风土系列小说《麻地》 骆驼客

三奶奶的父亲叫彭占元，原本不是汉人。彭大奎当年在驼道上拣到他时，也晓不得是谁家丢的蒙古娃子。拉骆驼的大多是察哈尔省一带的穷汉。人们对这种营干，好听些称呼“骆驼客”，一般就叫“拉骆驼的”，甚至喊“鞭杆子”。

麻防犀角地黄汤通过调控microRNA-491-5p影响PI3K/Akt/mTOR通路治疗银屑病的机制

目的 观察麻防犀角地黄汤对银屑病小鼠模型的影响,探讨麻防犀角地黄汤治疗银屑病的作用机制。方法 构建咪喹莫特银屑病小鼠模型,灌胃给药麻防犀角地黄汤,观察模型外观及组织病理学改变,Real time PCR检测皮损组织中microRNA-491-5p、PI3K、Akt、mTOR mRNA的表达,Western blot检测皮损组织中PI3K、p-PI3K、Akt、p-Akt、mTOR、p-mTOR蛋白的表达。结果 麻防犀角地黄汤能改善小鼠皮损、PASI评分、耳廓外缘厚度、组织病理、体质量等指标,上调microRNA-491-5p mRNA的表达,下调PI3K、Akt、mTOR mRNA的表达量,抑制p-PI3K、p-Akt、p-mTOR的蛋白表达,并表现出部分量效相关性。结论 麻防犀角地黄汤可能通过调控microRNA-491-5p影响PI3K/Akt/mTOR信号通路在银屑病的治疗中发挥作用。

修美乐联合麻防犀角地黄汤对中重度斑块型银屑病的临床疗效及相关免疫炎症指标的影响

目的探究修美乐联合麻防犀角地黄汤对中重度斑块型银屑病的临床疗效及对相关免疫炎症指标的影响。方法选择2019年1月—2019年12月收治的72例重度斑块型银屑病患者,随机将患者分为对照组和治疗组,每组36例,对照组给予修美乐皮下注射治疗,治疗组在对照组的基础上联合麻防犀角地黄汤进行治疗,治疗12周,观察两组患者的临床总有效率、银屑病面积与严重程度指数(PASI)评分、生活质量指数(DLQI)评分、血清炎性因子水平及不良反应发生情况。结果对照组临床总有效率为86.11%,治疗组临床总有效率为97.22%(P<0.05);治疗后,两组患者PASI评分、DLQI评分均显著降低(P<0.05),治疗组明显低于对照组(P<0.05);两组患者IL-2、IL-17、IL-23、TNF-α水平均显著降低(P<0.05),治疗组明显低于对照组(P<0.05);两组患者均无严重不良反应,差异无统计学意义(P>0.05)。结论修美乐联合麻防犀角地黄汤对中重度斑块型银屑病疗效确切,可有效减轻患者银屑病面积,提高生活质量,且在治疗过程中,无严重不良反应,安全有效,值得在临床上推广应用。

Effects of Seedling Cutivation with Mat-fiber Mulch on Quality and Quantity of Early-season Rice

[Objective] The aim was to explore effects of tray mat of fiber mulch on quality and yield of early rice-season rice transplanted by machine. [Method] Seedling quality, the rate of leaked rice, density of mechanical transplanting rice, mature rate and yield covered with fiber mulch were compared with groups not covered with mulch. Furthermore, different indices of cultivated rice with and without fiber mulch were analyzed and compared. [Result] The rice yield in the group with fiber mulch improved by 11.9% and rice quality enhanced as wel . What＇s more, rice plants were much easier to be col ected, and the rate of leaked rice lowered by machine. [Conclusion] The research provides theoretical references for seedling transplanting and cultivation of early-season rice by machine with tray mats.

Posterior lingual lidocaine: A novel method to improve tolerance in upper gastrointestinal endoscopy

AIM: To evaluate the effect of posterior lingual lidocaine swab on patient tolerance to esophagogastro-duodenoscopy, the ease of performance of the procedure, and to determine if such use will reduce the need for intravenous sedation. METHODS: Eighty patients undergoing diagnostic esophagogastroduodenoscopy in a tertiary care medical center were randomized to either lidocaine swab or spray. Intravenous meperidine and midazolam were given as needed during the procedure. RESULTS: Patients in the lidocaine swab group (SWG) tolerated the procedure better than those in the spray group (SPG) with a median tolerability score of 2 (1, 4) compared to 4 (2, 5) (P < 0.01). The endoscopists encountered less diffi culty performing the proceduresin the SWG with lower median difficulty scores of 1 (1, 5) compared to 4 (1, 5) in the SPG (P < 0.01). In addition, the need for intravenous sedation was also lower in the SWG compared to the SPG with fewer patients requiring intravenous sedation (13/40 patients vs 38/40 patients, respectively, P < 0.01). The patients in the SWG were more satisfi ed with the mode of local anesthesia they received as compared to the SPG. In addition, the endoscopists were happier with the use of lidocaine swab. CONCLUSION: The use of a posterior lingual lidocaine swab in esophagogastroduodenoscopy improves patient comfort and tolerance and endoscopist satisfaction and decreases the need for intravenous sedation.

