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《Cell》的编辑出版特色 被引量:11
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作者 张以民 赵琪 周爱莲 《编辑学报》 CSSCI 北大核心 2008年第3期280-282,共3页
通过对《Cell》的审稿原则及标准、栏目设置、编审体制等方面的探讨来认识《Cell》的编辑出版特色。
关键词 《cell》 编辑出版特色 审稿原则 编审体制 栏目设置
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2017年《Cell》封面设计的可视化研究 被引量:2
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作者 董岳 《美术大观》 北大核心 2020年第9期139-141,共3页
本文分析2017年(共25期)《Cell》封面设计,结合图像学、类型学等进行可视化的个案研究,阐述封面设计视觉主题、构成类型、色彩搭配、传播效应等,分析科学内容视觉转化的思路和缘由;论证可视互融机理表现素材、题材的趣味性和艺术性,明... 本文分析2017年(共25期)《Cell》封面设计,结合图像学、类型学等进行可视化的个案研究,阐述封面设计视觉主题、构成类型、色彩搭配、传播效应等,分析科学内容视觉转化的思路和缘由;论证可视互融机理表现素材、题材的趣味性和艺术性,明确封面设计与文章研究内容的紧密联系,指出科技期刊封面设计原则及趋势,为同行期刊设计提供参考。 展开更多
关键词 《cell》 艺术 科学 设计 可视化
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2015—2019年《Cell》期刊封面设计审美评价 被引量:3
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作者 董岳 《包装工程》 CAS 北大核心 2022年第4期302-313,共12页
目的以近5年(2015—2019年)《Cell》期刊的124幅封面为研究对象,分析设计形象的表现方式,探讨设计规范和模式,总结设计方法和思路,为国内科技期刊和人文类期刊封面设计提供实践经验。方法从设计学的视野,结合几何学、图像学等,对封面设... 目的以近5年(2015—2019年)《Cell》期刊的124幅封面为研究对象,分析设计形象的表现方式,探讨设计规范和模式,总结设计方法和思路,为国内科技期刊和人文类期刊封面设计提供实践经验。方法从设计学的视野,结合几何学、图像学等,对封面设计中图像素材应用与研究主题、中国传统艺术形式与文化传播、几何比例黄金分割与理性美,以及色彩美、艺术美、科学美的融合等进行阐释和分析,探究近5年期刊封面设计理念与设计审美。结论《Cell》期刊封面设计将研究主题通过视觉元素反应,运用多种设计手法、设计素材,形成与生物科学主题相关的多种艺术表现形式,在遵循4类黄金分割法则的规范下,向读者呈现出具备色彩美、艺术美、科学美的设计封面,给国内学术期刊的封面设计带来启示和裨益。 展开更多
关键词 cell封面 图像 设计 审美 启示
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采用Cell-SELEX技术的核酸适配体在肿瘤靶向治疗的研究进展
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作者 成志云 陈佳怡 +3 位作者 白如玉 杨会勇 MOHSAN Ullah 刁勇 《华侨大学学报(自然科学版)》 CAS 2024年第4期439-444,共6页
阐述细胞-配体指数富集系统进化(Cell-SELEX)技术特点,以及通过该技术筛选得到的核酸适配体在肿瘤靶向治疗中的应用进展和挑战,通过查阅近年的相关文献,综述核酸适配体作为药物及药物载体在肿瘤靶向治疗中的应用研究进展。结果表明:基于... 阐述细胞-配体指数富集系统进化(Cell-SELEX)技术特点,以及通过该技术筛选得到的核酸适配体在肿瘤靶向治疗中的应用进展和挑战,通过查阅近年的相关文献,综述核酸适配体作为药物及药物载体在肿瘤靶向治疗中的应用研究进展。结果表明:基于Cell-SELEX技术筛选得到的核酸适配体在肿瘤靶向治疗中的疗效显著,可开发成为肿瘤靶向治疗的潜力药物及良好的药物载体。 展开更多
关键词 核酸适配体 细胞-配体指数富集系统进化(cell-SELEX)技术 肿瘤 靶向治疗
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眼斑双锯鱼(Amphiprion ocellaris)发育中体色花纹时序发生的色素细胞变化和控制基因表达的分析Ⅱ.仔稚幼鱼时期
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作者 孙志宾 孙伟恒 +10 位作者 王新安 马爱军 黄智慧 李迎娣 苟冬惠 于宏 闫鹏飞 田蜜 Vorathep Muthuwan 曲江波 洪宜展 《海洋与湖沼》 CAS CSCD 北大核心 2024年第3期756-764,共9页
眼斑双锯鱼(Amphiprion ocellaris)属于鲈形目、雀鲷科、双锯鱼属,是热带珊瑚礁观赏鱼类的首选品种,其不同发育时期各种色素细胞的动态变化及其控制基因表达情况有待深入研究。记录了眼斑双锯鱼仔稚幼鱼体色花纹模式建成的发育过程,对... 眼斑双锯鱼(Amphiprion ocellaris)属于鲈形目、雀鲷科、双锯鱼属,是热带珊瑚礁观赏鱼类的首选品种,其不同发育时期各种色素细胞的动态变化及其控制基因表达情况有待深入研究。记录了眼斑双锯鱼仔稚幼鱼体色花纹模式建成的发育过程,对比不同发育时期体色变化的特点,筛选出仔稚幼鱼时期体色花纹变化较为明显的9个发育时期,并利用荧光定量PCR检测了眼斑双锯鱼各发育时期的10个体色控制基因的表达情况。结果显示:眼斑双锯鱼的体色发生存在明显的时序性,仔鱼时期鱼体呈现半透明状,黑色素细胞排列在身体两侧,随着生长发育数量逐渐增多;稚鱼时期,体表开始出现红色素细胞和黄色素细胞,身体慢慢变得不透明,9 dph开始出现第一道条纹,虹彩色素细胞数量逐渐增多,10 dph时期观察到第二道条纹出现;幼鱼时期,三道白色条纹完全形成,体表的橙红色和白色条纹被黑色素细胞分隔开来,界线逐渐清晰,长成完整的花纹。结合荧光定量PCR结果分析发现:在仔稚幼鱼阶段,10个体色控制基因在各发育时期均有表达,不同功能分类的基因在不同发育时期的表达变化趋势差异较大,在仔稚幼鱼前期表达量变化较大的基因主要为TYR、Dct、Ednrb、Sox10等与黑色素细胞迁移、分化、合成相关的基因;随着幼鱼不断的生长发育,白色条纹逐条出现,与虹彩色素细胞相关的Fms、Foxd3等基因也开始出现表达量显著上升的趋势。 展开更多
关键词 眼斑双锯鱼 发育 体色花纹 时序发生 色素细胞 表达分析
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眼斑双锯鱼(Amphiprion ocellaris)发育中体色花纹时序发生的色素细胞变化和控制基因表达的分析Ⅰ.胚胎时期 被引量:1
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作者 孙伟恒 孙志宾 +8 位作者 王新安 马爱军 李迎娣 苟冬惠 于宏 李昊喆 Vorathep Muthuwan 曲江波 洪宜展 《海洋与湖沼》 CAS CSCD 北大核心 2024年第2期489-498,共10页
