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沉浸式戏剧与传统话剧的特殊观演模式分析——以《Sleep No More》为例
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作者 刘则汐 《戏剧之家》 2023年第32期9-11,共3页
在多元化数字时代发展的视域下,戏剧正以一种崭新的姿态呈现出别样的艺术氛围。互动性、代入感更强的沉浸式戏剧刚诞生即成长为全球火爆的戏剧观演形式。区别于传统戏剧的旧式观演关系,沉浸式戏剧的本质脱离了老旧剧场,打破了斯坦尼斯... 在多元化数字时代发展的视域下,戏剧正以一种崭新的姿态呈现出别样的艺术氛围。互动性、代入感更强的沉浸式戏剧刚诞生即成长为全球火爆的戏剧观演形式。区别于传统戏剧的旧式观演关系,沉浸式戏剧的本质脱离了老旧剧场,打破了斯坦尼斯拉夫斯基的“第一堵墙”并建立了“一座壁垒”,建设了牢固的数字化虚拟空间场景,把参与者融入在流动的时空之中,让参与者的注意力停留在戏剧本身。沉浸式戏剧(Immersive Theatre)的定义及其观看与表演的独特性、沉浸式剧本的分析、沉浸式戏剧从业者表演的特性是本文的研究重点,笔者通过整理沉浸式戏剧资料并对其进行了大胆定义,并分析笔者观演的沉浸式《Sleep No More》话剧剧本中的沉浸式戏剧独特性、沉浸式参与体验模式、叙事策略等元素。 展开更多
关键词 沉浸式戏剧 一座壁垒 新型观演体验 《sleep No More》
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SLEEP-MAD模式护理策略在结直肠癌病人术后护理中的应用 被引量:1
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作者 周芳 黄钦 《全科护理》 2024年第9期1720-1724,共5页
目的:探讨SLEEP-MAD模式护理策略在结直肠癌病人术后护理中的应用价值。方法:2022年5月—2023年5月选取医院收治的86例结直肠癌病人为研究对象,按照随机数字表法将病人分为观察组、对照组各43例,对照组行常规护理,观察组实施SLEEP-MAD... 目的:探讨SLEEP-MAD模式护理策略在结直肠癌病人术后护理中的应用价值。方法:2022年5月—2023年5月选取医院收治的86例结直肠癌病人为研究对象,按照随机数字表法将病人分为观察组、对照组各43例,对照组行常规护理,观察组实施SLEEP-MAD模式护理策略,干预前后采用汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、视觉模拟疼痛评分表(VAS)、匹兹堡睡眠质量指数量表(PSQI)、癌因性疲乏评分及欧洲癌症研究与治疗组织生命质量量表(EORTC QLQ-C30)评价病人的不良情绪、疼痛感、癌因性疲乏、睡眠质量及生活质量。结果:干预后观察组病人HAMA、HAMD、VAS、PSQI及癌因性疲乏评分低于对照组(P<0.05);干预后观察组病人EORTC QLQ-C30评分高于对照组(P<0.05)。结论:SLEEP-MAD模式护理策略可有效减轻结直肠癌病人焦虑及抑郁情绪,减轻病人术后疼痛感及癌因性疲乏,改善病人睡眠质量及生活质量。 展开更多
关键词 sleep-MAD模式 结直肠癌 不良情绪 癌因性疲乏 生活质量
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Wild Nutrition’s Food-Grown® Magnesium Supplementation Increases Sleep Quality and Sleep Duration and Reduces Stress in a Healthy Adult Population: A Double-Blind, Randomised, Placebo-Controlled Study
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作者 David Briskey Jane Erickson +1 位作者 Chelsie Smith Amanda Rao 《Food and Nutrition Sciences》 CAS 2024年第7期509-523,共15页
Background: Magnesium, an essential mineral crucial for various bodily functions, has been shown to positively influence sleep patterns. This study aimed to evaluate the efficacy of Food-Grown® magnesium in enhan... Background: Magnesium, an essential mineral crucial for various bodily functions, has been shown to positively influence sleep patterns. This study aimed to evaluate the efficacy of Food-Grown® magnesium in enhancing sleep quality and duration, as well as overall well-being. Methods: Eighty participants were randomly assigned to receive either 80 mg of Food-Grown® magnesium or a placebo (microcrystalline cellulose) daily for 8 weeks. Participants completed questionnaires assessing sleep quality, daytime drowsiness, quality of life, anxiety, and stress levels. Additionally, participants maintained daily sleep diaries and wore wrist-worn actigraphy devices. The primary outcome measured was the change in sleep quality and duration. Results: Seventy-one participants fulfilled all study requirements (35 in the active group and 36 in the placebo group). Magnesium supplementation significantly improved reported sleep quality, with the active group showing a 32% increase compared to 16% in the placebo group (p = 0.034). Moreover, magnesium supplementation led to a decrease in reported stress scores at week 8 compared to the placebo group (3.7 ± 2.6 vs. 5.5 ± 3.1, respectively). Both the magnesium and placebo groups exhibited significant increases in reported sleep duration and reductions in time to fall asleep, sleep disturbance, sleep latency, sleep medication usage, and total Pittsburgh Sleep Quality Index score at week 8 compared to baseline. Conclusion: Magnesium supplementation notably enhanced sleep quality and reduced stress levels compared to the placebo group. These findings highlight the potential of magnesium as a beneficial supplement for improving sleep quality and overall well-being. 展开更多
