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TREATMENT OF 284 CASES OF INFANTILE APHASIS CHIEFLY WITH "SHESANZHEN

In the present paper, the therapeutic effect of acupuncture of "Shesanzhen" (three acupoints of the tongue)combined with acupoint injection and oral administration of Chinese patent drug ["Zhen Ren Yizhi Bao"(真人益智宝)] in the treatment of 284 cases of infantile aphasis was observed. After one course of treatment (4 months), 93 cases (32.75%) were cured, 76 (26.76%) experienced marked improvement, 102 (35.92%) had improvement, with an effective rate of 95.43%.

STUDY ON THE EFFECT OF ACUPUNCTURE ON CEREBRAL ISCHEMIA IN MICE

Objective: To explore the possible mechanisms of "JIN San Zhen" (JIN’s 3 acupoints groups) in treatment of mental retardation. Methods: A total of 38 female mice were randomly divided into normal control (n=10), sham operation (n=10), model (n=8) and acupuncture (n=10) groups. "Si Shen Zhen" [4 points around "Baihui" (GV 20): 0.3 cm anterior, posterior, left and right to GV 20 respectively], and "Zhi San Zhen" ["Shenting" (GV 24) and bilateral "Benshen" (GB 13)] of "JIN San Zhen" series are used. The memory ability, AChE positive fiber density and mono amines transmitters of the brain are used as the indexes. Results: After 8 days’ treatment, cerebral ischemia induced mental retardation (decline of learning memory ability) was improved significantly shown by Y maze test (P<0.05-0.01), simultaneously, AChE positive fiber density of the frontal cerebral cortex and hippocampus, serotonie (5 HT), noradrenaline (NA) and dopamine (DA) contents of the brain increased significantly (P<0.05). Conclusion: Acupuncture induced increase of AChE, 5 HT, NA and DA in the brain may contribute to the effect of acupuncture in improving the memory capability of the RD mice.

Clinical Application of the Triple Puncture

IntroductionTriple puncture, first appeared in Miraculous Pivot (灵枢), is an ancient method of acupuncture, which has been used to treat relatively small and deep disorders caused by pathogenic wind by puncturing the center of the affected area with one needle and the surrounding areas with two other needles.

Clinical Study on the Needling and Drug Treatment of Acute Cerebral Hemorrhage

Researches in recent years have shown that cellular immune factor plays an important role in the generation and development of cerebral hemorrhage1-3.

ANALYSIS ON THE THERAPEUTIC EFFECT OF ACUPUNCTURE TREATMENT OF 2656 CASES OF PRIMARY TRIGEMINAL NEURALGIA

In the present paper, the clinical therapeutic effect of acupuncture therapy for treatment of primary prosopalgia was observed and its influencing factors were analyzed in 2656 patients. Yuyao (EX HN 4), Touwei (ST 8), Sibai (ST 2), Quanliao (SI 18), Xiaguan (ST 7) and Jiachengjiang were punctured selectively according to the involvement of different branches of the trigeminal nerve. After treatment, of the 2656 cases, the trigeminal neuralgia disappeared in 1469 (55.31%), 727 (27.37%) had marked improvement, 430 (16.19%) had improvement and 30 (1.13%) had no any significant effect. The three years’ follow up visit in 245 cases showed a relapse in 187 cases (76.3%). We think that the therapeutic effect is closely related to the needling manipulations. Only when an electric shock like needling sensation appeared (i.e. “qi reaching the affected area") after inserting the acupuncture needle into the chief acupoints, a better therapeutic effect would be achieved.

CLINICAL STUDY ON TREATMENT OF TRIGEMINAL NEURALGIA BY NEEDLING MENTAL AND MANDIBULAR FORAMINA

In the present paper, 126 patients with neuralgia involving the mandibular branch of trigeminal nerve were treated mainly by puncturing the mental foramen and the mandibular foramen. The two foramina are both located in the focus through which the Stomach Channel of Foot Yangming passes. Among the 126 patients, 42 were attributed to the light type, 61 to the moderate type one and the other 23 to serious type. Acupuncture treatment was given once daily, 30 min every time, with 10 days being a therapeutic course. After 3 courses of treatment, results showed that 29 (69.1%) light type cases, 35(57.4%) moderate type cases and 6 (26.1%) serious type cases were cured. It displays that the less serious the symptom, the higher is the cure rate, and the shorter the duration of disease, the better is the therapeutic effect.

