A Schiff base ligand 4-[indol-3-yl]-but-3-en-2-one benzoyl hydrazone (HL), and its four transition metal complexes (ML2,M=Cu(, Ni(, Zn( and Co() have been prepared and characterized by means of elemental analysis, EI-...A Schiff base ligand 4-[indol-3-yl]-but-3-en-2-one benzoyl hydrazone (HL), and its four transition metal complexes (ML2,M=Cu(, Ni(, Zn( and Co() have been prepared and characterized by means of elemental analysis, EI-MS, molar conductivity, IR, UV-Vis and 1H NMR. The results showed that HL as a bidentate ligand coordinated with transition metal ions to form four-coordination complexes. The antibacterial activity was studied by using the filter scraps diffusion method, and the results indicated that the ligand and the complexes had a low bacteriostatic activity against S. Aureu, P. Aeruginosa and E. Coli. The low in vitro antitumor activity of the title complexes was also observed by using MTT method against KB, A2780, Bel7402 and HELF.展开更多
The trinuclear nickel? complex Ni3(C11H11N2O3)2(C5H5N)4 was prepared by the reaction of Ni(OAc)2· 4H2O with N butylsalicylhydrazide Schiff base ligand and characterized by X ray crystallography. The crystal belon...The trinuclear nickel? complex Ni3(C11H11N2O3)2(C5H5N)4 was prepared by the reaction of Ni(OAc)2· 4H2O with N butylsalicylhydrazide Schiff base ligand and characterized by X ray crystallography. The crystal belongs to triclinic, Mr=930.91, space group with cell parameters a=9.8489(2)? , b=12.3110(2)? , c=18.4035(3)? , α =71.353(2)° , β =76.638(2)° ,γ =84.815(2)° ,V=2056.72(6)? 3,Z=2,Dc=1.503g· cm- 3, μ (MoKα ) =1.417mm- 1, F(000)=964, R=0.0317, wR=0.0868. A total of 5393 independent reflections were collected, of which 4448 reflections with I ≥ 2σ (I) were observed. There are two centrosymmetrical trinuclear molecules in a unit cell, each molecule exhibits a linear trinuclear metal arrangement with the Ni... Ni... Ni angle of 180° . The interatomic distances between the nickel atoms on the two sides are 9.2030(8)? and 9.1876(9)? for the two molecules, respectively. The central nickel atom adopts an axially elongated octahedral geometry whereas the nickel atoms on the two sides have square planar coordination environment. CCDC: 194083.展开更多
The novel copper(Ⅱ)complex with 2-oxo-propionic acid benzoyl hydrazone and pyridine ligands, Cu(C10H8N2O3)·(C5H5N)·(H2O) (C10H8N2O32- is the dinegative ion of 2-oxo-propionicacid benzoyl hydrazone), has bee...The novel copper(Ⅱ)complex with 2-oxo-propionic acid benzoyl hydrazone and pyridine ligands, Cu(C10H8N2O3)·(C5H5N)·(H2O) (C10H8N2O32- is the dinegative ion of 2-oxo-propionicacid benzoyl hydrazone), has been synthesized and characterized by elemental analysis and IR. The crystal structure of the title complex was determined by single crystal X-ray diffraction technique. Complex crystallized in the triclinic space group P1 with a = 0.729 08(10) nm, b = 1.020 01(14) nm, c = 1.126 28(15) nm, α = 71.644(2) °, β = 80.437(2) °, γ = 89.160(2)°, V = 0.783 28(18) nm3, Z = 2, Dc = 1.547 Mg·m-3, μ(MoKa) = 1.417 mm-1, F(000) = 374. The final R1 = 0.030 6, wR2 = 0.084 2 for 2 992 observed reflections out of 3 357 unique reflections. In this complex, copper(Ⅱ)ion is square-pyramidally coordinated by two oxygen atoms and one nitrogen atom of tridentate C10H8N2O32- ligand, one nitrogen atom of the pyridine ligand, and one oxygen atom of water molecule with the oxygen atom of water molecule locating at the apical position. The analysis of the crystal structure indicates that the complex has a one-dimensional chain structure, which is formed by intermolecular hydrogen bonds. CCDC: 222656.展开更多
Sodium bis[N-2-oxyphenyl-5-substituted-salicylideneiminato-ONO]ruthenate（Ⅲ） hemitriethylamine compounds of general formula Na[Ru（N-R-5-X-salim）2]＇0.5Et3N, where, R = C6H40, X = El, Br, NO2, salim = salicylidenei...Sodium bis[N-2-oxyphenyl-5-substituted-salicylideneiminato-ONO]ruthenate（Ⅲ） hemitriethylamine compounds of general formula Na[Ru（N-R-5-X-salim）2]＇0.5Et3N, where, R = C6H40, X = El, Br, NO2, salim = salicylideneiminato, Et3N triethylamine, were synthesized and characterized on the basis of elemental analysis, MALDI-TOF （matrix-assisted laser desorption/ionization/time-of-flight） mass spectra, IH NMR （nuclear magnetic resonance）, electronic spectra and cyclic voltammograms. Ru（Ⅲ） is chelated with two O2N anionic tridentate Schiff bases derived from 5-X-salicyladehyde and 2-aminophenol. Spectroscopic titrations of the Ru（Ⅲ） compounds with CT DNA （calf thymus DNA） in the LMCT （ligand metal charge transfer） region have shown moderate intercalation properties of compounds with binding constants KD = 2.06-3.85 × 104 Ml. Electrochemical evidence of intercalative mode of binding is based on the decrease of current and shift of anodic and cathodic peaks towards higher values of potential with IxL-increment of CT DNA in Ru（Ⅲ） compound solution.展开更多
