The changes in the demographic profile of the population with longer life expectancy are mainly due to an improvement of lifestyle, prevention and care of chronic diseases, such as cardiovascular disease.
AIM:To evaluate the effects of ginger on gastric motility and emptying,abdominal symptoms,and hormones that influence motility in dyspepsia.METHODS:Eleven patients with functional dyspepsia were studied twice in a ran...AIM:To evaluate the effects of ginger on gastric motility and emptying,abdominal symptoms,and hormones that influence motility in dyspepsia.METHODS:Eleven patients with functional dyspepsia were studied twice in a randomized double-blind manner.After an 8-h fast,the patients ingested three capsules that contained ginger(total 1.2 g) or placebo,followed after 1 h by 500 mL low-nutrient soup.Antral area,fundus area and diameter,and the frequency of antral contractions were measured using ultrasound at frequent intervals,and the gastric half-emptying time was calculated from the change in antral area.Gastrointestinal sensations and appetite were scored using visual analog questionnaires,and blood was taken for measurement of plasma glucagon-like peptide-1(GLP-1),motilin and ghrelin concentrations,at intervals throughout the study.RESULTS:Gastric emptying was more rapid after ginger than placebo [median(range) half-emptying time 12.3(8.5-17.0) min after ginger,16.1(8.3-22.6) min after placebo,P ≤ 0.05].There was a trend for more antral contractions(P = 0.06),but fundus dimensions and gastrointestinal symptoms did not differ,nor did serum concentrations of GLP-1,motilin and ghrelin.CONCLUSION:Ginger stimulated gastric emptying and antral contractions in patients with functional dyspepsia,but had no impact on gastrointestinal symptoms or gut peptides.展开更多
Purpose： To evaluate midazolam sequential with dexmedetomidine for agitated patients undergoing weaning to implement light sedation in ICU. Methods： This randomized, prospective study was conducted in Tianjin Third ...Purpose： To evaluate midazolam sequential with dexmedetomidine for agitated patients undergoing weaning to implement light sedation in ICU. Methods： This randomized, prospective study was conducted in Tianjin Third Central Hospital, China. Using a sealed-envelope method, the patients were randomly divided into 2 groups （40 patients per group）. Each patient of group A received an initial loading dose of midazolam at 0.3 3 mg/kg-h 24 h before extubation, followed by an infusion of dexmedetomidine at a rate of 0.2-1 μg/kg-h until extubation. Each patient of group B received midazolam at a dose of 0.3 3 mg/kg.h until extubation. The dose of sedation was regulated according to PASS sedative scores maintaining in the range of-2-1. All patients were continuously monitored for 60 min after extubation. During the course, heart rate （HR）, mean artery pressure （MAP）, extubation time, adverse reactions, ICU stay, and hospital stay were observed and recorded continuously at the following time points： 24 h before extubation （T1）, 12 h before extubation （T2）, extubation （T3）, 30 rain after extubation （T4）, 60 min after extubation （TS）. Results： Both groups reached the goal of sedation needed for ICU patients. Dexmedetomidine was associated with a significant increase in extubation quality compared with midazolam, reflected in the prevalence of delirium after extubation （20% （8/40） vs 45% （18140））, respectively （p=0.017）. There were no clinically significant decreases in HR and MAP after infusing dexmedetomidine or midazolam. In the group A, HR was not significantly increased after extubation; however, in the group B, HR was significantly increased compared with the preextubation values （p 〈 0.05）. HR was significantly higher in the group B compared with the group A at 30 and 60 min after extubation （both, p 〈 0.05）. Compared with preextubation values, MAP was significantly increased at extubation in the group B （p 〈 0.05） and MAP was significantly higher at T3, T4, T5 in the group B than group A （p 〈 0.05）. There was a significant difference in extubation time （（3.0± 1.5） d vs （4.3 ± 2.2） d, p 〈 0.05）, ICU stay （（5.4 ± 2.1 ） d vs （8.0± 1.4） d, p 〈 0.05）, hospital stay （（10.1 ± 3.0） d vs （15.3 ± 2.6） d, p 〈 0.05） between group A and B. Conclusion： Midazolam sequential with dexmedetomidine can reach the goal of sedation for ICU agitated patients, meanwhile it can maintain the respiratory and circulation parameters and reduce adverse reactions.展开更多
OBJECTIVE: To evaluate the clinical effects of Xiyan-ping injection intervention in pediatric patients with mild hand foot and mouth disease(HFMD).METHODS: A total of 329 patients were stratified and block-randomized ...OBJECTIVE: To evaluate the clinical effects of Xiyan-ping injection intervention in pediatric patients with mild hand foot and mouth disease(HFMD).METHODS: A total of 329 patients were stratified and block-randomized for symptomatic treatment of HFMD and assigned to one of the following groups: Western Medicine(group A, n = 103), Xiyanping injection(group B, n = 109), or Xiyanping injection and symptomatic treatment using Western Medicine(group C, n = 117). During the trial, fever,rash, ulcers of the mouth were observed among participants in each group before and after treatment, and conversion rates from mild to severe HFMD were measured.RESULTS: After 3-7 days' treatment, no significant differences in the conversion rates from mild to severe HFMD were observed among the three groups(P > 0.05). There was a significantly low number of patients with the onset time of antifebrile effect,vanished time of hand and foot rashes and cumulative time for the ulcers in the mouth vanished,among the three groups(P < 0.05, P < 0.01). The onset time of antifebrile effect of patients in groups B and C were markedly shorter compared with those in group A(P < 0.05, P < 0.01); there was no statically significant difference observed between groups B and C(P > 0.05). No significant differences were observed in the time for body temperature recovery among the three groups(P > 0.05). There were no significant differences in adverse effects among the three groups(P > 0.05).CONCLUSION: Xiyanping injection together with use of Western Medicine is most effective for symptomatic treatment of mild HFMD. No severe adverse reactions were observed.展开更多
文摘The changes in the demographic profile of the population with longer life expectancy are mainly due to an improvement of lifestyle, prevention and care of chronic diseases, such as cardiovascular disease.
