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迟发性神经元坏死大鼠不同脑区组织中NO与SOD的关系
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作者 张见影 吕晓红 张巨 《吉林大学学报(医学版)》 CAS CSCD 北大核心 2006年第1期53-56,共4页
目的:探讨一氧化氮(NO)与超氧化物歧化酶(SOD)对迟发性神经元坏死(DND)发生、发展的影响及两者的关系。方法:Wistar大鼠制做血管阻断(four-vessel occlusion,4VO)模型,给予小剂量一氧化氮合酶(NOS)抑制剂干预,通过分光光度法测定不同脑... 目的:探讨一氧化氮(NO)与超氧化物歧化酶(SOD)对迟发性神经元坏死(DND)发生、发展的影响及两者的关系。方法:Wistar大鼠制做血管阻断(four-vessel occlusion,4VO)模型,给予小剂量一氧化氮合酶(NOS)抑制剂干预,通过分光光度法测定不同脑区中NO和SOD的含量。结果:实验组再灌流期一氧化氮代谢产物(NO x)(NO2+NO3)含量与对照组比较升高不明显(P>0.05),随再灌流时间的延长逐渐递减并低于对照组(P<0.05或0.01),SOD在海马区再灌流期明显下降(P<0.05或0.01),而NOS抑制剂对其无明显影响。相关性分析显示,脑组织中NO x与SOD含量呈正相关关系(r=0.9624,P<0.05或0.01)。结论:小剂量NOS抑制剂在DND中具有保护神经细胞受损伤作用,SOD不仅能够消除超氧阴离子,而且对 NO x自由基也有较强的消除作用。 展开更多
关键词 迟发性神经元坏死 一氧化氮/化学 氧化物歧化酶/化学 脑组织
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Kinetic modelling of NO+CO reaction on Pt/MoO_x/Al_2O_3 catalyst
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作者 焦宇兵 孙寿家 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2003年第2期151-153,共3页
A mathematical model has been developed to describe the dynamic behaviours of NO+CO reaction on supported Pt MO catalyst. The ignited state kinetics can be fit quantitatively using directly a Langmuir Henshelwood bimo... A mathematical model has been developed to describe the dynamic behaviours of NO+CO reaction on supported Pt MO catalyst. The ignited state kinetics can be fit quantitatively using directly a Langmuir Henshelwood bimolecular rate expression with a heat of adsorption of NO of 32 4 kJ/mol and of CO of 106 7 kJ/mol, respectively. 展开更多
关键词 modelling mechanism NO CO platinum catalyst
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Use of microelectrodes for electrochemical measurement of nitric oxide in natural seawater
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作者 张正斌 邢磊 +2 位作者 蔡卫君 任春艳 姜立庆 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2004年第4期373-380,共8页
In this paper, the application of a homemade Nafion and Co(Salen) modified platinum microelec-trode and an ISO-NOPMC microsensor (World Precision Instruments, USA ) to measure nitric oxide in natural seawater is repor... In this paper, the application of a homemade Nafion and Co(Salen) modified platinum microelec-trode and an ISO-NOPMC microsensor (World Precision Instruments, USA ) to measure nitric oxide in natural seawater is reported. These two microelectrodes are suitable for the measurement. In natural seawater, the sensitivity and stability of the ISO-NOPMC microsensor are higher than that of the homemade Nafion and Co(Salen) modified platinum microelectrode. 展开更多
关键词 Nafion and Co(Salen) modified platinum microelectrode ISO-NOPMC microsensor nitric oxide seawater
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The relationship between nNOS and Cyt-c in mitochondria of glioma
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作者 Na Li Zongze Guo Gangyu Li Weicheng Lu Weixin Zhang Yunjie Wang 《The Chinese-German Journal of Clinical Oncology》 CAS 2009年第10期582-584,共3页
Objective: The aim of this study was to investigate the association between neuronal nitric oxide synthase (nNOS) and the expression level of Cytochrome C (Cyt-c) in mitochondria. Methods: The pathological diagn... Objective: The aim of this study was to investigate the association between neuronal nitric oxide synthase (nNOS) and the expression level of Cytochrome C (Cyt-c) in mitochondria. Methods: The pathological diagnosis of glioma and tumor classification was by HE staining, and we use immunohistochemistry method to analyse the level of nNOS in different pathological grade glioma and the expression level of Cyt-c in mitochondria meanwhile. Results: The levels of nNOS were highest in grade Ⅲ tumors, moderate in grade Ⅱ tumors, and lowest different in grade I tumors. There was significant difference of the nNOS levels among different pathological grade tumors (P 〈 0.05). Furthermore, the similar phenomenon was observed in the expression level of Cyt-c in mitochondria (P 〈 0.05). Conclusion: The expression level of nNOS and Cyt-c in mitochondria was significantly related to the pathological grade of glioma. 展开更多
关键词 neuronal nitric synthale (nNOS) Cytochrome C (Cyt-c) pathological grade GLIOMA IMMUNOHISTOCHEMISTRY
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