Liquid-liquid equilibrium data of two ternary systems methyl palmitate+ethanol+glycerol and methyl stearate+ethanol+glycerol at(318.2 and 333.2)K and atmospheric pressure were measured. The values of distribution coef...Liquid-liquid equilibrium data of two ternary systems methyl palmitate+ethanol+glycerol and methyl stearate+ethanol+glycerol at(318.2 and 333.2)K and atmospheric pressure were measured. The values of distribution coefficient and selectivity were calculated, which indicates that glycerol can be separated from fatty acid ester by using ethanol as an extraction solvent. The consistency of the isothermal tie-line data were checked by the Othmer-Tobias equation. The correlation coefficients R2 are higher than 0.993,9 for all the fitted curves. The NRTL activity coefficient model was applied to the correlation of the measured tie-line data. The root mean square deviation(RMSD)values are less than 0.007 for all the systems, which shows a good predictive capability of this model for such systems.展开更多
The structured lipids are produced through sn-l,3-specific interesterification of soybean oil with medium-chain triacylglycerol （MCT） in continuous reactions catalyzed by Thermomyces lanuginose lipase （Lipozyme TL...The structured lipids are produced through sn-l,3-specific interesterification of soybean oil with medium-chain triacylglycerol （MCT） in continuous reactions catalyzed by Thermomyces lanuginose lipase （Lipozyme TL IM）. Cheap Lipozyme TL IM presents similar interesterification degree （ID）, sn-l,3-specificity and residual activity as expensive Rhizomucor miehei in batch reactions. In packed-bed interesterification of soybean oil with Mcr cat- alyzed by Lipozyme TL IM, the residence time has a significant effect on ID, while temperature has a small effect at 45-70 ℃. The sn-l,3-specificity of Lipozyme TI. IM is not satisfactory when reaction temperature is higher than 60 ℃. The optimal residence time and temperature are 30-40 min and 55 ℃, respectively. Among the solvents, including acetone, isopropanol, tert-butanol, and isobutanol, used to recover the activity of the used Lipozyme TL IM, acetone is the most suitable one than the other solvents.展开更多
Acute and repeat-dose toxic effects ofHOC （7-hydroxycoumarin）, ethanol and their mixture were studied in rats. Single oral administration of HOC （5,000 mg/kg） caused transitional glycosuria associated with lowered...Acute and repeat-dose toxic effects ofHOC （7-hydroxycoumarin）, ethanol and their mixture were studied in rats. Single oral administration of HOC （5,000 mg/kg） caused transitional glycosuria associated with lowered serum glucose levels, decreased urea clearance. HOC given orally during 28 days （200 mg/kg） decreased serum glucose, and increased serum triglyceride concentrations. No enhancement of acute toxic effect of HOC （5,000 mg/kg） and ethanol （6,000 mg/kg） mixture was found in the acute toxicity study phase. Effect of HOC （200 mg/kg） and ethanol （750 mg/kg） during 28 days of exposure was less pronounced in comparison with HOC effect only, as far as neither decrease of glucose, nor increase oftriglyceride serum concentrations were found.展开更多
OBJECTIVE: To demonstrate the potential to treat non-alcoholic fatty liver disease(NAFLD) with colon hydrotherapy(CHT) plus Traditional Chinese Medicine(TCM).METHODS: A total of 20 patients were enrolled into the stud...OBJECTIVE: To demonstrate the potential to treat non-alcoholic fatty liver disease(NAFLD) with colon hydrotherapy(CHT) plus Traditional Chinese Medicine(TCM).METHODS: A total of 20 patients were enrolled into the study and received CHT with TCM for 2 weeks.Body mass index(BMI) and levels of serum triglycerides(TG) and total cholesterol(TC) were compared between pre-treatment and post-treatment.RESULTS: Two-week treatment with CHT plus TCM significantly lowered BMI and reduced blood lipids.BMI decreased from 29.5 ± 4.3 to 25.4 ± 1.0, while mean TG levels decreased by 0.70 mmol/L on average from baseline and mean TC levels decreased by0.37 mmol/L. Forty-five percent of patients exhibited TC decreasing by more than 10% from baseline and25%ofpatientsexhibited TCdecreasingbymore than 20%. Sixty percent of patients exhibited TG decreasing by more than 20% and 20% of patients exhibited TG decreasing by more than 40%. However,high-density and low-density lipoprotein cholester-ol levels did not change significantly after intervention. No serious adverse events were reported.CONCLUSION: Our findings suggest that CHT plus TCM to treat NAFLD is promising and it might be a new treatment strategy for management of NAFLD.展开更多
基金Supported by Tianjin Natural Science Foundation(No.13JCYBJC19300)
文摘Liquid-liquid equilibrium data of two ternary systems methyl palmitate+ethanol+glycerol and methyl stearate+ethanol+glycerol at(318.2 and 333.2)K and atmospheric pressure were measured. The values of distribution coefficient and selectivity were calculated, which indicates that glycerol can be separated from fatty acid ester by using ethanol as an extraction solvent. The consistency of the isothermal tie-line data were checked by the Othmer-Tobias equation. The correlation coefficients R2 are higher than 0.993,9 for all the fitted curves. The NRTL activity coefficient model was applied to the correlation of the measured tie-line data. The root mean square deviation(RMSD)values are less than 0.007 for all the systems, which shows a good predictive capability of this model for such systems.
