Here, we provide data suggesting that the absence of silencing of the ectopic reprogramming factors used to reprogram somatic cells to induced pluripotent stem cells (iPSCs) may predispose iPSCs to genomic instabili...Here, we provide data suggesting that the absence of silencing of the ectopic reprogramming factors used to reprogram somatic cells to induced pluripotent stem cells (iPSCs) may predispose iPSCs to genomic instability. We encourage stem cell scientists to undertake an extensive characterization and standardization of much larger cohorts of iPSC lines in order to set up rigorous criteria to define safe and stable bonafide iPSCs.展开更多
Two dimensional Fourier transforrn electronic spectroscopy (2DES) in the visible region enables direct observation of complex dynamics of molecules including quantum coherence in the condensed phase. This review aim...Two dimensional Fourier transforrn electronic spectroscopy (2DES) in the visible region enables direct observation of complex dynamics of molecules including quantum coherence in the condensed phase. This review aims to provide a bridge between the principles and intuitive physical description of 2DES for tutorial purpose. Special emphasis is laid upon how 2DES circumvents the restrictions from both uncertainty principle and the wave-packet collapse during the coherent detection, leading to the successful detection of the coherence in terms of energy difference between the eigenstates showing as the quantum beats; then upon the possible mixing among the pure electronic transition, single-rnode and multi-mode coupled vibronic transition leading to the observed beating phenomena. Finally, recent ad- vances in experimentally distinguishing between the electronic coherence and the vibrational coherence are briefly discussed.展开更多
A nonlinear controller based on an extended second-order disturbance observer is presented to track desired position for an electro-hydraulic single-rod actuator in the presence of both external disturbances and param...A nonlinear controller based on an extended second-order disturbance observer is presented to track desired position for an electro-hydraulic single-rod actuator in the presence of both external disturbances and parameter uncertainties. The proposed extended second-order disturbance observer deals with not only the external perturbations, but also parameter uncertainties which are commonly regarded as lumped disturbances in previous researches. Besides, the outer position tracking loop is designed with cylinder load pressure as output; and the inner pressure control loop provides the hydraulic actuator the characteristic of a force generator. The stability of the closed-loop system is provided based on Lyapunov theory. The performance of the controller is verified through simulations and experiments. The results demonstrate that the proposed nonlinear position tracking controller, together with the extended second-order disturbance observer, gives an excellent tracking performance in the presence of parameter uncertainties and external disturbance.展开更多
Internal model control (IMC) yields very good performance for set point tracking, but gives sluggish response for disturbance rejection problem. A two-degree-of-freedom IMC (2DOF-IMC) has been developed to overcom...Internal model control (IMC) yields very good performance for set point tracking, but gives sluggish response for disturbance rejection problem. A two-degree-of-freedom IMC (2DOF-IMC) has been developed to overcome the weakness. However, the setting of parameter becomes a complicated matter if there is an uncertainty model. The present study proposes a new tuning method for the controller. The proposed tuning method consists of three steps. Firstly, the worst case of the model uncertainty is determined. Secondly, the parameter of set point con- troller using maximum peak (Mp) criteria is specified, and finally, the parameter of the disturbance rejection con- troller using gain margin (GM) criteria is obtained. The proposed method is denoted as Mp-GM tuning method. The effectiveness of Mp-GM tuning method has evaluated and compared with IMC-controller tuning program (IMCTUNE) as bench mark. The evaluation and comparison have been done through the simulation on a number of first order plus dead time (FOPDT) and higher order processes. The FOPDT process tested includes processes with controllability ratio in the range 0.7 to 2.5. The higher processes include second order with underdarnped and third order with nonminimum phase processes. Although the two of higher order processes are considered as difficult processes, the proposed Mp-GM tuning method are able to obtain the good controller parameter even under process uncertainties.展开更多
To explore the precise dynamic response of the levitation system with active controller, a maglev guide way-electromagnet-air spring-cabin coupled model is derived firstly. Based on the mathematical model, it shows th...To explore the precise dynamic response of the levitation system with active controller, a maglev guide way-electromagnet-air spring-cabin coupled model is derived firstly. Based on the mathematical model, it shows that the inherent nonlinearity, inner coupling, misalignments between the sensors and actuators, load uncertainties and external disturbances are the main issues that should be solved in engineering. Under the assumptions that the loads and external disturbance are measurable, the backstepping module controller developed in this work can tackle the above problems effectively. In reality, the load is uncertain due to the additions of luggage and passengers, which will degrade the dynamic performance. A load estimation algorithm is introduced to track the actual load asymptotically and eliminate its influence by tuning the parameters of controller online. Furthermore,considering the external disturbances generated by crosswind, pulling motor and air springs, the extended state observer is employed to estimate and suppress the external disturbance. Finally, results of numerical simulations illustrating closed-loop performance are provided.展开更多