眼斑双锯鱼(Amphiprion ocellaris)属于鲈形目、雀鲷科、双锯鱼属,是热带珊瑚礁观赏鱼类的首选品种。不同体色和花纹与色素细胞相关基因的表达直接相关,在其胚胎发育的过程中,色素细胞的形态和数量一直在变化,但不同发育时期各种色素细... 眼斑双锯鱼(Amphiprion ocellaris)属于鲈形目、雀鲷科、双锯鱼属,是热带珊瑚礁观赏鱼类的首选品种。不同体色和花纹与色素细胞相关基因的表达直接相关,在其胚胎发育的过程中,色素细胞的形态和数量一直在变化,但不同发育时期各种色素细胞的动态变化及其控制基因表达情况等仍需明确研究。记录了眼斑双锯鱼胚胎时期色素细胞变化较为明显的6个发育时期,观察了不同时期的体色及色素细胞的变化特点,并利用荧光定量PCR检测了各发育时期的10个体色控制基因的表达情况。结果显示:在胚胎发育阶段,整个胚胎的颜色从橙黄逐渐转变为暗红、黑红、黑色到最终透明,观察到卵黄囊表面幼体黑色素细胞到成体黑色素细胞的转变过程,鱼体表面在翻转期出现成体黑色素细胞、在器官形成期出现红色素细胞,眼睛及腹部在孵化期出现虹彩色素细胞。结合荧光定量PCR结果分析发现:卵黄囊表面幼体黑色素细胞推测是外胚层中的神经嵴细胞直接发育而成,不需要迁移过程;Ednrb、TYR、Tbx2b基因对幼体黑色素细胞的形成和发育有重要作用,Pax3、Dct、Aim1基因与成体黑色素细胞的分化、迁移、形成过程密切相关;其中TYR基因的相对表达量在体节期出现显著增加,说明TYR基因在胚胎发育初期就参与黑色素细胞的形成;Tbx2b基因不仅对黑色素细胞形成有影响,对眼斑双锯鱼心脏的形成也有一定作用;Fms基因对红色素细胞形成有重要作用;Ltk基因的表达要早于虹彩色素细胞的出现;相关性分析发现各基因之间存在相互作用。 展开更多
关键词 眼斑双锯鱼(Amphiprion ocellaris) 发育 体色 色素细胞 表达分析
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cell-in-cell的研究进展
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作者 冯锦丽 孙强 张家堂 《中国病理生理杂志》 CAS CSCD 北大核心 2024年第8期1511-1519,共9页
cell-in-cell(CIC)是指一个或多个活细胞进入到另一个活细胞中,形成细胞套叠结构并产生生物学效应的过程。早在100年前这一现象就已经被发现,但直到近10年才引起重视。随着研究的深入,人们发现CIC现象存在于许多生物系统和疾病中,在进... cell-in-cell(CIC)是指一个或多个活细胞进入到另一个活细胞中,形成细胞套叠结构并产生生物学效应的过程。早在100年前这一现象就已经被发现,但直到近10年才引起重视。随着研究的深入,人们发现CIC现象存在于许多生物系统和疾病中,在进化、发育、稳态和疾病中具有重要的生理和病理意义,尤其在肿瘤中具有重要的临床研究价值。目前有5种已知的CIC结构形式:cell canibalism、phagoptosis、enclysis、entosis和emperipolesis。本文就上述5种CIC结构的细胞构成类型、生物学特性、分子机制、病理生理学特点等进行综述,以期更好地认识这一现象,探讨CIC现象在人类疾病诊断、治疗和预后中潜在的临床意义。 展开更多
关键词 cell-in-cell 机制 病理生理学 肿瘤
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1.3 GHz 9-cell高性能超导腔高阶模耦合器电磁及热分析研究
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作者 王子晗 潘卫民 +5 位作者 米正辉 翟纪元 贺斐思 沙鹏 王光伟 刘铭 《强激光与粒子束》 CAS CSCD 北大核心 2024年第7期62-68,共7页
中国科学院高能物理研究所于2023年6月完成了高品质因数1.3 GHz超导加速模组研发,在国际上率先实现了中温退火高品质因数超导腔模组技术路线。模组中集成了八只经过中温退火工艺处理的1.3 GHz9-cell超导腔,在模组的测试过程中超导腔的... 中国科学院高能物理研究所于2023年6月完成了高品质因数1.3 GHz超导加速模组研发,在国际上率先实现了中温退火高品质因数超导腔模组技术路线。模组中集成了八只经过中温退火工艺处理的1.3 GHz9-cell超导腔,在模组的测试过程中超导腔的高阶模耦合器温升异常,导致超导腔无法在高梯度下稳定工作。通过HFSS软件和CST软件中的微波仿真模块对高阶模耦合器进行电磁分析,再通过理论和Ansys Workbench软件对高阶模耦合器进行热仿真分析,并结合模组的高功率实验,找到了超导腔性能异常的原因,并对超导腔高阶模耦合器的冷却方式进行了进一步的优化,解决了模组中超导腔高梯度下的不稳定性。 展开更多
关键词 1.3 GHz 9-cell超导腔 高阶模耦合器 电磁分析 稳态热分析
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基于模糊n-cell数的非线性投入产出模型解的存在性
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作者 陆星宇 叶国菊 刘尉 《湖北大学学报(自然科学版)》 CAS 2024年第2期225-232,共8页
将混合单调以及耦合不动点的概念引入到模糊n-cell数空间中,给出此空间上的混合单调型不动点定理。考虑到模糊n-cell数具有表示n维不确定信息的特点,将非线性投入产出模型与模糊n-cell数相结合,建立模糊非线性投入产出模型并给出相应的... 将混合单调以及耦合不动点的概念引入到模糊n-cell数空间中,给出此空间上的混合单调型不动点定理。考虑到模糊n-cell数具有表示n维不确定信息的特点,将非线性投入产出模型与模糊n-cell数相结合,建立模糊非线性投入产出模型并给出相应的平衡方程。最后利用本文中所给的不动点定理讨论此模型解存在的条件,验证模型的合理性。 展开更多
关键词 模糊n-cell 混合单调 不动点定理 非线性投入产出模型
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杂细胞对Lyocell级竹溶解浆溶解性能及可纺性能的研究 被引量:1
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作者 孔硕 龚琛 +6 位作者 倪建萍 范述捷 张羽 付显玲 杨彬 李楠 苏振华 《中国造纸》 CAS 北大核心 2024年第3期73-81,共9页
本研究以自制楠竹溶解浆为研究对象,探讨了杂细胞对楠竹溶解浆的纤维形态、溶解浆性能、溶解性能和可纺性能的影响。结果表明,未筛除杂细胞的楠竹溶解浆,其抗碱性(R_(10)和R_(18))以及聚戊糖和抽出物含量技术指标均优于市售进口溶解浆,... 本研究以自制楠竹溶解浆为研究对象,探讨了杂细胞对楠竹溶解浆的纤维形态、溶解浆性能、溶解性能和可纺性能的影响。结果表明,未筛除杂细胞的楠竹溶解浆,其抗碱性(R_(10)和R_(18))以及聚戊糖和抽出物含量技术指标均优于市售进口溶解浆,但在NMMO水溶液中的溶解性能和纤维溶解状态较差;筛除杂细胞后的楠竹溶解浆,其溶解浆的各项纯度指标均得到有效提升,溶解性能和可纺性能得到明显改善。 展开更多
关键词 竹溶解浆 杂细胞 溶解性能 可纺性能
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Promoting Sickle Cell Trait Awareness and Education: A Typology of Interventions in the United States to Inform Ongoing Efforts to Patients and Providers
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作者 Stacey Cunnington Jacey Greece 《Health》 2024年第4期280-308,共29页
