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三七液治疗前房出血
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《上海医学》 CAS 1978年第3期16-16,共1页
前房出血常见于眼球挫伤,儿童尤为多见。单纯少量出血于数天内可自行吸收,多量及反复出血可并发继发性青光眼及角膜血染,迁延数月,甚至影响视力。治疗方法一般采用卧床休息和止血药物,对并发青光眼的还需降压及前房穿刺。我们在天津眼... 前房出血常见于眼球挫伤,儿童尤为多见。单纯少量出血于数天内可自行吸收,多量及反复出血可并发继发性青光眼及角膜血染,迁延数月,甚至影响视力。治疗方法一般采用卧床休息和止血药物,对并发青光眼的还需降压及前房穿刺。我们在天津眼科医院用三七液治疗角膜化学灼伤的启发下,从1975年3月开始,用三七液治疗眼外伤前房出血21例。 展开更多
关键词 前房出血 前房积血 角膜血染 七液
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三七注射液对阿霉素肾纤维化大鼠炎症启动因子和终止因子的影响 被引量:9
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作者 黄志敏 黄仁发 +4 位作者 唐宇 江旖旎 邱少彬 邱菲 吴金玉 《中华中医药学刊》 CAS 北大核心 2021年第5期175-178,共4页
目的观察三七注射液对阿霉素诱导的肾纤维化大鼠LXA4/NF-κB信号转导通路的影响,探讨三七注射液抗肾纤维化的作用机制。方法将144只SD大鼠随机分为4组:正常组、假手术组、模型组和三七组,每组36只,每组在给药后第4周、8周、12周3个时间... 目的观察三七注射液对阿霉素诱导的肾纤维化大鼠LXA4/NF-κB信号转导通路的影响,探讨三七注射液抗肾纤维化的作用机制。方法将144只SD大鼠随机分为4组:正常组、假手术组、模型组和三七组,每组36只,每组在给药后第4周、8周、12周3个时间点各处死大鼠12只。Western blot检测IκB、p-IκB、LXA4蛋白的表达,ELISA法检测IL-6、IL-1β水平。结果与假手术组相比较,模型组大鼠肾组织IκBα、IκBβ、LXA4蛋白显著下调,差异有统计学意义(P<0.05或P<0.01);与模型组相比较,三七组大鼠肾组织IκBα、IκBβ、LXA4蛋白水平上调,差异有统计学意义(P<0.05或P<0.01)。与假手术组相比较,模型组大鼠肾组织p-IκBα、p-IκBβ蛋白表达的水平上调,差异有统计学意义(P<0.01);与模型组相比较,三七组大鼠肾组织p-IκBα、p-IκBβ蛋白表达的水平下调,差异有统计学意义(P<0.01);与假手术组相比较,模型组IL-1β、IL-6水平升高,三七组IL-1β、IL-6水平较模型组低(P<0.05或P<0.01)。结论三七注射液的抗肾纤维化作用可能与其调节LXA4/NF-κB炎症信号转导通路有关。 展开更多
关键词 肾纤维化 注射 NF-ΚB LXA4
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基于肠肾轴理论探讨三七注射液对慢性肾脏病大鼠肠黏膜功能和肠道菌群的影响 被引量:12
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作者 黄志敏 黄仁发 +5 位作者 唐宇 江旖旎 邱少彬 邱菲 陆良喜 吴金玉 《中华中医药学刊》 CAS 北大核心 2021年第9期156-159,共4页
目的探讨三七注射液对慢性肾衰竭大鼠肠黏膜和肠道菌群的影响。方法将120只SD大鼠随机分为6组:正常组、模型组、三七注射液低剂量组、三七注射液中剂量组、三七注射液高剂量组、阳性对照组。用生化检测、ELISA、鲎试剂检测和细菌平板计... 目的探讨三七注射液对慢性肾衰竭大鼠肠黏膜和肠道菌群的影响。方法将120只SD大鼠随机分为6组:正常组、模型组、三七注射液低剂量组、三七注射液中剂量组、三七注射液高剂量组、阳性对照组。用生化检测、ELISA、鲎试剂检测和细菌平板计数法分别检测肾功能、硫酸吲哚酚、血清D-乳酸、血浆内毒素、回肠内容物细菌培养鉴定及肠道菌群移位情况。结果 ①模型组大鼠较正常组大鼠肌酐、尿素氮、硫酸吲哚酚、D-乳酸、内毒素、肠道细菌移位率显著升高,致病菌大肠杆菌、肠球菌明显增多,益生菌双歧杆菌、乳杆菌明显减少。②与模型组比较,三七中剂量组、三七高剂量组、阳性对照组大鼠肌酐、尿素氮、硫酸吲哚酚、D-乳酸、内毒素、肠道细菌移位率显著降低,且致病菌大肠杆菌、肠球菌明显减少,益生菌双歧杆菌、乳杆菌明显增多。结论慢性肾功能衰竭会使大鼠肠道菌群失调,代谢毒素增多,肠黏膜屏障功能损伤,肠通透性增加,肠道菌群发生移位;三七注射液可以改善上述情况,以三七中、高剂量组作用显著,提示三七注射液延缓CKD大鼠肾纤维化进展的机制可能与其调节CKD大鼠肠道菌群,修复肠道黏膜屏障功能及抑制肠道菌群移位有关。 展开更多
关键词 注射 慢性肾衰竭 肠肾轴 肠道菌群
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三七注射液改善慢性肾衰竭大鼠肠道代谢组学的研究
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作者 黄志敏 陆良喜 +4 位作者 江旖旎 邱少彬 唐宇 邱菲 吴金玉 《中国中西医结合肾病杂志》 2023年第11期965-969,I0002,I0003,共7页
