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不同灸法对实验性RA模型IL-6、IL-8、MCP-1表达影响的研究 被引量:13
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作者 杨涵棋 刘旭光 +3 位作者 张耀 陈婷 柏琳娜 杨馨 《中华中医药学刊》 CAS 2012年第12期2625-2627,共3页
目的:观察不同灸法对实验性RA模型关节滑膜液中炎症因子IL-6、IL-8、MCP-1表达的影响,探索不同灸法治疗实验性RA的作用机制。方法:日本大耳兔40只,体重(2.5±0.25)kg,雌雄各半,分为空白对照组、RA模型组、直接灸治疗组、隔姜灸治疗... 目的:观察不同灸法对实验性RA模型关节滑膜液中炎症因子IL-6、IL-8、MCP-1表达的影响,探索不同灸法治疗实验性RA的作用机制。方法:日本大耳兔40只,体重(2.5±0.25)kg,雌雄各半,分为空白对照组、RA模型组、直接灸治疗组、隔姜灸治疗组、温和灸治疗组,每组8只日本大耳兔。采用福氏完全佐剂塑造实验性RA模型,于造模后第7天开始,分别用直接灸、隔姜灸、温和灸3种不同方法施灸日本大耳兔"肾俞"、"足三里"穴各5壮,两侧交替进行,每日1次。6天为1个疗程,共3个疗程。结果:直接灸、隔姜灸、温和灸均能明显降低RA模型动物关节滑膜液中IL-6、IL-8、MCP-1含量(P<0.05,0.01),其中尤以隔姜灸作用最为明显。结论:不同灸法治疗实验性RA均有明显的抗炎效应,且以隔姜灸作用最为显著;不同灸法抑制IL-6、IL-8、MCP-1炎症因子表达可能是其发挥抗炎效应的重要机制之一。 展开更多
关键词 不同灸法 实验性RA IL-6 IL-8 MCP-1
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不同灸法对类风湿关节炎家兔HPAA功能的影响 被引量:14
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作者 高秀花 王兴丽 +2 位作者 刘旭光 贾敏 黎海军 《中国中医基础医学杂志》 CAS CSCD 北大核心 2015年第9期1140-1142,共3页
目的:观察不同灸法对类风湿关节炎(RA)模型的抗炎效应,探索其对实验性RA下丘脑-垂体-肾上腺皮质轴(HPAA)功能的影响。方法:采用弗氏完全佐剂法造模,将家兔按随机数字表法分为空白组、模型组、直接灸组、隔姜灸组及温和灸组。于造模前及... 目的:观察不同灸法对类风湿关节炎(RA)模型的抗炎效应,探索其对实验性RA下丘脑-垂体-肾上腺皮质轴(HPAA)功能的影响。方法:采用弗氏完全佐剂法造模,将家兔按随机数字表法分为空白组、模型组、直接灸组、隔姜灸组及温和灸组。于造模前及治疗后第7、14、21天测量各组膝关节周长,用ELISA法检测各组血清中促肾上腺皮质激素释放因子(CRF)、促肾上腺皮质激素(ACTH)、皮质酮(CS)含量。结果:各艾灸组膝关节周长明显低于模型组;其中隔姜灸组下降幅度最大,但差异无统计学意义;相比模型组,各艾灸组CRF、CS含量明显降低,ACTH明显升高;各艾灸组间比较差异无统计学意义。结论:不同灸法对实验性RA均有明显的抗炎作用,隔姜灸可能有更好的作用趋势;不同灸法对HPAA功能均有明显的调整作用,这可能是艾灸抗炎效应的重要机制之一,但不同灸法比较差异无统计学意义。 展开更多
关键词 不同灸法 类风湿关节炎 下丘脑-垂体-肾上腺轴 CRF ACTH CS
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不同灸法对溃疡性结肠炎大鼠结肠黏膜黏蛋白调节作用的研究 被引量:16
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作者 赵天平 周爽 秦秀娣 《中华中医药学刊》 CAS 2010年第8期1590-1594,共5页
目的:观察UC大鼠结肠损伤与黏蛋白分泌情况,探讨不同灸法对UC大鼠结肠损伤的修复作用。方法:60只SD大鼠随机数字表法分为正常组、模型组、隔药灸组、隔姜灸组、隔蒜灸组和温和灸组6组。采用免疫学方法,并加局部刺激制备实验性溃疡性结... 目的:观察UC大鼠结肠损伤与黏蛋白分泌情况,探讨不同灸法对UC大鼠结肠损伤的修复作用。方法:60只SD大鼠随机数字表法分为正常组、模型组、隔药灸组、隔姜灸组、隔蒜灸组和温和灸组6组。采用免疫学方法,并加局部刺激制备实验性溃疡性结肠炎大鼠模型。隔药灸组、隔姜灸组、隔蒜灸组和温和灸组取天枢穴(双)、气海穴,分别施以相应的治疗,连续治疗14次。疗程结束后,分别观察各组动物的体重、大便、结肠大体形态及组织病理学改变、结肠黏膜黏蛋白分泌情况。结果:溃疡性结肠炎大鼠体重增长缓慢,出现腹泻症状;病理学观察可见溃疡形成;结肠黏膜中性黏蛋白和酸性黏蛋白分泌减少,与正常组比较具有显著差异(P<0.01)。隔药灸组、隔姜灸组、隔蒜灸组、温和灸组经相应治疗后,大鼠体重增加,腹泻症状得到明显改善,结肠肠壁各层结构明显改善。除温和灸组溃疡面尚未愈合外,隔药灸组、隔姜灸组、隔蒜灸组溃疡面已经基本愈合。结肠黏膜中性黏蛋白和酸性黏蛋白分泌上调,与模型组比较具有显著差异(P<0.05~0.01)。结论:隔药灸、隔姜灸、隔蒜灸、温和灸可以通过调节黏蛋白表达,起到修复UC大鼠结肠损伤的作用。 展开更多
关键词 溃疡性结肠炎 大鼠 不同灸法 黏蛋白 组织病理学
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Efficacy assessment for different acupuncture therapies in the treatment of frozen shoulder 被引量:8
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作者 石慧 方剑乔 +3 位作者 李邦伟 丛文杰 张奕 陈雷 《World Journal of Acupuncture-Moxibustion》 2012年第2期6-11,共6页