Research Background: Sickle cell trait has no treatment or cure and predominantly affects people who are Black, but can affect anyone of any race or ethnicity. While commonly incorrectly considered benign by providers... Research Background: Sickle cell trait has no treatment or cure and predominantly affects people who are Black, but can affect anyone of any race or ethnicity. While commonly incorrectly considered benign by providers and the public, people with a sickle cell trait experience life-threatening outcomes that are exacerbated by extreme conditions. There is a severe lack of awareness and understanding of sickle cell trait and the associated health complications among sickle cell trait carriers and healthcare providers. Purpose/Aim: Interventions that aim to improve awareness of sickle cell trait differ in approaches and are not well documented in the literature. This typology aims to highlight current efforts to inform targeted interventions that raise awareness through consistent messaging, educate people and providers on sickle cell trait and the related health complications, and support the design and implementation of comprehensive sickle cell trait awareness initiatives. Methods: We conducted a scoping review of United States-based sickle cell trait interventions and performed a content analysis to identify the categories and characteristics of these efforts. We then organized the results into a typology according to established protocols. Results: Among 164 interventions, twenty-five (15%) met the typology inclusion criteria described above and were grouped into categories: Seven of twenty-five interventions were Educational Interventions (28%), three of twenty-five interventions (12%) were Combined Screening and Educational-Based Interventions, eight of twenty-five interventions (32%) were Policy and Guideline-Based Intervention, and six of twenty-five interventions (24%) were Sickle Cell Trait Organization-Led Interventions. Conclusions: There is a lack of consistency in messaging across interventions whether delivered by credible healthcare institutions or national organizations, which can result in lack of education and awareness and confusion around sickle cell trait. Categorizing interventions through a typology allows clarity and informs consistency in messaging, which should be at the forefront of future sickle cell trait efforts. 展开更多
关键词 Sickle cell Trait Awareness Sickle cell Trait Messaging Sickle cell Trait Intervention TYPOLOGY Scoping Review
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Enhancing Erectile Function and Alleviating Andropause Symptoms: Clinical Efficacy of a Human Stem Cell Conditioned Medium Cream
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作者 Hoichi Amano 《Health》 2024年第7期626-634,共9页
Erectile dysfunction (ED) is increasingly prevalent in Japan, exceeding 30%, and increasing with age. Unhealthy lifestyle habits, obesity, insufficient exercise, and smoking have been implicated in its pathogenesis, a... Erectile dysfunction (ED) is increasingly prevalent in Japan, exceeding 30%, and increasing with age. Unhealthy lifestyle habits, obesity, insufficient exercise, and smoking have been implicated in its pathogenesis, along with endothelial dysfunction of the corpora cavernosa and impaired blood flow to the penis considered underlying factors. However, the current treatments are limited to Phosphodiesterase-5 (PDE5) inhibitors. ED