Petrology, geochemistry and geodynamics of basic granulite from the Altay area, North Xinjiang, China

The basic granulite of the Altay orogenic belt occurs as tectonic lens in the Devonian medium- to lower-grade metamorphic beds through fault contact. The Altay granulite (AG) is an amphibole plagioclase two-pyroxene granulite and is mainly composed of two pyroxenes, plagioclase, amphibole and biotite. Its melano-minerals are rich in Mg/(Mg+Fe2+), and its amphibole and biotite are rich in TiO2. The AG is rich in Mg/(Mg+Fe2+), Al2O3 and depletion of U, Th and Rb contents. The AG has moderate ∑REE and LREE-enriched with weak positive Eu anomaly. The AG shows island-arc pattern with negative Nb, P and Ti anomalies, reflecting that formation of the AG may be associated with subduction. Geochemical and mineral composition data reflect that the protolith of the AG is calc-alkaline basalt and formed by granulite facies metamorphism having peak P-T conditions of 750 °C?780 °C and 0.6?0.7 Gpa. The AG formation underwent two stages was suggested. In the early stage of oceanic crustal subduction, calc-alkaline basalt with island-arc environment underwent granulite facies metamorphism to form the AG in deep crust, and in the late stage, the AG was thrust into the upper crust.

Comparison and Evaluation of Several Dermatophagoides Pteronyssinus Allergen Extracts for Skin Prick Test

Objective To evaluate the significance of several Dermatophagoides pteronyssinus allergen extracts for skin prick test(SPT) in patients allergic to Dermatophagoides pteronyssinus.Methods Two hundred and nineteen patients enrolled in Peking Union Medical College Hospital underwent SPT and serum specific IgE assay to detect the Dermatophagoides pteronyssinus allergen.Three kinds of house dust mite allergen extracts were used for SPT,including the Dermatophagoides pteronyssinus extract prepared by our laboratory(group A),standardized Dermatophagoides pteronyssinus extract(group B),and mixed extracts of Dermatophagoides pteronyssinus and Dermatophagoides farinae(group C).Human serum specific IgE result was regarded as the reference standard for diagnosis of Dermatophagoides pteronyssinus allergy.The receiver operating characteristic(ROC) curve was used to evaluate the diagnostic performance of SPT with the extracts of three groups.Results SPT results showed that the median wheal diameter of group A,group B,and group C was 0.43,0.35,and 0.28 cm,respectively,with significant difference among three groups(P<0.05).The difference was significant between group A and B(P<0.01) as well as group A and C(P<0.01),but not between group B and C(P>0.05).There was no local urticaria or systemic allergic reactions following the procedure of SPT.Local reaction was observed in 5 patients and delayed reaction was in 2 patients of group A.As for group B and C,local reaction occurred in 3 cases and delayed reaction in 2 cases in each group.The area under ROC curve of SPT with extract in group A,group B,and group C was 0.765,0.801,and 0.782,respectively.Based on the detection results of serum specific IgE,the sensitivity of SPT in diagnosis of Dermato-phagoides pteronyssinus allergy with extract of group A,group B,and group C was 92.4%,87.0%,and 81.5%,and the specificity was 60.6%,73.2%,and 74.8%,respectively.Conclusion The Dermatophagoides pteronyssinus extract for SPT prepared by our laboratory offers good sensitivity and specificity comparable to commercially available allergen extracts,and it may be an appropriate candidate for clinical screening and diagnosis of Dermatophagoides pteronyssinus allergy.

KINETIC CHANGES OF ANTIBODY TO M.LEPRAE AND ITS RELATION WITH CLINICAL DISEASE

A sero epidemiological survey on 1 833 healthy residents was carried out in 6 villages of a leprosy high endemic area in Wenshan and Guangnan counties, Yunnan Province. The part of the residents with initially antibody positive as well as the part of residents with initially antibody negative have been followed up for 3 consecutive years by serology and clinical examination for studying kinetic changes of antibody to M.leprae and its relation with clinical disease. The results showed that the rates of subclinical infection of leprosy in a high endemic area are different from village to village, and the risk of developing clinical disease does not associate with subclinical infection rate. It correlates with the number of cured accumulative leprosy cases and active cases within the village. The authors consider that in leprosy high endemic villages, especially those cropped up new multi bacillary leprosy cases frequently in recent years, it may be helpful to use serology to detect early leprosy cases.

