method of extracting astaxanthin from Phaffia rhodozyma with various solvents after acid washing was investigated. The extraction efficiency was distinctly increased after acid washing of P. rhodozyma cells. When the ...method of extracting astaxanthin from Phaffia rhodozyma with various solvents after acid washing was investigated. The extraction efficiency was distinctly increased after acid washing of P. rhodozyma cells. When the concentration of HCl was 0.4 mol.L^-1, the highest extraction efficiency of astaxanthin was achieved which was about three times higher than the control. Acetone or benzene as single polar or non-polar solvent was the most ef- fective solvent in our research. With a combination of isopropanol and n-hexane （volume ratio of 2 ： 1）, the maxi- mal extraction efficiency was achieved, approximately 60% higher than that obtained with a single solvent. The liquid-solid ratio and the extracting time were also optimized. Under the optimum extraction conditions, the extraction yield of astaxanthin exceeded 98%.展开更多
The pathogenesis of autoimmune hepatitis (AIH) is complex. However,it is believed that a susceptible individual,owing to his genetic background,sex and age,can develop the disease following exposure to an environmenta...The pathogenesis of autoimmune hepatitis (AIH) is complex. However,it is believed that a susceptible individual,owing to his genetic background,sex and age,can develop the disease following exposure to an environmental trigger. Autoimmune hepatitis does not follow a Mendelian pattern of inheritance; hence no single causative genetic locus has been identified. However,several genes,inside and outside the HLA locus,have been linked to an increased susceptibility to AIH. Epidemiological evidence also suggests that the sex and age of the patient plays a role in AIH pathogenesis as the disease onset occurs mainly in the two first decades of life and a higher disease incidence is observed in females. No environmental trigger has been identified,but several have been proposed,mainly viruses and xenobiotics. This article aims at reviewing the current knowledge on susceptibility factors leading to AIH and putative triggers,emphasizing fundamental mechanisms responsible for the break of liver immunological tolerance.展开更多
Autoimmune hepatitis (AIH) is a necroinflammatory liver disease of unknown etiology that occurs in children and adults of all ages. Characteristics are its autoimmune features,hyperglobulinemia (IgG),and the presence ...Autoimmune hepatitis (AIH) is a necroinflammatory liver disease of unknown etiology that occurs in children and adults of all ages. Characteristics are its autoimmune features,hyperglobulinemia (IgG),and the presence of circulating autoantibodies,as well as a response to immunosuppressant drugs. Current treatment consists of prednisone and azathioprine and in most patients this disease has become very treatable. Over the past 2 years,a couple of new insights into the genetic aspects,clinical course and treatment of AIH have been reported,which will be the focus of this review. In particular,we concentrate on genome-wide microsatellite analysis,a novel mouse model of AIH,the evaluation of a large AIH cohort for overlap syndromes,suggested novel criteria for the diagnosis of AIH,and the latest studies on treatment of AIH with budenoside and mycophenolate mofetil.展开更多
We study the dynamic cavity method for dilute kinetic Ising models with synchronous update rules. For the parallel update rule we find for fully asymmetric models that the dynamic cavity equations reduce to a Markovia...We study the dynamic cavity method for dilute kinetic Ising models with synchronous update rules. For the parallel update rule we find for fully asymmetric models that the dynamic cavity equations reduce to a Markovian dynamics of the (time-dependent) marginal probabilities. For the random sequential update rule, also an instantiation of a synchronous update rule, we find on the other hand that the dynamic cavity equations do not reduce to a Markovian dynamics, unless an additional assumption of time factorization is introduced. For symmetric models we show that a fixed point of ordinary Belief propagation is also a fixed point of the dynamic cavity equations in the time factorized approximation. For clarity, the conclusions of the paper are formulated as three lemmas.展开更多
