Objective To observe the value of real-time shear wave elastography(SWE)combined with biochemical indicators for evaluating liver injury in patients with chronic kidney disease(CKD).Methods Totally 210 patients with C...Objective To observe the value of real-time shear wave elastography(SWE)combined with biochemical indicators for evaluating liver injury in patients with chronic kidney disease(CKD).Methods Totally 210 patients with CKD(CKD group)and 64 healthy subjects(control group)were retrospectively enrolled.Patients in CKD group were further divided into CKD1—5 subgroups according to CKD stages.SWE parameters of liver and kidney,including mean value,the maximum value and the median value of Young's modulus(EQI mean,EQI max and EQI med)were compared between CKD subgroups and control group.Spearman correlation analysis were performed to explore the correlations of liver and kidney SWE parameters with CKD stage,as well as of liver SWE parameters with biochemical indicators.Multivariate logistic regression analysis was used to screen independent predictors of liver injury in CKD patients.Receiver operating characteristic curves were drawn,the area under the curves(AUC)were calculated to evaluate the efficacy of the independent predictors alone and their combination for assessing liver injury in CKD patients.Results Significant differences of liver and kidney SWE parameters were found among CKD subgroups and control group(all P≤0.001).Pairwise comparison showed that liver SWE parameters in CKD5 subgroup and liver EQI max in CKD4 subgroup were all higher than those in control group(all P<0.003).Kidney SWE parameters in CKD3 subgroup were all higher than those in control group,while in CKD4 subgroup were all higher than those in control group and CKD1—3 subgroup(all P<0.003).Kidney EQI mean and EQI med in CKD5 subgroup were all higher than those in control group and CKD1—4 subgroup,while kidney EQI max in CKD5 subgroup were higher than those in control group and CKD1—3 subgroup(all P<0.003).Liver and kidney SWE parameters were lowly-moderately and positively correlated with CKD stages(r=0.364—0.665,all P<0.001).Liver SWE parameters of CKD were weakly and positively correlated with alkaline phosphatase(ALP)(r=0.229—0.248,all P<0.01).Theγ-glutamyl transferase,ALP and liver EQI max were all independent predictors of liver injury in CKD patients(all P<0.01),with AUC for evaluating liver injury in CKD patients alone of 0.645,0.756 and 0.741,respectively,lower than that of their combination(0.851,all P<0.01).Conclusion Real-time SWE combined with liver function indicators could reflect degree of liver injury in patients with different CKD stages.展开更多
Today, a new industry is born in the era of numerous industries rapidly developing. It represents environmental, none-pollution and clean. This is the new energy industry. Its birth is iconic. In a world where resourc...Today, a new industry is born in the era of numerous industries rapidly developing. It represents environmental, none-pollution and clean. This is the new energy industry. Its birth is iconic. In a world where resources are increasingly strained, exploitation and utilization of non-renewable resources cannot meet the demand for per capita and traditional energy consumption of resources with environmental pollution worsening. In the global environment today it is not sufficient. People have to develop new sources of energy to replace the past non-renewable energy. The new energies include： wind, solar, nuclear, geothermal energy, tidal energy and bio-energy.展开更多
The partial regularity of the weak heat flow of harmonic maps from a Riemannian manifold Al with boundary into general compact Riemannian manifold N without boundary is consid-ered. It is shown that the singular set S...The partial regularity of the weak heat flow of harmonic maps from a Riemannian manifold Al with boundary into general compact Riemannian manifold N without boundary is consid-ered. It is shown that the singular set Sing(u) of the weak heat flow satisfies H(Sing(u)) 0, with is = dimensionM. Here is Hausdorff measure with respect to parabolic metric ρ(x,t),(y,s)=max{|x-y|, }.展开更多
文摘Objective To observe the value of real-time shear wave elastography(SWE)combined with biochemical indicators for evaluating liver injury in patients with chronic kidney disease(CKD).Methods Totally 210 patients with CKD(CKD group)and 64 healthy subjects(control group)were retrospectively enrolled.Patients in CKD group were further divided into CKD1—5 subgroups according to CKD stages.SWE parameters of liver and kidney,including mean value,the maximum value and the median value of Young's modulus(EQI mean,EQI max and EQI med)were compared between CKD subgroups and control group.Spearman correlation analysis were performed to explore the correlations of liver and kidney SWE parameters with CKD stage,as well as of liver SWE parameters with biochemical indicators.Multivariate logistic regression analysis was used to screen independent predictors of liver injury in CKD patients.Receiver operating characteristic curves were drawn,the area under the curves(AUC)were calculated to evaluate the efficacy of the independent predictors alone and their combination for assessing liver injury in CKD patients.Results Significant differences of liver and kidney SWE parameters were found among CKD subgroups and control group(all P≤0.001).Pairwise comparison showed that liver SWE parameters in CKD5 subgroup and liver EQI max in CKD4 subgroup were all higher than those in control group(all P<0.003).Kidney SWE parameters in CKD3 subgroup were all higher than those in control group,while in CKD4 subgroup were all higher than those in control group and CKD1—3 subgroup(all P<0.003).Kidney EQI mean and EQI med in CKD5 subgroup were all higher than those in control group and CKD1—4 subgroup,while kidney EQI max in CKD5 subgroup were higher than those in control group and CKD1—3 subgroup(all P<0.003).Liver and kidney SWE parameters were lowly-moderately and positively correlated with CKD stages(r=0.364—0.665,all P<0.001).Liver SWE parameters of CKD were weakly and positively correlated with alkaline phosphatase(ALP)(r=0.229—0.248,all P<0.01).Theγ-glutamyl transferase,ALP and liver EQI max were all independent predictors of liver injury in CKD patients(all P<0.01),with AUC for evaluating liver injury in CKD patients alone of 0.645,0.756 and 0.741,respectively,lower than that of their combination(0.851,all P<0.01).Conclusion Real-time SWE combined with liver function indicators could reflect degree of liver injury in patients with different CKD stages.
文摘Today, a new industry is born in the era of numerous industries rapidly developing. It represents environmental, none-pollution and clean. This is the new energy industry. Its birth is iconic. In a world where resources are increasingly strained, exploitation and utilization of non-renewable resources cannot meet the demand for per capita and traditional energy consumption of resources with environmental pollution worsening. In the global environment today it is not sufficient. People have to develop new sources of energy to replace the past non-renewable energy. The new energies include： wind, solar, nuclear, geothermal energy, tidal energy and bio-energy.
基金the National Natural Science Foundation of China (No.10071013).
文摘The partial regularity of the weak heat flow of harmonic maps from a Riemannian manifold Al with boundary into general compact Riemannian manifold N without boundary is consid-ered. It is shown that the singular set Sing(u) of the weak heat flow satisfies H(Sing(u)) 0, with is = dimensionM. Here is Hausdorff measure with respect to parabolic metric ρ(x,t),(y,s)=max{|x-y|, }.