The Lake of Domat AI-Jandal between Ambitions and Reality： An Ecological Study

A pioneer ecological research was carried out to assess the credence of Domat AI-Jandal Lake at AI-JoufProvince in KSA for natural habitats, aquatic lives, agricultural and tourism resorts purposes. The results showed a poor inhabitant of aquatic birds i.e. yellow wagtail （Motacillaflava）; Black-winged Stilt （Himantopus himantopus）; shelduck （Tadorna tadorna）; Squacco heron （Ardeola ralloides）; Moorhen （Gallinula chloropus）; the bolti （Tilapia nilti）. Equally, only four plant species were predominant in the lake area i.e. synonym （Tamarix aucheriana）, a large perennial grass Phragmites australis, Athel pine or tamrisk （Tamarix aphylla） and synonym Zygophyllum simplex. Twelve fishes failed to survive longer than 45 minutes while another 6 fishes survived only in tributary water. Student T-Test biostatics analysis regarding the concentrations of the Total Dissolved Salts （TDS） in designated three parts of the lake showed significantly higher （P〈0.01〈0.0001） than acceptable limits for human usage, aquatic and natural habitat and perhaps for agricultural purposes. Similarly, the pHs of the waters were significantly alkaline （pH 8.9） and Eutrification of the lake waters clearly stand inappropriate for irrigation unless treated. The domestic pollutants were scattered almost all over the beaches as well as within the lake itself denoting unsafe of the lake as neither for natural habitats nor for tourism unless further attention is given by the municipal of Al-Jouf

Geometrical and Geotechnical Characteristics of Landslides in Korea under Various Geological Conditions

The goal of this study is to determine the geometrical and geotechnical characteristics of landslides under various geological conditions using detailed field surveys, laboratory soil tests and precipitation records. Three study areas are selected to consider different rocks, including gneiss in Jangheung, granite in Sangju and sedimentary rocks in Pohang, South Korea. Many landslides have occurred in these three areas during the rainy season.Precipitation records indicate that landslides occurring in the gneiss area of Jangheung and granite area of Sangju may be influenced by the hourly rainfall intensity rather than cumulative rainfall.However, landslides occurring in the sedimentary rock area of Pohang may be influenced by hourly rainfall intensity and cumulative rainfall. To investigate the factors that influence these types of landslides, a detailed landslide survey was performed and a series of laboratory soil tests were conducted.According to the detailed field survey, most landslides occurred on the flanks of mountain slopes, and the slope inclination where they occurred mostly ranged from 26 to 30 degrees, regardless of the geological conditions. The landslide in the gneiss area of Jangheung is larger than the landslides in the granite area of Sangju and sedimentary rock area of Pohang.Particularly, the landslide in the sedimentary rock area is shorter and shallower than the landslides in the gneiss and granite areas. Thus, the shape and size of the landslide are clearly related to the geological conditions. According to the integrated soil property and landslide occurrence analyses results, the average dry unit weight of the soils from the landslide sites is smaller than that of the soils obtained from the nonlandslide site. The average coefficient of permeability of soils obtained from the landslide sites is greater than that of soils obtained from the non-landslide sites with the same geology. These results indicate that the soils from the landslide sites are more poorly graded or looser than the soils from the non-landslide sites.

Effect of Microclimatic Modification on Growth and Yield of Sesame （Sesamum indicum L.） in a Semi-Desert Region of Northern Sudan

An investigation was carried out in the semi- desert region of northern Sudan, during 2000, to study the influence of different micrometeorological parameters on growth and yield of sesame under alley cropping system. Sesame, cv. Kenana-2, was grown in 6-m wide alleys formed by 3 year old Acacia ampliceps and Acacia stenophylla. Air temperature, relative humidity, wind speed, solar energy and shade behaviour were measured throughout the growing season. Irrigation was measured by water meter and soil moisture by gravimetric sampling at depths of 15, 30, 45 and 60 cm, in alley cropping and control plots. Sesame was evaluated for growth and yield performance in southern, central and northern parts of each alley. The results showed substantial reduction in wind runs, solar radiation and air temperature, while relative humidity was increased under alley conditions. Soil moisture content, especially in the upper 045 cm soil depth, was much higher in alley cropped plots than in the control plots. A. stenophylla resulted in the highest saving of irrigation water and considerably increased （40%） sesame seed yield. In contrast, sesame seed yield was reduced by 46% under A. ampliceps-alley cropping. Competition for light and water were highly responsible for variation in sesame seed yield in the different zones of the alley. A. stenophylla tree is, therefore, recommended in an alley cropping system in the semi-desert region of northern Sudan for its superiority in optimizing radiation and saving of irrigation water.