目的:研究三七注射液对慢性肾衰竭大鼠肠道代谢物的影响。方法:将28只SD大鼠制备成5/6肾切除肾纤维化大鼠模型,随机分为模型组(n=5)、三七注射液低剂量组(n=6)、三七注射液中剂量组(n=6)、三七注射液高剂量组(n=6)、阳性对照组(n=5),另... 目的:研究三七注射液对慢性肾衰竭大鼠肠道代谢物的影响。方法:将28只SD大鼠制备成5/6肾切除肾纤维化大鼠模型,随机分为模型组(n=5)、三七注射液低剂量组(n=6)、三七注射液中剂量组(n=6)、三七注射液高剂量组(n=6)、阳性对照组(n=5),另设相同周龄SD大鼠5只为正常组(n=5)。采用UPLC-TOF/MS代谢组学方法,进行PLS-DA分析,对差异代谢物进行鉴别;采用KEGG通路分析,对各组鉴别出的潜在生物标志物作通路拓扑分析以及通路富集分析。结果:PLS-DA图中可以看到,正常组和模型组轮廓完全的分离,代谢的轮廓有差异;三七注射液高剂量组和三七注射液中剂量组在正常组和模型组之间,更靠近正常组,而与模型组大体分离,说明与正常组的代谢轮廓相近而与模型组的代谢轮廓有差异。对差异代谢物进行鉴别,最终从模型组与正常组肠道内容物中鉴别出67个差异代谢物,经三七注射液高剂量治疗后对41个差异代谢物有调节作用。鉴别三七注射液高剂量组和模型组的潜在生物标志物并作通路拓扑分析以及通路富集分析,发现潜在靶向通路有11条。其中牛磺酸参与5条通路,甜菜碱参与3条通路。结论:三七注射液可能通过调节牛磺酸和甜菜碱的代谢过程及相关通路发挥调控CKD大鼠肠道功能和抗肾纤维化作用。 展开更多
关键词 注射 慢性肾衰竭 代谢组学 牛磺酸 甜菜碱
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运动训练与铁牛七提取液干预对高脂膳食大鼠心功能影响的研究 被引量:1
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作者 吕志伟 《伊犁师范学院学报(自然科学版)》 2012年第3期66-70,共5页
探讨了运动训练和铁牛七提取液联合干预对高脂膳食大鼠心功能的影响.将雄性SD大鼠56只随机分为7组,分别为安静对照组、有氧运动组、疲劳运动组、高脂对照组、有氧运动高脂对照组、高脂加药组、高脂运动加药组,检测大鼠心脏的血流动力学... 探讨了运动训练和铁牛七提取液联合干预对高脂膳食大鼠心功能的影响.将雄性SD大鼠56只随机分为7组,分别为安静对照组、有氧运动组、疲劳运动组、高脂对照组、有氧运动高脂对照组、高脂加药组、高脂运动加药组,检测大鼠心脏的血流动力学指标.与安静对照组比较,高脂对照组LVSP、±dp/dtmax、±d2p/dt2max显著降低,HR及LVEDP显著升高;与高脂对照组比较,高脂加药组的HR、mSP、mDP降低;高脂运动组和高脂运动加药组的HR、LVEDP降低,LVSP、±dp/dtmax、±d2p/dt2max有所升高.研究结果表明,有氧运动可以改善高脂膳食大鼠心脏功能,有氧运动联合铁牛七提取液对高脂膳食大鼠心脏功能的提高效果优于单纯的有氧运动. 展开更多
关键词 运动训练 铁牛提取 高脂膳食 大鼠心功能
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蒙药七针液的化学成分和药理作用研究概况
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作者 包满达 巴日格其 《求医问药(下半月刊)》 2011年第1期67-69,共3页
本文综述了蒙药七针液的化学成分及药理作用等方面的研究状况,为该蒙药的进一步深入研究和推广及开发应用提供参考。
关键词 蒙药 化学成分 药理作用
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浅谈蒙药七针液的化学成分和药理作用分析概况
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作者 白莲 《大观周刊》 2011年第41期87-87,共1页
本文综述了蒙药七针液的化学成分及药理作用等方面的研究状况.为该蒙药的进一步深入研究和推广及开发应用提供参考。
关键词 蒙药 化学成分 药理作用
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七宝美髯口服液对SAMP8小鼠海马神经元凋亡的影响 被引量:1
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作者 吴倩 魏江平 +2 位作者 郑航 张占军 徐世军 《中药药理与临床》 CAS CSCD 北大核心 2016年第6期14-17,共4页
目的:考察七宝美髯口服液对SAMP8小鼠学习记忆功能及海马Neu N、Nampt和Aβ和表达的影响。方法:SAMP8小鼠灌胃给予七宝美髯口服液,SAMR1小鼠平行对照,连续干预60d,采用Morris水迷宫法考察小鼠学习记忆功能,采用免疫组化法考察小鼠海马Ne... 目的:考察七宝美髯口服液对SAMP8小鼠学习记忆功能及海马Neu N、Nampt和Aβ和表达的影响。方法:SAMP8小鼠灌胃给予七宝美髯口服液,SAMR1小鼠平行对照,连续干预60d,采用Morris水迷宫法考察小鼠学习记忆功能,采用免疫组化法考察小鼠海马Neu N、Aβ和Nampt的表达。结果:与模型对照组比较,七宝美髯口服液(1.44g/kg)能显著提高SAMP8小鼠的学习记忆能力,缩短逃避潜伏期,增加小鼠进入平台象限次数,提高进入平台象限百分比;能显著促进海马Neu N和Nampt的表达,提高其平均光密度值;能显著抑制小鼠海马Aβ的表达,降低其平均光密度值。结论:七宝美髯口服液能够改善SAMP8小鼠的学习记忆功能,该作用与其增强SAMP8小鼠海马Neu N和Nampt表达,抑制Aβ的表达有关。 展开更多
关键词 宝美髯口服 SAMP8 神经元核抗原 尼克酰胺磷酸核糖转移酶 Β淀粉样蛋白
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Simultaneous determination of five nucleosides and nucleobases in Panax notoginseng using high-performance liquid chromatography 被引量:1
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作者 王静 王一涛 李绍平 《Journal of Chinese Pharmaceutical Sciences》 CAS 2007年第2期79-83,共5页
