In this paper, we present an asymmetry conformational potential with a reflecting boundary and an absorbing boundary, in which the diffusive search of the free head of kinesin motor can be biased toward its forward bi...In this paper, we present an asymmetry conformational potential with a reflecting boundary and an absorbing boundary, in which the diffusive search of the free head of kinesin motor can be biased toward its forward binding site. Under a wide range of condition, using first-passage time analysis we perform numerical simulation to the Langevin equation, and obtain the dependence of the dwell time for forward steps on the load force. And we calculate the expression for the dwell time by the Laplace transform method. Both numerical and analytical results show that the dwell times exponentially depend on the load force, which provide a simple physical explanation for experimental data. Our results suggest that ATP binding-conformation change in the neck linker plays an important role in unidirectional steps during kinesin＇s mechanochemical cycle.展开更多
In the design,construction and operation periods of the Three Gorges Project (TGP),great challenges have been met in different fields such as water resources and hydropower project construction,electromechanical equip...In the design,construction and operation periods of the Three Gorges Project (TGP),great challenges have been met in different fields such as water resources and hydropower project construction,electromechanical equipment manufacture and ecological environment protection.In view of the key techniques and difficulties in the construction period,scientific and technological breakthroughs have been made by the experts and scholars of various fields and a series of innovative achievements are gained,which make the scientific and technological levels in relevant fields improved.Some major innovative achievements in the construction and operation of TGP are enumerated,which are significant for the hydropower project construction and clean energy development in the future in China.展开更多
In this paper, it presents a project of a fuzzy controller and a neural estimator to control a coordinate table powered by three-phase induction motor, aiming to implement an intelligent milling system. The position/s...In this paper, it presents a project of a fuzzy controller and a neural estimator to control a coordinate table powered by three-phase induction motor, aiming to implement an intelligent milling system. The position/speed control is performed using vector techniques of three-phase induction machines. The estimation of the motor electromagnetic torque is used for setting the feedrate of the table. The speed control is developed using TS （Takagi-Sugeno） fuzzy logic model and electromagnetic torque estimation using neural network type LMS （least mean square） algorithm. The induction motor is powered by a frequency inverter driven by a DSP （digital signal processor）. Control strategies are implemented in DSP. Simulation results are presented for evaluating the performance of the system.展开更多
基金Supported by Beijing National Science Foundation under Grant No. 4102031
文摘In this paper, we present an asymmetry conformational potential with a reflecting boundary and an absorbing boundary, in which the diffusive search of the free head of kinesin motor can be biased toward its forward binding site. Under a wide range of condition, using first-passage time analysis we perform numerical simulation to the Langevin equation, and obtain the dependence of the dwell time for forward steps on the load force. And we calculate the expression for the dwell time by the Laplace transform method. Both numerical and analytical results show that the dwell times exponentially depend on the load force, which provide a simple physical explanation for experimental data. Our results suggest that ATP binding-conformation change in the neck linker plays an important role in unidirectional steps during kinesin＇s mechanochemical cycle.
文摘In the design,construction and operation periods of the Three Gorges Project (TGP),great challenges have been met in different fields such as water resources and hydropower project construction,electromechanical equipment manufacture and ecological environment protection.In view of the key techniques and difficulties in the construction period,scientific and technological breakthroughs have been made by the experts and scholars of various fields and a series of innovative achievements are gained,which make the scientific and technological levels in relevant fields improved.Some major innovative achievements in the construction and operation of TGP are enumerated,which are significant for the hydropower project construction and clean energy development in the future in China.
文摘In this paper, it presents a project of a fuzzy controller and a neural estimator to control a coordinate table powered by three-phase induction motor, aiming to implement an intelligent milling system. The position/speed control is performed using vector techniques of three-phase induction machines. The estimation of the motor electromagnetic torque is used for setting the feedrate of the table. The speed control is developed using TS （Takagi-Sugeno） fuzzy logic model and electromagnetic torque estimation using neural network type LMS （least mean square） algorithm. The induction motor is powered by a frequency inverter driven by a DSP （digital signal processor）. Control strategies are implemented in DSP. Simulation results are presented for evaluating the performance of the system.