The robust control problem for a class of underactuated mechanical systems called acrobots is addressed. The goal is to drive the acrobots away from the straight-down position and balance them at the straight-up unsta...The robust control problem for a class of underactuated mechanical systems called acrobots is addressed. The goal is to drive the acrobots away from the straight-down position and balance them at the straight-up unstable equilibrium position in the presence of parametric uncertainties and external disturbance. First, in the swing-up area, it is shown that the time derivative of energy is independent of the parameter uncertainties, but exogenous disturbance may destroy the characteristic of increase in mechanical energy. So, a swing-up controller with compensator is designed to suppress the influence of the disturbance. Then, in the attractive area, the control problem is formulated into a H~ control framework by introducing a proper error signal, and a sufficient condition of the existence of Hoo state feedback control law based on linear matrix inequality (LMI) is proposed to guarantee the quadratic stability of the control system. Finally, the simulation results show that the proposed control approach can simultaneously handle a maximum ±10% parameter perturbation and a big disturbance simultaneously.展开更多
There is presented a degradation case study of the Romanian shoreline belonging to the seaside of the Black Sea. The Romanian coastal Black Sea is in a continuously degradation due to the destructive action exerted by...There is presented a degradation case study of the Romanian shoreline belonging to the seaside of the Black Sea. The Romanian coastal Black Sea is in a continuously degradation due to the destructive action exerted by waves on the shore and, respectively, to the instability phenomena that manifest itself in the area. There are presented the influences of different causes of the degradation, the characteristics of the seaside shoreline and the interventions already made. There are done evolution foresights of the ground instability phenomena as well as shoreline degradation and recommend measures for rehabilitation.展开更多
duniperus sabina Linnaeus, an evergreen shrub with prostrate life form, can effectively prevent sand moving and is an important tree species for reforestation in semiarid areas of China. It has laterally distributed a...duniperus sabina Linnaeus, an evergreen shrub with prostrate life form, can effectively prevent sand moving and is an important tree species for reforestation in semiarid areas of China. It has laterally distributed adventitious roots and a deeply distributed main root system. To detect water movement between the main root system and adventitious roots, we adopted heat pulse sensors using the Heat Ratio Method, a high precision method for measuring low sap flow rates. Two sensors were implanted in each individual in the stem between the main root system and adventitious roots, and another two in lateral stems distal to all the roots. Positive sap flows during nighttime, even under saturated air moisture conditions, were detected only between the main root system and adventitious roots under drought conditions, and the rate of flow increased as drought progressed and decreased or disappeared after rain events. The results demonstrated the existence of water movement from the main root system to adventitious roots, and combined with the high contribution of nighttime sap flow to transpiration (11%-16%) the results indicate that it also involves the process of hydraulic lift, a water movement from moist subsoil to dry surface soils. Integrated water use strategy between the main root system and adventitious roots via the process of hydraulic lift of soil water maximizes water acquisition efficiency from both subsoil water and water from rain pulses on the soil surface; this increases survivability in the water-limited environment of semiarid areas.展开更多
The linear stability of fiber suspensions between two concentric cylinders rotating independently is studied. The modified stability equation is obtained based on the fiber orientation model and Hinch-Leal closure app...The linear stability of fiber suspensions between two concentric cylinders rotating independently is studied. The modified stability equation is obtained based on the fiber orientation model and Hinch-Leal closure approximation. The primary instabilities and bicritical curves have been calculated numerically. The critical Reynolds number,wavenumber and wave speeds of fiber suspensions as functions of the aspect ratio,volume concentration of the fibers and the gap width of cylinders are obtained.展开更多
The uncertainty principle is a crucial aspect of quantum mechanics.It has been shown that quantum entanglement as well as more general notions of correlations,such as quantum discord,can relax or tighten the entropic ...The uncertainty principle is a crucial aspect of quantum mechanics.It has been shown that quantum entanglement as well as more general notions of correlations,such as quantum discord,can relax or tighten the entropic uncertainty relation in the presence of an ancillary system.We explored the behaviour of entropic uncertainty relations for system of two qubits—one of which subjects to several forms of independent quantum noise,in both Markovian and non-Markovian regimes.The uncertainties and their lower bounds,identified by the entropic uncertainty relations,increase under independent local unital Markovian noisy channels,but they may decrease under non-unital channels.The behaviour of the uncertainties(and lower bounds)exhibit periodical oscillations due to correlation dynamics under independent non-Markovian reservoirs.In addition,we compare different entropic uncertainty relations in several special cases and find that discord-tightened entropic uncertainty relations offer in general a better estimate of the uncertainties in play.展开更多
文摘Here, we provide data suggesting that the absence of silencing of the ectopic reprogramming factors used to reprogram somatic cells to induced pluripotent stem cells (iPSCs) may predispose iPSCs to genomic instability. We encourage stem cell scientists to undertake an extensive characterization and standardization of much larger cohorts of iPSC lines in order to set up rigorous criteria to define safe and stable bonafide iPSCs.
