向心路径定义及其在网络节点聚类中的应用

复杂网络为复杂系统的经典表现形式,依靠网络内部复杂关系进行网络节点聚类是理解复杂网络的一个重要途径。依据子类中心节点对于同一个类别中其他节点具有更强的控制力的思想,提出了子类中心点的概念及其确定方法,进一步提出了上通路和向心路径的概念。在子类中心节点基础上通过计算向心路径数量,实现网络节点的快速聚类算法,即向心路径节点聚类算法(Toward to Subheart Roads Defining Network Clustering Algorithm)。相比于传统算法,TSRDNCA算法具有较高的网络社区判断的准确性。

Exploitation of the nicotinic anti-inflammatory pathway for the treatment of epithelial inflammatory diseases

Discoveries in the first few years of the 21st century have led to an understanding of important interactions between the nervous system and the inflammatory response at the molecular level, most notably the acetylcholine （ACh）- triggered,α7-nicotinic acetylcholine receptor （α7nAChR）- dependent nicotinic antinflammatory pathway. Studies using the α7nAChR agonist, nicotine, for the treatment of mucosal inflammation have been undertaken but the efficacy of nicotine as a treatment for inflammatory bowel diseases remains debatable. Further understanding of the nicotinic anti-inflammatory pathway and other endogenous anti-inflammatory mechanisms is required in order to develop refined and specific therapeutic strategies for the treatment of a number of inflammatory diseases and conditions, including periodontitis, psoriasis, sarcoidosis, and ulcerative colitis.

Operation reliability for on-ramp junction of urban freeway

A disorder situation of traffic operation always appears in on-ramp junction area of urban freeway,because the operation action for vehicles presents the weaving condition,especially for different vehicle types.Based on the analysis on the cellular automata theory,and combining with on-site survey data,several key parameters were defined,namely,cellular length,cellular speed,cellular acceleration,updating time interval.In addition,cellular acceleration rule,cellular deceleration rule,random rule,lane-changing rule and other micro-simulation rules were set,and cellular automaton micro-simulation model was set up.Further-more,a micro-simulation module was developed for traffic operation actions of on-ramp junction with Matlab toolbox.Finally,a simulation experiment for traffic operation reliability was done with this micro-simulation module,and the situation of change for on-ramp junction area was obtained under the conditions of different mainline design speed,acceleration lane length,vehicle generation probability and lane-changing probability.The results show that operation reliability for on-ramp junction is determined by the parameters of the probability of vehicle generation and the length of acceleration lane,especially for on-ramp.

The role of the hedgehog/patched signaling pathway in epithelial stem cell proliferation: from fly to human

The hedgehog-patched (hh-ptc) intercellular signaling pathway has recently been shown to control the proliferation of epithelial stem cells in both Drosophila and vertebrates. Mutant and ectopic expression analyses in Drosophila suggest that the HH protein diffuses from the signaling cells to promote the proliferation of nearby ovarian somatic stem cells by antagonizing the suppression of its receptor PTC towards the CI transcription factor in the stem cells. Consequently, the transcription of CIdependent genes leads to stem cell proliferation. This regulatory pathway appears to function also in vertebrates,where defects in ptc cause basal cell carcinoma, tumors of epidermal stem cell origin. Basal cell carcinoma can also be induced by ectopic expression of Sonic hedgehog (shh) or Glil, the vertebrate homolog of ci. These studies suggest the conservation of the hh signaling pathway in controlling epithelial stem cell divisions among different organisms.

The Proposal of the Remedy for the Endangered Remote-Island Routes

In this study, the authors prove the necessity for the remote island route which will face the crisis of continuation in the near future in Japan, and aims at showing the concrete policy for the continuation. The new policy which shares the reserve ship which uses the traffic ship with a capacity of 12 in addition to cooperation not only with the usual liner route entrepreneur but an occasional service entrepreneur or a passenger ship, and operates until now was proposed, and the validity was shown. In this paper, as approach of the beginning for materializing the policy, it is focused on the island of the inland sea where especially population is small, and the new policy using the craft from which Japan Coast Guard retired was proposed. By this, it does not depend only on the revenue grant money by the country or a municipal corporation, but maintenance of a remote island route is attained.

Effect of Chaihushugan San on expression of the Raf/mitogen-activated protein kinase/extracellular signal-regulated kinase pathway in the hippocampi of perimenopausal rats induced by immobilization stress

OBJECTIVE: We wished to study the impact of Chaihushugan San(CSS) on the behavior of perimenopausal rats with liver-Qi stagnation(LQS) and to investigate the effect of CSS on signal transduction of the Raf/mitogen-activated protein kinase(MEK)/extracellular signal-regulated kinase(ERK) cascade in the hippocampi of rats induced by immobilization.METHODS: Twenty 52-week-old female rats were divided into two groups by the random number table method: model control group(MCG) and CSS group(CSSG), with 10 rats in each group.Ten-week-old female rats were used as the normal control group(NCG). CSS effects were assessed using rats exposed to immobilization stress by measuring body weight and sucrose consumption, serum hormone levels, and observing performance in the open field test(OFT). Molecular mechanisms were examined by measuring the effect of CSS on expression of Raf1, MEK1/2 and ERK1/2 m RNA in hippocampi using quantitative real-time polymerase chain reaction and by measuring levels of these proteins and related phospho-proteins using Western blotting.RESULTS: Perimenopausal rats with LQS had decreased locomotor activity; reduced sucrose consumption; and increased serum levels of corticotropin releasing hormone(CRH) and corticosterone(CORT). Activation of hippocampal Raf/MEK/ERK cascade was suppressed significantly in the MCG,and activation was increased after 21 days of CSS treatment.CONCLUSION: CSS has significant effects upon relief of the symptoms of LQS in immobilization-induced rats. The mechanism underlying this action might(at least in part) be mediated by reversal of disruption of the Raf/MEK/ERK pathway.