TREATMENT OF 18 CASES OF TRIGEMINAL NEURALGIA WITH ELONGATED NEEDLE

In this paper, a total of 18 cases of primary trigeminal neuralgia were treated with elongated needle. Of the 18 cases, 5 were male and 15 female, ranging in age from 27 to 58 years and in disease duration from 3 days to 8 years. Main acupoints used were Taiyang (EX-HN 5) to Xiaguan (ST 7, for penetration needling), Xiajiache, Fengchi (GB 20), Yanglingquan (GB 34) and Taichong (LR 3). The treatment was given once daily, with 12 sessions being a therapeutic course. After 2 courses of treatment, of the 18 cases, 10 cases were cured, 7 experienced improvement in pain and one failed in the treatment, with an effective rate of 94.4%. The key point for treating trigeminal neuralgia is applying penetrative needling from EX-HN 5 to ST 7 to achieve ideal needling sensations.

EFFECT OF ACUPUNCTURE OF "ZUSANLI" AND "WEISHU" ACUPOINTS ON EXPERIMENTAL GASTRIC ULCER

Objective: To observe the therapeutic effect of electroacupuncture (EA) of "Zusanli"(ST 36) and "Weishu"(BL 21)on the experimental gastric ulcer in Xu period of a day for analyzing the best opportunity of acupuncture treatment of gastric ulcer. Methods:49 Wistar rats were randomly divided into ① control group, ② ST 36 Xu group, ③ BL 21 Xu group, ④ ST 36 Chen group, ⑤ BL 21 Chen group, ⑥ ST 36 IT group, and ⑦ BL 21 IT group, with 7 rats in each group. Rat gastric ulcer model was established using intra gastric administration of glacial acetic acid. Gastric mucosal thickness,mucosal muscular defect width,superficial mucosal mucus index (MI),intramucosal MI ,Total MI,plasma 6 keto PGF1α ,serum NO and gastric tissue CGRP concentrations were used as the indexes. The EA treatment was conducted once daily at Xu period (7-9 o’clock in the evening), Chen period (8-10 o’clock in the morning) and irregular time (IT) with 6 days being a therapeutic course, two courses altogether. Results:After EA treatment,①the regenerated mucosal thickness values of the aforementioned 6 EA groups, particularly ST 36 Xu group and BL 21 Xu group, were all apparently higher than that of control group (P<0.05-0.01), while the mucosal muscle layer defect width values of different EA groups, particularly ST 36 Xu group and BL 21 Xu group, were strikingly lower than that of control group (P<0.05-0.01); ②the 3 MI of the 6 EA groups, particularly those of ST 36 Xu group were all significantly higher than those of control group (P<0.05-0.01); ③plasma 6 keto PGF1α contents of the 6 EA groups, particularly those of ST 36 Xu and BL 21 Xu groups, were all significantly higher than that of control group (P<0.05-0.01); ④serum NO and gastric tissue CGRP concentrations of the 6 EA groups, particularly those of ST 36 Xu and BL 21 Xu groups and CGRP concentration of ST 36 Chen group, were all significantly higher than those of control group (P<0.05-0.01);and ⑤there were positive correlation between superficial MI or total MI and NO level (r=0.858, 0.987, P<0.05,and 0.01),and between the superficial mucus index and CGRP concentration (r=0.9051, t=4.68, P<0.01), suggesting that the increase of the secretion function of the regenerated mucosal mucus is related to acupuncture induced increase of release of both NO and CGRP.Conclusion:The therapeutic effect of EA of ST 36 and BL 21 in Xu period is better in the treatment of gastric ulcer,and that of EA of ST 36 is the best.

CLINICAL OBSERVATION ON THE TREATMENT OF KNEE OSTEOARTHRITIS BY ACUPUNCTURE IN BA-HE TECHNIQUE

Objective: To observe the clinical therapeutic effect of Ba-He techniqu e of acupuncture in the treatment of knee osteoarthritis. Methods: A total of 90 cases of knee osteoarthritis were evenly randomized into Ba-He technique group (observation group) and common technique group (control group), with 45 cases in each group. Zusanli (足三里 ST 36), Heding (鹤顶 EX-LE 2) and Dubi (犊鼻 ST 35 ) were punctured respectively in Ba-He technique and common technique in the two gr oups. The therapeutic effects of the two groups were compared after one course o f treatment (10 sessions) in accordance with Japanese assessment criteria for kn ee-joint functions. Results: After treatment, among the 74 and 7 1 affected knees in the observation and control groups, the therapeutic effect was excellent in 42 (56.8%) and 26 (36.6%) knees, fine in 14 (18.9%) and 20 (28.2%), OK in 10 (13 .5%) and 11 (15.5%), and poor in 8 (10.8%) and 14 (19.7%) respectively. The ther apeutic effect of the observation group was significantly better than that of co ntrol group (P<0.01). Conclusion: The Ba- He technique of acupuncture applied to the above-mentioned three acupoints exerted remarkable therapeutic effect for k n ee osteoarthritis, which is obviously better than that of the common needling te chnique.