基金Supported by Grant from National Research Program from National Science Council (NMRP870071)
文摘AIM:To evaluate the effects of ginger on gastric motility and emptying,abdominal symptoms,and hormones that influence motility in dyspepsia.METHODS:Eleven patients with functional dyspepsia were studied twice in a randomized double-blind manner.After an 8-h fast,the patients ingested three capsules that contained ginger(total 1.2 g) or placebo,followed after 1 h by 500 mL low-nutrient soup.Antral area,fundus area and diameter,and the frequency of antral contractions were measured using ultrasound at frequent intervals,and the gastric half-emptying time was calculated from the change in antral area.Gastrointestinal sensations and appetite were scored using visual analog questionnaires,and blood was taken for measurement of plasma glucagon-like peptide-1(GLP-1),motilin and ghrelin concentrations,at intervals throughout the study.RESULTS:Gastric emptying was more rapid after ginger than placebo [median(range) half-emptying time 12.3(8.5-17.0) min after ginger,16.1(8.3-22.6) min after placebo,P ≤ 0.05].There was a trend for more antral contractions(P = 0.06),but fundus dimensions and gastrointestinal symptoms did not differ,nor did serum concentrations of GLP-1,motilin and ghrelin.CONCLUSION:Ginger stimulated gastric emptying and antral contractions in patients with functional dyspepsia,but had no impact on gastrointestinal symptoms or gut peptides.
文摘Purpose： To evaluate midazolam sequential with dexmedetomidine for agitated patients undergoing weaning to implement light sedation in ICU. Methods： This randomized, prospective study was conducted in Tianjin Third Central Hospital, China. Using a sealed-envelope method, the patients were randomly divided into 2 groups （40 patients per group）. Each patient of group A received an initial loading dose of midazolam at 0.3 3 mg/kg-h 24 h before extubation, followed by an infusion of dexmedetomidine at a rate of 0.2-1 μg/kg-h until extubation. Each patient of group B received midazolam at a dose of 0.3 3 mg/kg.h until extubation. The dose of sedation was regulated according to PASS sedative scores maintaining in the range of-2-1. All patients were continuously monitored for 60 min after extubation. During the course, heart rate （HR）, mean artery pressure （MAP）, extubation time, adverse reactions, ICU stay, and hospital stay were observed and recorded continuously at the following time points： 24 h before extubation （T1）, 12 h before extubation （T2）, extubation （T3）, 30 rain after extubation （T4）, 60 min after extubation （TS）. Results： Both groups reached the goal of sedation needed for ICU patients. Dexmedetomidine was associated with a significant increase in extubation quality compared with midazolam, reflected in the prevalence of delirium after extubation （20% （8/40） vs 45% （18140））, respectively （p=0.017）. There were no clinically significant decreases in HR and MAP after infusing dexmedetomidine or midazolam. In the group A, HR was not significantly increased after extubation; however, in the group B, HR was significantly increased compared with the preextubation values （p 〈 0.05）. HR was significantly higher in the group B compared with the group A at 30 and 60 min after extubation （both, p 〈 0.05）. Compared with preextubation values, MAP was significantly increased at extubation in the group B （p 〈 0.05） and MAP was significantly higher at T3, T4, T5 in the group B than group A （p 〈 0.05）. There was a significant difference in extubation time （（3.0± 1.5） d vs （4.3 ± 2.2） d, p 〈 0.05）, ICU stay （（5.4 ± 2.1 ） d vs （8.0± 1.4） d, p 〈 0.05）, hospital stay （（10.1 ± 3.0） d vs （15.3 ± 2.6） d, p 〈 0.05） between group A and B. Conclusion： Midazolam sequential with dexmedetomidine can reach the goal of sedation for ICU agitated patients, meanwhile it can maintain the respiratory and circulation parameters and reduce adverse reactions.
基金Supported by State Administration of Traditional Chinese Medicine(No.200907001)Natural Science Foundation of China(No.81603574)
文摘OBJECTIVE: To evaluate the clinical effects of Xiyan-ping injection intervention in pediatric patients with mild hand foot and mouth disease(HFMD).METHODS: A total of 329 patients were stratified and block-randomized for symptomatic treatment of HFMD and assigned to one of the following groups: Western Medicine(group A, n = 103), Xiyanping injection(group B, n = 109), or Xiyanping injection and symptomatic treatment using Western Medicine(group C, n = 117). During the trial, fever,rash, ulcers of the mouth were observed among participants in each group before and after treatment, and conversion rates from mild to severe HFMD were measured.RESULTS: After 3-7 days' treatment, no significant differences in the conversion rates from mild to severe HFMD were observed among the three groups(P > 0.05). There was a significantly low number of patients with the onset time of antifebrile effect,vanished time of hand and foot rashes and cumulative time for the ulcers in the mouth vanished,among the three groups(P < 0.05, P < 0.01). The onset time of antifebrile effect of patients in groups B and C were markedly shorter compared with those in group A(P < 0.05, P < 0.01); there was no statically significant difference observed between groups B and C(P > 0.05). No significant differences were observed in the time for body temperature recovery among the three groups(P > 0.05). There were no significant differences in adverse effects among the three groups(P > 0.05).CONCLUSION: Xiyanping injection together with use of Western Medicine is most effective for symptomatic treatment of mild HFMD. No severe adverse reactions were observed.