Autoimmune hepatitis (AIH) is a chronic disease of unknown etiology that is characterized by the presence of circulatory autoantibodies and inflammatory histological changes in the liver. Although the pathogenesis of ...Autoimmune hepatitis (AIH) is a chronic disease of unknown etiology that is characterized by the presence of circulatory autoantibodies and inflammatory histological changes in the liver. Although the pathogenesis of AIH is not known, it is thought that, in a genetically predisposed individual, environmental factors such as viruses can trigger the autoimmune process. Herpes simplex virus, Epstein-Barr virus, measles virus, and hepatitis viruses are thought to play a role in the etiology of AIH. Proteins belonging to these viruses may be similar to the amino acid chains of different autoantigens in the liver, this causes immune cross reactions and liver tissue damage. We report a case of severe AIH following varicella zoster infection in a 23-year-old man, and speculate that, based on the molecular mimicry hypothesis, the liver damage was caused by an immune cross reaction to the viral proteins. Varicella-zoster-induced AIH has not been reported previously.展开更多
In order to predict the levels of corona noise from high-voltage alternating current （AC） transmission lines, the mechanism of corona noise and the corresponding theoretical prediction model are investigated. On the...In order to predict the levels of corona noise from high-voltage alternating current （AC） transmission lines, the mechanism of corona noise and the corresponding theoretical prediction model are investigated. On the basis of Drnde model, the motion of positive and negative ions produced by high-voltage corona is analyzed, and the mechanism of corona noise is discovered. The theoretical prediction model is put forward by using Kirchhoff formula, which is verified by the well agreement between our result and others＇ , considering the case of three- phase single lines. Moreover, the calculation results show that for both single and bundled lines, the sound pres- sure level of the typical frequency, i.e. twice the power frequency, attenuates slowly and leads to an obviously in- terferential phenomenon near the transmission lines, but the level of the bundled lines is smaller than that of the single ones under the same transmission voltage. Based on the mechanism of corona noise and the prediction model, it is obvious that bundled lines and/or increased line radius can be adopted to reduce corona noise in the practical engineering applications effectively. This model can also provide a theoretical guidance for the high-volt- age AC transmission line design.展开更多
This paper describes the procedure of using the GM (1,1) weighted Markov chain (GMWMC) to forecast the utility water supply, a quantity that usually has significant temporal variability. The GMWMC is formulated into f...This paper describes the procedure of using the GM (1,1) weighted Markov chain (GMWMC) to forecast the utility water supply, a quantity that usually has significant temporal variability. The GMWMC is formulated into five steps: (1) use GM (1,1) to fit the trend of the data, and obtain the relative error of the fitted values; (2) divide the relative error into ‘state’ data based on pre-set intervals; (3) calibrate the weighted Markov chain model: herein the parameters are the pre-set interval and the step of transition matrix (TM); (4) by using auto-correlation coefficient as the weight, the Markov chain provides the prediction interval. Then the mid-value of the interval is selected as the relative error for the data. Upon combining the data and its relative error, the predicted magnitude in a specific time period is obtained; and, (5) validate the model. Commonly, static intervals are used in both model calibration and validation stages, usually causing large errors. Thus, a dynamic adjustment interval (DAI) is proposed for a better performance. The proposed procedure is described and demonstrated through a case study, which shows that the DAI can usually achieve a better performance than the static interval, and the best TM may exist for certain data.展开更多