关键词 Magnesium sleep Quality sleep Duration STRESS Food-Grown
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An Investigation of Lighting Levels and Sleep Quality
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作者 Kathy Sexton-Radek Amina Mira 《Health》 2024年第9期794-800,共7页
Sleep quality in young adults is compromised. Instead of the recommended 7 hours, young adults’ schedule interruptions disturb sleep to a typical six and a half hours, with common disturbances in falling asleep and s... Sleep quality in young adults is compromised. Instead of the recommended 7 hours, young adults’ schedule interruptions disturb sleep to a typical six and a half hours, with common disturbances in falling asleep and staying asleep. Recent literature has identified an association between academic performance, negative mood state and low activity level in young adults with sleep disturbances. Young adulthood is a time for the installation of sleep health. Both individual and schedule impositions to the young adults’ sleep schedule are to be modified to obtain Sleep Health. Recent research has identified daytime light effects on sleep such as blue light from electronics as alerting and low level light for relaxation. The aim of this study was to identify sleep quality effects with varying light exposures. It was hypothesized that bright (>450 lux) light conditions would be considered focusing and low light (<220 lux) would be considered calming. We hypothesized that sleep quality would improve by 5% with the introduction of a calm light condition. Undergraduates from a small midwestern university were invited to participate in the study in exchange for a gift card. Six participants completed the study, two males, four females all between 21 - 24 years old. Both hypotheses were supported by qualitative analysis. 展开更多
关键词 LIGHT sleep Quality LIGHTING sleep Disturbance
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观察重症肺炎伴睡眠障碍患者SLEEP-MAD模式干预对睡眠质量的影响
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作者 庄红燕 洪小梅 陈丽媛 《世界睡眠医学杂志》 2024年第8期1684-1687,共4页
目的:研究重症肺炎睡眠障碍患者实施SLEEP-MAD模式干预的效果。方法:选取2022年1月至2022年12月福建医科大学附属泉州市第一医院收治的重症监护室(ICU)重症肺炎伴睡眠障碍患者40例作为研究对象,按照随机数字表法分为对照组和观察组,每... 目的:研究重症肺炎睡眠障碍患者实施SLEEP-MAD模式干预的效果。方法:选取2022年1月至2022年12月福建医科大学附属泉州市第一医院收治的重症监护室(ICU)重症肺炎伴睡眠障碍患者40例作为研究对象,按照随机数字表法分为对照组和观察组,每组20例。观察组实施SLEEP-MAD模式干预,对照组实施常规护理。采用匹兹堡睡眠质量指数(PSQI)比较2组患者干预前后睡眠质量的变化,采用汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)比较2组患者干预前后焦虑、抑郁的变化情况,并比较2组患者的失眠发生率及护理满意度。结果:干预后,观察组PSQI评分、HAMA评分、HAMD评分显著低于对照组,观察组满意度显著高于对照组,观察组失眠发生率显著低于对照组,差异有统计学意义(P<0.05)。结论:给予ICU重症肺炎睡眠障碍患者SLEEP-MAD模式干预,实施效果相对较好,患者满意度较高,失眠发生率显著降低,患者的负性情绪得到改善,睡眠质量随之提高,值得临床推广应用。 展开更多
关键词 ICU护理 重症肺炎 睡眠障碍 sleep-MAD模式 睡眠状况 焦虑 抑郁
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SLEEP-MAD护理模式对ICU重症肺炎睡眠障碍患者睡眠改善的效果
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作者 池毓琪 林梅莲 《世界睡眠医学杂志》 2024年第6期1374-1376,共3页
目的:分析SLEEP-MAD护理模式对ICU重症肺炎睡眠障碍患者睡眠的改善效果。方法:选取2021年11月至2023年11月厦门大学附属第一医院收治的ICU重症肺炎睡眠障碍患者86例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组43例。对... 目的:分析SLEEP-MAD护理模式对ICU重症肺炎睡眠障碍患者睡眠的改善效果。方法:选取2021年11月至2023年11月厦门大学附属第一医院收治的ICU重症肺炎睡眠障碍患者86例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组43例。对照组采用常规护理模式,观察组采用SLEEP-MAD护理模式。对比2组的睡眠质量、心理弹性及自我负担。结果:在睡眠质量各维度评分方面,观察组均低于对照组(P<0.05);观察组较对照组,心理弹性评分更高,自我负担评分更低(P<0.05)。结论:SLEEP-MAD护理模式有利于改善ICU重症肺炎睡眠障碍患者的睡眠质量,减轻自我负担,临床可进一步推广应用。 展开更多
关键词 ICU 重症肺炎 睡眠障碍 sleep-MAD护理模式 常规护理 睡眠质量 心理弹性 自我负担
