AIM: To compare a lansoprazole-based triple versus quadruple therapy for Helicobacter pylori (H pylori) eradication with emphasis on side effect prof ile,patient compliance and eradication rate at a rural district gen...AIM: To compare a lansoprazole-based triple versus quadruple therapy for Helicobacter pylori (H pylori) eradication with emphasis on side effect prof ile,patient compliance and eradication rate at a rural district general hospital in Wales,United Kingdom. METHODS: One hundred one patients with H pylori infection were included in the study. Patients were randomised to receive triple therapy comprising of lansoprazole 30 mg,amoxycillin 1 g,clarithromycin 500 mg,all b.d. (LAC),or quadruple therapy comprising of lansoprazole 30 mg b.d.,metronidazole 500 mg t.d.s.,bismuth subcitrate 240 mg b.d.,and tetracycline chloride 500 mg q.d.s. (LMBT). Cure was defi ned as a negative 13C urea breath test 2 mo after treatment. RESULTS: Seven patients were withdrawn after randomisation. Fifty patients were assigned to LAC group and 44 to LMBT group. The intention-to-treat cure rates were 92% and 91%,whereas the per-protocol cure rates were 92% and 97%,respectively. Side effects were common,with 56% experiencingmoderate to severe symptoms in the LAC group and 59% in the LMBT group. Symptoms of vomiting,diarrhoea and black stools were significantly more common in the LMBT group. Patient compliance was 100% for triple therapy and 86% for quadruple therapy (P < 0.01). One-third of patients in both groups were still taking acid-reducing medications at six-month follow-up. CONCLUSION: One-week triple and quadruple therapies have similar intention-to-treat eradication rates. Certain side effects are more common with quadruple therapy,which can compromise patient compliance. Patient education or modifi cations to the regimen are alternative options to improve compliance of the quadruple regimen.展开更多
OBJECTIVE To investigate the clinical efficacy and toxic effect of the 3-dimensional conformal radiation therapy （3DCRT） for non- small cell lung cancer （NSCLC）. METHODS Fifty-two patients with the Stage-I and IV ...OBJECTIVE To investigate the clinical efficacy and toxic effect of the 3-dimensional conformal radiation therapy （3DCRT） for non- small cell lung cancer （NSCLC）. METHODS Fifty-two patients with the Stage-I and IV NSCLC were treated with 3DCRT. Cross analysis of the clinical data was conducted in the comparison between the 52 cases with 3DCRT and the other 50 cases with the conventional radiation therapy （CRT）. In the 3DCRT group, only the primary tumor and positive lymph-node draining area were included in the clinical target area, setting 4 to 6 coplanar or non-coplanar irradiation fields, with 2 Gy or 3 Gy/fraction, 1 fraction a day and 5 fractions per week. The total dose ranged from a test dose （DT） of 66 Gy to 72 Gy. In the CRT group, the field area contained the primary tumor plus the homolateral hilum of the lung, the mediastinum superior or hol-mediastinum, and opposed anteroposterior irradiation. When the dosage reached DT 36-40 Gy, an oblique portal administered radiation was conducted in order to avoid injuring the spinal cord. The DT was 1.8-2.0 Gy/fraction, 1 fraction a day, 5 fractions per week, with a total dose of 60 Gy to 70 Gy. RESULTS The therapeutic effect （CR ＋ PR） was 90.4% in the 3DCRT group, and was 72% in the CRT group. There was statistically significant difference between the two groups, P 〈 0.01. There was a clinical symptom improvement attained by 96.5% and 86.4% respectively in the two groups, and there was a statistically significant difference between the groups, P 〈 0.01. The 6-month, 1 and 2-year overall survival rates were 92.3%, 75.0% and 42.3% in the 3DCRT group, and 76%, 60% and 30% in the CRT group, respectively. There was a significant difference in the 6-month overall survival rate between the groups, P 〈 0.05. There was no obvious significant difference in the 1 and 2-year overall survival rates between the two groups, P 〉 0.05. The toxic reaction was 12.5% and 23.7% respectively in the 3DCRT and CRT groups. Acute radioactive esophagitis and leucopenia were markedly lower in the 3DCRT group than in the CRT group. There was a statistically significant difference between the groups, P 〈 0.05. No toxic reaction of Stage-III and over was found in the 3DCRT group during radiation therapy. CONCLUSION The 3DCRT method has a satisfactory shortterm efficacy and improvement of clinical symptoms in treating NSCLC, with a mild toxic reaction and good tolerance in patients. It can be used for enhancing the tumor-control rate and bettering the quality of life.展开更多