Objective To explore better therapies for the treatment of frozen shoulder. Methods One hundred and seventy-four cases were divided into a filiform needle group (56 cases), an electroacupuncture group (57 cases) a... Objective To explore better therapies for the treatment of frozen shoulder. Methods One hundred and seventy-four cases were divided into a filiform needle group (56 cases), an electroacupuncture group (57 cases) and a warming needle group (61 cases) according to the randomized, controlled and single-blind study principles. Jiānqián (肩前 Extra), Jiānyú (肩髃 LI 15), Jiānliáo (肩髎 TE 14), Nàoshū (臑俞 SI 10), Wàiguān (外关 TE 5), Hégǔ (合谷 LI 4) were used in all three groups but treated with filiform needle, electroacupuncture and warming needle technique respectively. The needles were retained for 30 min. It was given once every other day and 5 times constituted as one course. Pain indices and activity degree of shoulders were measured and recorded before and after treatment every time. Results The total effective rate was 93.0% (53/57) in the electroacupuncture group and 95.1% (58/61) in the warming needle group, both superior to that of 78.6% (44/56) in the filiform needle group (both P〈0.01), but there was no significant difference between electroacupuncture group and warming needle group (P〉0.05). After one course of treatment, the decline indices of shoulder pain of electroacupuncture group (4.28±0.22) and warming needle group (3.74±0.17) were both significantly greater than that of filiform needle group (2.78±0.18)(both P〈0.01). And the decline indices of electroacupuncture group was also greater than that of warming needle group (P〈0.05). The improvements of shoulder activity degree of warming needle group (76.92±5.53) and electroacupuncture group (60.37±3.80) were both greater than that of filiform needle group (42.50±3.67) (both P〈0.01). And shoulder activity degree of warming needle group was also greater than that of electroacupuncture group (P〈0.01). After one course of treatment, improvement of shoulder activity degree and decline indices of shoulder pain in these three groups were better than that after the first time treatment (all P〈0.01). Conclusion All these three acupuncture therapies can achieve good therapeutic effects for frozen shoulder. The therapeutic effects of electroacupuncture and warming needle groups are superior to that of filiform needle group. All these three therapies could significantly reduce patients’ pain and improve their shoulder activity degree. The analgesic effect of electroacupuncture is the best, and the shoulder activity degree improved by warming needle is the best. The improvement of clinical therapeutic effect mainly depends on the therapy and the treatment times when the same acupoints are selected and the condition of illness are similar. 展开更多
关键词 frozen shoulder different acupuncture therapies efficacyassessment randomized control trial
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