基金supported by the National Natural Science Foundation of China (No.21227003, No.21433014, No.11721404)
文摘Two dimensional Fourier transforrn electronic spectroscopy (2DES) in the visible region enables direct observation of complex dynamics of molecules including quantum coherence in the condensed phase. This review aims to provide a bridge between the principles and intuitive physical description of 2DES for tutorial purpose. Special emphasis is laid upon how 2DES circumvents the restrictions from both uncertainty principle and the wave-packet collapse during the coherent detection, leading to the successful detection of the coherence in terms of energy difference between the eigenstates showing as the quantum beats; then upon the possible mixing among the pure electronic transition, single-rnode and multi-mode coupled vibronic transition leading to the observed beating phenomena. Finally, recent ad- vances in experimentally distinguishing between the electronic coherence and the vibrational coherence are briefly discussed.
基金Project(51221004)supported by the Science Fund for Creative Research Groups of National Natural Science Foundation of ChinaProject(2012AA041801)supproted by the High-tech Research and Development Program of China
文摘A nonlinear controller based on an extended second-order disturbance observer is presented to track desired position for an electro-hydraulic single-rod actuator in the presence of both external disturbances and parameter uncertainties. The proposed extended second-order disturbance observer deals with not only the external perturbations, but also parameter uncertainties which are commonly regarded as lumped disturbances in previous researches. Besides, the outer position tracking loop is designed with cylinder load pressure as output; and the inner pressure control loop provides the hydraulic actuator the characteristic of a force generator. The stability of the closed-loop system is provided based on Lyapunov theory. The performance of the controller is verified through simulations and experiments. The results demonstrate that the proposed nonlinear position tracking controller, together with the extended second-order disturbance observer, gives an excellent tracking performance in the presence of parameter uncertainties and external disturbance.
基金Supported by Postgraduate Fellowship of UMP,Fundamental Research Grant Scheme of Malaysia(GRS070120)Joint Research Grant between Universiti Malaysia Pahang (UMP) and Institut Teknologi Sepuluh Nopember (ITS) Surabaya
文摘Internal model control (IMC) yields very good performance for set point tracking, but gives sluggish response for disturbance rejection problem. A two-degree-of-freedom IMC (2DOF-IMC) has been developed to overcome the weakness. However, the setting of parameter becomes a complicated matter if there is an uncertainty model. The present study proposes a new tuning method for the controller. The proposed tuning method consists of three steps. Firstly, the worst case of the model uncertainty is determined. Secondly, the parameter of set point con- troller using maximum peak (Mp) criteria is specified, and finally, the parameter of the disturbance rejection con- troller using gain margin (GM) criteria is obtained. The proposed method is denoted as Mp-GM tuning method. The effectiveness of Mp-GM tuning method has evaluated and compared with IMC-controller tuning program (IMCTUNE) as bench mark. The evaluation and comparison have been done through the simulation on a number of first order plus dead time (FOPDT) and higher order processes. The FOPDT process tested includes processes with controllability ratio in the range 0.7 to 2.5. The higher processes include second order with underdarnped and third order with nonminimum phase processes. Although the two of higher order processes are considered as difficult processes, the proposed Mp-GM tuning method are able to obtain the good controller parameter even under process uncertainties.
基金Projects(60404003,11202230)supported by the National Natural Science Foundation of China
文摘To explore the precise dynamic response of the levitation system with active controller, a maglev guide way-electromagnet-air spring-cabin coupled model is derived firstly. Based on the mathematical model, it shows that the inherent nonlinearity, inner coupling, misalignments between the sensors and actuators, load uncertainties and external disturbances are the main issues that should be solved in engineering. Under the assumptions that the loads and external disturbance are measurable, the backstepping module controller developed in this work can tackle the above problems effectively. In reality, the load is uncertain due to the additions of luggage and passengers, which will degrade the dynamic performance. A load estimation algorithm is introduced to track the actual load asymptotically and eliminate its influence by tuning the parameters of controller online. Furthermore,considering the external disturbances generated by crosswind, pulling motor and air springs, the extended state observer is employed to estimate and suppress the external disturbance. Finally, results of numerical simulations illustrating closed-loop performance are provided.