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“Active Feedback” Fitbit-Based Physical Activity and Sleep Hygiene Intervention for Memory Assessment Service (MAS) Patients with Cognitive Deficits: Feasibility, Acceptability, Sleep Quality, Stress, and Wellbeing Outcomes
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作者 Chris Griffiths Farah Hina +6 位作者 Chee Siang Ang Louise Birkett-Swan Casey Bonham Lauren Currell Emily Ward Natasha Stace-Wood Jessica Plumbridge 《Advances in Aging Research》 CAS 2024年第4期61-74,共14页
Research Background: Compared to the general population, people experiencing age-related cognitive decline are more likely to have low levels of physical activity and sleep problems. Sufficient physical activity and q... Research Background: Compared to the general population, people experiencing age-related cognitive decline are more likely to have low levels of physical activity and sleep problems. Sufficient physical activity and quality sleep are protective factors against cognitive decline and poor health and can improve coping with stressors. The “Active Feedback” intervention comprises a wearable activity and sleep tracker (Fitbit), access to Fitbit software healthy lifestyle software apps;one session with Memory Assessment Service (MAS) staff providing physical activity and sleep hygiene advice and two further engagement, discussion, and feedback sessions. Purpose/Aim: This study investigates the acceptability and feasibility of Active Feedback and the effect on stress, mental wellbeing, and sleep quality, and the links between these factors. Methods: An open-label patient cohort design with no control group was used. Pre-intervention, 4-week and 8-week intervention assessments were performed using participant self-report measures: Perceived Stress Scale (PSS), Warwick-Edinburgh Mental Wellbeing Scale (WEMWBS), and Sleep Conditioning Index (SCI). Twenty-five participants completed an eight-week three-session intervention (18 males and 7 females), with the age range of 66 - 84 years old, and average age of 73.8 years (SD = 5.09). Fifteen participants had a diagnosis of MCI, ten participants did not. Results: There were non-significant improvements in SCI scores from 21.0 (SD = 8.84) to 21.6 (SD = 6.20) at 8 weeks, PSS scores from 17.5 (SD = 5.89) to 17.0 (SD = 6.20) at 8 weeks, and WEMWBS scores from 46.9 (SD = 9.23) to 48.8 (SD = 9.69) at 8 weeks. There were negative correlations between WEMWBS and PSS. Conclusion: Active Feedback intervention was found to be feasible and acceptable. Active Feedback could be enhanced to include motivational interviewing and goal setting. 展开更多
关键词 Fitbit TRACKER MCI Exercise INSOMNIA Physical Activity Wearables sleep
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A Proposal on the Novel Method to Estimate Optimal Sleep Duration Based on Self-Reported Survey Data
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作者 Jun Kohyama 《Journal of Behavioral and Brain Science》 2024年第8期227-239,共13页
Background: Many adolescents have a sleep debt. Individuals sleeping for their optimal sleep duration are expected to experience no sleepiness. Then, it is important to recognize one’s optimal sleep duration to reduc... Background: Many adolescents have a sleep debt. Individuals sleeping for their optimal sleep duration are expected to experience no sleepiness. Then, it is important to recognize one’s optimal sleep duration to reduce sleep debt. However, there is no simple method to determine this value. Since body mass index and sleep duration exhibit a U-shaped association, it is expected that a person taking optimal