基金Supported by the National High Technology Research and Development Program of China(2010AA101505)the National Natural Science Foundation of China(21106013)
文摘The structured lipids are produced through sn-l,3-specific interesterification of soybean oil with medium-chain triacylglycerol （MCT） in continuous reactions catalyzed by Thermomyces lanuginose lipase （Lipozyme TL IM）. Cheap Lipozyme TL IM presents similar interesterification degree （ID）, sn-l,3-specificity and residual activity as expensive Rhizomucor miehei in batch reactions. In packed-bed interesterification of soybean oil with Mcr cat- alyzed by Lipozyme TL IM, the residence time has a significant effect on ID, while temperature has a small effect at 45-70 ℃. The sn-l,3-specificity of Lipozyme TI. IM is not satisfactory when reaction temperature is higher than 60 ℃. The optimal residence time and temperature are 30-40 min and 55 ℃, respectively. Among the solvents, including acetone, isopropanol, tert-butanol, and isobutanol, used to recover the activity of the used Lipozyme TL IM, acetone is the most suitable one than the other solvents.
文摘Acute and repeat-dose toxic effects ofHOC （7-hydroxycoumarin）, ethanol and their mixture were studied in rats. Single oral administration of HOC （5,000 mg/kg） caused transitional glycosuria associated with lowered serum glucose levels, decreased urea clearance. HOC given orally during 28 days （200 mg/kg） decreased serum glucose, and increased serum triglyceride concentrations. No enhancement of acute toxic effect of HOC （5,000 mg/kg） and ethanol （6,000 mg/kg） mixture was found in the acute toxicity study phase. Effect of HOC （200 mg/kg） and ethanol （750 mg/kg） during 28 days of exposure was less pronounced in comparison with HOC effect only, as far as neither decrease of glucose, nor increase oftriglyceride serum concentrations were found.
文摘OBJECTIVE: To demonstrate the potential to treat non-alcoholic fatty liver disease(NAFLD) with colon hydrotherapy(CHT) plus Traditional Chinese Medicine(TCM).METHODS: A total of 20 patients were enrolled into the study and received CHT with TCM for 2 weeks.Body mass index(BMI) and levels of serum triglycerides(TG) and total cholesterol(TC) were compared between pre-treatment and post-treatment.RESULTS: Two-week treatment with CHT plus TCM significantly lowered BMI and reduced blood lipids.BMI decreased from 29.5 ± 4.3 to 25.4 ± 1.0, while mean TG levels decreased by 0.70 mmol/L on average from baseline and mean TC levels decreased by0.37 mmol/L. Forty-five percent of patients exhibited TC decreasing by more than 10% from baseline and25%ofpatientsexhibited TCdecreasingbymore than 20%. Sixty percent of patients exhibited TG decreasing by more than 20% and 20% of patients exhibited TG decreasing by more than 40%. However,high-density and low-density lipoprotein cholester-ol levels did not change significantly after intervention. No serious adverse events were reported.CONCLUSION: Our findings suggest that CHT plus TCM to treat NAFLD is promising and it might be a new treatment strategy for management of NAFLD.