Percutaneous planter fasciitis release under local anesthesia： A prospective study

Purpose： Plantar fasciitis is the most common cause of pain on the bottom of the heel. It occurs when the strong band of the tissue supporting the arch of foot becomes irritated and inflamed. The majority of patients can be treated conservatively but some resistant cases need surgery eventually. This study aims to evaluate the outcome results of percutaneous planter fascia release under local anesthesia for chronic planter fasciitis. Methods： This prospective study was conducted in the Department of Orthopaedic Surgery in the School of Medical Science and Research, Sharda University, India from December 2010 to December 2013. Totally 78 patients with planter fasciitis for more than 6-12 months were recruited from the outpatient department. All patients were operated on under local anesthesia and followed up for a year. Results： The clinical results were evaluated in terms of pain, activity level and patient satisfaction. Pain relief was achieved averagely at eight weeks after surgery. The results were excellent in 88.46% （69/78） patients and good in 6.41% （9/78） patients. Neither complications of lateral column instability, sinus tarsitis and metatarsalgia nor wound-related complications were encountered. On subjective evalua- tions, 88.46% （69J78） patients reported full satisfaction and 6.41% （9/78） reported partial satisfaction after treatment. Conclusion： Percutaneous planter fasciitis release under local anesthesia is a minimally invasive pro- cedure that can be performed in the outpatient setting. It is easy, quick, effective and moreover with few coml^lications.

Geochemistry, geochronology, and petro-genesis of the early Paleozoic granitic plutons in the central-southern Jiangxi Province,China

This paper reports the systematic study on petrology, geochemistry, LA ICPMS zircons U-Pb dating, and in situ Hf isotope geology of the four plutons in the central-southern Jiangxi Province, an important part of the South China Block. In the outcrops, rocks are gradually changed from wall rock （slate or schist） to pluton （gneissic granite）; some residual blocks of sandy rock occur in the margin of pluton, and the foliations of residual blocks are parallel to those of both wail rock and gneissic granite. The thin-section observations show that the four plutons contain peraluminous minerals such as muscovite and sillimanite. The flattened and elongated feldspar and quartz grains are often visible in the gneissic granite, parallel to direction of lineation, suggesting that the granitic rock were subjected to a strong ductile sheafing. Geochemically, the A/CNK values from 13 granitic samples are between 1.03 and 1.37 with an average of 1.16, indicating that the granites are of strongly peraluminous plutons. The REE compositions of the 13 samples are similar, showing higher EREE contents, with enrichment in LREEs, depletion in Eu and REE patterns with relative LREE-enrichment and negligible Eu anomalies. They show enrichment in Rb, Th, U and depletion in Ba, Sr, Nb, Ti, belonging to a low Ba-Sr type of granite. Thus, the four bodies should be derived from the same magmatic source. Zircons used as U-Pb dating mostly exhibit euhedral shape and high Th/U values from 0.52 to 1.54 with an average of 1.08, suggesting that most zircons are of magmatic genesis. The zircons from four plutons yielded rather similar 206pb/238U vs. 207Tpb/235U concordia ages： 436.1±5.7 Ma for the Tangwan granite, 440.6±4 Ma for the Jiekou gneissic granite, 435.9±6.2 Ma for the Dongbao gneissic granite, and 441.9±3.1 Ma for the Jinxi K-granite, respectively, corresponding to Silurian Llandovery. Several xenocrysts yielded U-Pb ages around 700 Ma, implying that a breakup event took place during Neoproterozoic in the South China Block. In situ Lu-Hf isotopic analysis shows that all εHf（t） values of zircons are negative and have two-stage Hf model ages （TDM2） from 1.4 to 3.6 Ga, indicating that the Silurian granitic magma came from the re- cycle of Meso-Paleoproterozoic basement and even partly Archean rocks, and had not been effected by mantle magma. Re- searches on regional geology suggest that an intracontinental tectono-magmatic event took place during the early Paleozoic in the study areas, which is characterized by folding and thrusting, leading to crustal shortening and thickening, up to 20 km thickness. The high geothermal temperature from thickening crust and accumulation of producing high-heat radioactive elements gradually softened crustal rocks and caused a partial melting, forming peraluminous granitic magma. Under the post-orogenic extensional and de-pressure condition, these granitic magma rose and was emplaced in the upper crust, leading to development of S-type plutons

