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49AISNP:东亚北方三个族群遗传来源推断 被引量:3
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作者 郭晓媛 孙昌春 +3 位作者 薛思瑶 赵慧 江丽 李彩霞 《遗传》 CAS CSCD 北大核心 2021年第9期880-889,I0002-I0009,共18页
样本的族群来源推断在法医调查中可发挥重要作用,一个理想的推断体系是用一组较少的遗传标记实现较高的族群推断准确性。本研究调研搜集了区分东亚北方三个族群北方汉族、日本人和韩国人的428个祖先信息SNP(ancestry informative SNP,AI... 样本的族群来源推断在法医调查中可发挥重要作用,一个理想的推断体系是用一组较少的遗传标记实现较高的族群推断准确性。本研究调研搜集了区分东亚北方三个族群北方汉族、日本人和韩国人的428个祖先信息SNP(ancestry informative SNP,AISNP),获取了其在三个族群307份样本中的分型,通过位点Fst值及等位基因频率聚类等信息进一步精简位点,最终得到了一组49AISNP组合。基于307份样本利用留一法对49AISNP进行推断准确性验证,结果表明其在北方汉族、日本和韩国族群中的推断准确性均高于99%。49AISNP组合将有助于东亚地区亚族群的进一步区分。 展开更多
关键词 法医遗传学 祖先信息SNP 族群推断 FST 东亚北方族群
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古DNA解析东亚南北方人群的迁徙与演化历史
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作者 平婉菁 薛家旸 付巧妹 《遗传》 北大核心 2025年第1期18-33,共16页
过去10余年里,古基因组学技术和研究不断发展,极大提高了学界和公众对人类演化历史的理解和认识。2017年起,东亚,特别是中国地区早期人类古基因组研究大规模开展,使得东亚不同时间和地点人类古基因组数据得以大量涌现,为东亚数万年来人... 过去10余年里,古基因组学技术和研究不断发展,极大提高了学界和公众对人类演化历史的理解和认识。2017年起,东亚,特别是中国地区早期人类古基因组研究大规模开展,使得东亚不同时间和地点人类古基因组数据得以大量涌现,为东亚数万年来人群演化历史带来许多全新的认识。特别是2022年以来,中国南北方万年内古人群基因组研究成果大量涌现,为揭示东亚不同区域人群之间的迁徙扩散与互动交流历史带来诸多新证据,但目前尚无针对东亚地区该时段古人群基因组研究最新进展的系统性综述。因此,本文以中国地区古人群基因组研究为重点,系统梳理了东亚地区自旧石器时代晚期以来人群的遗传格局和迁移交流历史。综合现有研究表明,东亚古人群早在1.9万年前已经发生南北分化,形成不同的人群谱系,并从新石器时代早期开始发生双向的基因交流与互动;新石器时代中期,这种互动出现强化趋势;到历史时期,以东亚北方人群相关祖源成分对南方地区古人群影响更为显著,形成现今中国人群的遗传结构。在这一过程中,中国南北方古人群通过沿海和内陆通道与西伯利亚、日韩、东南亚、太平洋岛屿等其他周边地区古人群发生广泛的互动交流,对不同语系人群的形成发挥了重要作用。这些研究揭示出东亚万年以来人群遗传演化与交流融合的历史脉络,但仍留有许多尚未解决的谜团,有待更多时间段和更广泛区域范围的古人群样本基因组数据得以展开更加全面和细致的探索研究,推动相关科学问题进一步突破。 展开更多
关键词 古基因组 东亚南方人群 东亚北方人群 二层假说 基因交流
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东亚三族群SNP高分辨推断模型构建与效能评估 被引量:3
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作者 文豪 魏以梁 +5 位作者 郭晓媛 孙昌春 薛思瑶 刘京 范虹 江丽 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2021年第8期973-981,共9页
单核苷酸多态性(single nucleotide polymorphism,SNP)是法医遗传学个体识别和族群推断常用的遗传标记.本研究集合文献和公共库中祖先信息SNP位点(ancestry informative SNPs,AISNPs),应用softmax回归、支持向量机和随机森林3种算法,研... 单核苷酸多态性(single nucleotide polymorphism,SNP)是法医遗传学个体识别和族群推断常用的遗传标记.本研究集合文献和公共库中祖先信息SNP位点(ancestry informative SNPs,AISNPs),应用softmax回归、支持向量机和随机森林3种算法,研究东亚北方的3个主体人群(中国北方汉族人、日本人和韩国人)的族群推断效果.我们分析了来自千人基因组计划的103份中国北方汉族人样本、104份日本人样本和亚洲多样性计划的100份韩国人样本的428个AISNP位点分型,采用多元线性回归共线性诊断筛选出67个高信息量的AISNPs位点组合,构建了softmax回归和支持向量机算法的两种族群推断模型,采用随机森林平均降准分析筛选出42个高信息量的AISNPs位点组合,并构建了随机森林算法的族群推断模型,将softmax回归、支持向量机与随机森林3种模型用于北方汉族人、日本人、韩国人的族群推断,五次十折交叉验证(training∶testing=9∶1)测试3种模型的平均准确率分别为95.19%、95.77%、94.53%.本研究建立的3种族群推断模型均可用于东亚北方三大人群的遗传推断,42 AISNPs组合的位点数目较少,更适于构建法医检测体系,具有较高的实际应用价值. 展开更多
关键词 法医遗传学 祖源SNP 东亚北方 softmax回归 支持向量机 随机森林
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Formation Mechanism for the Anomalous Anticyclonic Circulation over Northeast Asia and the Japan Sea in Boreal Winter 1997/98 and the Spring of 1998 被引量:4
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作者 WANG Hai LIU Qinyu ZHENG Jian 《Journal of Ocean University of China》 SCIE CAS 2013年第2期312-317,共6页
A robust anomalous anticyclonic circulation (AAC) was observed over Northeast Asia and the Japan Sea in boreal win-ter 1997/98 and over the Japan Sea in spring 1998. The formation mechanism is investigated. On the bac... A robust anomalous anticyclonic circulation (AAC) was observed over Northeast Asia and the Japan Sea in boreal win-ter 1997/98 and over the Japan Sea in spring 1998. The formation mechanism is investigated. On the background of the vertically sheared winter monsoonal flow, anomalous rainfall in the tropical Indo-Western Pacific warm pool excited a wave train towards East Asia in the upper troposphere during boreal winter of 1997/98. The AAC over Northeast Asia and the Japan Sea is part of the wave train of equivalent barotropic structure. The AAC over the Japan Sea persisted from winter to spring and even intensified in spring 1998. The diagnostic calculations show that the vorticity and temperature fluxes by synoptic eddies are an important mechanism for the AAC over the Japan Sea in spring 1998. 展开更多
关键词 anomalous anticyclonic circulation Northeast Asia Japan Sea wave train synoptic eddy
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The Second Decadal Leading Mode of East Asian Summer Monsoon Rainfall 被引量:1
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作者 BAO Qing YU Pei 《Atmospheric and Oceanic Science Letters》 CSCD 2014年第5期417-421,共5页