is the primary symptom of andropathy. This study reports the clinical efficacy of human stem cell-conditioned medium cream for ED treatment. Ten men without underlying diseases suspected of andropause with ED (mean age 43.2 ± 4.4 y, Hb 15.2 ± 0.6 gm/dL, AST/ALT 30.2/37.9 ± 12.4/14.0, eGFR 82.7 ± 12.4 mL/min/1.73 m2) were targeted. The cream was applied twice daily to the genital and scrotal areas. The erectile hardness score (EHS), International Index of Erectile Function-5 (IIEF-5), and Aging Male Symptoms (AMS) scale were used to evaluate the participants before and 30 days after use, and the results were compared using paired t-tests. The post-use qualitative opinions were collected through interviews. Significant improvements were observed compared to baseline in the IIEF-5 (11.8 ± 4.6→17.2 ± 5.1, P < 0.001), and AMS (46.3 ± 6.7→37.6 ± 5.3, P < 0.001) scores post cream use. EHS did not show a statistically significant difference, but a trend towards improvement was observed. Qualitative feedback included increased morning erection, improved maintenance of erection during intercourse, and reduced post work fatigue. Human stem cell-conditioned medium contains endothelial growth factors that potentially contribute to the improvement of ED and andropause by enhancing corporal endothelial function. Future studies should include control groups to further investigate the efficacy of these treatments. 展开更多
关键词 Erectile Dysfunction ANDROPAUSE Human Stem cell Conditioned Medium Cream Stem cell
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Review on Hydroxyurea Usage in Young Children with Sickle Cell Disease: Examining Hemoglobin Induction, Potential Benefits, Responses, Safety, and Effectiveness
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作者 Maiko Charles Mkwambe Youping Deng Dongchi Zhao 《International Journal of Clinical Medicine》 CAS 2024年第1期1-18,共18页
Sickle cell disease (SCD) is a prevalent condition, particularly in the countries of sub-Saharan Africa, where the presence of specific genes associated with Malaria contributes to its high prevalence. Patients with s... Sickle cell disease (SCD) is a prevalent condition, particularly in the countries of sub-Saharan Africa, where the presence of specific genes associated with Malaria contributes to its high prevalence. Patients with sickle cell disease frequently experience painful episodes necessitating hospitalization, and their hemoglobin levels are typically lower than those of the general population. There are different treatment options available to manage complications, such as transfusing blood, hydroxyurea, and strong anti-pains. However, with all these treatments, patients still commonly experience pain crises and suffer from organ damage. Hydroxyurea, the sole approved medication for sickle cell anemia in developed and developing countries, is widely used in children despite being primarily indicated for adults. Multiple studies have demonstrated the efficacy of hydroxyurea in inducing HbF production in young children with SCD. Elevated HbF levels have been associated with improved clinical outcomes, including a reduction in vaso-occlusive crises, acute chest syndrome, and the need for blood transfusions. Furthermore, increased HbF levels have been shown to ameliorate disease-related organ damage, such as pulmonary hypertension and sickle cell retinopathy. The response to hydroxyurea treatment in