Aim To quantitatively determine five nucleosides and nucleobases, including cytidine, uridine, guanosine, adenosine and uracil in different parts of Panax notoginseng. Methods Separation was performed on a Zorbax SB-A... Aim To quantitatively determine five nucleosides and nucleobases, including cytidine, uridine, guanosine, adenosine and uracil in different parts of Panax notoginseng. Methods Separation was performed on a Zorbax SB-Aq column using a gradient elution with mobile phase of 8 mmol^L-1 ammonium acetate aqueous solution (A) and methanol (B). The assay was carried out at a flow rate of 1 mL·min^-1 at 25 ℃ with the diode-array detection at 260 nm. Results Cytidine, uridine, guanosine, adenosine and uracil had good linearity in the ranges of 1.79 - 57.40 μg·mL^-1 (r^2 = 1.0000), 3.30 - 105.60 μg·mL^-1 (r^2 = 1.0000), 3.09 - 98.80 μg·mL^ -1(r^2 = 0.9999), 2.77 - 88.60 μg·mL^-1 (r^2 = 1.0000) and 0.38 - 12.30 μg·mL ^-1 (r^2 = 1.0000) with average recoveries of 93.9%, 96.5%, 92.7%, 93.2% and 98.8%, respectively. The content of cytidine, uridine, guanosine, adenosine and uracil in different parts of P. notogingeng were significantly different. Conclusion This is the first report on quantitative determination of nucleosides and nucleobases in P notoginseng. 展开更多
关键词 Panax notoginseng NUCLEOSIDE NUCLEOBASE High-performance liquid chromatography (HPLC)
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Effects of San Qi on Gastric Secretion and Protective Factors of Gastric Mucosa in the Rat with Precancerous Lesion of Stomach 被引量:5
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作者 石雪迎 赵凤志 +4 位作者 戴欣 董秀云 方杰 杨会敏 王友京 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2003年第3期220-224,共5页
In the model rat with precancerous lesion of stomach induced by the combined method of insertion of a spring into the pylorus and high salt hot paste,effects of San Qi (三七 Radix Notoginseng) on gastric secretion and... In the model rat with precancerous lesion of stomach induced by the combined method of insertion of a spring into the pylorus and high salt hot paste,effects of San Qi (三七 Radix Notoginseng) on gastric secretion and protective factors of stomach were investigated.The results indicated that gastric secretion,gastric mucosal blood flow (GMBF) and aminohexose content lowered significantly,and malondialdehyde (MDA) increased significantly (P<0.01) in the model group as compared with the normal group;after treatment with San Qi Powder for 12 weeks,both gastric secresion and GMBF increased,and MDA content decreased as compared with the negative control group (P<0.01),with no significant increase of aminohexose content.It is suggested that San Qi (三七 Radix Notoginseng) may improve gastric secretion,and that increase of GMBF and antagonism against the lesion of oxygen free radicals are possibly one of its mechanisms. 展开更多