sleep duration would show no marked deviation from the mean body mass index value for the population evaluated. By using self-reported sleepiness and standardized body mass index, this study aimed to estimate individual optimal sleep duration. Methods: Data from 2540 grade 5 - 11 students were used. Students who declared no sleepiness during class and also had a gender- and grade-standardized body mass index of ±1.5 were termed ideal students. The average sleep durations of ideal students were compared with those of non-ideal students. The differences of sleep duration between ideal and no-ideal students were added to habitual sleep duration of each non-ideal student to obtain assumed optimal sleep duration. A multiple regression line to predict assumed optimal sleep duration was calculated using the least squares method. Results: The mean sleep duration of 666 ideal students exceeded the lower limit of daily sleep duration proposed as “may be appropriate” for children aged 6 - 17 years by National Sleep Foundation of the USA, being longer than those of non-ideal students. Significant regression formula for assumed optimal sleep duration was obtained (adjusted R2 = 0.996, p Conclusions: No contradiction was identified in the sleep duration obtained from ideal students as with optimal sleep duration. Although further studies to confirm the current estimation are needed, a simple formula to estimate individual optimal sleep duration through easily obtainable parameters was proposed. 展开更多
关键词 Body Mass Index Catch-Up sleep Insufficient sleep Syndrome Optimal sleep Duration sleepINESS
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A Problem Not to Be Ignored: The Influencing Factors of Mobile Phone Addiction and Its Influence on Sleep Quality
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作者 Zihan Ji Lian Zhou 《Health》 2024年第5期459-469,共11页
Background and Objective: With the popularity and widespread use of mobile phones, the effects of mobile phone dependence and addiction on individuals’ physical and mental health have attracted more and more attentio... Background and Objective: With the popularity and widespread use of mobile phones, the effects of mobile phone dependence and addiction on individuals’ physical and mental health have attracted more and more attention. The present study aims to analyze the current state of mobile phone addiction and its impact on sleep quality within the population, while also exploring the influence of related factors on sleep quality. Ultimately, this research will provide a scientific foundation for targeted intervention measures and strategies. Methods: A total of 253 permanent residents in Nanjing were randomly selected as study subjects. The Mobile Phone Addiction Index (MPAI) and Pittsburgh Sleep Quality Index (PSQI) were used to evaluate the degree of smartphone addiction and sleep quality of the study subjects. Body mass index (BMI) was measured according to standardized procedures. Independent sample t-test, Chi-square test, rank sum test and multiple linear regression were used to analyze the correlation between mobile phone addiction and sleep quality, and P Results: 117 people (46.2%) were addicted to mobile phones. Chi-square test showed that the rate of mobile phone addiction in drinking group was significantly higher than that in non-drinking group (P P P P P P P P P P Conclusion: Mobile phone addiction may lead to shorter sleep duration and reduce sleep efficiency. The withdrawal of mobile phone addiction may have a negative impact on sleep quality. According to the characteristics of the population, appropriate comprehensive intervention measures should be taken to build an effective evaluation system, so as to reduce the impact of mobile phone addiction and withdrawal problems on sleep and improve sleep quality. 展开更多
