Liver metastases of colorectal cancer are rarely rapidly resectable. The efficacy of new chemotherapy regimen, in particular the combination of 5FU and oxaliplatin make further surgical resection possible in the case ...Liver metastases of colorectal cancer are rarely rapidly resectable. The efficacy of new chemotherapy regimen, in particular the combination of 5FU and oxaliplatin make further surgical resection possible in the case of on objective response in some patients. Three patients with metastatic colorectal cancer received oxaliplatin-based chemotherapy; only minimal and transient neurosensory toxicity occured. After a partial response to treatment, surgical resection of metastases was performed. Patients reported major exacerbation of oxaliplatin-induced neurosensory toxicity following surgery (between day 7 and day 15). One patient experienced sensory loss of the extremities with functional impairment (grade 3 on Levis scale). The symptoms persisted for 8-12 month after surgery in the three patients. Only seven similar cases have been reported. Toxicity could be associated with the concentration of oxaliplatin in the red blood cells: oxaliplatin binds irreversibly to erythrocytes. This exacerbation could be the consequence of peroperative hemolysis with a redistribution of the pool of intra-erythrocytic oxaliplatin biotransformation products into the plasma. We did not find any relationship with anesthesic or per-operative medications. Studies are necessary to define the precise mechanism and the frequency of this reaction.展开更多
晚期糖基化终末产物(advanced glycation end products,AGEs)在糖尿病患者体内大量生成,其生成具有不可逆性,会随着时间逐渐累积,因此AGEs在组织内的含量可以代表糖尿病发展的程度与时间[1]。此外AGEs与糖尿病及各种并发症的发生发展有...晚期糖基化终末产物(advanced glycation end products,AGEs)在糖尿病患者体内大量生成,其生成具有不可逆性,会随着时间逐渐累积,因此AGEs在组织内的含量可以代表糖尿病发展的程度与时间[1]。此外AGEs与糖尿病及各种并发症的发生发展有着密不可分的关系[2]。牙周炎是糖尿病的第六并发症,糖尿病患者的牙周炎病情发展迅速,病损严重且治疗较为困难。两者的双向影响关系已经得到大量研究的支持[3],近年研究显示AGEs在糖尿病患者牙周炎的发生发展中起着重要的作用,本文对近年的研究梳理后就AGEs对牙周组织影响作一综述。展开更多
文摘Liver metastases of colorectal cancer are rarely rapidly resectable. The efficacy of new chemotherapy regimen, in particular the combination of 5FU and oxaliplatin make further surgical resection possible in the case of on objective response in some patients. Three patients with metastatic colorectal cancer received oxaliplatin-based chemotherapy; only minimal and transient neurosensory toxicity occured. After a partial response to treatment, surgical resection of metastases was performed. Patients reported major exacerbation of oxaliplatin-induced neurosensory toxicity following surgery (between day 7 and day 15). One patient experienced sensory loss of the extremities with functional impairment (grade 3 on Levis scale). The symptoms persisted for 8-12 month after surgery in the three patients. Only seven similar cases have been reported. Toxicity could be associated with the concentration of oxaliplatin in the red blood cells: oxaliplatin binds irreversibly to erythrocytes. This exacerbation could be the consequence of peroperative hemolysis with a redistribution of the pool of intra-erythrocytic oxaliplatin biotransformation products into the plasma. We did not find any relationship with anesthesic or per-operative medications. Studies are necessary to define the precise mechanism and the frequency of this reaction.
文摘晚期糖基化终末产物(advanced glycation end products,AGEs)在糖尿病患者体内大量生成,其生成具有不可逆性,会随着时间逐渐累积,因此AGEs在组织内的含量可以代表糖尿病发展的程度与时间[1]。此外AGEs与糖尿病及各种并发症的发生发展有着密不可分的关系[2]。牙周炎是糖尿病的第六并发症,糖尿病患者的牙周炎病情发展迅速,病损严重且治疗较为困难。两者的双向影响关系已经得到大量研究的支持[3],近年研究显示AGEs在糖尿病患者牙周炎的发生发展中起着重要的作用,本文对近年的研究梳理后就AGEs对牙周组织影响作一综述。
