米非司酮配伍或不配伍三苯氧胺治疗子宫肌瘤的临床观察

目的 :评价米非司酮配伍与不配伍三苯氧胺治疗子宫肌瘤的临床效果。方法 :将有症状的子宫肌瘤患者 10 0例随机分两组 ,每组 5 0例。A组 :口服米非司酮 10 mg,每日 1次 ,三苯氧胺 10 m g,每日 2次 ,连服 90 d;B组 :米非司酮 10 mg,每日 1次 ,连服 90 d。结果 :两组治疗后均闭经。两组治疗后经量减少 ,子宫肌瘤体积缩小。两组间有差异显著性 (P<0 .0 1) ,A组经量减少和子宫肌瘤的体积缩小明显。结论 :米非司酮配伍三苯氧胺是保守性治疗子宫肌瘤较为理想的方法。

长庆白豹油田注水井结垢的防治

长庆白豹油田剖16井区注水2年后注水压力上升,注水量减小。注入水为富含SO42-(0.171 g/L)和HCO3-(0.366 g/L)的洛河层水;生产层长4+5和长3地层水则富含Ba2+和Sr2+(1.69和2.19 g/L)及Ca2+、Mg2+。用X射线能谱法检测,储层岩心中不含Ba2+、Sr2+。50℃下实测,注入水、地层水均不结垢,混合水中注入水和地层水体积比由2/8增至8/2时,硫酸钡锶垢生成量由0.0831 g/L增至0.332 g/L,碳酸钙垢生成量由0.169、0.182 g/L减至0.040、0.000 g/L,总结垢量由0.252、0.265增至0.373、0.332 g/L。集输系统垢样表面主要元素经测定为Ba、Sr、O、S,用X射线衍射法测得主要垢成分为Ba0.75Sr0.25SO4。按行业标准筛选出的含磷复合防垢剂YHS-1,当加量为20 mg/L时对硫酸钡垢的防垢率达75%。从2005-09-03起,在剖16井区按20 mg/L加量在注入水中连续投加YHS-1,注水压力下降并趋于稳定,注水量上升并趋于稳定,油井生产平稳,未出现因结垢而检泵的情况。

水基压裂液伤害因素分析

由于低渗储层孔喉细小,渗透率低,物性差的特点,为了达到较好的开发效果,往往需要对储层进行改造。目前主要以水力压裂方式为主。但采用水力压裂在改造储层的时候,压裂液也对储层造成一定的伤害。本文对低渗储层水基压裂液伤害的因素进行分析。结果显示,水基压裂液对低渗储层伤害的主要方式为水锁伤害、水敏伤害、残渣造成的伤害、不配伍造成的伤害、吸附滞留伤害、乳化伤害。

Compatible stability study of Xing NaoJing injection based on physical-chemical properties analysis

Objective:The clinical treatment of brain diseases is urgent. Xingnaojing (XNJ) injection is often used in combination with other injection drugs. Due to the possible interaction between the injections in vivo, the particle size, osmotic pressure, pH value change and component stability decrease, that is one of the important factors causing various adverse reactions. Based on the above situation, this study investigated the physical properties and chemical composition changes of XNJ injection and its compatibility solvent and 13 kinds of clinical injection, speculated the possible interactions between the drugs in vivo from the perspective of in vitro compatibility stability, find out the safety risks of adverse reactions and provide guidance for the safe and rational use of XNJ injection. Methods:According to the clinical application, XNJ injection was mixed with 13 combination injections based on 250 mL 5% glucose injection, and placed at room temperature for 6 h. Then, the clarity, particle size, pH, osmolality, and the contents of camphor, d-borneol, and muscone of the compatible solutions were detected at 0, 1, 2, 4, and 6 h, respectively. Results:The results showed that the physical-chemical properties of compatibility solution were slightly influenced when XNJ was combined with Alprostadil injection and Danhong injection. The change of particle size and the degradation of muscone content were the main factors affecting the compatibility stability of XNJ injection, indicating that there are some problems in compatibility stability, which may be one of the causes of clinical adverse reactions. Conclusion:This study suggests that XNJ injection in combination with other injections during intravenous administration should be performed cautiously.