Marine fish are incapable or have a deft- cient capacity to synthesize highly unsaturated fatty acids （HUFA） from C18 precursors, and thus fish meal and fish oil （FO） are needed in their formulated diets.
Natural product elansolid A belongs to one type of polyketide macrolactone with promising antibiotic activity.Pre-viously,the first total synthesis of elansolid A in 28 longest linear sequence(LLS)and 41 steps in tota...Natural product elansolid A belongs to one type of polyketide macrolactone with promising antibiotic activity.Pre-viously,the first total synthesis of elansolid A in 28 longest linear sequence(LLS)and 41 steps in total has been achieved.Herein,the simplified analog of elansolid A,featured with a cyclohexyl-fused 19-memebered macrolactone,was proposed,and its asymmetric total synthesis based on a convergent strategy and key reactions exemplified by desymmetric alcoholysis of anhydride,Pd-catalyzed Stille coupling,Suzuki-Miyaura coupling as well as Mukaiyama macrolactonization was finished.展开更多
As a traditional Chinese herbal medicine exhibiting analgesic,fever-reducing and anti-inflammatory effects,Radix Bupleuri（Chai-Hu） is commonly used for the treatment of influenza,which is derived from the dried root...As a traditional Chinese herbal medicine exhibiting analgesic,fever-reducing and anti-inflammatory effects,Radix Bupleuri（Chai-Hu） is commonly used for the treatment of influenza,which is derived from the dried roots of Bupleurum chinense DC.and Bupleurum scorzonerifolium Willd.Among of diverse chemical components,saikosaponins are the key active components of the herb medicine.In the present study,we established a method of high performance liquid chromatography（HPLC） coupled with evaporative light scattering detection（ELSD） for simultaneous determination of saikosaponin a,c and d in root,stem,leaf and flower of Bupleurum chinense（B chinense） collected from different areas of Shanxi Province,China.The results from 16 samples of root,stem,leaf and flower of B chinense demonstrated that the total contents of the three saikosaponins in the root of B chinense collected from Dongshan Taiyuan,Xishan,Tianlongshan and Pangquangou were 4.26 mg/g,3.22 mg/g,4.23 mg/g and 3.05 mg/g,respectively.However,there was scarcely any saikosaponins in the stem,leaf and flower of B chinense collected from above-mentioned areas.The method of HPLC coupled with ELSD was suitable for quality control of Radix Bupleuri.The result also confirmed that the root of B chinense was the best medicinal part.展开更多
文摘Marine fish are incapable or have a deft- cient capacity to synthesize highly unsaturated fatty acids （HUFA） from C18 precursors, and thus fish meal and fish oil （FO） are needed in their formulated diets.
基金Project supported by the High-Level Talent Program of Yunnan Province(No.Y93D321261)the Regional Development Program for Young Scholars,Chinese Academy of Sciences(CAS)(No.E323521311)the Science and Technology Department of Yunan Province(Nos.202305AH34005,202401AS070096)。
文摘Natural product elansolid A belongs to one type of polyketide macrolactone with promising antibiotic activity.Pre-viously,the first total synthesis of elansolid A in 28 longest linear sequence(LLS)and 41 steps in total has been achieved.Herein,the simplified analog of elansolid A,featured with a cyclohexyl-fused 19-memebered macrolactone,was proposed,and its asymmetric total synthesis based on a convergent strategy and key reactions exemplified by desymmetric alcoholysis of anhydride,Pd-catalyzed Stille coupling,Suzuki-Miyaura coupling as well as Mukaiyama macrolactonization was finished.
基金Shanxi Educational Committee(Grant No.20111113)Shanxi Science and Technology Department(Grant No.2016ZD0201)
文摘As a traditional Chinese herbal medicine exhibiting analgesic,fever-reducing and anti-inflammatory effects,Radix Bupleuri（Chai-Hu） is commonly used for the treatment of influenza,which is derived from the dried roots of Bupleurum chinense DC.and Bupleurum scorzonerifolium Willd.Among of diverse chemical components,saikosaponins are the key active components of the herb medicine.In the present study,we established a method of high performance liquid chromatography（HPLC） coupled with evaporative light scattering detection（ELSD） for simultaneous determination of saikosaponin a,c and d in root,stem,leaf and flower of Bupleurum chinense（B chinense） collected from different areas of Shanxi Province,China.The results from 16 samples of root,stem,leaf and flower of B chinense demonstrated that the total contents of the three saikosaponins in the root of B chinense collected from Dongshan Taiyuan,Xishan,Tianlongshan and Pangquangou were 4.26 mg/g,3.22 mg/g,4.23 mg/g and 3.05 mg/g,respectively.However,there was scarcely any saikosaponins in the stem,leaf and flower of B chinense collected from above-mentioned areas.The method of HPLC coupled with ELSD was suitable for quality control of Radix Bupleuri.The result also confirmed that the root of B chinense was the best medicinal part.
