中药质量一致性评价体系-基于定量指纹图谱检查的中药标准制剂控制模式的解析

目的阐述中药质量一致性评价体系的基本架构。方法解析中药标准制剂概念和建立方法,剖析中药参比制剂的基本内涵。二者既有区别又有必然联系。增加【指纹图谱检查】是中药质量一致性评价体系的基础,用宏定性相似度大于0.90,宏定量相似度在80%≤Pm≤120%作为基本控制方法。结果基于系统指纹定量法的标准制剂控制模式或者参比制剂控制模式是中药质量一致性评价的有效方法,从宏观战略角度拓展中国药典应采用定量指纹图谱对中药化学指纹物质进行整体幅度控制。结论中药标准制剂和中药参比制剂都是新生事物,二者是中药质量一致性评价体系的基石。基于三固色谱柱和指纹系统定量校正系数,采用中国药典的标准指纹图谱法可实现中药质量一致性的宏观定量控制。

浅谈整车企业车辆产品生产一致性管理体系

近年来,各汽车主管部门逐步加强车辆产品一致性监管的管控力度,并出台了一系列的规范,车辆生产一致性管理成为车辆生产企业非常关注的问题,而因产品一致性问题导致的车辆无法销售、公告产品撤销、企业资质撤销的情况也时有发生。企业生产车辆参数不一致、生产过程未能按照法规要求有效执行等问题严重困扰着企业,因此,车辆生产企业需搭建产品生产一致性管理体系,实现对产品全生命周期的一致性管理,满足国家及企业对一致性管控的要求。

学业评价与课程标准一致性指标体系的构建研究

深入探讨学业评价与课程标准的一致性问题具有重要意义。综合运用文献研究法、德尔菲法、问卷调查法等方法,构建了适合我国教育实情的本土化学业评价与课程标准一致性指标体系。该体系包含“学业评价目标与课程标准的一致性”等5项一级指标、“评价内容深度与课程标准的一致性”等12项二级指标。实证调查结果表明,该体系具有良好的信度和效度,专家及中小学教师普遍认为各项指标非常重要。为在基础教育实践领域有效推广应用该体系,未来研究可从构建一致性指标相对权重体系、结合具体学科加强一致性指标体系的应用研究等方面着力进行。

以工作过程为导向构建“学员制+学徒制”人才培养模式

文章结合首批国家示范性高等职业建设院校的建设方案,重点介绍南宁职业技术学院机电工程系在坚持以就业为导向,走产学研结合道路的体会和做法。

内存管理系统对NUMA的支持及优化

阐述非一致性存储访问(NUMA)体系结构中存储结构的特点,分析该结构对操作系统存储管理子系统的影响,介绍针对NUMA存储结构特点在操作系统存储管理子系统的不连续内存支持、节点存储关系描述、存储资源分配等方面所作的工作和优化技术。通过实际系统的验证,文中所提出的技术方案较好地支持了NUMA系统复杂存储结构的管理需求,减少了存储访问延迟,提高了系统性能。

Consensus control for multi-agents in a non-rectangular bounded space: algorithmand experiments

Aiming for the coordinated motion and cooperative control of multi-agents in a non-rectangular bounded space, a velocity consensus algorithm for the agents with double- integrator dynamics is presented. The traditional consensus algorithm for bounded space is only applicable to rectangular bouncing boundaries, not suitable for non-rectangular space. In order to extend the previous consensus algorithm to the non- rectangular space, the concept of mirrored velocity is introduced, which can convert the discontinuous real velocity to continuous mirrored velocity, and expand a bounded space into an infinite space. Using the consensus algorithm, it is found that the mirrored velocities of multi-agents asymptotically converge to the same values. Because each mirrored velocity points to a unique velocity in real space, it can be concluded that the real velocities of multi-agents also asymptotically converge. Finally, the effectiveness of the proposed consensus algorithm is examined by theoretical proof and numerical simulations. Moreover, an experiment is performed with the algorithm in a real multi-robot system successfully.

