偏头痛多巴胺机制研究进展

偏头痛是一种常见的神经系统疾病,病理机制复杂,有临床研究显示多巴胺在偏头痛的发病过程中发挥重要作用。本文将从多巴胺的合成与代谢,多巴胺与偏头痛的发生及其遗传易感性,多巴胺与三叉神经血管通路及药物治疗等方面阐述多巴胺与偏头痛的相关性。在三叉神经颈复合体分布有多巴胺受体,偏头痛病人出现多巴胺水平、多巴胺受体敏感性及多巴胺相关基因表达的异常,多巴胺受体拮抗剂在偏头痛急性期治疗及预防性治疗中都有重要作用。多巴胺能神经元可能是偏头痛治疗的作用靶点。

Specific effect of acupuncture on the neural pathway in the acute stage of migraine headache

To discuss the hazard of migraine in acute phase and analgesic effect, acupoint selection features, method as well as mechanism of acupuncture; to put forward relevant questions, answer these questions, propose relative specificity hypothesis on neural pathway of analgesic effect of acupoints in different nerve distribution areas（trigeminal nerve distribution area, occipital nerve distribution area, and spinal nerve distribution area） in treatment of migraine in acute phase, and analyze the deficiencies of hypothesis.