The world is entering into a new era of economic globalization. Realizing the benefits of globalization depends on a host of realistic conditions including technology and infrastructure, geopolitical pattern and the s...The world is entering into a new era of economic globalization. Realizing the benefits of globalization depends on a host of realistic conditions including technology and infrastructure, geopolitical pattern and the structure of market power, and international institutional arrangements, i.e., the global governance structure, among others. In this new era of economic globalization, international competition boils down to the ＂good governance＂ of countries rather than the use of force and hegemonism. Most importantly, a country must promote the vibrancy of innovation in order to stay competitive and creative. In this sense, China＇s position in the new era of economic globalization hinges upon its transition from being the ＂leader of world economic growth＂ to being a future ＂leader of good governance and vibrancy. ＂ Interests of various economies become interlocked, intertwined and overlap. Despite the inevitability of conflicts and frictions, more inclusive and balanced global development serves the interests of most nations. For great powers with extended boundaries of interests across the world, the maintenance of the new balance of power in economic globalization is consistent with their respective national interests. Hence, in the new era of economic globalization characterized by the inevitability of intricate interests and inevitable conflicts, the world is likely to be more peaceful, competitive and inclusive than any previous age of economic globalization.展开更多
5-aminosalicylate(5-ASA)agents remain the mainstay treatment in ulcerative colitis(UC).A number of oral 5-ASA agents are commercially available,including azobond pro-drugs,as well as delayed-and controlledrelease form...5-aminosalicylate(5-ASA)agents remain the mainstay treatment in ulcerative colitis(UC).A number of oral 5-ASA agents are commercially available,including azobond pro-drugs,as well as delayed-and controlledrelease forms of mesalazine.However,poor adherence due to frequent daily dosing and a large number of tablets has been shown to be an important barrier to successful management of patients with UC.Recently, new,once-daily formulations of mesalazine,including the unique multi-matrix delivery system and mesalazine granules,were proven to be efficacious in inducing and maintaining remission in mild-to-moderate UC,with a good safety profile comparable to that of other oral mesalazine formulations.In addition,they offer the advantage of a low pill burden and might contribute to increased long-term compliance and treatment success in clinical practice.This editorial summarizes the available literature on the short-and medium-term efficacy and safety of the new once-daily mesalazine formulations.展开更多
AIM： To investigate the cellular mechanisms of action of Yiguanjian （YGJ） decoction in treatment of chronic hepatic injury. METHODS： One group of mice was irradiated, and received enhanced green fluorescent prote...AIM： To investigate the cellular mechanisms of action of Yiguanjian （YGJ） decoction in treatment of chronic hepatic injury. METHODS： One group of mice was irradiated, and received enhanced green fluorescent protein （EGFP）- positive bone marrow transplants followed by 13 wk of CCh injection and 6 wk of oral YGJ administration. A second group of Institute for Cancer Research mice was treated with 13 wk of CCI4 injection and 6 wk of oral YGJadministration. Liver function, histological changes in the liver, and Hyp content were analyzed. The expres- sion of m-smooth muscle actin （α-SMA）, F4/80, albumin （AIb）, EGFP, mitogen-activated protein kinase-2 （PKM2）, Ki-67, fetoprotein （AFP）, monocyte chemotaxis pro- tein-1 and CC chemokine receptor 2 were assayed. RESULTS： As hepatic damage progressed, EGFP-po- sitive marrow cells migrated into the liver and were mainly distributed along the fibrous septa. They showed a conspicuous coexpression of EGFP with ^-SMA and F4/80 but no coexpression with AIb. Moreover, the expression of PKM2, AFP and Ki-67 was enhanced dy- namically and steadily over the course of liver injury. YGJ abrogated the increases in the number of bone marrow-derived fibrogenic cells in the liver, inhibited expression of both progenitor and mature hepatocyte markers, and reduced fibrogenesis. CONCLUSION： YGJ decoction improves liver fibrosis by inhibiting the migration of bone marrow cells into the liver as well as inhibiting their differentiation and suppressing the proliferation of both progenitors and hepatocytes in the injured liver.展开更多
A wide range of quantum systems are time-invariant and the corresponding dynamics is dic- tated by linear differential equations with constant coefficients. Although simple in math- ematical concept, the integration o...A wide range of quantum systems are time-invariant and the corresponding dynamics is dic- tated by linear differential equations with constant coefficients. Although simple in math- ematical concept, the integration of these equations is usually complicated in practice for complex systems, where both the computational time and the memory storage become limit- ing factors. For this reason, low-storage Runge-Kutta methods become increasingly popular for the time integration. This work suggests a series of s-stage sth-order explicit Runge- Kutta methods specific for autonomous linear equations, which only requires two times of the memory storage for the state vector. We also introduce a 13-stage eighth-order scheme for autonomous linear equations, which has optimized stability region and is reduced to a fifth-order method for general equations. These methods exhibit significant performance improvements over the previous general-purpose low-stage schemes. As an example, we ap- ply the integrator to simulate the non-Markovian exciton dynamics in a 15-site linear chain consisting of perylene-bisimide derivatives.展开更多
The bound state solutions of the Klein-Gordon equation with the rotating Deng-Fan molecular potential are presented by using a proper approximation to the centrifugal term within the framework of equal scalar and vect...The bound state solutions of the Klein-Gordon equation with the rotating Deng-Fan molecular potential are presented by using a proper approximation to the centrifugal term within the framework of equal scalar and vector Deng-Fan potentials. It is shown that the solutions can be expressed by the generalized hypergeometric functions. The normalized wavefunctions are also derived.展开更多
文摘The world is entering into a new era of economic globalization. Realizing the benefits of globalization depends on a host of realistic conditions including technology and infrastructure, geopolitical pattern and the structure of market power, and international institutional arrangements, i.e., the global governance structure, among others. In this new era of economic globalization, international competition boils down to the ＂good governance＂ of countries rather than the use of force and hegemonism. Most importantly, a country must promote the vibrancy of innovation in order to stay competitive and creative. In this sense, China＇s position in the new era of economic globalization hinges upon its transition from being the ＂leader of world economic growth＂ to being a future ＂leader of good governance and vibrancy. ＂ Interests of various economies become interlocked, intertwined and overlap. Despite the inevitability of conflicts and frictions, more inclusive and balanced global development serves the interests of most nations. For great powers with extended boundaries of interests across the world, the maintenance of the new balance of power in economic globalization is consistent with their respective national interests. Hence, in the new era of economic globalization characterized by the inevitability of intricate interests and inevitable conflicts, the world is likely to be more peaceful, competitive and inclusive than any previous age of economic globalization.