A2A Relationships in Service Contexts

This work aims at developing the actor-to-actor （A2A） relationship concept in service contexts enhancing the contribution of the systems theories. The most recent progresses related to the research on the service, as a matter of fact, highlight how the nowadays co-creation processes are key elements in each service context. Both the Service Science （SS） and the Service Dominant （S-D） logic analyse the importance of the role played by the numerousness of actors involved in the service exchange because of the resources held （and released） and the contribution they can offer. System theories, and in particular the Viable System Approach, offer the possibility of an holistic perspective able to re-interpret the same characterizing mechanisms of the value co-creation. In the following parts of the work it will presented a conceptual analysis based on the contribution of the VSA, the SS and the S-D logic, whose scientific proposals will be developed and critically analysed in order to verify the proposition coherence in terms of A2A relationships within the value co-creation process. The relational perspective of the Service Eco-systems shows a view open to network in relation to economic and social actors, where each organization can be considered as an actor because it is actively committed in the value co-creation development, going beyond the difference between the user, the producer, or the exchange facilitator. Therefore, the contribution proposes some progresses compared with the business to business （B2B） approach and literature, through the introduction of the new A2A interaction concept within the service context for the indistinct role that the actors play in the value co-creation process. In this perspective, the contribution introduces the research line focused on the service, giving attention, afterwards, to the service system context, in order to analyse the features of these systems with the specific goal of identifying its peculiarity. The contribution proceed with the presentation of the systems thinking, and in particular the VSA contribution, directed toward the description of the gaps that the authors identify in the present research attempting to offer some orientations for the comprehension and the improvement of the service systems and of their planning and management implications. The contribution finally proposes an integrated interpretation of the several emerging paradigms （VSA, SS and S-D logic） seeking an in-depth-analysis of the A2A relationships in the service contexts.

《中图法》新旧版衔接工作的方法及途径

《中图法》换版,部分图书必须另行改编,怎样改编?我馆自今年六月以来,开始进行这一工作,目前已摸索了一些经验,本文就是据此着重讲述解决《中图法》新旧版衔接图书改编工作实际问题的方法和途径。我们认为做好衔接工作,既是实际问题也是科学问题,应为图书馆学中一个内容。

Measurement and Correlation of Vapor-Liquid Equilibrium of the 1,2-Epoxycyclohexane-Cyclohexanone Binary System at 101.3kPa

Many by-products are generated in the process of oxidizing cyclohexene to produce 1,2-epoxycyclohexane by hydrogen peroxide, including cyclohexanol, cyclohexanone, etc. To obtain high-purity 1,2-epoxycyclohexane, the by-products must be removed through rectification. Refining 1,2-epoxycyclohexane through rectification requires vapor-liquid equilibrium(VLE) data of the related system. Therefore, the VLE data of 1,2-epoxycyclohexane- cyc-lohexanone system were measured at 101.3 kPa using an improved EC-2 VLE still. The thermodynamic consistency of the data was then tested by Herington's method and the rigorous point-to-point method. The results obtained were exemplary. The VLE data were correlated by the Wilson and non-random two-liquid(NRTL) equations, using the error sum squares of the vapor composition as the objective function to obtain the model parameters. The difference between the calculated values and the experimental data is minor, indicating that the VLE data are suitable for engineering design.