Effect of acupuncture at Bǎihuì (百会GV 20) and Zúsānlǐ (足三里ST 36) on the level of serum inflammatory cytokines in patients with depression

Objective To investigate the immunologic mechanism of acupuncture at Bǎihuì（百 会 GV 20） and Zúsānlǐ（足三里 ST 36） for treatment of depression. Methods Eighty-four cases of depression patients were randomly divided into an electroacupuncture observation group（group A）, an electroacupuncture control group（group B） and a medication control group（group C）, 28 cases in each group. Bǎihuì（百会 GV 20） and Zúsānlǐ（足三里 ST 36） were used in the group A; Tàichōng （太冲 LR 3）, Sānyīnjiāo （三阴交 SP 6）, Nèiguān （内关 PC 6） and Shénmén （神门 HT 7） were used in the group B; and the group C was treated with oral administration of Fluoxetine. The scores of Hamilton Depression Scale （HAMD） were tested and the level of serum interleukin 1（IL-1β）, interleukin 6 （IL-6）, and tumor necrosis factor α （TNF-α） were measured by Enzyme Linked Immunosorbent Assay （ELISA）before and after treatment. Results Their scores of HAMD were obviously decreased after treatment in three groups（all P0.01）. In the group A, 2 cases were cured, 19 cases were markedly effective, 5 cases were effective and 2 cases were failed. In the group B, 16 cases were markedly effective, 12 cases were effective. While in the group C, 1 case was cured, 17 cases were markedly effective, 7 cases were effective and 3 cases were failed. The grade distribution of clinical effect showed that the effect of group A was better （P0.05）. The levels of serum IL-1β and IL-6 in the three groups were obviously decreased after treatment （P0.05, P0.01）, while there was no significant difference between the level of serum TNF-α before and after treatment. Conclusion The effect of electroacupuncture observation group is superior to those of electroacupuncture control group and medication control group.All of these three methods can clear the inflammatory cytokines such as IL-1β and IL-6 away and improve the symptoms of depression.

Introduction to professor HE Pu-ren's three-edged needle therapy techniques

Dr.He＇s bloodletting therapy utilizing three edged needles is one of his ＂three adjusting methods of acupuncture＂. During his 70 years of clinical practice, he developed the theory that most diseases are caused by qi stagnation, and in order to restore qi circulation one needs to improve the blood circulation first. Based on this theory, in combination with empirical insights from clinical practice, he has developed a unique technique for using three-edged needles. He has also categorized and extended the application of bloodletting therapy with three edged needles to cover over 150 diseases. In addition, Dr. He＇s bloodletting therapy with three edged needles is an innovation that may inspire other physicians to develope and expand the use of acupuncture-related therapies to treat disease.

Effects on activities of daily life and quality of life of post-stroke depression treated with electroacupuncture at temple-three-needle

Objective To explore the better treatment of post-stroke depression. Methods Sixty cases of post-stroke depression ranged from mild to middle degree were randomly divided into comprehensive therapy group and medication group, 30 cases in each group. In comprehensive therapy group, electroacupuncture at temple-three-needle was mainly applied and Fluoxetine Hydrochloride capsule was taken by oral administration; in medication group, Fluoxetine Hydrochloride capsule was applied by oral administration. Functional Independent Measure （FIM） Scale and WHOQOL-BREF evaluation results before and after treatment were compared after 4 weeks treatment. Results Comparing with the FIM scores before treatment, the differences in the two groups were significant （both P0.01）, and the improvement in comprehensive therapy group （74.97±9.52） was superior to that in medication group （66.70±9.23） （P0.01）. Signif icant differences were presented statistically in comparison of index scores of WHOQOL-BREF before and after treatment in two groups （P0.05, P0.01）, and it in comprehensive therapy group was superior to that in medication group （P0.05, P0.01）. Conclusion Activities of daily life and quality of life of post-stroke depression can be significantly improved by electroacupuncture at temple-three-needle and oral administration of Fluoxetine Hydrochloride capsule.