young children with SCD is variable. Some patients achieve substantial increases in HbF levels and experience significant clinical benefits, while others may have a more modest response. Factors influencing the response include baseline HbF levels, genetic modifiers, treatment adherence, and dose optimization. Safety is a crucial consideration when using hydroxyurea in young children. Studies have shown that hydroxyurea is generally well-tolerated, with the most common adverse effects being myelosuppression, gastrointestinal symptoms, and dermatological manifestations. However,long-term effects and potential risks, such as renal dysfunction and reproductive impacts, require further investigation. The effectiveness of hydroxyurea in young children with SCD has been demonstrated in various clinical trials and observational studies. These studies have shown a significant reduction in disease-related complications and improved quality of life. However, optimal dosing, treatment duration, and long-term outcomes are still areas of ongoing research. This review focuses on recent studies investigating the benefits, effectiveness, responses, and safety of hydroxyurea in pediatric individuals diagnosed with sickle cell disease. 展开更多
关键词 EFFECTIVENESS HYDROXYUREA Sickle cell Disease Sickle cell Anemia Minimally Effective Dose Maximum Tolerated Dose
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Current Research Status of MicroRNAs in Squamous Cell Carcinoma of the Tongue
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作者 Wenjing Wang Yi Liu 《Open Journal of Stomatology》 2024年第2期55-63,共9页
Tongue squamous cell carcinoma (TSCC) is the most invasive type of oral malignant tumor, posing a serious threat to human life and health. Its pathogenesis is complex and has a high degree of malignancy. Recurrence an... Tongue squamous cell carcinoma (TSCC) is the most invasive type of oral malignant tumor, posing a serious threat to human life and health. Its pathogenesis is complex and has a high degree of malignancy. Recurrence and metastasis often lead to poor prognosis. MicroRNAs are a type of single stranded small molecule RNA with only 18 - 25 nucleotides, which can regulate the expression of various genes and participate in the occurrence and development of tumors. Studies have found that microRNA expression profiling can serve as a reliable and stable biological indicator for early diagnosis and prognosis of tumors. This article provides a review of the research status of MicroRNAs in squamous cell carcinoma of the tongue. 展开更多
关键词 MICRORNAS Tongue Squamous cell Carcinoma cells TUMOR PATHOGENESIS
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Insight into Function and Subcellular Localization of a Type III-Secreted Effector in Pseudomonas syringae pv. tomato DC3000
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作者 Jianzhong Huang Kai Chen +4 位作者 Zhuojun Li Hongbin Zhang Xiuying Guan Xiaoju Zhong Peng Jia 《American Journal of Plant Sciences》 CAS 2024年第10期835-846,共12页