The first decadal leading mode of East Asian summer rainfall(EASR) is characterized by rainfall anomalies along the East Asian subtropical rain belt. This study focuses on the second decadal leading mode(2DLM), accoun... The first decadal leading mode of East Asian summer rainfall(EASR) is characterized by rainfall anomalies along the East Asian subtropical rain belt. This study focuses on the second decadal leading mode(2DLM), accounting for 17.3% of rainfall decadal variance, as distinct from the other two neighboring modes of EAMR, based on the state-of-the-art in-situ rainfall data.This mode is characterized by a South-China-wet–HuaiheRiver-dry pattern, and is dominated by a quasi-30-yr period. Further analysis reveals the 2DLM corresponds to an enhanced lower-level monsoon jet, an eastward extension of the western North Pacific subtropical high, and a weakened East Asian upper-level westerly jet flow. The Tibetan Plateau surface temperature and Pacific Decadal Oscillation(PDO) are closely linked with the 2DLM. The regressed SST pattern indicates the PDO-like pattern of sea surface temperature anomalies may have a teleconnection relationship with the 2DLM of EASR. 展开更多
关键词 decadal leading mode East Asian summermonsoon Tibetan Plateau Pacific Decadal Oscillation
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A climatological northern boundary index for the East Asian summer monsoon and its interannual variability 被引量:17
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作者 CHEN Jie HUANG Wei +3 位作者 JIN LiYa CHEN JianHui CHEN ShengQian CHEN FaHu 《Science China Earth Sciences》 SCIE EI CAS CSCD 2018年第1期13-22,共10页
A long-term perspective on the spatial variation of the northern boundary of the East Asian summer monsoon(EASM) and the related physical mechanisms is important for understanding past climate change in Asia and for p... A long-term perspective on the spatial variation of the northern boundary of the East Asian summer monsoon(EASM) and the related physical mechanisms is important for understanding past climate change in Asia and for predicting future changes. However, most of the meteorological definitions of the EASM northern boundary do not correspond well to the actual geographical environment, which is problematic for paleoclimatic research. Here, we use monthly CMAP and GPCP precipitation data to define a new EASM northern boundary index by using the concept of the global monsoon, which is readily applicable to paleoclimatic research. The results show that the distribution of the 2 mm day^(-1) precipitation isoline(i.e., 300 mm precipitation)has a good relationship with the spatial distribution of modern land cover types, the transitional climate zone and the potential natural vegetation types, in China. The locations of the precipitation isolines also correspond well to the locations of major shifts in wind direction. These results suggest that the 2 mm day^(-1) isoline has a clear physical significance since the climatic, ecological,and geographical boundary can be used as the northern boundary index of the EASM(which we call the climatological northern boundary index). The index depicts the northeast-southwest orientation of the climatological(1981-2010) EASM northern boundary, along the eastern part of the Qilian Mountains-southern foothills of the Helan Mountains-Daqing Mountains-western margin of the Greater Khingan Range, from west to east across Northwest and Northeast China. The interannual change of the EASM northern boundary from 1980 to 2015 covers the central part of Gansu, the northern part of Ningxia, the eastern part of Inner Mongolia and the northeastern region in China. It can extend northward to the border between China and Mongolia and retreat southward to Shangdong-central Henan. There is a 200-700 km fluctuation range of the interannual EASM northern boundaries around the locations of the climatological northern boundary. In addition, the spatial variation of the interannual EASM northern boundaries gradually increases from west to east, whereas the trend of north-south fluctuations maintains a roughly consistent location in different regions. 展开更多
关键词 East Asian summer monsoon Climatological northern boundary index Interannual change Spatial fluctuations
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