The attitude control problem and the guidance problem are solved in 3-D for a buoyancy-driven airship actuated by the combined effects of an internal air bladder which modulates the airshiprs net weight and of two mov...The attitude control problem and the guidance problem are solved in 3-D for a buoyancy-driven airship actuated by the combined effects of an internal air bladder which modulates the airshiprs net weight and of two moving masses which modulate its center of mass. A simple and clear modeling is introduced to derive the 8 degree of freedom （DOF） mathematical model. Nonlinear control loops are derived through maximal feedback linearization with internal stability for both dynamics in the longitudinal plane and in the lateral plane. Based on a singular perturbation approach, the superposition of these two control actions in the longitudinal plane and in the lateral plane is shown to achieve the control of the dynamics in 3-D space. The simulations of the airship tracking specified attitude, moving direction and speed in 3-D space are presented.展开更多
Cellular spheroids serving as three-dimensional(3D) in vitro tissue models have attracted increasing interest for pathological study and drug-screening applications. Various methods, including microwells in particular...Cellular spheroids serving as three-dimensional(3D) in vitro tissue models have attracted increasing interest for pathological study and drug-screening applications. Various methods, including microwells in particular, have been developed for engineering cellular spheroids. However, these methods usually suffer from either destructive molding operations or cell loss and non-uniform cell distribution among the wells due to two-step molding and cell seeding. We have developed a facile method that utilizes cellembedded hydrogel arrays as templates for concave well fabrication and in situ MCF-7 cellular spheroid formation on a chip. A custom-built bioprinting system was applied for the fabrication of sacrificial gelatin arrays and sequentially concave wells in a high-throughput, flexible, and controlled manner. The ability to achieve in situ cell seeding for cellular spheroid construction was demonstrated with the advantage of uniform cell seeding and the potential for programmed fabrication of tissue models on chips. The developed method holds great potential for applications in tissue engineering, regenerative medicine, and drug screening.展开更多
Additive manufacturing and 3D printing tech-nology have been developing rapidly in the last 30 years, and indicate great potential for future development. The promising future of this technology makes its impact on tr...Additive manufacturing and 3D printing tech-nology have been developing rapidly in the last 30 years, and indicate great potential for future development. The promising future of this technology makes its impact on traditional industry unpredictable. 3D printing will propel the revolution of fabrication modes forward, and bring in a new era for customized fabrication by realizing the five "any"s: use of almost any material to fabricate any part, in any quantity and any location, for any industrial field. Innovations in material, design, and fabrication processes will be inspired by the merging of 3D-printing technology and processes with traditional manufacturing processes. Finally, 3D printing will become as valuable for manufacturing industries as equivalent and subtractive manufacturing processes.展开更多
基金Supported by the Scholarship Foundation of China Scholarship Council~~
文摘The attitude control problem and the guidance problem are solved in 3-D for a buoyancy-driven airship actuated by the combined effects of an internal air bladder which modulates the airshiprs net weight and of two moving masses which modulate its center of mass. A simple and clear modeling is introduced to derive the 8 degree of freedom （DOF） mathematical model. Nonlinear control loops are derived through maximal feedback linearization with internal stability for both dynamics in the longitudinal plane and in the lateral plane. Based on a singular perturbation approach, the superposition of these two control actions in the longitudinal plane and in the lateral plane is shown to achieve the control of the dynamics in 3-D space. The simulations of the airship tracking specified attitude, moving direction and speed in 3-D space are presented.
基金supported by the National Natural Science Foundation of China (11372243, 11532009, and 11522219)the China Postdoctoral Science Foundation (2013M540742)+2 种基金the Doctoral Program of Higher Education of China (20130201120071)the Natural Science Basic Research Plan in Shaanxi Province of China (2014JQ1004)the Fun- damental Research Funds for the Central Universities
文摘Cellular spheroids serving as three-dimensional(3D) in vitro tissue models have attracted increasing interest for pathological study and drug-screening applications. Various methods, including microwells in particular, have been developed for engineering cellular spheroids. However, these methods usually suffer from either destructive molding operations or cell loss and non-uniform cell distribution among the wells due to two-step molding and cell seeding. We have developed a facile method that utilizes cellembedded hydrogel arrays as templates for concave well fabrication and in situ MCF-7 cellular spheroid formation on a chip. A custom-built bioprinting system was applied for the fabrication of sacrificial gelatin arrays and sequentially concave wells in a high-throughput, flexible, and controlled manner. The ability to achieve in situ cell seeding for cellular spheroid construction was demonstrated with the advantage of uniform cell seeding and the potential for programmed fabrication of tissue models on chips. The developed method holds great potential for applications in tissue engineering, regenerative medicine, and drug screening.
文摘Additive manufacturing and 3D printing tech-nology have been developing rapidly in the last 30 years, and indicate great potential for future development. The promising future of this technology makes its impact on traditional industry unpredictable. 3D printing will propel the revolution of fabrication modes forward, and bring in a new era for customized fabrication by realizing the five "any"s: use of almost any material to fabricate any part, in any quantity and any location, for any industrial field. Innovations in material, design, and fabrication processes will be inspired by the merging of 3D-printing technology and processes with traditional manufacturing processes. Finally, 3D printing will become as valuable for manufacturing industries as equivalent and subtractive manufacturing processes.
