuncture with muscle region, and three yin meridians of the hand were treated with dermal needles; the patients in the group B was treated with conventional western medication with piracetam injection and cerebroprotein hydrolysate included. Clinical efficacy was evaluated among patients in the two groups after three weeks of continuous treatment, and upper limb spasticity and motor functions were observed through modified Asworth Scale and FugI-Meyer Assessment Scale (FMA) before and after treatment. Results For Asworth Scale, group A was significantly superior to group B (3.04 ± 1.29 vs 3.88 ± 1.54, P〈0.05); for FMA scale, group A was also significantly superior to group B (48.67± 15.64 vs 42.96±14.72, P〈0.05); mitigations of motor status of upper limb joints in group A, such as remission of shoulder adduction (90.5%), pronation of forearm (70.7%), elbow joint flexion (73.1%), wrist joint flexion (80.9%) and finger flexion (88.1%), were superior to those of group B (70.0%, 60.0%, 61.9%, 57.4%, 63.2%, all P〈0.05). Conclusion Good clinical efficacy of the treatment with combined with dermal needling on spasticity of post-stroke patients with upper limb hemiparalysis is achieved.展开更多
Objective: To observe the effect of warm joint needling plus rehabilitation techniques on the balance function and quality of life (QOL) of patients with spastic hemiplegia after ischemic cerebral stroke. Methods:...Objective: To observe the effect of warm joint needling plus rehabilitation techniques on the balance function and quality of life (QOL) of patients with spastic hemiplegia after ischemic cerebral stroke. Methods: Ninety patients with spastic hemiplegia after ischemic cerebral stroke were randomized into a rehabilitation group, a warm joint needling group and an observation group, with 30 cases in each group. The rehabilitation group was intervened by Bobath therapy, the warm joint needling group was treated with joint needling on the affected side plus warm needling, and the observation group was given the same rehabilitation treatment as the rehabilitation group together with the same warm joint needling as the warm joint needling group. The three groups were treated once another day, 1 month as a treatment course for 6 months. Before the treatment, and respectively after 2-week, 1-month, 3-month, and 6-month treatment, the modified Ashworth scale (MAS) was used to measure the anti-spasm ability of the lower limb, the Berg balance scale (BBS) was adopted to evaluate the balance function, and the stroke-specific quality of life scale (SS-QOL) was employed to estimate the QOL. Results: After 3-month and 6-month treatment, the lower-limb MAS scores in the observation group were significantly better than those in the rehabilitation group and the warm joint needling group (all P〈0.05). After 1-month, B-month and 6-month treatment, the BBS scores in the observation group were significantly better than those in the rehabilitation group and the warm joint needling group (all P〈0.05). After 2-week, 1-month, 3-month and 6-month treatment, the SS-QOL scores in the observation group were markedly better than those in the rehabilitation group and the warm joint needling group (all P〈0.05). Conclusion: Warm joint needling plus rehabilitation can effectively improve the lower-limb spasticity state, balance function and QOL in patients with spastic hemiplegia after ischemic cerebral stroke.展开更多
文摘AIM: To study whether N-acetyltransferase 2 (NAT2) genotypes and phenotypes are associated with increased risk factor for gastric cancer in Omani patients and to study the clinico-pathological correlations and the prognostic significance of NAT2. METHODS: Genomic DNA was extracted from peripheral blood of 100 gastric cancer patients and 100 control subjects. NAT2 genotyping was performed using DNA sequencing. The prognostic significance of NAT2 and other clinicopathological features was assessed by univariate and multivariate analyses. RESULTS: We observed no significant association between NAT2 genotypes and phenotypes and gastric cancer risk. The IVAT2 phenotype polymorphisms and gastric cancer risk predisposition were not modified by concomitant Hpylori infection and smoking. There was no significant association between NAT2 and clinicopathological features, and NAT2 had no independent prognostic significance. CONCLUSION: In the current study, NAT2 genotypes and phenotypes are not associated with gastric cancer risk predisposition. Moreover NAT2 phenotypes had no clinicopathological associations or prognostic significance.