The novel copper?complex with salicylaldehyde benzoylhydrazone and pyridine ligands, Cu(C14H10N2O2)(C5H5N), has been synthesized and characterized by elemental analysis, IR and thermal analysis. The crystal structure ...The novel copper?complex with salicylaldehyde benzoylhydrazone and pyridine ligands, Cu(C14H10N2O2)(C5H5N), has been synthesized and characterized by elemental analysis, IR and thermal analysis. The crystal structure of the title complex has been determined by single crystal X ray diffraction techniques. The crystal belongs to monoclinic with space group P21/c. The cell parameters are: a=1.6362(9)nm, b=1.7140(9)nm, c=1.2255(7)nm, β=105.168(9)°, V=3.317(3)nm3, Z=8, Dc=1.525g·cm-3, μ(MoKα)=1.334mm-1, F(000)=1560. The structure wasrefined to final R1=0.0376, wR2=0.0909. The copper?ion lies in a distorted square planar environment composed of two oxygen atoms, one nitrogen atom of tridentate acyhydrazone Schiff base ligand and one nitrogen atom of the pyridine ligand. CCDC: 193111.展开更多
A novel nickel(II) complex with 2,4-dihydroxybenzalidene benzoylhydrazone a nd pyridine ligands, Ni(C14H10N2O3)(C5H5N), has been synthesized and characteriz ed by elemental analysis and IR. The crystal structure of th...A novel nickel(II) complex with 2,4-dihydroxybenzalidene benzoylhydrazone a nd pyridine ligands, Ni(C14H10N2O3)(C5H5N), has been synthesized and characteriz ed by elemental analysis and IR. The crystal structure of the title complex has been determined by single crystal X-ray diffraction techniques. The crystal belo ngs to orthorhombic, space group Pbca. The cell parameters are: a=1.580 20(19) n m, b=1.362 18(16) nm, c=1.616 50(19) nm, and V=3.479 5(7) nm3, Z=8, Dc=1.497 Mg ·m-3, composed of two oxygen atoms, one n itrogen atom of tridentate acyhydrazone schiff base ligand and one nitrogen atom of the pyridine ligand. The analysis of the crystal structure indicates that th e complex has a one-dimensional chain structure, which is formed by intermolecul ar hydrogen bonds. CCDC: 244668.展开更多
文摘A Schiff base ligand 4-[indol-3-yl]-but-3-en-2-one benzoyl hydrazone (HL), and its four transition metal complexes (ML2,M=Cu(, Ni(, Zn( and Co() have been prepared and characterized by means of elemental analysis, EI-MS, molar conductivity, IR, UV-Vis and 1H NMR. The results showed that HL as a bidentate ligand coordinated with transition metal ions to form four-coordination complexes. The antibacterial activity was studied by using the filter scraps diffusion method, and the results indicated that the ligand and the complexes had a low bacteriostatic activity against S. Aureu, P. Aeruginosa and E. Coli. The low in vitro antitumor activity of the title complexes was also observed by using MTT method against KB, A2780, Bel7402 and HELF.
文摘The trinuclear nickel? complex Ni3(C11H11N2O3)2(C5H5N)4 was prepared by the reaction of Ni(OAc)2· 4H2O with N butylsalicylhydrazide Schiff base ligand and characterized by X ray crystallography. The crystal belongs to triclinic, Mr=930.91, space group with cell parameters a=9.8489(2)? , b=12.3110(2)? , c=18.4035(3)? , α =71.353(2)° , β =76.638(2)° ,γ =84.815(2)° ,V=2056.72(6)? 3,Z=2,Dc=1.503g· cm- 3, μ (MoKα ) =1.417mm- 1, F(000)=964, R=0.0317, wR=0.0868. A total of 5393 independent reflections were collected, of which 4448 reflections with I ≥ 2σ (I) were observed. There are two centrosymmetrical trinuclear molecules in a unit cell, each molecule exhibits a linear trinuclear metal arrangement with the Ni... Ni... Ni angle of 180° . The interatomic distances between the nickel atoms on the two sides are 9.2030(8)? and 9.1876(9)? for the two molecules, respectively. The central nickel atom adopts an axially elongated octahedral geometry whereas the nickel atoms on the two sides have square planar coordination environment. CCDC: 194083.