This study investigates the regional distribution of marine aerosol originated species （Na＋, CI-, nss-SO42- and MSA） in the snow pits （or firn cores） collected along a transect between Zhongshan Station and the G...This study investigates the regional distribution of marine aerosol originated species （Na＋, CI-, nss-SO42- and MSA） in the snow pits （or firn cores） collected along a transect between Zhongshan Station and the Grove Mountain area （450 km inland） on the eastern side of the Lambert Glacier Basin. Concentrations of Na＋ and Cl- decrease exponentially with distance from the coast to 100 km inland （i.e., 1500 m a.s.1.）. Statistical results demonstrate that distance from the coast inland and elevation af-fect the concentration of sea-salt originated ions in inland areas significantly. Increase of Cl-/Na＋ ratio and higher variability in its standard deviation suggest that there are other sources of ions in addition to sea-salt in inland areas of the Antarctic conti- nent. The concentrations of Na＋ and Cl- from nine sampling sites in the Grove Mountain area are relatively higher than those from sites along CHINARE transect, although all sites are at similar distance inland. This phenomenon indicates that the barri- er effect of the mountain may be the most important factor influencing ion deposition. In addition, nss-SO42- and MSA vary differently, with nss-SO42- decreasing with distance more significantly. This implies that sources and transporting pathways influence the deposition of the two sulfur compounds considerably, being supported by the spatial pattern of correlation coeffi- cients between the nss-SO42- and MSA.展开更多
The non-Markov process exists widely in thermodymanic process,while it usually requires the packing of many transistors and memories with great system complexity in a traditional device structure to minic such functio...The non-Markov process exists widely in thermodymanic process,while it usually requires the packing of many transistors and memories with great system complexity in a traditional device structure to minic such functions.Two-dimensional(2D)material-based resistive random access memory(RRAM)devices have the potential for next-generation computing systems with much-reduced complexity.Here,we achieve a non-Markov chain in an individual RRAM device based on 2D mineral material mica with a vertical metal/mica/metal structure.We find that the potassium ions(K+)in 2D mica gradually move in the direction of the applied electric field,making the initially insulating mica conductive.The accumulation of K+is changed by an electric field,and the 2D-mica RRAM has both single and double memory windows,a high on/off ratio,decent stability,and repeatability.This is the first time a non-Markov chain process has been established in a single RRAM,in which the movement of K+is dependent on the stimulated voltage as well as their past states.This work not only uncovers an intrinsic inner ionic conductivity of 2D mica,but also opens the door for the production of such RRAM devices with numerous functions and applications.展开更多
基金Supported by the Fundamental Research Funds for the Central Universities （FRF-AS-10-001B） and the National Natural Science Foundation of China （11071013）.
文摘method of extracting astaxanthin from Phaffia rhodozyma with various solvents after acid washing was investigated. The extraction efficiency was distinctly increased after acid washing of P. rhodozyma cells. When the concentration of HCl was 0.4 mol.L^-1, the highest extraction efficiency of astaxanthin was achieved which was about three times higher than the control. Acetone or benzene as single polar or non-polar solvent was the most ef- fective solvent in our research. With a combination of isopropanol and n-hexane （volume ratio of 2 ： 1）, the maxi- mal extraction efficiency was achieved, approximately 60% higher than that obtained with a single solvent. The liquid-solid ratio and the extracting time were also optimized. Under the optimum extraction conditions, the extraction yield of astaxanthin exceeded 98%.
文摘The pathogenesis of autoimmune hepatitis (AIH) is complex. However,it is believed that a susceptible individual,owing to his genetic background,sex and age,can develop the disease following exposure to an environmental trigger. Autoimmune hepatitis does not follow a Mendelian pattern of inheritance; hence no single causative genetic locus has been identified. However,several genes,inside and outside the HLA locus,have been linked to an increased susceptibility to AIH. Epidemiological evidence also suggests that the sex and age of the patient plays a role in AIH pathogenesis as the disease onset occurs mainly in the two first decades of life and a higher disease incidence is observed in females. No environmental trigger has been identified,but several have been proposed,mainly viruses and xenobiotics. This article aims at reviewing the current knowledge on susceptibility factors leading to AIH and putative triggers,emphasizing fundamental mechanisms responsible for the break of liver immunological tolerance.