基金Projects(61074112,60674044) supported by the National Natural Science Foundation of China
文摘The robust control problem for a class of underactuated mechanical systems called acrobots is addressed. The goal is to drive the acrobots away from the straight-down position and balance them at the straight-up unstable equilibrium position in the presence of parametric uncertainties and external disturbance. First, in the swing-up area, it is shown that the time derivative of energy is independent of the parameter uncertainties, but exogenous disturbance may destroy the characteristic of increase in mechanical energy. So, a swing-up controller with compensator is designed to suppress the influence of the disturbance. Then, in the attractive area, the control problem is formulated into a H~ control framework by introducing a proper error signal, and a sufficient condition of the existence of Hoo state feedback control law based on linear matrix inequality (LMI) is proposed to guarantee the quadratic stability of the control system. Finally, the simulation results show that the proposed control approach can simultaneously handle a maximum ±10% parameter perturbation and a big disturbance simultaneously.
文摘There is presented a degradation case study of the Romanian shoreline belonging to the seaside of the Black Sea. The Romanian coastal Black Sea is in a continuously degradation due to the destructive action exerted by waves on the shore and, respectively, to the instability phenomena that manifest itself in the area. There are presented the influences of different causes of the degradation, the characteristics of the seaside shoreline and the interventions already made. There are done evolution foresights of the ground instability phenomena as well as shoreline degradation and recommend measures for rehabilitation.
文摘duniperus sabina Linnaeus, an evergreen shrub with prostrate life form, can effectively prevent sand moving and is an important tree species for reforestation in semiarid areas of China. It has laterally distributed adventitious roots and a deeply distributed main root system. To detect water movement between the main root system and adventitious roots, we adopted heat pulse sensors using the Heat Ratio Method, a high precision method for measuring low sap flow rates. Two sensors were implanted in each individual in the stem between the main root system and adventitious roots, and another two in lateral stems distal to all the roots. Positive sap flows during nighttime, even under saturated air moisture conditions, were detected only between the main root system and adventitious roots under drought conditions, and the rate of flow increased as drought progressed and decreased or disappeared after rain events. The results demonstrated the existence of water movement from the main root system to adventitious roots, and combined with the high contribution of nighttime sap flow to transpiration (11%-16%) the results indicate that it also involves the process of hydraulic lift, a water movement from moist subsoil to dry surface soils. Integrated water use strategy between the main root system and adventitious roots via the process of hydraulic lift of soil water maximizes water acquisition efficiency from both subsoil water and water from rain pulses on the soil surface; this increases survivability in the water-limited environment of semiarid areas.
基金Project (Nos. 10632070 and 40231017) supported by the National Natural Science Foundation of China
文摘The linear stability of fiber suspensions between two concentric cylinders rotating independently is studied. The modified stability equation is obtained based on the fiber orientation model and Hinch-Leal closure approximation. The primary instabilities and bicritical curves have been calculated numerically. The critical Reynolds number,wavenumber and wave speeds of fiber suspensions as functions of the aspect ratio,volume concentration of the fibers and the gap width of cylinders are obtained.
基金supported by the National Natural Science Foundation of China(Grant Nos.61144006,11201427 and 10901103)the Foundation of China Scholarship Council,the Project Fund of Hunan Provincial Scienceand Technology Department(Grant No.2010FJ3147)the Fund of Hunan Provincial Key Laboratory of Photoelectric Information Integration and Optical Manufacturing Technology,the Educational Committee of the Hunan Province of China through the Overseas Famous Teachers Programme
文摘The uncertainty principle is a crucial aspect of quantum mechanics.It has been shown that quantum entanglement as well as more general notions of correlations,such as quantum discord,can relax or tighten the entropic uncertainty relation in the presence of an ancillary system.We explored the behaviour of entropic uncertainty relations for system of two qubits—one of which subjects to several forms of independent quantum noise,in both Markovian and non-Markovian regimes.The uncertainties and their lower bounds,identified by the entropic uncertainty relations,increase under independent local unital Markovian noisy channels,but they may decrease under non-unital channels.The behaviour of the uncertainties(and lower bounds)exhibit periodical oscillations due to correlation dynamics under independent non-Markovian reservoirs.In addition,we compare different entropic uncertainty relations in several special cases and find that discord-tightened entropic uncertainty relations offer in general a better estimate of the uncertainties in play.