IntroductionTriple puncture, first appeared in Miraculous Pivot (灵枢), is an ancient method of acupuncture, which has been used to treat relatively small and deep disorders caused by pathogenic wind by puncturing the...IntroductionTriple puncture, first appeared in Miraculous Pivot (灵枢), is an ancient method of acupuncture, which has been used to treat relatively small and deep disorders caused by pathogenic wind by puncturing the center of the affected area with one needle and the surrounding areas with two other needles.展开更多
Objective： To evaluate the clinical effect of combined acupuncture and electrophoresis in treating trigeminal neuralgia. Methods： Sixty patients were randomly allocated to two groups. The treatment group received ac...Objective： To evaluate the clinical effect of combined acupuncture and electrophoresis in treating trigeminal neuralgia. Methods： Sixty patients were randomly allocated to two groups. The treatment group received acupuncture plus electrophoresis, and the control group took Carbamazepine and Methylcobalamin. The therapeutic effects would be evaluated after 30 d. Results： The total effective rate was 93.3% in the treatment group versus 70.0% in the control group. During the follow-up study （6 months to 1 year）, 3 cases got relapsed in the treatment group, occupying 11.1%, and 6 got relapsed in the control group, occupying 28.6%. Conclusion： Combined acupuncture and electrophoresis has a precise effect in treating trigeminal neuralgia, and it bears an advantage of simple operation and maintaining cutaneous sensation.展开更多
Objective:To observe the effect of Anrou-pressing and kneading Hegu(LI 4)and Sanyinjiao(SP 6)on uterine inertia during painless parturition.Methods:A total of 100 cases of patients with uterine inertia during painless...Objective:To observe the effect of Anrou-pressing and kneading Hegu(LI 4)and Sanyinjiao(SP 6)on uterine inertia during painless parturition.Methods:A total of 100 cases of patients with uterine inertia during painless parturition were randomized into an acupoint group and a medicine group by the SPSS programming,with 50 cases in each group.Patients in the acupoint group received the treatment of Anrou-pressing and kneading bilateral Hegu(LI 4)and Sanyinjiao(SP 6),while patients in the medicine group received intravenous oxytocin.The labor time and maternal-child safety were evaluated,and the labor stage was compared.Results:The latent and active phases in the 1st labor stage and the 2nd labor stage in the acupoint group were substantially shorter than those in the medicine group,and the between-group comparisons showed statistical significance(all P<0.05).The between-group comparison of the 3rd labor stage showed no statistical significance(P>0.05).The postpartum hemorrhage amount in both groups was within the safe range,and the between-group comparison showed no statistical significance(P>0.05).The newborn 1 min Apgar score was ranged 8-10 points,and the between-group comparison showed no statistical significance(P>0.05).The between-group comparison of the labor stage efficacy showed statistical significance(P<0.01),with a better progression in the acupoint group.Conclusion:Anrou-pressing and kneading Hegu(LI 4)and Sanyinjiao(SP 6)is both effective and safe for uterine inertia during painless parturition.展开更多
Objective： To observe the clinical efficacy and action mechanism of Jin＇s three-needle acupuncture plus Long＇s chiropractic tuina manipulations in treating cervical vertigo. Methods： By adopting a randomized contr...Objective： To observe the clinical efficacy and action mechanism of Jin＇s three-needle acupuncture plus Long＇s chiropractic tuina manipulations in treating cervical vertigo. Methods： By adopting a randomized controlled method, 80 eligible patients were randomized into an observation group of 41 cases and a control group of 39 cases. The control group was intervened by Jin＇s cervical three-needle acupuncture plus acupuncture at the vertigo-pain points and Fengchi （GB 20）; the observation group was by Long＇s chiropractic tuina manipulations in addition to the treatment given to the control. For both groups, the intervention was given once a day, 7 sessions as a treatment course, with a 1-day interval after a course, for 2 courses in total. The therapeutic efficacy was evaluated after the first session and the second treatment course, at the 3-month and 6-month follow-ups. Results： After the first session, the recovery plus markedly effective rate of the observation group was significantly higher than that of the control group （P〈0.01）; the rate was markedly higher in the observation group than that in the control group after 2 treatment courses （P〈0.01）; at the 3-month follow-up, the relapse rate was 2.5% in the observation group versus 23.5% in the control, and the between-group difference was statistically insignificant （P〉0.05）; the 6-month follow-up study showed that the relapse rate was 5.0% in the observation group versus 21.6% in the control group, and the between-group difference was statistically significant （P〈0.05）; at the 6-month follow-up, the total relapse rate was 7.5% in the observation group versus 35.1% in the control group, and the inter-group difference was statistically significant （P〈O.01）. Conclusion： The two treatment protocols are both effective in treating cervical vertigo. However, due to its more significant efficacy, more efficient action and lower relapse rate compared to acupuncture alone, acupuncture plus tuina can be regarded as a verified protocol for cervical vertigo.展开更多