关键词 Mobile Phone Addiction Influencing Factors WITHDRAWAL sleep Quality
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The Impact of Sleep Patterns on Academic Performance and Social Integration among Medical Students
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作者 Livia-Ștefana Găgilă Tudor Cojocaru +5 位作者 Giulia-Mihaela Pînzariu Daria Georgiana Sauciuc Diana Elena Lupașcu Livia Amira Sauciuc Ioana Ilinca Ursachianu Elena Cojocaru 《Journal of Biosciences and Medicines》 2024年第8期189-198,共10页
Introduction: The impact of sleep on student life is crucial, particularly for those in demanding fields such as medicine. This study examines the relationships between sleep patterns, academic performance, and social... Introduction: The impact of sleep on student life is crucial, particularly for those in demanding fields such as medicine. This study examines the relationships between sleep patterns, academic performance, and social integration among medical students, who often face irregular sleep cycles and sleep deprivation due to rigorous academic demands. Aim: This study aims to assess how sleep issues affect academic achievement and social relationships among medical students. Method: Data were collected from 215 medical students through surveys and academic records. Quantitative data provided insights into sleep quality and academic performance, while qualitative interviews explored the effects of sleep on social interactions. Results: The findings revealed a significant correlation between sleep quality and academic performance, with students reporting better sleep hygiene achieving higher grades. Qualitative data indicated that poor sleep negatively impacts social interactions, leading to feelings of isolation and reduced social participation. Conclusions: The study highlights the importance of promoting good sleep practices in medical schools to enhance academic success and social well-being. Interventions aimed at improving sleep quality may help reduce burnout and improve overall well-being among medical students. Future research should focus on longitudinal studies to better understand the long-term effects of sleep on academic and social outcomes in this population. 展开更多
关键词 STUDENT MEDICINE sleep Quality Academic Performance
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Evaluation of Sleep Quality in Undergraduated Medical Students
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作者 Isaac Filipe Melo de Freitas Poliana Pinheiro Pascoal +6 位作者 Rafaela Cruz Sampaio Carla Maria de Lima Barbosa João Pedro Palmeira Lopes Diêgo Lucas Ramos e Silva Gabriel Arthur Gomes Cavalcante Milton Vieira Costa Euclides Mauricio Trindade Filho 《Journal of Behavioral and Brain Science》 2024年第10期265-275,共11页
Objective: The aim of this study was to evaluate the sleep quality of medical students to identify the main factors that affect sleep patterns. Methods: According to the methodology, 154 students participated in the r... Objective: The aim of this study was to evaluate the sleep quality of medical students to identify the main factors that affect sleep patterns. Methods: According to the methodology, 154 students participated in the research, attending from the first to the sixth year of the course. The Pittsburg Sleep Quality Index questionnaire and the Epworth sleepiness scale were applied. Descriptive statistics techniques were applied and demonstrated in