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基于Pro/E的三维总剂量分析软件实现及其在微小卫星中的应用 被引量:6
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作者 张振力 李郑发 +2 位作者 唐心春 韩飞 刘宽俊 《航天器环境工程》 2014年第6期620-624,共5页
微小卫星基于成本和重量的考虑使用了大量COTS(commercial off-the-shelf,商用货架产品)器件。总剂量效应是制约COTS器件航天应用的主要因素之一。为了更加准确地计算COTS器件的辐射剂量,避免过设计,采用Pro/E二次开发技术自主开发了三... 微小卫星基于成本和重量的考虑使用了大量COTS(commercial off-the-shelf,商用货架产品)器件。总剂量效应是制约COTS器件航天应用的主要因素之一。为了更加准确地计算COTS器件的辐射剂量,避免过设计,采用Pro/E二次开发技术自主开发了三维总剂量分析软件。与商业软件Space Radiation在简单模型上进行了对比验证,结果表明自研软件计算结果可信。采用自研软件对在研的型号开展三维总剂量分析,降低了对总剂量敏感器件的抗总剂量要求,减小了屏蔽厚度。 展开更多
关键词 三维总剂量 二次开发 COTS器件 抗辐射设计 数值分析
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Clinical study of three dimensional conformal radiotherapy combined with intracavitary brachytherapy in the treatment of cervical cancer
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作者 Yeqin Zhou Daiyuan Ma Tao Ren Xianfu Li Jing Hu Bangxian Tan 《The Chinese-German Journal of Clinical Oncology》 CAS 2011年第6期340-343,共4页
Objective: The aim of our study was to evaluate the outcome and complications of cervical cancer patients undergoing conventional intracavitary brachytherapy (ICBT) treated with 3D-conformal radiotherapy (3DCRT). Meth... Objective: The aim of our study was to evaluate the outcome and complications of cervical cancer patients undergoing conventional intracavitary brachytherapy (ICBT) treated with 3D-conformal radiotherapy (3DCRT). Methods: Sixty cervical cancer patients were divided randomly into the conformal group and the conventional group. Thirty patients treated with 3D-conformal radiotherapy in the 3DCRT group, when the whole pelvic received DT 40 Gy, a planning CT scan of each patient was obtained and the second 3DCRT therapy plan was taken. Then, continued to irradiate to 50 Gy. At last, 3DCRT was boosted at local involved volumes to the total dose of 60 Gy. When 3DCRT was combined with intracavitary brachytherapy, the dose of brachytherapy to point A was 30 Gy/5 fractions. In the conventional group, after a total tumor dose of 40 Gy was delivered by the whole pelvic irradiation, the four-field technique was used to irradiate the total pelvic and regional nodes (median dose of 10 Gy), and the involved volumes were boosted to 60 Gy and the dose of brachytherapy to point A was 30 Gy-36 Gy/5-6 fractions. Moreover, both groups were combined with intracavitary brachytherapy respectively. Results: The 1, 2, 3-year survival rates for the 3DCRT group and the conventional group were 96.7%, 93.3%, 90.0% and 86.6%, 76.7%, 70% respectively (P = 0.04, P = 0.02 and P = 0.02). There was a statistically significant difference between the two groups. Compared to the two groups each other in toxic effects, except for the I-II grade rectal and bladder reaction and pelvic fibrosis which was lower in the 3DCRT group (P = 0. 007, P = 0. 006 and P = 0. 015), the side effects were similar and well tolerated in two groups. Conclusion: The all-course 3DCRT combined with intracavitary brachytherapy can be considered as an effective and feasible approach to cervical cancer and may significantly improve the survival rate and reduce the late toxicity. This new role for 3DCRT merits need further evaluation with large patient numbers and longer follows up. 展开更多
关键词 cervical cancer external radiotherapy three dimensional conformal radiotherapy CHEMOTHERAPY intracavitary brachytherapy
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