关键词 PANAX Animals Drugs Chinese Herbal Gastric Mucosa Male MALONDIALDEHYDE Precancerous Conditions RATS Rats Wistar Regional Blood Flow Stomach Neoplasms
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High-Performance Liquid Chromatographical Analysis of Ginsenosides in Panax ginseng,P.quinquef(?)lium and P.notoginseng 被引量:1
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作者 郎文生 楼之岑 毕培曦 《Journal of Chinese Pharmaceutical Sciences》 CAS 1993年第2期133-143,共11页
The compositions and contents of ginsenbsides in Panax ginseng,P.quinquefolium and P.notoginseng were determined and compared by reversed-phase High-Performance Liquid Chro- matography(HPLC).The method was performed o... The compositions and contents of ginsenbsides in Panax ginseng,P.quinquefolium and P.notoginseng were determined and compared by reversed-phase High-Performance Liquid Chro- matography(HPLC).The method was performed on an Alltech Adsorbosphere HS C_(18) column,using 5×10^(-3)M NaH_2PO_4-H_3PO_4 buffer solution(pH 3.0)and acetonitrile-water(50:50)as gradient eluents. The baseline separation of ginsenosides Rb_1,Rb_2,Rb_1,Rc,Rd,Rf,Ro,and Re+Rg_1 was obtained in one analytical run.The ginsenosides are directly detected at 203 nm.The detection limit is 40μg at a signal to noise ratio of 3:1.The improved sample preparation and clean-up prior to injection with SEP-PAK C_(18)cartridge strongly reduced the front peaks caused by the impurities in the methanolic extracts of samples to afford a smooth baseline and clear background.The HPLC patterns of methanolic extracts mainly including the ginsenosides were found capable of serving as chemical fingerprints to differentiate the three species from each other.It was also found that there are no significant diffe- rences of the HPLC patterns between the wild Panax ginseng and the cultivated,the white and the red ginsengs,Chinese and Korean red ginsengs,and the tap roots of Panax ginseng collected in four consecutive months,only certain differences in contents of ginsenosides do exist.The contents of the nine major ginsenosides present in the rhizome,tap root and rootlet as well as the leaf of Panax quinquefolium were also determined and compared. 展开更多
关键词 Panax ginseng Panax quinquefolium Panax notoginseng GINSENOSIDES High-Performance Liquid Chromatography(HPLC)