文摘AIM: To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR). METHODS: According to GCIR, 191 Helicobacter pylori (H pylori)-positive patients were classified into groups A (high GCIR, n = 101) and B (low GCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1β and IL-10 by PCRRFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 GC patients was utilized for comparative purposes. RESULTS: Cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach (mixed strain infection) were more frequently found in group A than in group B, and cagA and vacA s1b were significantly associated with high GCIR (P = 0.026 and 0.041, respectively). IL- 1β+3954_T/C (OR 2.1, 1.0-4.3), IL-1RN^*2/L (OR 3.5, 1.7-7.3) and IL-10-592_C/A (OR 3.2, 1.5-6.8) were individually associated with GC, and a combination of these cytokine polymorphisms with Hpylori vacA slb and ml further increased the risk (OR 7.2, 1.4-36.4). CONCLUSION: Although a proinflammatory cytokine genetic profile showed an increased risk for developing GC, the characteristics of Hpylori infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica.
文摘This study presents a robust design method for autonomous photovoltaic (PV)-wind hybrid power systems to obtain an optimum system configuration insensitive to design variable variations. This issue has been formulated as a constraint multi-objective optimization problem, which is solved by a multi-objective genetic algorithm, NSGA-II. Monte Carlo Simulation (MCS) method, combined with Latin Hypercube Sampling (LHS), is applied to evaluate the stochastic system performance. The potential of the proposed method has been demonstrated by a conceptual system design. A comparative study between the proposed robust method and the deterministic method presented in literature has been conducted. The results indicate that the proposed method can find a large mount of Pareto optimal system configurations with better compromising performance than the deterministic method. The trade-off information may be derived by a systematical comparison of these configurations. The proposed robust design method should be useful for hybrid power systems that require both optimality and robustness.
基金Projects 04JK197T supported by Shaanxi Education Bureau Science Foundation and 2005E202 by Shaanxi Science Foundation
文摘In order to reduce the probability of fault occurrence of local ventilation system in coal mine and prevent gas from exceeding the standard limit, an approach incorporating the reliability analysis, rough set theory, genetic algorithm (GA), and intelligent decision support system (IDSS) was used to establish and develop a fault diagnosis system of local ventilation in coal mine. Fault tree model was established and its reliability analysis was performed. The algorithms and software of key fault symptom and fault diagnosis rule acquiring were also analyzed and developed. Finally, a prototype system was developed and demonstrated by a mine instance. The research results indicate that the proposed approach in this paper can accurately and quickly find the fault reason in a local ventilation system of coal mines and can reduce difficulty of the fault diagnosis of the local ventilation system, which is significant to decrease gas exploding accidents in coal mines.
文摘Non-alcoholic fatty liver disease(NAFLD) has a prevalence of approximately 30% in western countries, and is emerging as the first cause of liver cirrhosis and hepatocellular carcinoma(HCC). Therefore, risk stratification emerges as fundamental in order to optimize human and economic resources, and genetics displays intrinsic characteristics suitable to fulfill this task. According to the available data, heritability estimates for hepatic fat content range from 20% to 70%, and an almost 80% of shared heritability has been found between hepatic fat content and fibrosis. The rs738409 single nucleotide polymorphism(SNP) in patatin-like phospholipase domain-containing protein 3 gene and the rs58542926 SNP in transmembrane 6 superfamily member 2 gene have been robustly associated with NAFLD and with its progression, but promising results have been obtained with many other SNPs. Moreover, there has been proof of the additive role of the different SNPs in determining liver damage, and there have been preliminary experiences in which risk scores created through a few genetic variants, alone or in combination with clinical variables, were associated with a strongly potentiated risk of NAFLD, non-alcoholic steatohepatitis(NASH), NASH fibrosis or NAFLD-HCC. However, to date, clinical translation of genetics in the field of NAFLD has been poor or absent. Fortunately, the research we have done seems to have placed us on the right path: We should rely on longitudinal rather than on cross-sectional studies; we should focus on relevant outcomes rather than on simple liver fat accumulation; and we should put together the genetic and clinical information. The hope is that combined genetic/clinical scores, derived from longitudinal studies and built on a few strong genetic variants and relevant clinical variables, will reach a significant predictive power, such as to have clinical utility for risk stratification at the single patient level and even to esteem the impact of intervention on the risk of disease-related outcomes. Well-structured future studies would demonstrate if this vision can become a reality.