Pseudomonas syringae pv. tomato DC3000 (Pst DC3000) is a bacterial pathogen of tomato and of the model plants Arabidopsis and Nicotiana benthamiana (N. benthamiana). Like numerous Gram-negative bacterial pathogens of ... Pseudomonas syringae pv. tomato DC3000 (Pst DC3000) is a bacterial pathogen of tomato and of the model plants Arabidopsis and Nicotiana benthamiana (N. benthamiana). Like numerous Gram-negative bacterial pathogens of animals and plants, Pst DC3000 exploits the conserved type III secretion system (TTSS) to deliver multiple virulence effectors directly into the host cells. Type III effectors (T3Es) collectively participate in causing disease, by mechanisms that are not well clarity. Elucidating the virulence function of individual effector is fundamental for understanding bacterial infection of plants. Here, we focused on studying one of these effectors, HopAA1-1, and analyzed its potential function and subcellular localization in N. benthamiana. Using an Agrobacterium-mediated transient expression system, we found that HopAA1-1 can trigger domain-dependent cell death in N. benthamiana. The observation using confocal microscopy showed that the YFP-tagged HopAA1-1 localizes to diverse cellular components containing nucleus, cytoplasm and cell membrane, which was demonstrated through immunoblot analysis of membrane fractionation and nuclear separation. Enforced HopAA1-1 subcellular localization, by tagging with a nuclear localization sequence (NLS) or a nuclear export sequence (NES), shows that HopAA1-1-induced cell death in N. benthamiana is suppressed in the nucleus but enhanced in the cytoplasm. Our research is lay a foundation for revealed the molecular pathogenesis of Pseudomonas syringae pv. tomato. 展开更多
关键词 cell Death HopAA1-1 Nicotiana benthamiana Pst DC3000
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Using Optical Tweezers to Study the Friction of the Red Blood Cells
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作者 Edoukoua Jean Michel Konin Pavel Yale +3 位作者 Abadê Ange-Boris N’guessan Kouassi Benoit Kouakou Abaka Michel Kouacou Eugene Megnassan 《Advances in Bioscience and Biotechnology》 CAS 2024年第2期100-111,共12页
In the last two decades the study of red blood cell elasticity using optical tweezers has known a rise appearing in the scientific research with regard to the various works carried out. Despite the various work done, ... In the last two decades the study of red blood cell elasticity using optical tweezers has known a rise appearing in the scientific research with regard to the various works carried out. Despite the various work done, no study has been done so far to study the influence of friction on the red blood cell indentation response using optical tweezers. In this study, we have developed a new approach to determine the coefficient of friction as well as the frictional forces of the red blood cell. This approach therefore allowed us to simultaneously carry out the indentation and traction test, which allowed us to extract the interfacial properties of the microbead red blood cell couple, among other things, the friction coefficient. This property would be extremely important to investigate the survival and mechanical features of cells, which will be of great physiological and pathological significance. But taking into account the hypothesis of friction as defined by the isotropic Coulomb law. The experiment performed for this purpose is the Brinell Hardness Test (DB). 展开更多
关键词 FRICTION INDENTATION Optical Tweezers TRIBOLOGY Red Blood cells
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Influence of Hemoglobin S Haplotypes on the Responses to Hydroxyurea Treatment in Children with Sickle Cell Disease in Abidjan, Côte d’Ivoire