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Holistic quality evaluation of Panax notoginseng extract and injection using an UPLC-QTOF-MS^E based metabolomics approach 被引量:5
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作者 赵一懿 郭洪祝 +1 位作者 陈有根 傅欣彤 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2017年第5期335-345,共11页
In the present study, we established an UPLC-QTOF-MSE based metabolomic approach in order to evaluate the holistic qualities and compare the quality difference by finding characteristic components of Panax notoginseng... In the present study, we established an UPLC-QTOF-MSE based metabolomic approach in order to evaluate the holistic qualities and compare the quality difference by finding characteristic components of Panax notoginseng extracts (PNE) and Xuesaitong (XST) injection samples from different manufacturers. The data were processed through unsupervised principal component analysis (PCA) and supervised orthogonal partial least squared discrimination analysis (OPLS-DA) to compare the quality differences. Two-dimensional PCA score plots showed a tendency to separate the XST injections and extracts, and most XST injection samples were clearly clustered into two groups. Especially, the injections from He and YB companies were distinguished into two groups. In addition, only injection samples of Hu company were near the cluster of PNE. To explore the potential chemical components contributing most to the differences between XST injection samples from different manufacturers and PNE, an S-plot was constructed following the OPLS-DA. Ginsenoside Rd, ginsenoside Rgl, ginsenoside Re, ginsenoside Rbl, 20(S)-ginsenoside Rhl, gypenoside VII, ginsenoside Rg2, ginsenoside Rh4, ginsenoside Rkl or Rgs, notoginsenoside Fc, 20(R)-ginsenoside Rg3, ginsenoside F2 and protopanaxadiol were recognized as characteristic chemical markers that contributed most to reflect the difference between XST injections and PNE. Ginsenoside Rd, ginsenoside Rgl, ginsenoside Re, ginsenoside Rbl and gypenoside VII were revealed as index components contributing most to the differences of PNE and XST injections, and quantitative analysis of these components could ensure the consistent quality of XST injections. Based on the fact that the injections should be standardized with the characteristic components as quality control chemical markers, it is most important to keep the quality of extracts of raw materials stable and reliable. 展开更多
关键词 Panax notoginseng extract XST injection UPLC-QTOF-MSE Metabolomics Holistic quality evaluation
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