基金Supported by Key Laboratory of Condition Monitoring and Control for Power Plant Equipment of Ministry of Education of China
文摘Variable-air-volume (VAV) air-conditioning system is a multi-variable system and has multi coupling control loops. While all of the control loops are working together, they interfere and influence each other. A multivariable decoupling PID controller is designed for VAV air-conditioning system. Diagonal matrix decoupling method is employed to eliminate the coupling between the loop of supply air temperature and that of thermal-space air temperature. The PID controller parameters are optimized by means of an improved genetic algorithm in floating point representations to obtain better performance. The population in the improved genetic algorithm mutates before crossover, which is helpful for the convergence. Additionally the micro mutation algorithm is proposed and applied to improve the convergence during the later evolution. To search the best parameters, the optimized parameters ranges should be amplified 10 times the initial ideal parameters. The simulation and experiment results show that the decoupling control system is effective and feasible. The method can overcome the strong coupling feature of the system and has shorter governing time and less over-shoot than non-optimization PID control.
基金Supported by Natural Science Foundation of Guangxi Bureau of Aquatic Products and Animal Husbandry(GYMK201452035 and GYMK1304510)~~
文摘Intramuscular fat (IMF), an important flavor precursor of porcine meat, is closely related to pork quality traits such as pH, color, tenderness, water-holding capacity (WHC) and juiciness, and thus is one of the important factors affecting pork quality. Pork IMF content is not only associated with swine breed on heredity, but also influenced by the alteration of nutrients in diet. These may give a possibility for researchers to improve the IMF content and pork quality by their work on swine breed or heredity, and nutrition regulation in diet. Therefore, this article summarizes the effects of swine breed and nutrition regulation on IMF content briefly to provide some information for future researches.
文摘Objective: To observe the effect of acupuncture on blood oxygen free radical (OFR) and nitric oxide (NO) levels in the treatment of apoplectic sequelae. Methods: A total of 61 cases of apoplectic patients were subjected into this study and randomly divided into "JIN San Zhen" group (n=30) and control group (n=31). Blood lipid peroxidase (LPO), superoxide dismutase (SOD), glutathione peroxidase(GSH Px) and nitric oxide (NO) contents before and after acupuncture treatment were determined with radioimmunoassay. In both groups, acupuncture was given once daily, six times a week, with 4 weeks being a therapeutic course and with the interval between two weeks being a week, 3 courses all together. In "JIN San Zhen" group, acupoints of "JIN San Zhen" were used predominately, while in control group, scalp point Motor Sensory Area (MS 8) was used as the main point. Results: Self comparison showed that after 3 courses of treatment, in both groups, LPO and NO levels decreased significantly (P<0.05-0.01), SOD and GST Px values increased considerably (P<0.05-0.01). Comparison between two groups indicated that the effects of "JIN San Zhen" group are significantly superior to those of control group in raising blood SOD and GST Px levels (P<0.05-0.01) and in lowering blood NO content (P<0.01). Analysis on the correlation between the restoration of neural function and the changes of LPO, SOD and GST Px levels suggested that the effect of acupuncture in improving neural function may be related to changes of the aforementioned indexes. Conclusion: Acupuncture therapy can significantly lower blood LPO and NO levels and evidently raise blood SOD and GST Px levels in stroke patients.