文摘The novel copper(Ⅱ)complex with 2-oxo-propionic acid benzoyl hydrazone and pyridine ligands, Cu(C10H8N2O3)·(C5H5N)·(H2O) (C10H8N2O32- is the dinegative ion of 2-oxo-propionicacid benzoyl hydrazone), has been synthesized and characterized by elemental analysis and IR. The crystal structure of the title complex was determined by single crystal X-ray diffraction technique. Complex crystallized in the triclinic space group P1 with a = 0.729 08(10) nm, b = 1.020 01(14) nm, c = 1.126 28(15) nm, α = 71.644(2) °, β = 80.437(2) °, γ = 89.160(2)°, V = 0.783 28(18) nm3, Z = 2, Dc = 1.547 Mg·m-3, μ(MoKa) = 1.417 mm-1, F(000) = 374. The final R1 = 0.030 6, wR2 = 0.084 2 for 2 992 observed reflections out of 3 357 unique reflections. In this complex, copper(Ⅱ)ion is square-pyramidally coordinated by two oxygen atoms and one nitrogen atom of tridentate C10H8N2O32- ligand, one nitrogen atom of the pyridine ligand, and one oxygen atom of water molecule with the oxygen atom of water molecule locating at the apical position. The analysis of the crystal structure indicates that the complex has a one-dimensional chain structure, which is formed by intermolecular hydrogen bonds. CCDC: 222656.
文摘Sodium bis[N-2-oxyphenyl-5-substituted-salicylideneiminato-ONO]ruthenate（Ⅲ） hemitriethylamine compounds of general formula Na[Ru（N-R-5-X-salim）2]＇0.5Et3N, where, R = C6H40, X = El, Br, NO2, salim = salicylideneiminato, Et3N triethylamine, were synthesized and characterized on the basis of elemental analysis, MALDI-TOF （matrix-assisted laser desorption/ionization/time-of-flight） mass spectra, IH NMR （nuclear magnetic resonance）, electronic spectra and cyclic voltammograms. Ru（Ⅲ） is chelated with two O2N anionic tridentate Schiff bases derived from 5-X-salicyladehyde and 2-aminophenol. Spectroscopic titrations of the Ru（Ⅲ） compounds with CT DNA （calf thymus DNA） in the LMCT （ligand metal charge transfer） region have shown moderate intercalation properties of compounds with binding constants KD = 2.06-3.85 × 104 Ml. Electrochemical evidence of intercalative mode of binding is based on the decrease of current and shift of anodic and cathodic peaks towards higher values of potential with IxL-increment of CT DNA in Ru（Ⅲ） compound solution.
文摘The novel copper?complex with salicylaldehyde benzoylhydrazone and pyridine ligands, Cu(C14H10N2O2)(C5H5N), has been synthesized and characterized by elemental analysis, IR and thermal analysis. The crystal structure of the title complex has been determined by single crystal X ray diffraction techniques. The crystal belongs to monoclinic with space group P21/c. The cell parameters are: a=1.6362(9)nm, b=1.7140(9)nm, c=1.2255(7)nm, β=105.168(9)°, V=3.317(3)nm3, Z=8, Dc=1.525g·cm-3, μ(MoKα)=1.334mm-1, F(000)=1560. The structure wasrefined to final R1=0.0376, wR2=0.0909. The copper?ion lies in a distorted square planar environment composed of two oxygen atoms, one nitrogen atom of tridentate acyhydrazone Schiff base ligand and one nitrogen atom of the pyridine ligand. CCDC: 193111.
文摘A novel nickel(II) complex with 2,4-dihydroxybenzalidene benzoylhydrazone a nd pyridine ligands, Ni(C14H10N2O3)(C5H5N), has been synthesized and characteriz ed by elemental analysis and IR. The crystal structure of the title complex has been determined by single crystal X-ray diffraction techniques. The crystal belo ngs to orthorhombic, space group Pbca. The cell parameters are: a=1.580 20(19) n m, b=1.362 18(16) nm, c=1.616 50(19) nm, and V=3.479 5(7) nm3, Z=8, Dc=1.497 Mg ·m-3, composed of two oxygen atoms, one n itrogen atom of tridentate acyhydrazone schiff base ligand and one nitrogen atom of the pyridine ligand. The analysis of the crystal structure indicates that th e complex has a one-dimensional chain structure, which is formed by intermolecul ar hydrogen bonds. CCDC: 244668.