Late Mesoarchean crust growth event： evidence from the ca. 2.8 Ga granodioritic gneisses of the Xiaoqinling area, southern North China Craton

Recently, more attention has been paid to Precambrian magma events and crustal growth of the North China Craton(NCC), accompanying with controversy in activity stages and dynamic mechanism. In this study, we report the Archean(2802 ± 13 Ma) granodioritic gneisses in the Taihua Complex from the Xiaoqinling area, located in the southern margin of the NCC. The zircon Lu–Hf isotope analysis of the rocks showed ^(176)Hf/^(177)Hf ratios of0.280977–0.281228, corresponding to ε_(Hf)(t) values ranging from-3.5 to +6.6, and two–stage Hf model ages varying from 2836 to 3409 Ma. It was confirmed that late Mesoarchean(2.9–2.8 Ga) juvenile crust made contribution to the source material of these ca. 2.8 Ga granodioritic gneisses in the Xiaoqinling area. The whole rock geochemical data indicate that the granodioritic gneisses are high-K calc-alkaline series, probably generated at relatively high pressure and temperature, and formed under the continental arc setting. Statistically, we conclude that the magmatic activities during 2.9–2.7 Ga may represent the most intense crustal growth events in the NCC and these Archean rocks at different locations in southern NCC underwent a similar crustal evolution history.

Effects of Forest Types and Environmental Factors on Soil Microbial Biomass in a Coastal Sand Dune of Subtropical China

Coastal sand dune ecosystems generally have infertile soil with low water-holding capacity and high salinity. However, many plant species have adapted to the harsh sand environment along the southeastern coast of China. Studying the microbial biomass in such an ecosystem can improve our understanding of the roles that microbes play in soil fertility and nutrient cycling. We investigated the differences in soil microbial biomass carbon(MBC) and nitrogen(MBN) contents and their seasonal dynamics in five forest types(a secondary forest and plantations of Casuarinas, Pine, Acacia, and Eucalyptus). The results indicated that the seasonal variations of soil MBC and MBN contents in all five forest stands were higher in spring and winter, but lower in summer and autumn. The MBC content was lower in the Casuarinas plantation than in the other plantations in the same soil layer. However, no significant differences were observed in MBN contents among the different forest types. The MBC and MBN concentrations were positively correlated with soil moisture, but negatively correlated with soil temperature. The MBC and MBN contents also decreased with increasing soil depth. Across all soil layers, secondary forest had the highest MBC and MBN concentrations. Our study also showed that the MBC and MBN contents were positively affected by total soil carbon(TC), pH, and litter N content, but were negatively impacted by soil bulk density and litter C content. Moreover, the MBN content was positively correlated with root N content. In summary, environmental factors and the differences in litter and fine roots, soil nutrient contents, as well as the soil physical and chemical properties caused by different tree species collectively affected the concentrations of the soil MBC and MBN.

Warmer springs, laying date and clutch size of tree sparrows Passer montanus in Croatia

Global surface air temperatures increased during the past 100 years. Many long-term studies of birds have reported a climatic influence on breeding performance. We analysed long-term changes in first laying date and clutch size for first clutches of sedentary, hole-nesting and socially monogamous tree sparrows Passer montanus during 1980-2009 in northwestern Croatia. Laying date advanced and spring temperature increased significantly during the study. Date of laying was significantly correlated with mean air spring temperature and advanced by 8.6 days during the 30 years period. Laying date was delayed in extremely cold, but not in extremely warm springs compared to years with normal temperatures. These results suggest that current climate change including extreme change does not have negative effects on timing of laying or clutch size. In contrast to laying date, clutch size did not vary systematically during the study period or with mean spring air temperature changes [Current Zoology 57 （3）： 414-418, 2011].

Biomass and Energy of Casuarina equisetiofolia Plantations in Southeast Coast of China

The biomass and energy production of Casuarina equisetifolia plantations aged 14 were studied in Huian County, Fujian Province, Southeast of China. The standing crop biomass was 152.60 t/ha, in which the biomass of bole was 67.02 t/ha, accounting for 43.94 % of the total, while that of root was 36.83 t/ha and 24.14 %, respectively. Net primary productivity was 10.17t/(ha.a).The range of gross caloric of components was 19.29～20.23 kJ/g, with the average 19.70 kJ/g. The standing crop energy was 2 987×10^6 kJ/ha. Net energy production was 196.8×10^6 kJ/ha, while solar energy conversion efficiency was 0.90%.