基于双重效应原则的道德责任与刑事责任的关系

作为传统上被视为对严重违法行为确定和分配责任的部门法,刑法的重要性日益凸显。公众不仅将有罪判决视为违法的证明,也将其视为某种道德谴责。因此有罪判决无疑也代表某种道德评价。事实上,立法者与犯罪化有关的决策很大程度上都与公民的道德信念相符合,这一现象尤其体现在故意杀人或盗窃行为这样的传统刑法领域。刑法与道德信念之间的联系在上述禁止性行为中显而易见。因此,这种关系是否存在于刑法的一般领域更值得分析。这一关系的存在既与道德上的双重效应原则有关,同时也可能对刑法中的违法阻却事由产生影响。双重效应原则源于圣托马斯提出的理论,随后新托马斯主义者详细阐述了这一原则,现如今,这一原则无论在道德还是法律领域都引起了广泛讨论。双重效应原则现在常被应用于与医疗相关的法律决策中,特别是一些复杂的情况,如拯救怀孕母亲的生命会导致胎儿的死亡,或者分离连体双胞胎会导致其中一人死亡等。综上可以得出如下结论,基于双重效应原则被认为合理的行为在刑法上也应被视为根本合法。

Analysis of plastid and nuclear DNA data in plant phylogenetics——evaluation and improvement

Correct combination of plastid(cp)and nuclear(nr)DNA data for plant phylogenetic reconstructions is not a new issue,but with an increasing number of nrDNA loci being used,it is of ever greater practical concern.For accurately reconstructing the phylogeny and evolutionary history of plant groups,correct treatment of phylogenetic incongruence is a vital step in the proper analysis of cpDNA and nrDNA data.We first evaluated the current status of analyzing cpDNA and nrDNA data by searching all articles published in the journal Systematic Botany between 2005 and 2011.Many studies combining cpDNA and nrDNA data did not rigorously assess the combinability of the data sets,or did not address in detail possible reasons for incongruence between the two data sets.By reviewing various methods,we outline a procedure to more accurately analyze and/or combine cpDNA and nrDNA data,which includes four steps:identifying significant incongruence,determining conflicting taxa,providing possible interpretations for incongruence,and reconstructing the phylogeny after treating incongruence.Particular attention is given to explanation of the cause of incongruence.We hope that our procedure will help raise awareness of the importance of rigorous analysis and help identify the cause of incongruence before combining cpDNA and nrDNA data.

Output Consensus for Heterogeneous Nonlinear Multi-Agent Systems Based on T-S Fuzzy Model

In this paper, the output consensus problem of general heterogeneous nonlinear multi-agent systems subject to different disturbances is considered. A kind of Takagi-Sukeno fuzzy modeling method is used to describe the nonlinear agents' dynamics. Based on the model, a distributed fuzzy observer and controller are designed based on parallel distributed compensation scheme and internal reference models such that the heterogeneous nonlinear multi-agent systems can achieve output consensus. Then a necessary and sufficient condition is presented for the output consensus problem. And it is shown that the consensus trajectory of the global fuzzy model is determined by the network topology and the initial states of the internal reference models. Finally, some simulations are given to illustrate and verify the effectiveness of the proposed scheme.

Designing a novel consensus protocol for multiagent systems with general dynamics under directed networks

The consensus problem for general linear multi-agent systems （MASs） under directed topology is investigated. First, a novel consensus protocol based on proportional-integral-derivative （PID） control is proposed. Second, the consensus problem is converted into an asymptotic stability problem through transformations. Third, through a state projection method the consensus condition is proved and the explicit expression of the consensus function is given. Then, a Lyapunov function is constructed and the gain matrices of the protocol are given based on the linear matrix inequality. Finally, two experiments are conducted to explain the advantages of the method. Simulation results show the effectiveness of the proposed algorithm.

CONSENSUS CONTROL DESIGN FOR MULTI-AGENT SYSTEMS USING RELATIVE OUTPUT FEEDBACK

This paper studies the consensus problem of multi-agent systems in which all agents are modeled by a general linear system. The authors consider the case where only the relative output feedback between the neighboring agents can be measured. To solve the consensus problem, the authors first construct a static relative output feedback control under some mild constraints on the system model. Then the authors use an observer based approach to design a dynamic relative output feedback control. If the adjacent graph of the system is undirected and connected or directed with a spanning tree, with the proposed control laws, the consensus can be achieved. The authors note that with the observer based approach, some information exchange between the agents is needed unless the associated adjacent graph is completely connected.