文摘5-aminosalicylate(5-ASA)agents remain the mainstay treatment in ulcerative colitis(UC).A number of oral 5-ASA agents are commercially available,including azobond pro-drugs,as well as delayed-and controlledrelease forms of mesalazine.However,poor adherence due to frequent daily dosing and a large number of tablets has been shown to be an important barrier to successful management of patients with UC.Recently, new,once-daily formulations of mesalazine,including the unique multi-matrix delivery system and mesalazine granules,were proven to be efficacious in inducing and maintaining remission in mild-to-moderate UC,with a good safety profile comparable to that of other oral mesalazine formulations.In addition,they offer the advantage of a low pill burden and might contribute to increased long-term compliance and treatment success in clinical practice.This editorial summarizes the available literature on the short-and medium-term efficacy and safety of the new once-daily mesalazine formulations.
基金Supported by National Natural Science Foundation of China,No. 30772758National Science and Technology Major Project of China,No. 2009ZX09311-003
文摘AIM： To investigate the cellular mechanisms of action of Yiguanjian （YGJ） decoction in treatment of chronic hepatic injury. METHODS： One group of mice was irradiated, and received enhanced green fluorescent protein （EGFP）- positive bone marrow transplants followed by 13 wk of CCh injection and 6 wk of oral YGJ administration. A second group of Institute for Cancer Research mice was treated with 13 wk of CCI4 injection and 6 wk of oral YGJadministration. Liver function, histological changes in the liver, and Hyp content were analyzed. The expres- sion of m-smooth muscle actin （α-SMA）, F4/80, albumin （AIb）, EGFP, mitogen-activated protein kinase-2 （PKM2）, Ki-67, fetoprotein （AFP）, monocyte chemotaxis pro- tein-1 and CC chemokine receptor 2 were assayed. RESULTS： As hepatic damage progressed, EGFP-po- sitive marrow cells migrated into the liver and were mainly distributed along the fibrous septa. They showed a conspicuous coexpression of EGFP with ^-SMA and F4/80 but no coexpression with AIb. Moreover, the expression of PKM2, AFP and Ki-67 was enhanced dy- namically and steadily over the course of liver injury. YGJ abrogated the increases in the number of bone marrow-derived fibrogenic cells in the liver, inhibited expression of both progenitor and mature hepatocyte markers, and reduced fibrogenesis. CONCLUSION： YGJ decoction improves liver fibrosis by inhibiting the migration of bone marrow cells into the liver as well as inhibiting their differentiation and suppressing the proliferation of both progenitors and hepatocytes in the injured liver.
基金This work is supported by the National Natural Science Foundation of China （No.21373064）, the Program for Innovative Research Team of Guizhou Province （No.QKTD[2014]4021）, and the Natural Sci- entific Foundation from Guizhou Provincial Department of Education （No.ZDXK[2014]IS）. All the calculations were performed at Guizhou Provincial High- Performance Computing Center of Condensed Mate- rials and Molecular Simulation in Guizhou Education University.
文摘A wide range of quantum systems are time-invariant and the corresponding dynamics is dic- tated by linear differential equations with constant coefficients. Although simple in math- ematical concept, the integration of these equations is usually complicated in practice for complex systems, where both the computational time and the memory storage become limit- ing factors. For this reason, low-storage Runge-Kutta methods become increasingly popular for the time integration. This work suggests a series of s-stage sth-order explicit Runge- Kutta methods specific for autonomous linear equations, which only requires two times of the memory storage for the state vector. We also introduce a 13-stage eighth-order scheme for autonomous linear equations, which has optimized stability region and is reduced to a fifth-order method for general equations. These methods exhibit significant performance improvements over the previous general-purpose low-stage schemes. As an example, we ap- ply the integrator to simulate the non-Markovian exciton dynamics in a 15-site linear chain consisting of perylene-bisimide derivatives.
基金Supported partly by Projects 20110491-SIP-IPN and COFAA-IPN,Mexico
文摘The bound state solutions of the Klein-Gordon equation with the rotating Deng-Fan molecular potential are presented by using a proper approximation to the centrifugal term within the framework of equal scalar and vector Deng-Fan potentials. It is shown that the solutions can be expressed by the generalized hypergeometric functions. The normalized wavefunctions are also derived.