基金Wyeth,United Kingdom and North West Wales NHS Trust
文摘AIM: To compare a lansoprazole-based triple versus quadruple therapy for Helicobacter pylori (H pylori) eradication with emphasis on side effect prof ile,patient compliance and eradication rate at a rural district general hospital in Wales,United Kingdom. METHODS: One hundred one patients with H pylori infection were included in the study. Patients were randomised to receive triple therapy comprising of lansoprazole 30 mg,amoxycillin 1 g,clarithromycin 500 mg,all b.d. (LAC),or quadruple therapy comprising of lansoprazole 30 mg b.d.,metronidazole 500 mg t.d.s.,bismuth subcitrate 240 mg b.d.,and tetracycline chloride 500 mg q.d.s. (LMBT). Cure was defi ned as a negative 13C urea breath test 2 mo after treatment. RESULTS: Seven patients were withdrawn after randomisation. Fifty patients were assigned to LAC group and 44 to LMBT group. The intention-to-treat cure rates were 92% and 91%,whereas the per-protocol cure rates were 92% and 97%,respectively. Side effects were common,with 56% experiencingmoderate to severe symptoms in the LAC group and 59% in the LMBT group. Symptoms of vomiting,diarrhoea and black stools were significantly more common in the LMBT group. Patient compliance was 100% for triple therapy and 86% for quadruple therapy (P < 0.01). One-third of patients in both groups were still taking acid-reducing medications at six-month follow-up. CONCLUSION: One-week triple and quadruple therapies have similar intention-to-treat eradication rates. Certain side effects are more common with quadruple therapy,which can compromise patient compliance. Patient education or modifi cations to the regimen are alternative options to improve compliance of the quadruple regimen.
基金supported by a grant from the Natural Science Foundation of Ningxia Hui Autonomous Region,China(No.NZ0680)
文摘OBJECTIVE To investigate the clinical efficacy and toxic effect of the 3-dimensional conformal radiation therapy （3DCRT） for non- small cell lung cancer （NSCLC）. METHODS Fifty-two patients with the Stage-I and IV NSCLC were treated with 3DCRT. Cross analysis of the clinical data was conducted in the comparison between the 52 cases with 3DCRT and the other 50 cases with the conventional radiation therapy （CRT）. In the 3DCRT group, only the primary tumor and positive lymph-node draining area were included in the clinical target area, setting 4 to 6 coplanar or non-coplanar irradiation fields, with 2 Gy or 3 Gy/fraction, 1 fraction a day and 5 fractions per week. The total dose ranged from a test dose （DT） of 66 Gy to 72 Gy. In the CRT group, the field area contained the primary tumor plus the homolateral hilum of the lung, the mediastinum superior or hol-mediastinum, and opposed anteroposterior irradiation. When the dosage reached DT 36-40 Gy, an oblique portal administered radiation was conducted in order to avoid injuring the spinal cord. The DT was 1.8-2.0 Gy/fraction, 1 fraction a day, 5 fractions per week, with a total dose of 60 Gy to 70 Gy. RESULTS The therapeutic effect （CR ＋ PR） was 90.4% in the 3DCRT group, and was 72% in the CRT group. There was statistically significant difference between the two groups, P 〈 0.01. There was a clinical symptom improvement attained by 96.5% and 86.4% respectively in the two groups, and there was a statistically significant difference between the groups, P 〈 0.01. The 6-month, 1 and 2-year overall survival rates were 92.3%, 75.0% and 42.3% in the 3DCRT group, and 76%, 60% and 30% in the CRT group, respectively. There was a significant difference in the 6-month overall survival rate between the groups, P 〈 0.05. There was no obvious significant difference in the 1 and 2-year overall survival rates between the two groups, P 〉 0.05. The toxic reaction was 12.5% and 23.7% respectively in the 3DCRT and CRT groups. Acute radioactive esophagitis and leucopenia were markedly lower in the 3DCRT group than in the CRT group. There was a statistically significant difference between the groups, P 〈 0.05. No toxic reaction of Stage-III and over was found in the 3DCRT group during radiation therapy. CONCLUSION The 3DCRT method has a satisfactory shortterm efficacy and improvement of clinical symptoms in treating NSCLC, with a mild toxic reaction and good tolerance in patients. It can be used for enhancing the tumor-control rate and bettering the quality of life.