文摘Autoimmune hepatitis (AIH) is a necroinflammatory liver disease of unknown etiology that occurs in children and adults of all ages. Characteristics are its autoimmune features,hyperglobulinemia (IgG),and the presence of circulating autoantibodies,as well as a response to immunosuppressant drugs. Current treatment consists of prednisone and azathioprine and in most patients this disease has become very treatable. Over the past 2 years,a couple of new insights into the genetic aspects,clinical course and treatment of AIH have been reported,which will be the focus of this review. In particular,we concentrate on genome-wide microsatellite analysis,a novel mouse model of AIH,the evaluation of a large AIH cohort for overlap syndromes,suggested novel criteria for the diagnosis of AIH,and the latest studies on treatment of AIH with budenoside and mycophenolate mofetil.
基金Supported by the Academy of Finland as part of Its Finland Distinguished Professor Program, Project 129024/Aurellin part by the Project of Knowledge Innovation Program (PKIP) of Chinese Academy of Sciences under Grant No. KJCX2.YW.W10
文摘We study the dynamic cavity method for dilute kinetic Ising models with synchronous update rules. For the parallel update rule we find for fully asymmetric models that the dynamic cavity equations reduce to a Markovian dynamics of the (time-dependent) marginal probabilities. For the random sequential update rule, also an instantiation of a synchronous update rule, we find on the other hand that the dynamic cavity equations do not reduce to a Markovian dynamics, unless an additional assumption of time factorization is introduced. For symmetric models we show that a fixed point of ordinary Belief propagation is also a fixed point of the dynamic cavity equations in the time factorized approximation. For clarity, the conclusions of the paper are formulated as three lemmas.
文摘Autoimmune hepatitis (AIH) is a chronic disease of unknown etiology that is characterized by the presence of circulatory autoantibodies and inflammatory histological changes in the liver. Although the pathogenesis of AIH is not known, it is thought that, in a genetically predisposed individual, environmental factors such as viruses can trigger the autoimmune process. Herpes simplex virus, Epstein-Barr virus, measles virus, and hepatitis viruses are thought to play a role in the etiology of AIH. Proteins belonging to these viruses may be similar to the amino acid chains of different autoantigens in the liver, this causes immune cross reactions and liver tissue damage. We report a case of severe AIH following varicella zoster infection in a 23-year-old man, and speculate that, based on the molecular mimicry hypothesis, the liver damage was caused by an immune cross reaction to the viral proteins. Varicella-zoster-induced AIH has not been reported previously.
文摘In order to predict the levels of corona noise from high-voltage alternating current （AC） transmission lines, the mechanism of corona noise and the corresponding theoretical prediction model are investigated. On the basis of Drnde model, the motion of positive and negative ions produced by high-voltage corona is analyzed, and the mechanism of corona noise is discovered. The theoretical prediction model is put forward by using Kirchhoff formula, which is verified by the well agreement between our result and others＇ , considering the case of three- phase single lines. Moreover, the calculation results show that for both single and bundled lines, the sound pres- sure level of the typical frequency, i.e. twice the power frequency, attenuates slowly and leads to an obviously in- terferential phenomenon near the transmission lines, but the level of the bundled lines is smaller than that of the single ones under the same transmission voltage. Based on the mechanism of corona noise and the prediction model, it is obvious that bundled lines and/or increased line radius can be adopted to reduce corona noise in the practical engineering applications effectively. This model can also provide a theoretical guidance for the high-volt- age AC transmission line design.
基金Project supported by the National Natural Science Foundation of China (No. 50778121)the National Basic Research Program of China (No. 2007CB407306-1)the National Water Pollution Control and Management of Science and Technology Project of China (No. 2008ZX07317-005)
文摘This paper describes the procedure of using the GM (1,1) weighted Markov chain (GMWMC) to forecast the utility water supply, a quantity that usually has significant temporal variability. The GMWMC is formulated into five steps: (1) use GM (1,1) to fit the trend of the data, and obtain the relative error of the fitted values; (2) divide the relative error into ‘state’ data based on pre-set intervals; (3) calibrate the weighted Markov chain model: herein the parameters are the pre-set interval and the step of transition matrix (TM); (4) by using auto-correlation coefficient as the weight, the Markov chain provides the prediction interval. Then the mid-value of the interval is selected as the relative error for the data. Upon combining the data and its relative error, the predicted magnitude in a specific time period is obtained; and, (5) validate the model. Commonly, static intervals are used in both model calibration and validation stages, usually causing large errors. Thus, a dynamic adjustment interval (DAI) is proposed for a better performance. The proposed procedure is described and demonstrated through a case study, which shows that the DAI can usually achieve a better performance than the static interval, and the best TM may exist for certain data.