the form of tables and graphs. The comparison of variables was carried out using statistical tests. Results: The results showed that most students do not sleep very well. It was observed that 68.83% of a total of 106 students are bad sleepers. Conclusion: It is concluded that medical students sleep a low number of hours by period, which could interfere in impairment of attention, learning and memory formation, interfering in academic performance. On the other hand, they showed greater daytime sleepiness compared to the general population. 展开更多
关键词 sleep Quality Daytime sleepiness Medical Students
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Observation of the Effectiveness of Rapid Recovery Nursing on Lung Cancer Surgery Patients and Its Impact on Sleep Quality
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作者 Weiwei Chen Dandan Liu 《Journal of Cancer Therapy》 2024年第2期29-32,共4页
Objective: To investigate the nursing effects of rapid recovery care measures on lung cancer surgery patients. Methods: 42 cases of lung cancer surgery patients were divided into control group and study group, with 21... Objective: To investigate the nursing effects of rapid recovery care measures on lung cancer surgery patients. Methods: 42 cases of lung cancer surgery patients were divided into control group and study group, with 21 cases in each group. The sleep quality and postoperative recovery indicators were compared between the two groups. Results: The study group showed better results than the control group in terms of PSQI scores, venting time, extubation time, time to getting out of bed, and duration of antibiotic use, with P Conclusion: Rapid recovery nursing has a positive impact on improving sleep quality and promoting postoperative recovery in lung cancer surgery patients. 展开更多
关键词 Rapid Recovery Nursing Lung Cancer Surgery sleep Quality
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Sleep Disorders among Professional Oil Tanker Drivers in Ouagadougou Burkina Faso
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作者 Guy Alain Ouédraogo Dofinihanou Dite Inessa Coulibaly +3 位作者 Mênonli Adjobimey Abdoul Risgou Ouédraogo Rose Mikponhoue Antoine Vikkey Hinson 《Occupational Diseases and Environmental Medicine》 2024年第1期1-20,共20页
Introduction: Sleep disorders among professional drivers are a major road safety problem. They cause fatigue and drowsiness at the wheel, which can lead to road traffic accidents and even accidents at work. The aim of... Introduction: Sleep disorders among professional drivers are a major road safety problem. They cause fatigue and drowsiness at the wheel, which can lead to road traffic accidents and even accidents at work. The aim of this study was to assess sleep disorders among professional drivers of oil tankers in Ouagadougou, Burkina Faso. Methods: This was a descriptive and analytical cross-sectional study carried out from 11 April 2020 to 11 September 2020 in the national hydrocarbon company’s fuel depot. All the drivers present at the time were included and accomplished a questionnaire incorporating the commonly scales using to assess sleep disorders, sleep quality and sleep apnoea. Data analysis using R 3.6.1 software enabled to perform univariate and multivariate analyses to identify associated factors. Adjusted odd ratios were used to measure the strength of association. The significance level chosen was p ≤ 0.05. Results: All the 339 respondents were male. A proportion of 33.6% suffered from insomnia, including 12.7% with moderate to severe insomnia, and 18.58% were at risk of sleep apnoea. On the Epworth scale, 26.6% of drivers showed sleep debt and 4.1% excessive daytime sleepiness. The risk factors associated with insomnia were the use of psychostimulants. A history of diabetes and insomnia were risk factors associated with sleep apnoea syndrome. Conclusion: The prevalence of sleep disturbance and insomnia among the respondents were 52.2% and 33.6% respectively. Use of psychostimulants was the identified risk factor. The prevalence of SAS was 4.72%, with diabetes and insomnia as associated factors. 展开更多