Sinew-bone three-needle therapy and myofascial power zones following the fourteen meridian-sinew

＂Sinew-bone three-needle therapy＂ was introduced in the paper. The innovation of needle instrument was micro Sinew-bone needles and big Sinew-bone needles; the Innovation of acupuncture techniques were fascia rotating separation, fascia plucked separation, fascia cutting separation, fascia fan separation, flying flicking therapy, and fascia knocking and pricking. The six myofascial power zones i.e three yang hand meridian, three yin hand meridian, three yang foot meridian, three yin foot meridian, conception vessel and governor vessel were put forward. The meridian-sinew flow and move, connecting at the peks of bones where the bones protrude, the sinews connect, movement and stillness harmoniously shift here. Bones have leaks on the sides, there are blood vessels and nerves. Joints peak and protrude, and three points meet. Fascia and muscles meet in a balanced triangle. Meridiansinew knot and form nodes, when soft tissue is damaged there is pain here. Needling manipulation can loose and break this apart, the sinew connection is the key. Treatment method was invented and the location and treatment points using the three needles were summarized.

Therapeutic observation on electroacupuncture at Zusanli(ST 36) and Fenglong(ST 40) for senile dementia

Objective： To explore the clinical effects of electroacupuncture（EA） at Zusanli（ST 36） and Fenglong（ST 40） in treating senile dementia. Methods： A total of 74 patients were randomly divided into an EA group and a medication group based upon the random digital table, 37 cases in each group. EA at Zusanli（ST 36） and Fenglong（ST 40） was given in the EA group, once every day, for six treatments per week. Donepezil Hydrochloride Tablets were given to the medication group, 5 mg per time and once a day in the former four weeks, 10 mg per time and once a day after 4 weeks, oral administration before sleep at night. The courses of the treatment were 12 weeks in both groups. The scores of mini-mental state examination（MMSE） and Barthel index（BI） were observed before and after the treatment, for processing the comparative analysis of the clinical effects after the course of the treatment. Results： The total effective rate was 86.5% in the EA group and 70.3% in the medication group. The therapeutic effect was better in the EA group than that in the medication group, and the difference between the two groups was statistically significant（P〈0.05）. MMSE and BI scores after the treatment in the two groups were all elevated than those of the same groups before the treatment（P〈0.05, P〈0.01）. The improving situation was obviously better in the EA group than that in the medication group, and the difference between the two groups was statistically significant（P〈0.05）. Conclusion： EA at Zusanli（ST 36） and Fenglong（ST 40） is affirmative in the therapeutic effect for senile dementia and can also improve the cognitive function and enhance the patients＇ quality of life.

Observation on the therapeutic efficacy of acupuncture plus tuina for cervical vertigo

Objective： To observe the clinical efficacy and action mechanism of Jin＇s three-needle acupuncture plus Long＇s chiropractic tuina manipulations in treating cervical vertigo. Methods： By adopting a randomized controlled method, 80 eligible patients were randomized into an observation group of 41 cases and a control group of 39 cases. The control group was intervened by Jin＇s cervical three-needle acupuncture plus acupuncture at the vertigo-pain points and Fengchi （GB 20）; the observation group was by Long＇s chiropractic tuina manipulations in addition to the treatment given to the control. For both groups, the intervention was given once a day, 7 sessions as a treatment course, with a 1-day interval after a course, for 2 courses in total. The therapeutic efficacy was evaluated after the first session and the second treatment course, at the 3-month and 6-month follow-ups. Results： After the first session, the recovery plus markedly effective rate of the observation group was significantly higher than that of the control group （P〈0.01）; the rate was markedly higher in the observation group than that in the control group after 2 treatment courses （P〈0.01）; at the 3-month follow-up, the relapse rate was 2.5% in the observation group versus 23.5% in the control, and the between-group difference was statistically insignificant （P〉0.05）; the 6-month follow-up study showed that the relapse rate was 5.0% in the observation group versus 21.6% in the control group, and the between-group difference was statistically significant （P〈0.05）; at the 6-month follow-up, the total relapse rate was 7.5% in the observation group versus 35.1% in the control group, and the inter-group difference was statistically significant （P〈O.01）. Conclusion： The two treatment protocols are both effective in treating cervical vertigo. However, due to its more significant efficacy, more efficient action and lower relapse rate compared to acupuncture alone, acupuncture plus tuina can be regarded as a verified protocol for cervical vertigo.