基金supported by the Innovative Research Group of the National Natural Science Foundation of China(Grant No.41121001)the National Basic Research Program of China(Grant No.2013CBA01804)+2 种基金the Foundation for Excellent Youth Scholars of CAREERI,Chinese Academy of Sciences,the National Natural Science Foundation of China(Grant Nos.41201069,40776002,40825017,41171052)the Hundred Talent Project of Chinese Academy of Sciences,the Polar Scientific Explore Organizing Committee Foundation(Grant Nos20080202,0852H71001)State Oceanic Administration of People’s Republic of China Project on Climate in Polar Regions(Grant Nos.CHINARE 2012-04-04,CHINARE 2012-02-02)
文摘This study investigates the regional distribution of marine aerosol originated species （Na＋, CI-, nss-SO42- and MSA） in the snow pits （or firn cores） collected along a transect between Zhongshan Station and the Grove Mountain area （450 km inland） on the eastern side of the Lambert Glacier Basin. Concentrations of Na＋ and Cl- decrease exponentially with distance from the coast to 100 km inland （i.e., 1500 m a.s.1.）. Statistical results demonstrate that distance from the coast inland and elevation af-fect the concentration of sea-salt originated ions in inland areas significantly. Increase of Cl-/Na＋ ratio and higher variability in its standard deviation suggest that there are other sources of ions in addition to sea-salt in inland areas of the Antarctic conti- nent. The concentrations of Na＋ and Cl- from nine sampling sites in the Grove Mountain area are relatively higher than those from sites along CHINARE transect, although all sites are at similar distance inland. This phenomenon indicates that the barri- er effect of the mountain may be the most important factor influencing ion deposition. In addition, nss-SO42- and MSA vary differently, with nss-SO42- decreasing with distance more significantly. This implies that sources and transporting pathways influence the deposition of the two sulfur compounds considerably, being supported by the spatial pattern of correlation coeffi- cients between the nss-SO42- and MSA.
基金This work was supported by the National Natural Science Foundation of China(51920105002,51991340,51722206,and 51991343)Guangdong Innovative and Entrepreneurial Research Team Program(2017ZT07C341)+1 种基金the Bureau of Industry and Information Technology of Shenzhen for the“2017 Graphene Manufacturing Innovation Center Project”(201901171523)the Shenzhen Basic Research Program(JCYJ20200109144620815 and JCYJ20200109144616617).
文摘The non-Markov process exists widely in thermodymanic process,while it usually requires the packing of many transistors and memories with great system complexity in a traditional device structure to minic such functions.Two-dimensional(2D)material-based resistive random access memory(RRAM)devices have the potential for next-generation computing systems with much-reduced complexity.Here,we achieve a non-Markov chain in an individual RRAM device based on 2D mineral material mica with a vertical metal/mica/metal structure.We find that the potassium ions(K+)in 2D mica gradually move in the direction of the applied electric field,making the initially insulating mica conductive.The accumulation of K+is changed by an electric field,and the 2D-mica RRAM has both single and double memory windows,a high on/off ratio,decent stability,and repeatability.This is the first time a non-Markov chain process has been established in a single RRAM,in which the movement of K+is dependent on the stimulated voltage as well as their past states.This work not only uncovers an intrinsic inner ionic conductivity of 2D mica,but also opens the door for the production of such RRAM devices with numerous functions and applications.