关键词 sleep Disorders sleep Apnoea Occupational Health Burkina
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SLEEP-MAD干预模式对ICU患者睡眠质量的影响 被引量:4
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作者 刘艳 许久玲 《中国临床护理》 2023年第6期331-334,共4页
目的探讨SLEEP-MAD干预模式对ICU患者睡眠质量和负性情绪的影响。方法将2020年1月-12月ICU收治的58例重症患者设为对照组,将2021年1月-12月ICU收治的60例重症患者设为观察组。在实施重症专科护理基础上,对照组给予常规睡眠管理,观察组采... 目的探讨SLEEP-MAD干预模式对ICU患者睡眠质量和负性情绪的影响。方法将2020年1月-12月ICU收治的58例重症患者设为对照组,将2021年1月-12月ICU收治的60例重症患者设为观察组。在实施重症专科护理基础上,对照组给予常规睡眠管理,观察组采用SLEEP-MAD干预模式实施睡眠管理,比较2组失眠严重程度、睡眠质量及负性情绪。结果干预后观察组失眠严重程度轻于对照组(Z=-3.585,P<0.001),睡眠质量优于对照组(t=7.431,P<0.001),焦虑及抑郁评分均低于对照组(t=16.765,P<0.001;t=16.245,P<0.001)。结论将SLEEP-MAD干预模式应用于ICU睡眠障碍患者中,可有效改善患者的睡眠质量,减轻其负性情绪,从而减轻患者的失眠严重程度。 展开更多
关键词 ICU 睡眠障碍 sleep-MAD干预模式 睡眠质量 负性情绪
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用Sleeping Beauty转座子筛选肺癌相关基因及功能研究
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作者 朱祥平 高增鸿 +3 位作者 马若骛 汪瑾 刘颖 郭雅彬 《岭南现代临床外科》 2023年第2期118-126,134,共10页
目的探讨睡美人(SB)转座子筛选肺癌相关基因的应用。方法采用Sleeping Beauty转座子插入T2/Onc盒子(T2/Onc cassette)诱变人支气管上皮细胞(HBEC)的模型,挑选阳性克隆,高通量测序筛选共同插入位点(CIS)及候选基因。在非小细胞肺癌(NSCLC... 目的探讨睡美人(SB)转座子筛选肺癌相关基因的应用。方法采用Sleeping Beauty转座子插入T2/Onc盒子(T2/Onc cassette)诱变人支气管上皮细胞(HBEC)的模型,挑选阳性克隆,高通量测序筛选共同插入位点(CIS)及候选基因。在非小细胞肺癌(NSCLC)细胞系NCI⁃H1299中验证筛选出的COL11A1基因功能,采用CCK⁃8细胞增殖实验等检测NCI⁃H1299细胞系敲低COL11A1前后的增殖能力及其对顺铂的敏感性变化,采用Transwell细胞迁移、侵袭实验比较其迁移、侵袭能力变化。结果使用转座子筛选中通用的蒙特卡洛模拟法确定CIS,以P<0.05为界,共找到252个CIS,包括675个候选基因。结果显示,筛选出的COL11A1基因可以促进NCI⁃H1299细胞系增殖(P<0.01)、迁移(P<0.001)、侵袭(P<0.001)并介导其顺铂耐药(P<0.001)。结论本研究证明了使用SB转座子插入T2/Onc诱变HBEC的模型能够很好地筛选出肺癌相关基因,并证实了COL11A1可以促进NSCLC细胞增殖、迁移、侵袭并介导顺铂耐药及上皮间质转换。 展开更多
关键词 非小细胞肺癌 睡美人转座子 基因筛选 COL11A1
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基于气机升降理论的针灸组方对心肾不交型失眠患者睡眠质量和睡眠进程的影响 被引量:3
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作者 胡亚丹 蒋进枝 《辽宁中医杂志》 CAS 北大核心 2024年第1期166-170,共5页
目的探讨分析基于气机升降理论的针灸组方对心肾不交型失眠患者睡眠质量和睡眠进程的影响。方法前瞻性选取2019年1月—2021年12月收治入院的84例心肾不交型失眠患者根据随机数字表法分为治疗A组(42例)和治疗B组(42例)。治疗A组予以常规... 目的探讨分析基于气机升降理论的针灸组方对心肾不交型失眠患者睡眠质量和睡眠进程的影响。方法前瞻性选取2019年1月—2021年12月收治入院的84例心肾不交型失眠患者根据随机数字表法分为治疗A组(42例)和治疗B组(42例)。治疗A组予以常规针法治疗,治疗B组患者则予以基于气机升降理论的针灸组方治疗。评估两组患者的实际睡眠总时间、PSQI量表评分、睡眠进程参数、入睡时间、日间功能障碍以及不良反应。结果干预后两组纳入患者的PSQI量表评分较干预前均有了显著改善(P<0.05),且干预后治疗B组患者的PSQI量表评分显著低于治疗A组(P<0.05);干预后两组纳入患者的睡眠进程参数指标较干预前均有显著改善(P<0.05),且干预后治疗B组患者的总睡眠时间、睡眠效率指标显著高于治疗A组,而睡眠潜伏期、觉醒时间指标则显著低于治疗A组(P<0.05);干预后两组纳入患者入睡时间、日间功能障碍较干预前均显著降低(P<0.05),且干预后治疗B组患者的入睡时间、日间功能障碍均显著低于治疗A组(P<0.05);干预后两组纳入患者的实际睡眠总时间较干预前均有了显著改善(P<0.05),且干预后治疗B组患者的实际睡眠总时间显著高于治疗A组(P<0.05);两组心肾不交型失眠患者在治疗期间均未出现严重不良反应,干预方案安全性良好。治疗A组患者出现穿刺处血肿4例、穿刺处感染2例、滞针4例,总出现率为23.81%(10/42);治疗B组患者出现穿刺处血肿1例、穿刺处感染0例、滞针1例,总出现率为4.76%(2/42),且治疗B组患者的总出现率显著低于治疗A组(P<0.05)。结论基于气机升降理论的针灸组方治疗心肾不交型失眠患者,其临床干预效果显著,可有效改善患者的PSQI量表评分以及睡眠进程参数,缩短入睡时间,提高实际睡眠总时间,缓解日间功能障碍,且不良反应少。 展开更多
关键词 气机升降理论 针灸 心肾不交型失眠 睡眠质量 睡眠进程
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网络成瘾对大学生学业压力的影响:睡眠质量与自我控制的中介作用 被引量:3
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作者 张陆 孙山 游志麒 《心理发展与教育》 CSSCI 北大核心 2024年第2期279-287,共9页