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作者 Mireille Aye-Yayo Vincent Yapo +5 位作者 Boidy Kouakou Missa Louis Adjé Adia Eusèbe Adjambri Ebah Hermance Kassi Taïratou Kamagate Duni Sawadogo 《Open Journal of Genetics》 CAS 2024年第1期1-12,共12页
Background: In Côte d’Ivoire so far, the circulating haplotypes have been inferred on the phenotypic profiling of SCD patients. The impact of the circulating haplotypes on the use of Hydroxyurea has not been ass... Background: In Côte d’Ivoire so far, the circulating haplotypes have been inferred on the phenotypic profiling of SCD patients. The impact of the circulating haplotypes on the use of Hydroxyurea has not been assessed yet. Therefore the objective of this study is to identify in Abidjan the HbS haplotypes that modulate HU treatment responses. Methods: In a cross-sectional descriptive and analytical study, children aged 5 to 15 years with SCD, and carrying the hemoglobin phenotypes SSFA2 and SFA2, were recruited into a HU treatment cohort. Various parameters on the haplotypes and the outcomes of the treatment were analyzed. Results: Thirty nine children with SCD were included. The phenotypic profile of the cohort was 86.6% of SSFA2 and 15.4% of SFA2. Three haplotypes were found, the Benin haplotype, the Senegal haplotype, and an atypical one. The participants belonged to three genotypes, Benin/atypical (64.1%), Benin/Senegal (33.3%) and Senegal/Senegal (2.6%). Overall, HU treatment was successful in all haplotypes with 12 out of 39 patients failing treatment after 12 months in the Benin haplotype group. The association between HU treatment success and the Benin haplotype was found in terms of the decrease in the number of white blood cells and the students missing class. Conclusion: The study revealed that inferring haplotype based on the phenotypic profile could be inaccurate. The proportion of atypical haplotype that were not previously described in Côte d’Ivoire was high. All the haplotypes seemed to be associated with HU treatment success but some patients with Benin haplotype did not respond well. 展开更多
关键词 Sickle cell Disease CHILDREN HAPLOTYPE HYDROXYUREA Côte d’Ivoire
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Lentivirus Transduced T Cell Lines Response to Pro-Inflammatory and Antiviral Cytokines in the Presence of HIV
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作者 Kevin Ventocilla Daniel Miranda Jr. David Jesse Sanchez 《Journal of Biosciences and Medicines》 2024年第10期222-235,共14页
Various studies have attempted to understand HIV infection under a diverse range of stimulants including cytokine stimulation. Pro-inflammatory cytokines, such as TNF-α, have been shown to reactivate HIV latency by i... Various studies have attempted to understand HIV infection under a diverse range of stimulants including cytokine stimulation. Pro-inflammatory cytokines, such as TNF-α, have been shown to reactivate HIV latency by inducing NF-κB mediated activation of the HIV LTR (long terminal repeats) that contain κB transcriptional binding sites. Interferon-alpha (IFN-α), an anti-viral cytokine, is not well studied as an inducer of HIV activation. However, previous work from our group has shown that HIV can block IFN-α signaling in CD4+ T cells presumably to allow for further viral replication. Initially using HEK 293T cells, we moved to CD4+ T cells lines to develop a system to determine how stimulation with different cytokines impacts signaling within T cell lines. We confirmed that in our system TNF-α triggers activation of NF-κB driven reporters but not in the presence of HIV. In addition, we show that the presence of HIV blocks IFN-α signaling. Taken together, our system demonstrates that HIV by TNF-α, will continue to block IFN-α signaling preventing it from impacting HIV activation. This system can now be used to screen for cytokine based and other molecule activators that may be influenced by the presence of HIV. 展开更多