文摘Many scientific and irrational factors exist in the cultural development of the country, in the current housing reconstruction project in the village, residential style, building materials, and architectural culture are not conducive to the Wa architectural culture, history, culture and home and other cultural heritage' s protection and development, there is lack of integrity, long-term, historical, cultural, ethnic, heritage qualities and so on. Increased emphasis is on the development of national culture, implementing the development of a good culture, protection, inheritance. Development of national culture is a broad and urgent and we need to address issues that require more in-depth study of scholars and experts, and play to their strengths to further increase the cultural industry development.
文摘Telomere maintenance genes play an important role in maintaining the integrity of the telomere structure that protects chromosome ends,and telomere dysfunction may lead to tumorigenesis.Genetic variation in telomere maintenance genes has been confirmed.Cumulative evidence shows that the difference of telomere length and stability among the individual depends on the genetic variants of telomere maintenance genes.Genetic variants in telomere maintenance genes may affect telomere length and stability,thus the increased cancer risk.This review intends to summarize the association of genetic variants in telomere maintenance genes with bladder cancer risk.
文摘This study discusses the analysis of various modeling approaches such as genetic algorithms, fuzzy logic and evidential reasoning, and maintenance techniques applicable to the liquefied natural gas (LNG) carrier operations in the maritime environment. The usefulness of these algorithms in the LNG carrier industry in the areas of risk assessment and maintenance modeling as a standalone or hybrid algorithm are identified. This is evidenced with illustrative case studies.
基金Supported by the National Natural Science Foundation of China(60772159)
文摘Used genetic algorithm (GA) to optimize the network of ventilation in order toavoid artificial convergence and speed up the convergence rate to introduce the Powellalgorithm. The Powell algorithm had been integrated into GA. Powell had the effectivecapacity of solving the local optimal solution. Powell and the cross as a method ofchoice, a variation of the parallel operator, can be a better solution to the prematureconvergence of the GA problem. The two methods will be improved to make it an effective combination of hybrid GA called hybrid genetic algorithm (HGA) for the introductionof mine ventilation network optimization and to be used to solve the problem of regulating mine optimization.
文摘The greater part of urban heritage, especially of the medium and small Algerian cities, is subject to a major seismic risk. The probability of a happening earthquake is strong, and the territories vulnerability is great. Legislative procedures are implemented to support urban heritage and managing natural disasters. In fact, the PPSMVSS (permanent plan of safeguard and enhancement of saved sectors) as an instrument of protection, preservation and enhancement of this heritage, in its content, does not guide decision makers on how to manage the vulnerability of preserved areas from the earthquake. After the disaster of the earthquake that hit the Algerian Centre (wilaya of Boumerdes) in 2003. A legislative framework was created while other texts have been adapted. Emergency measures operations are launched to preserve the under threat monuments and protected areas. Saved sectors of Dellys, in the wilaya of Boumerdes and T6n^s in the wilaya of Chlef, are all the time subjected to seismic risk. This article presents a comparative study of two PPSMVSS, Dellys and T6n6s, and the management of the vulnerability of their two safeguarded areas. As a result of this study, some indicators were identified to allow the development of plans for the protection and management natural risks of these protected areas.
文摘Objective:To observe the clinical efficacy of body acupuncture combined with FANG’s scalp acupuncture in treating limb dysfunction in the remission stage of stroke and explore the mechanism.Methods:Sixty patients in the remission stage of stroke with limb dysfunction were divided into a control group and a treatment group using the random number table method,with 30 cases in each group.The control group was treated with ordinary acupuncture based on the conventional rehabilitation treatment,and the treatment group was additionally offered FANG’s scalp acupuncture.The interventions were conducted once daily with 10 sessions as 1 course.The Fugl-Meyer assessment(FMA)and Barthel index(BI)scores and serum malondialdehyde(MDA)and superoxide dismutase(SOD)levels were compared after 2 treatment courses,and the clinical efficacy was evaluated.Results:After treatment,the FMA and BI scores increased in both groups(P<0.05)and were higher in the treatment group than in the control group(P<0.05).Both groups showed a decreased MDA level and an increased SOD level after the intervention,all showing statistical significance(P<0.05);there were significant differences between the two groups(P<0.05).Conclusion:Based on the conventional rehabilitation treatment,ordinary acupuncture used alone or in combination with FANG’s scalp acupuncture can lower the oxidative stress level and improve limb function in treating limb dysfunction in the remission stage of stroke;body acupuncture plus FANG’s scalp acupuncture can produce better results.