本研究基于资源保存理论,运用日志法调查了153名大学生,采用多水平结构方程模型,探讨了睡眠质量和自我控制在网络成瘾与大学生学业压力关系间的中介机制。结果发现:(1)早期测量的网络成瘾能够预测后来测量的总体学业压力、睡眠质量和自... 本研究基于资源保存理论,运用日志法调查了153名大学生,采用多水平结构方程模型,探讨了睡眠质量和自我控制在网络成瘾与大学生学业压力关系间的中介机制。结果发现:(1)早期测量的网络成瘾能够预测后来测量的总体学业压力、睡眠质量和自我控制水平;(2)自我控制能够独立中介网络成瘾与学业压力间的关系;(3)睡眠质量和自我控制能够序列中介网络成瘾与学业压力间的关系。本研究结果提示,可以通过预防和干预网络成瘾减轻大学生感知的学业压力,对于有学业压力的网络成瘾大学生,可以通过提高睡眠质量等方式增强其自我控制资源,来缓解他们的学业压力。 展开更多
关键词 学业压力 网络成瘾 睡眠质量 自我控制 日志法
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乐眠操对抑郁伴失眠患者睡眠质量的效果观察 被引量:1
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作者 骆蕾 徐文静 +1 位作者 李丽霞 孙伟 《中国医学科学院学报》 CAS CSCD 北大核心 2024年第1期49-54,共6页
目的探讨乐眠操对抑郁伴失眠患者睡眠质量的影响。方法选取2022年2至8月在北京大学第六医院住院的抑郁伴失眠患者79例,根据是否进行乐眠操干预分为对照组(n=40)和试验组(n=39)。试验组患者除常规治疗、护理外,每天早晚各1次乐眠操干预,... 目的探讨乐眠操对抑郁伴失眠患者睡眠质量的影响。方法选取2022年2至8月在北京大学第六医院住院的抑郁伴失眠患者79例,根据是否进行乐眠操干预分为对照组(n=40)和试验组(n=39)。试验组患者除常规治疗、护理外,每天早晚各1次乐眠操干预,对照组患者进行常规治疗和护理。采用匹兹堡睡眠质量指数量表(PSQI)、失眠严重程度指数(ISI)、健康调查量表36(SF-36)评估患者在干预前、后的相应指标。结果试验组和对照组一般资料比较差异均无统计学意义(P均>0.05)。乐眠操干预2周后,与对照组比较,试验组患者PSQI、ISI总分明显减少,SF-36总分明显增加(P均<0.001)。结论乐眠操可以改善抑郁伴失眠患者的睡眠质量。 展开更多
关键词 乐眠操 抑郁症 失眠 睡眠质量
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Cognitive and Emotional Factors Related to Obstructive Sleep Apnea Diagnoses: A Brief Review
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作者 Kathy Sexton-Radek 《Health》 2023年第9期944-953,共10页
Sleep apnea is a clinical condition characterized by cessation of breathing in the sleeper due to pharyngeal airway closure. The reduction in air exchange results in decreased cerebral blood circulation with consequen... Sleep apnea is a clinical condition characterized by cessation of breathing in the sleeper due to pharyngeal airway closure. The reduction in air exchange results in decreased cerebral blood circulation with consequential behavioral deficits cognitively and emotionally. Untreated sleep apnea is associated with chronic illnesses of depression, cardiovascular disorder, obesity and diabetes mellitus. Measured cognitive behavior before and following CPAP treatment demonstrates the cognitive deficit as the effectiveness of CPAP treatment. Emotional factors related to sleep apnea diagnosis and adherence to treatment are facilitated in patients with cognitive behavior therapy (CBT) interventions by sleep specialists. This is a brief review paper that presents findings about cognition and emotional factors related to sleep apnea. This is a brief review paper. 展开更多
关键词 OSA sleep Apnea sleepINESS Executive Functioning Reactive Depression Death Anxiety Compliance sleep Intellectual Ability
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维生素D联合右佐匹克隆治疗老年慢阻肺合并睡眠障碍疗效及对认知功能的保护作用研究 被引量:3
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作者 古力巴克然木·阿布拉 阿布都萨拉木·阿布拉 马瑞 《临床肺科杂志》 2024年第2期216-221,共6页
目的探讨维生素D联合右佐匹克隆治疗老年慢阻肺合并睡眠障碍疗效及对认知功能的保护作用。方法收集140例老年慢阻肺合并睡眠障碍患者作为研究对象,随机分为对照组和研究组,每组70例。对照组给予右佐匹克隆治疗,研究组给予维生素D联合右... 目的探讨维生素D联合右佐匹克隆治疗老年慢阻肺合并睡眠障碍疗效及对认知功能的保护作用。方法收集140例老年慢阻肺合并睡眠障碍患者作为研究对象,随机分为对照组和研究组,每组70例。对照组给予右佐匹克隆治疗,研究组给予维生素D联合右佐匹克隆治疗。采用匹茨堡睡眠质量指数(PSQI)评估睡眠质量。采用简易精神状态量表(MMSE)和蒙特利尔认知评估量表(MoCA)评估认知功能。比较两组睡眠障碍临床疗效、睡眠监测指标、PSQI评分、认知功能和神经营养因子水平。结果研究组睡眠障碍治疗总有效率高于对照组(92.8%vs 80.0%,P<0.05)。睡眠监测指标显示,研究组治疗后总睡眠时间长于对照组[(371.77±27.22)min vs(334.71±28.80 min)],觉醒时间和觉醒次数少于对照组[(32.51±3.89)min vs(46.88±7.32)min,(1.36±0.51)次vs(3.11±0.77)次,P<0.05]。治疗前、治疗后1月和治疗后3月时,不同时间点PSQI评分差异有统计学意义(P<0.05),研究组与对照组PSQI评分变化趋势差异有统计学意义,研究组降低更明显[(15.78±2.02)分vs(15.67±2.05)分,(9.31±2.01)分vs(11.60±2.04)分,(7.60±0.95)分vs(9.40±1.21)分,P<0.05]。研究组治疗后MMSE评分和MoCA评分高于对照组[(28.24±0.92)分vs(26.24±1.53)分,(27.88±1.23)分vs(25.21±1.02)分],脑源性神经生长因子(BDNF)和神经生长因子(NGF)水平高于对照组[(672.29±66.60)pg/mL vs(626.89±55.46)pg/mL,(31.49±5.62)pg/mL vs(23.75±5.18)pg/mL,P<0.05]。结论维生素D联合右佐匹克隆治疗老年慢阻肺合并睡眠障碍疗效良好,而且对认知功能具有一定程度的保护作用。 展开更多
关键词 维生素D 右佐匹克隆 老年 慢阻肺 睡眠障碍 认知功能
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