关键词 HIV CYTOKINE INTERFERON cell TNF
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Allogenic Stem Cell Transplantation and COVID-19 Antibodies: Mechanistic Insights and Recipient Concerns
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作者 Amna Umer Asma Umer Khayam +3 位作者 Nasar Khan David Lawrence Greene Umm E. Habiba Sabiha Shamim 《Open Journal of Immunology》 2024年第2期16-32,共17页
Collecting umbilical cord stem cells is widely practiced due to its numerous benefits. Over the past decade, umbilical cord stem cells (UCSCs) have shown effectiveness in treating various conditions, such as bone path... Collecting umbilical cord stem cells is widely practiced due to its numerous benefits. Over the past decade, umbilical cord stem cells (UCSCs) have shown effectiveness in treating various conditions, such as bone pathologies, neuropsychiatry disorders, hereditary diseases, and metabolic disorders. However, factors like immunization affect the quantity and quality of cord harvesting. Studies suggest that antibodies from the mother pass through the umbilical cord to protect the infant against infections. Cleaning the umbilical cord before stem cell extraction is crucial to maintain sterility and cell integrity. Vaccinating a female donor, including for COVID-19, typically does not directly affect the stem cells. Although vaccines aim to trigger an immunological response, they generally do not affect the donor’s stem cells. 展开更多
关键词 Vaccination Stem cell ALLOGENEIC COVID ANTIBODIES
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Gold Standard for Skin Cancer Treatment: Surgery (Mohs) or Microscopic Molecular-Cellular Therapy (Curaderm)?
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作者 Bill Elliot Cham 《Journal of Cancer Therapy》 2024年第2期33-47,共15页
Non-melanoma skin cancers or keratinocyte cancers such as basal cell carcinoma and squamous cell carcinoma make up approximately 80% and 20% respectively, of skin cancers with the 6 million people that are treated ann... Non-melanoma skin cancers or keratinocyte cancers such as basal cell carcinoma and squamous cell carcinoma make up approximately 80% and 20% respectively, of skin cancers with the 6 million people that are treated annually in the United States. 1 in 5 Americans and 2 in 3 Australians develop skin cancer by the age of 70 years and in Australia it is the most expensive, amassing $1.5 billion, to treat cancers. Non-melanoma skin cancers are often self-detected and are usually removed by various means in doctors’ surgeries. Mohs micrographic surgery is acclaimed to be the gold standard for the treatment of skin cancer. However, a novel microscopic molecular-cellular non-invasive topical therapy described in this article, challenges the status of Mohs procedure for being the acclaimed gold standard. 展开更多
关键词 Skin Cancer Basal cell Carcinoma Squamous cell Carcinoma Mohs Surgery Microscopic Molecular-cellular Curaderm Actinic Keratosis COSMESIS
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