Insomnia treated with abdominal acupuncture combined three-route relaxation therapy

Objective To evaluate the clinical efficacy on insomnia treated with abdominal acupuncture and three-route relaxation therapy. Methods Seventy-six cases were randomly divided into an observation group and a control group, 38 cases in each one. In observation group, abdominal acupuncture was applied to Yinqi Guiyuan Xue [引气归元穴： conduct qi back to the origin, Zhōngwǎn （中 脘 CV 12）, Xiàwǎn （下脘 CV 10）, Qìhǎi （气海 CV 6）, Guānyuán （关元 CV 4）], combined with three-route relaxation therapy. In control group, according to syndrome differentiation, modified Guipi Decoction （归脾汤）, Anshen Dingzhi Pill （安神定智丸） plus Suanzaoren Decoction （酸枣仁汤）, Huanglian Ejiao Decoction （黄连阿胶汤）, Longdan Xiegan Decoction （龙胆泻肝汤）, Huanglian Wendan Decoction （黄 连温胆汤） were administered. Pittsburgh Sleep Quality Index （PSQI） score was compared between two groups. Results After treatment, PSQI total score and the scores of 7 factors all decreased in two groups as compared with those before treatment （all P0.05）, but the improvements in PSQI total score and the scores of 7 factors in observation group were remarkable compared with those in control group （all P0.05）. Conclusion Abdominal acupuncture plus three-route relaxation therapy has good clinical efficacy on insomnia, which is superior to Chinese herbal medicine.

Treatment of 32 Cases of Primary Trigeminal Neuralgia by Acupuncture plus Moxibustion with Warming Needle on Xiaguan （ST 7）

The main acupoints of Acupuncture therapy were Xiaguan （ST 7）, Sanjian （LI 3）, Xiangu （ST 43）, Zulinqi （GB 41）, Sanyinjiao （SP 6） and Taixi （KI 3）. Moxibustion with warming needle on Xiaguan （ST 7）, reduction method on Sanjian （LI 3） on the unaffected side and Xiangu （ST 43） and Zulinqi （GB 41） on the affected side, reinforcement method on Sanyinjiao （SP 6） and Taixi （KI 3） on the affected side were given. Moreover, according to the affected area, the local acupoints were added, Yangbai （GB 14） for the opthalmic branch, Quanliao （SI 18） for the maxillary branch and Jiache （ST 6） for the mandibular branch. Among 32 cases, after 24 acupuncture treatments, 4 cases were cured, 19 cases got marked effectiveness, 7 cases was improved and 2 cases had no effectiveness.

Treatment of 90 Cases of Simple Obesity with Intermuscular Needling Method

Summary： The patient takes a supine position, 10-20 needles were inserted thickly with intermuscular needling method in the two rounds, whose centers were both Tianshu （ST 25） and radii were 2 cun. Then, the electric acupuncture apparatus was connected. Meanwhile, bilateral Yanglingquan （GB 34）, Sanyinjiao （SP＇6）, Taichong （LR 3）, Ouchi （LI 11） and Zhigou （TE 6） were needled. Total 60 cases of obesity were treated with these methods, and 30 cases with conservative acupuncture as a control. The treatment results showed that the effective rates were 91.7% and 70.0%, respectively in the two groups.

Clinical study on Jin's three-needle therapy for post-stroke cognitive impairment

Objective:To observe the clinical efficacy of Jin's three-needle therapy on post-stroke cognitive impairment(PSCI)and the effect on neuroelectrophysiology(event-related potentials).Methods:A total of 60 PSCI patients were selected and divided into a treatment group and a control group according to the method of random number table,with 30 cases in each group.The patients in the control group received routine treatment while the patients in the treatment group received additional Jin's three-needle therapy.The treatment for both groups lasted four weeks.Mini-mental state examination(MMSE)and Montreal cognitive assessment(MoCA)scores as well as amplitude and latency of potential 300(P300)were adopted to compare the between-group results before and after treatment.Results:Before treatment,there were no significant differences(all P>0.05)in MMSE and MoCA scores,P300 latency and P300 amplitude between the two groups.After 4 weeks of treatment,the MMSE and MoCA scores and P300 amplitudes were improved in both groups,and the P300 latencies became shorter.The results showed significant intra-group and between-group differences(all P<0.05).Conclusion:Based on the routine treatment,Jin's three-needle therapy is effective for PSCI.The mechanism is probably through its regulation on the patients'neuroelectrophysiology.