文摘IntroductionTriple puncture, first appeared in Miraculous Pivot (灵枢), is an ancient method of acupuncture, which has been used to treat relatively small and deep disorders caused by pathogenic wind by puncturing the center of the affected area with one needle and the surrounding areas with two other needles.
文摘Objective： To evaluate the clinical effect of combined acupuncture and electrophoresis in treating trigeminal neuralgia. Methods： Sixty patients were randomly allocated to two groups. The treatment group received acupuncture plus electrophoresis, and the control group took Carbamazepine and Methylcobalamin. The therapeutic effects would be evaluated after 30 d. Results： The total effective rate was 93.3% in the treatment group versus 70.0% in the control group. During the follow-up study （6 months to 1 year）, 3 cases got relapsed in the treatment group, occupying 11.1%, and 6 got relapsed in the control group, occupying 28.6%. Conclusion： Combined acupuncture and electrophoresis has a precise effect in treating trigeminal neuralgia, and it bears an advantage of simple operation and maintaining cutaneous sensation.
文摘Objective:To observe the effect of Anrou-pressing and kneading Hegu(LI 4)and Sanyinjiao(SP 6)on uterine inertia during painless parturition.Methods:A total of 100 cases of patients with uterine inertia during painless parturition were randomized into an acupoint group and a medicine group by the SPSS programming,with 50 cases in each group.Patients in the acupoint group received the treatment of Anrou-pressing and kneading bilateral Hegu(LI 4)and Sanyinjiao(SP 6),while patients in the medicine group received intravenous oxytocin.The labor time and maternal-child safety were evaluated,and the labor stage was compared.Results:The latent and active phases in the 1st labor stage and the 2nd labor stage in the acupoint group were substantially shorter than those in the medicine group,and the between-group comparisons showed statistical significance(all P<0.05).The between-group comparison of the 3rd labor stage showed no statistical significance(P>0.05).The postpartum hemorrhage amount in both groups was within the safe range,and the between-group comparison showed no statistical significance(P>0.05).The newborn 1 min Apgar score was ranged 8-10 points,and the between-group comparison showed no statistical significance(P>0.05).The between-group comparison of the labor stage efficacy showed statistical significance(P<0.01),with a better progression in the acupoint group.Conclusion:Anrou-pressing and kneading Hegu(LI 4)and Sanyinjiao(SP 6)is both effective and safe for uterine inertia during painless parturition.
文摘Objective： To observe the clinical efficacy and action mechanism of Jin＇s three-needle acupuncture plus Long＇s chiropractic tuina manipulations in treating cervical vertigo. Methods： By adopting a randomized controlled method, 80 eligible patients were randomized into an observation group of 41 cases and a control group of 39 cases. The control group was intervened by Jin＇s cervical three-needle acupuncture plus acupuncture at the vertigo-pain points and Fengchi （GB 20）; the observation group was by Long＇s chiropractic tuina manipulations in addition to the treatment given to the control. For both groups, the intervention was given once a day, 7 sessions as a treatment course, with a 1-day interval after a course, for 2 courses in total. The therapeutic efficacy was evaluated after the first session and the second treatment course, at the 3-month and 6-month follow-ups. Results： After the first session, the recovery plus markedly effective rate of the observation group was significantly higher than that of the control group （P〈0.01）; the rate was markedly higher in the observation group than that in the control group after 2 treatment courses （P〈0.01）; at the 3-month follow-up, the relapse rate was 2.5% in the observation group versus 23.5% in the control, and the between-group difference was statistically insignificant （P〉0.05）; the 6-month follow-up study showed that the relapse rate was 5.0% in the observation group versus 21.6% in the control group, and the between-group difference was statistically significant （P〈0.05）; at the 6-month follow-up, the total relapse rate was 7.5% in the observation group versus 35.1% in the control group, and the inter-group difference was statistically significant （P〈O.01）. Conclusion： The two treatment protocols are both effective in treating cervical vertigo. However, due to its more significant efficacy, more efficient action and lower relapse rate compared to acupuncture alone, acupuncture plus tuina can be regarded as a verified protocol for cervical vertigo.