基金Supported by Hebei Administration of Traditional Chinese Medicine(2009180)
文摘Objective To explore the effect of meridian sinew row needling combined with dermal needling on spasticity of post-stroke patients with upper limb hemiparalysis. Methods Four hundred and eighty-eight cases of post-stroke patients with upper limb spasticity were randomly divided into two groups at the ratio of 1: 1, the group of meridian sinew row needling combined with dermal needling (group A, 244 cases) and western medication group (group B, 244 cases). Coupled with rehabilitation, the patients in the group A were given meridian sinew row needling combined with dermal needling where five shu points were specifically selected, and three yang meridians of the hand were treated with acupuncture with muscle region, and three yin meridians of the hand were treated with dermal needles; the patients in the group B was treated with conventional western medication with piracetam injection and cerebroprotein hydrolysate included. Clinical efficacy was evaluated among patients in the two groups after three weeks of continuous treatment, and upper limb spasticity and motor functions were observed through modified Asworth Scale and FugI-Meyer Assessment Scale (FMA) before and after treatment. Results For Asworth Scale, group A was significantly superior to group B (3.04 ± 1.29 vs 3.88 ± 1.54, P〈0.05); for FMA scale, group A was also significantly superior to group B (48.67± 15.64 vs 42.96±14.72, P〈0.05); mitigations of motor status of upper limb joints in group A, such as remission of shoulder adduction (90.5%), pronation of forearm (70.7%), elbow joint flexion (73.1%), wrist joint flexion (80.9%) and finger flexion (88.1%), were superior to those of group B (70.0%, 60.0%, 61.9%, 57.4%, 63.2%, all P〈0.05). Conclusion Good clinical efficacy of the treatment with combined with dermal needling on spasticity of post-stroke patients with upper limb hemiparalysis is achieved.
文摘Objective: To observe the effect of warm joint needling plus rehabilitation techniques on the balance function and quality of life (QOL) of patients with spastic hemiplegia after ischemic cerebral stroke. Methods: Ninety patients with spastic hemiplegia after ischemic cerebral stroke were randomized into a rehabilitation group, a warm joint needling group and an observation group, with 30 cases in each group. The rehabilitation group was intervened by Bobath therapy, the warm joint needling group was treated with joint needling on the affected side plus warm needling, and the observation group was given the same rehabilitation treatment as the rehabilitation group together with the same warm joint needling as the warm joint needling group. The three groups were treated once another day, 1 month as a treatment course for 6 months. Before the treatment, and respectively after 2-week, 1-month, 3-month, and 6-month treatment, the modified Ashworth scale (MAS) was used to measure the anti-spasm ability of the lower limb, the Berg balance scale (BBS) was adopted to evaluate the balance function, and the stroke-specific quality of life scale (SS-QOL) was employed to estimate the QOL. Results: After 3-month and 6-month treatment, the lower-limb MAS scores in the observation group were significantly better than those in the rehabilitation group and the warm joint needling group (all P〈0.05). After 1-month, B-month and 6-month treatment, the BBS scores in the observation group were significantly better than those in the rehabilitation group and the warm joint needling group (all P〈0.05). After 2-week, 1-month, 3-month and 6-month treatment, the SS-QOL scores in the observation group were markedly better than those in the rehabilitation group and the warm joint needling group (all P〈0.05). Conclusion: Warm joint needling plus rehabilitation can effectively improve the lower-limb spasticity state, balance function and QOL in patients with spastic hemiplegia after ischemic cerebral stroke.