To study the clinical therapeutic e ffect of anisodamine on respiratory function after severe brain injury. Methods: Ninety patients with respiratory dysfunction following severe brain injury were divided into two gro...To study the clinical therapeutic e ffect of anisodamine on respiratory function after severe brain injury. Methods: Ninety patients with respiratory dysfunction following severe brain injury were divided into two groups: a treatment group (n=45, trea ted with routine therapy plus anisodamine) and a control group (n=45, treated wi th routine therapy only). The pulmonary ventilation function and oxygenation fun ction were compared between the two groups. Results: In the treatment group, 12 hours after treatment the r espiratory rate reduced, the partial pressure of carbon dioxide (PCO 2), the pa rtial pressure of oxygen in arterial blood (PaO 2) and oxygenation exponent inc reased, the dead space ventilation dose and the pulmonary alveolus partial pres sure of arterial oxygen difference decreased, and the ventilation function of th e respiratory tract and pulmonary oxygenation function improved. There was a sig nificant difference between the two groups (P< 0.01 ). N o side effect was found except a slight increase of intracranial pressure and h eart rate. Conclusions: Anisodamine can improve pulmonary ventilation func tion and oxygenation function and decrease the incidence of hypoxemia markedly. It is effective in treating respiratory dysfunction after severe brain injury.展开更多
文摘To study the clinical therapeutic e ffect of anisodamine on respiratory function after severe brain injury. Methods: Ninety patients with respiratory dysfunction following severe brain injury were divided into two groups: a treatment group (n=45, trea ted with routine therapy plus anisodamine) and a control group (n=45, treated wi th routine therapy only). The pulmonary ventilation function and oxygenation fun ction were compared between the two groups. Results: In the treatment group, 12 hours after treatment the r espiratory rate reduced, the partial pressure of carbon dioxide (PCO 2), the pa rtial pressure of oxygen in arterial blood (PaO 2) and oxygenation exponent inc reased, the dead space ventilation dose and the pulmonary alveolus partial pres sure of arterial oxygen difference decreased, and the ventilation function of th e respiratory tract and pulmonary oxygenation function improved. There was a sig nificant difference between the two groups (P< 0.01 ). N o side effect was found except a slight increase of intracranial pressure and h eart rate. Conclusions: Anisodamine can improve pulmonary ventilation func tion and oxygenation function and decrease the incidence of hypoxemia markedly. It is effective in treating respiratory dysfunction after severe brain injury.
